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公开(公告)号：US08478402B2
公开(公告)日：2013-07-02
申请号：US12263346
申请日：2008-10-31
IPC分类号： A61N1/00
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译： 公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调节直流电流信号的信号发生器装置，用于调制可调直流电信号以产生调制信号的调制器，用于传播的至少一个电极 跨越心肌的调制信号，用于检测来自心肌的输出的调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。 所述至少一个电路包括放大器，解调器和积分器。 最终输出的调制信号的振幅和相位表示心肌的复阻抗。 心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。 该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。
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公开(公告)号：US08352030B2
公开(公告)日：2013-01-08
申请号：US13182276
申请日：2011-07-13
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： A61N1/362
CPC分类号： G01D5/24
摘要： A capacitive interface circuit for a low power system is described. The capacitive interface circuit is configured to achieve very low noise sensing of capacitance-based transducers, such as a micro-electro-mechanical system (MEMS)-based sensor, with high resolution and low power. The capacitive interface circuit uses a differential amplifier and correlated triple sampling (CTS) to substantially eliminate, or at least reduce, kT/C noise, as well as amplifier offset and flicker (1/f) noise, from the output of the amplifier. The capacitive interface circuit may further include an output stage that reduces glitching, i.e., clock transients, in the output signal by allowing transients in the amplifier output to settle. In this manner, the circuit can be used in a low power system to produce a stable, low-noise output.
摘要翻译： 描述了用于低功率系统的电容接口电路。 电容接口电路被配置为实现基于电容的换能器的非常低的噪声感测，例如具有高分辨率和低功率的基于微机电系统（MEMS）的传感器。 电容接口电路使用差分放大器和相关三倍采样（CTS）从放大器的输出基本上消除或至少降低kT / C噪声以及放大器偏移和闪烁（1 / f）噪声。 电容接口电路还可以包括通过允许放大器输出中的瞬变稳定来减少输出信号中的时钟瞬变的输出级。 以这种方式，电路可以用在低功率系统中以产生稳定的低噪声输出。
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公开(公告)号：US08290596B2
公开(公告)日：2012-10-16
申请号：US12238025
申请日：2008-09-25
IPC分类号： A61N1/36
CPC分类号： A61N1/36542 , A61N1/36132 , A61N1/36135 , A61N1/37 , G06F19/00 , G06F19/3481
摘要： A therapy program is selected based on a patient state, where the patient state comprises at least one of a movement state, sleep state or speech state. In this way, therapy delivery is tailored to the patient state, which may include specific patient symptoms. The therapy program is selected from a plurality of stored therapy programs that comprise therapy programs associated with a respective one at least two of the movement, sleep, and speech states. Techniques for determining a patient state include receiving volitional patient input or detecting biosignals generated within the patient's brain. The biosignals are nonsymptomatic and may be incidental to the movement, sleep, and speech states or generated in response to volitional patient input.
摘要翻译： 基于患者状态选择治疗程序，其中患者状态包括运动状态，睡眠状态或语音状态中的至少一个。 以这种方式，治疗递送是针对患者状态而定制的，其可以包括特定的患者症状。 治疗程序选自包括与运动，睡眠和言语状态中的至少两个相关的治疗程序的多个存储的治疗程序。 用于确定患者状态的技术包括接收患者输入或检测患者大脑内生成的生物信号。 生物信号是无症状的，可能与运动，睡眠和言语状态有关，或者是响应于患者输入的意图产生的。
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公开(公告)号：US08192398B2
公开(公告)日：2012-06-05
申请号：US12047779
申请日：2008-03-13
申请人： Jason J. Hoendervoogt , Timothy J. Denison , Todd A. Kallmyer , Scott L. Kalpin , Scott A. Sarkinen
发明人： Jason J. Hoendervoogt , Timothy J. Denison , Todd A. Kallmyer , Scott L. Kalpin , Scott A. Sarkinen
IPC分类号： A61M5/00
CPC分类号： A61M5/14276 , A61M5/427 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3515 , A61M2205/3523 , A61M2209/045
摘要： Systems and methods for orienting a medical instrument relative to at least a portion of a medical device include a first tilt detector associated with the medical instrument and a second tilt detector associated with the medical device. The first tilt detector may be within an orientation device that is coupled to or separate from the medical instrument. The tilt detectors generate signals that may be used to determine the relative orientation between at least a portion of the medical device and medical instrument. For example, in some embodiments, the signals may be used to determine whether the orientations of the portion of the medical device and the medical instrument substantially match.
摘要翻译： 用于使医疗器械相对于医疗装置的至少一部分定向的系统和方法包括与医疗器械相关联的第一倾斜检测器和与医疗装置相关联的第二倾斜检测器。 第一倾斜检测器可以在与医疗器械联接或分离的定向装置内。 倾斜检测器产生可用于确定医疗装置的至少一部分与医疗器械之间的相对取向的信号。 例如，在一些实施例中，信号可以用于确定医疗设备和医疗器械的部分的取向是否基本匹配。
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公开(公告)号：US20120066534A1
公开(公告)日：2012-03-15
申请号：US12879164
申请日：2010-09-10
申请人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
发明人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
IPC分类号： G06F1/26 , H03K17/687
摘要： Aspects of this disclosure relate to coupling and decoupling a power source of a device with circuitry within the device. For example, in aspects of this disclosure, when a short develops within the device, a switch circuit may decouple the power source from the some of the circuitry within the device. Decoupling the power source when a short develops may extent the operational time of the power source, and may reduce thermal excursion.
摘要翻译： 本公开的方面涉及将设备的电源与设备内的电路耦合和去耦合。 例如，在本公开的方面中，当器件内发生短路时，开关电路可以将电源与器件内的一些电路分离。 短路发生时的电源解耦可能会延长电源的工作时间，并可能减少热偏移。
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公开(公告)号：US08121694B2
公开(公告)日：2012-02-21
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US20110301575A1
公开(公告)日：2011-12-08
申请号：US12793457
申请日：2010-06-03
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2205/3317 , A61M2205/3331 , G01L9/0072 , G01L15/00 , G01L19/0023 , G01L19/0069 , G01L19/086 , G01L19/143 , G01L19/148 , G01L19/149
摘要： The disclosure is directed to a pressure sensor of an implantable medical device. The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self-aligning housing shape that occludes an opening in the pump bulkhead of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.
摘要翻译： 本公开涉及可植入医疗装置的压力传感器。 压力传感器可以利用基于两个电容元件之间的变化的电容的检测流体压力。 压力传感器可以限定IMD的流体外壳的至少一部分。 在一个示例中，压力传感器具有封闭IMD的泵舱壁中的开口的自对准壳体形状。 压力的操作表面和流体外壳的一部分可以由耐腐蚀和/或生物相容的材料形成。 压力传感器的第一电容元件可以是响应于外部流体压力而偏转的金属合金膜片。 压力传感器的第二电容元件可以是通过隔膜和传感器的壳体与流体密封的刚性绝缘体上的金属涂层。
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公开(公告)号：US20110245629A1
公开(公告)日：2011-10-06
申请号：US12751508
申请日：2010-03-31
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/1116 , A61B5/4094 , A61B5/6823 , A61B5/6828 , A61B5/686 , A61B5/6868 , A61B5/742 , A61B5/7435 , A61B5/744 , A61B2560/0219 , A61B2562/043 , G06F19/00
摘要： The temporal correlation between a bioelectrical brain signal of a patient and patient motion data, such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.
摘要翻译： 患者的生物电脑信号与患者运动数据（例如指示患者运动的信号或患者姿势指示器）之间的时间相关性由显示装置显示。 在一些示例中，患者姿势指示器包括患者身体的至少一部分的图形表示。 在一些示例中，显示装置显示生物电脑信号，指示患者运动的信号与指示患者的心脏活动的信号之间的时间相关性。
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公开(公告)号：US20110125077A1
公开(公告)日：2011-05-26
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。
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30.发明申请公开(公告)号：US20100280574A1
公开(公告)日：2010-11-04
申请号：US12694042
申请日：2010-01-26
IPC分类号： A61N1/08
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N20/00 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译： 用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。 在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。 此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。 示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。
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