公开(公告)号：US20170176424A1

公开(公告)日：2017-06-22

申请号：US15244484

申请日：2016-08-23

Applicant: International Business Machines Corporation

Inventor： Yann Astier ,  Huan Hu ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt

IPC: G01N33/543 ,  G01N21/64 ,  G01N15/14 ,  B01L3/00

CPC classification number: H01L31/173 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/12 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/6428 ,  G01N33/54306 ,  G01N33/54373 ,  G01N2015/0065 ,  G01N2201/062 ,  H01L27/156 ,  H01L31/02164 ,  H01L31/035227 ,  H01L31/105 ,  H01L31/125 ,  H01L31/167 ,  H01L31/18 ,  H01L33/0012 ,  H01L33/18 ,  H01L33/20 ,  H01L33/58

Abstract: In one example, a device includes a trench formed in a substrate. The trench includes a first end and a second end that are non-collinear. A first plurality of semiconductor pillars is positioned near the first end of the trench and includes integrated light sources. A second plurality of semiconductor pillars is positioned near the second end of the trench and includes integrated photodetectors.

公开(公告)号：US20170160195A1

公开(公告)日：2017-06-08

申请号：US15264360

申请日：2016-09-13

Applicant: International Business Machines Corporation

Inventor： Ning Li ,  Devendra K. Sadana ,  William T. Spratt

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N2021/6463 ,  G01N2021/6484 ,  G01N2201/08

Abstract: A fluorescence detection system is provided. The fluorescence detection system includes a light source adapted to emit excitation light; a sample unit in which a sample is disposed; a first optical fiber adapted to connect the light source to the sample unit; an avalanche photodiode array detector adapted to receive fluorescent light generated by the sample when the sample is irradiated with the excitation light; and a second optical fiber adapted to connect the sample unit to the avalanche photodiode array detector, wherein the second optical fiber has a numerical aperture of equal to or greater than about 0.15 and the second optical fiber is positioned such that a longitudinal axis of the second optical fiber is orthogonal to a longitudinal axis of the first optical fiber. A method for detecting fluorescence and a computer-implemented method for detecting fluorescence are also provided.

公开(公告)号：US09559240B1

公开(公告)日：2017-01-31

申请号：US14972996

申请日：2015-12-17

Applicant: International Business Machines Corporation

Inventor： Yann Astier ,  Huan Hu ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt

IPC: H01L31/12 ,  H01L31/18 ,  H01L33/58 ,  H01L33/20

CPC classification number: H01L31/173 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/12 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/6428 ,  G01N33/54306 ,  G01N33/54373 ,  G01N2015/0065 ,  G01N2201/062 ,  H01L27/156 ,  H01L31/02164 ,  H01L31/035227 ,  H01L31/105 ,  H01L31/125 ,  H01L31/167 ,  H01L31/18 ,  H01L33/0012 ,  H01L33/18 ,  H01L33/20 ,  H01L33/58

Abstract: In one example, a device includes a trench formed in a substrate. The trench includes a first end and a second end that are non-collinear. A first plurality of semiconductor pillars is positioned near the first end of the trench and includes integrated light sources. A second plurality of semiconductor pillars is positioned near the second end of the trench and includes integrated photodetectors.

Abstract translation: 在一个示例中，器件包括形成在衬底中的沟槽。 沟槽包括非共线的第一端和第二端。 第一多个半导体柱位于沟槽的第一端附近并且包括集成的光源。 第二多个半导体柱位于沟槽的第二端附近，并且包括集成的光电检测器。

公开(公告)号：US09518923B1

公开(公告)日：2016-12-13

申请号：US14960667

申请日：2015-12-07

Applicant: International Business Machines Corporation

Inventor： Ning Li ,  Devendra K. Sadana ,  William T. Spratt

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N2021/6463 ,  G01N2021/6484 ,  G01N2201/08

Abstract: A fluorescence detection system is provided. The fluorescence detection system includes a light source adapted to emit excitation light; a sample unit in which a sample is disposed; a first optical fiber adapted to connect the light source to the sample unit; an avalanche photodiode array detector adapted to receive fluorescent light generated by the sample when the sample is irradiated with the excitation light; and a second optical fiber adapted to connect the sample unit to the avalanche photodiode array detector, wherein the second optical fiber has a numerical aperture of equal to or greater than about 0.15 and the second optical fiber is positioned such that a longitudinal axis of the second optical fiber is orthogonal to a longitudinal axis of the first optical fiber. A method for detecting fluorescence and a computer-implemented method for detecting fluorescence are also provided.

Abstract translation: 提供荧光检测系统。 荧光检测系统包括适于发射激发光的光源; 其中设置样品的样品单元; 适于将光源连接到样品单元的第一光纤; 雪崩光电二极管阵列检测器，其适于在用所述激发光照射所述样品时接收由所述样品产生的荧光; 以及第二光纤，其适于将所述采样单元连接到所述雪崩光电二极管阵列检测器，其中所述第二光纤具有等于或大于约0.15的数值孔径，并且所述第二光纤被定位成使得所述第二光纤的纵向轴线 光纤与第一光纤的纵向轴线正交。 还提供了用于检测荧光的方法和用于检测荧光的计算机实现的方法。

公开(公告)号：US09513220B1

公开(公告)日：2016-12-06

申请号：US14982740

申请日：2015-12-29

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Yann Astier ,  Stephen W. Bedell ,  Ning Li ,  Devendra K. Sadana ,  William T. Spratt ,  Chao Wang

IPC: G01N21/64 ,  H01L31/0216 ,  H01L31/0232

CPC classification number: G01N21/6428 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/168 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/05 ,  G01N21/645 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  H01L25/167 ,  H01L31/02162 ,  H01L31/02164 ,  H01L31/02322 ,  H01L31/03044 ,  H01L31/036 ,  H01L31/1856

Abstract: A semiconductor device used for fluorescent-based molecule detection and a method for manufacturing the same are provided. The semiconductor device has a fluid channel layer defining a fluid channel through which a sample stream flows. A target cell coupled with a fluorescent source is contained by the sample stream. The semiconductor device also has an excitation light source for generating excitation light that reaches the target cell coupled with the fluorescent source to generate fluorescent light. The semiconductor device also has a light filter layer for permitting the fluorescent light to pass through and to block the excitation light and a light detection layer for detecting the fluorescent light. The functional components of the device are highly integrated. Leakage of the excitation light and background noise into the light detection component can be minimized to improve the quality of detection.

Abstract translation: 提供了一种用于荧光基分子检测的半导体器件及其制造方法。 半导体器件具有限定流体通道的流体通道层，样品流通过该流体通道流动。 与荧光源耦合的靶细胞被样品流包含。 半导体器件还具有用于产生到与荧光源耦合的目标单元产生荧光的激发光的激发光源。 半导体器件还具有用于允许荧光通过并阻挡激发光的滤光层和用于检测荧光的光检测层。 设备的功能组件高度集成。 将激发光和背景噪声泄漏到光检测部件中可以最小化以提高检测质量。