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    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
    22.
    发明授权
    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress 有权
    使用具有抗氧化性能的碳纳米材料来治疗氧化应激

    公开(公告)号：US09572834B2

    公开(公告)日：2017-02-21

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K31/335 ,  A61K9/00 ,  A61K38/00 ,  A61K47/00 ,  A61K33/44 ,  B82Y5/00 ,  A61K45/06 ,  A61K47/48 ,  A61K31/713

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS
    23.
    发明申请
    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS 有权
    使用碳纳米微粒与抗氧化性能来处理氧化应激

    公开(公告)号：US20140120081A1

    公开(公告)日：2014-05-01

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K33/44 ,  A61K45/06 ,  A61K47/48

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    Solvent-based methods for production of graphene nanoribbons
    24.
    发明授权
    Solvent-based methods for production of graphene nanoribbons 有权
    用于生产石墨烯纳米带的基于溶剂的方法

    公开(公告)号：US09493355B2

    公开(公告)日：2016-11-15

    申请号：US14345016

    申请日：2012-09-14

    申请人： James M. Tour ,  Wei Lu ,  Bostjan Genorio

    发明人： James M. Tour ,  Wei Lu ,  Bostjan Genorio

    IPC分类号： C01B31/02 ,  C07C29/32 ,  C08F112/08 ,  C01B31/04

    CPC分类号： C08F112/08 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B32/178 ,  C01B32/18 ,  C01B32/184 ,  C01B32/194 ,  C01B2202/06 ,  C01B2204/06 ,  C07C2/76 ,  C07C15/56 ,  C07C29/32 ,  C07C67/035 ,  C07C69/76 ,  D01F9/12 ,  Y10S977/734 ,  Y10S977/846 ,  Y10S977/961

    摘要： The present invention provides methods of preparing functionalized graphene nanoribbons. Such methods include: (1) exposing a plurality of carbon nanotubes (CNTs) to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to an electrophile to form functionalized graphene nanoribbons (GNRs). The methods may also include a step of exposing the opened CNTs to a protic solvent to quench any reactive species on them. Additional methods include preparing unfunctionalized GNRs by: (1) exposing a plurality of CNTs to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to a protic solvent to form unfunctionalized GNRs.

    摘要翻译： 本发明提供了制备官能化石墨烯纳米带的方法。 这些方法包括：（1）在非质子溶剂的存在下将多个碳纳米管（CNT）暴露于碱金属源以将其打开; 和（2）将开放的CNT暴露于亲电子试剂以形成官能化的石墨烯纳米带（GNR）。 所述方法还可以包括将开放的CNT暴露于质子溶剂以淬灭其上的任何反应性物质的步骤。 另外的方法包括：通过以下步骤制备未官能化的GNR：（1）在非质子溶剂存在下将多个CNT暴露于碱金属源以打开它们; 和（2）将开放的CNT暴露于质子溶剂以形成未官能化的GNR。

    Fabrication of graphene nanoribbons and nanowires using a meniscus as an etch mask
    25.
    发明授权
    Fabrication of graphene nanoribbons and nanowires using a meniscus as an etch mask 有权
    使用弯月面作为蚀刻掩模制造石墨烯纳米带和纳米线

    公开(公告)号：US09356151B2

    公开(公告)日：2016-05-31

    申请号：US14171642

    申请日：2014-02-03

    申请人： James M. Tour ,  Vera Abramova ,  Alexander Slesarev

    发明人： James M. Tour ,  Vera Abramova ,  Alexander Slesarev

    IPC分类号： H01L21/44 ,  H01L29/786 ,  C01B31/04 ,  H01L21/3065 ,  H01L21/311 ,  H01L21/3213 ,  H01L29/66 ,  B82Y40/00

    CPC分类号： H01L29/78684 ,  B82Y40/00 ,  C01B32/182 ,  C01B32/194 ,  H01L21/3065 ,  H01L21/31116 ,  H01L21/32131 ,  H01L29/66742 ,  H01L29/78606 ,  H01L29/78696

    摘要： In some embodiments, the present disclosure pertains to methods of preparing graphene nanoribbons from a graphene film associated with a meniscus, where the method comprises patterning the graphene film while the meniscus acts as a mask above a region of the graphene film, and where the patterning results in formation of graphene nanoribbons from the meniscus-masked region of the graphene film. Additional embodiments of the present disclosure pertain to methods of preparing wires from a film associated with a meniscus, where the method comprises patterning the film while the meniscus acts as a mask above a region of the film, and where the patterning results in formation of a wire from the meniscus-masked region of the film. Additional embodiments of the present disclosure pertain to chemical methods of preparing wires from water-reactive materials.

    摘要翻译： 在一些实施方案中，本公开涉及从与弯液面相关联的石墨烯膜制备石墨烯纳米带的方法，其中所述方法包括图案化所述石墨烯膜，同时所述弯液面用作所述石墨烯膜的区域上方的掩模，并且其中所述图案化 导致从石墨烯膜的弯液面掩蔽区域形成石墨烯纳米带。 本公开的另外的实施例涉及从与弯液面相关联的膜制备线的方法，其中所述方法包括图案化所述膜，同时所述弯月面用作所述膜的区域上方的掩模，并且其中所述图案化导致形成 电线从弯月面掩盖的区域。 本公开的另外的实施方案涉及从水反应性材料制备电线的化学方法。

    REBAR HYBRID MATERIALS AND METHODS OF MAKING THE SAME
    27.
    发明申请
    REBAR HYBRID MATERIALS AND METHODS OF MAKING THE SAME 有权
    REBAR混合材料及其制备方法

    公开(公告)号：US20150023858A1

    公开(公告)日：2015-01-22

    申请号：US14335566

    申请日：2014-07-18

    申请人： James M. Tour ,  Zheng Yan ,  Zhiwei Peng ,  Robert H. Hauge ,  Yilun Li

    发明人： James M. Tour ,  Zheng Yan ,  Zhiwei Peng ,  Robert H. Hauge ,  Yilun Li

    IPC分类号： C01B31/36 ,  B29C39/00 ,  H01B1/04 ,  C01B31/04 ,  C01B31/02

    CPC分类号： C01B32/956 ,  B29C39/003 ,  B29K2105/124 ,  B29K2995/0005 ,  B29L2007/00 ,  C01B21/064 ,  C01B32/178 ,  C01B32/18 ,  C01B32/184 ,  C01B32/186 ,  C01P2004/13

    摘要： In some embodiments, the present disclosure pertains to methods of forming a reinforcing material by: (1) depositing a first material onto a catalyst surface; and (2) forming a second material on the catalyst surface, where the second material is derived from and associated with the first material. In some embodiments, the first material includes, without limitation, carbon nanotubes, graphene nanoribbons, boron nitride nanotubes, chalcogenide nanotubes, carbon onions, and combinations thereof. In some embodiments, the formed second material includes, without limitation, graphene, hexagonal boron nitride, chalcogenides, and combinations thereof. In additional embodiments, the methods of the present disclosure also include a step of separating the formed reinforcing material from the catalyst surface, and transferring the separated reinforcing material onto a substrate without the use of polymers. Additional embodiments of the present disclosure pertain to reinforcing materials formed by the aforementioned methods.

    摘要翻译： 在一些实施方案中，本公开涉及通过以下步骤形成增强材料的方法：（1）将第一材料沉积到催化剂表面上; 和（2）在所述催化剂表面上形成第二材料，其中所述第二材料衍生并与所述第一材料相关联。 在一些实施方案中，第一材料包括但不限于碳纳米管，石墨烯纳米带，氮化硼纳米管，硫族化物纳米管，碳鎓和它们的组合。 在一些实施例中，所形成的第二材料包括但不限于石墨烯，六方氮化硼，硫族化合物及其组合。 在另外的实施方案中，本公开的方法还包括将形成的增强材料从催化剂表面分离并将分离的增强材料转移到基材上而不使用聚合物的步骤。 本公开的另外的实施方案涉及通过上述方法形成的增强材料。

    COMPOSITE MATERIALS FOR REVERSIBLE CO2 CAPTURE
    28.
    发明申请
    COMPOSITE MATERIALS FOR REVERSIBLE CO2 CAPTURE 有权
    用于可逆二氧化碳捕获的复合材料

    公开(公告)号：US20140076158A1

    公开(公告)日：2014-03-20

    申请号：US13881428

    申请日：2011-10-25

    申请人： James M. Tour ,  Garry Chih-Chau Hwang ,  Jay R. Lomeda

    发明人： James M. Tour ,  Garry Chih-Chau Hwang ,  Jay R. Lomeda

    IPC分类号： B01D53/04 ,  B01J20/26

    CPC分类号： B01D53/04 ,  B01D53/02 ,  B01D2253/102 ,  B01D2253/202 ,  B01D2253/25 ,  B01D2257/504 ,  B01J20/20 ,  B01J20/261 ,  B01J20/262 ,  B01J20/28069 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/46 ,  Y02C10/08

    摘要： Composite materials for carbon dioxide (C02) capture that include: (1) a mesoporous carbon source; and (2) an in situ polymerized polymer that is associated with the mesoporous carbon source, where the in situ polymerized polymer is selected from the group consisting of thiol-based polymers, amine-based polymers, and combinations thereof. Methods of making the composite materials for C02 capture include: (1) associating a mesoporous carbon source with monomers, where the monomers are selected from the group consisting of thiol-based monomers, amine-based monomers, and combinations thereof; and (2) polymerizing the monomers in situ to form said composite materials. Further embodiments of the present invention pertain to methods of capturing C02 from an environment by associating the environment with one or more of the aforementioned composite materials.

    摘要翻译： 用于二氧化碳（CO 2）捕获的复合材料包括：（1）介孔碳源; 和（2）与介孔碳源相关联的原位聚合的聚合物，其中原位聚合的聚合物选自硫醇基聚合物，胺基聚合物及其组合。 制备用于CO 2捕获的复合材料的方法包括：（1）将介孔碳源与单体缔合，其中单体选自硫醇基单体，胺基单体及其组合; 和（2）原位聚合单体以形成所述复合材料。 本发明的其它实施方案涉及通过将环境与一种或多种上述复合材料相关联来从环境捕获CO 2的方法。