公开(公告)号：US5196337A

公开(公告)日：1993-03-23

申请号：US513933

申请日：1990-04-24

申请人： Hiroshi Ochi ,  Hiroshi Ohtsuka ,  Shinichi Yokota ,  Hiroshi Noguchi ,  Masazumi Terashima ,  Ikuko Uezumi ,  Kenji Irie

发明人： Hiroshi Ochi ,  Hiroshi Ohtsuka ,  Shinichi Yokota ,  Hiroshi Noguchi ,  Masazumi Terashima ,  Ikuko Uezumi ,  Kenji Irie

IPC分类号： G01N33/569 ,  A61K38/00 ,  A61K39/395 ,  A61P31/04 ,  C07K16/12 ,  C12N5/10 ,  C12N15/02 ,  C12P19/44 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC分类号： C07K16/1214 ,  C12P19/44 ,  A61K38/00

摘要： A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Committee's Classification, and the epitope of which is located at the common structure in the O-antigen of Pseudomonas aeruginosa of serotypes A and H. A hybridoma producing said human monoclonal antibody, and processes for preparing said hybridoma and antibody are also provided.

公开(公告)号：US5001421A

公开(公告)日：1991-03-19

申请号：US458228

申请日：1989-12-28

申请人： Kazuo Kawada ,  Hiroshi Noguchi

发明人： Kazuo Kawada ,  Hiroshi Noguchi

IPC分类号： G01R1/04 ,  G01R1/067

CPC分类号： G01R1/04 ,  G01R1/06788

摘要： An electric parts unit is located between a pair of holders formed inside surface of a jointing portion of a frame of an assembly. When the assembly is inserted into a cylinder, a projection(s), which is on an outer surface of the jointing portion and has relation to the positions of the holders, is (are) pressed by an inner surface of the cylinder so that the jointing portion bends inward and the holders hold the electric parts unit. Therefore, even if the probe is used under a quaking condition, the electric parts unit will not be quaked so that any noise will not be produced.

摘要翻译： 电气部件单元位于组件的框架的接合部的表面内的一对保持件之间。 当组件插入到气缸中时，在接合部分的外表面上并且与保持器的位置有关的突起被气缸的内表面压紧，使得 接合部分向内弯曲，并且保持器保持电气部件单元。 因此，即使在震动条件下使用探头，电气部件单元也不会发生晃动，因此不会产生任何噪音。

公开(公告)号：US4823755A

公开(公告)日：1989-04-25

申请号：US137528

申请日：1987-12-23

申请人： Katsuhiko Hirose ,  Hiroshi Noguchi ,  Toyokazu Baika ,  Kingo Horii ,  Hideo Nagaosa ,  Toshio Tanahashi ,  Toshio Itoh

发明人： Katsuhiko Hirose ,  Hiroshi Noguchi ,  Toyokazu Baika ,  Kingo Horii ,  Hideo Nagaosa ,  Toshio Tanahashi ,  Toshio Itoh

IPC分类号： F02D41/04 ,  F02D41/24 ,  F02D41/26 ,  F02M51/00

CPC分类号： F02B25/145 ,  F02D41/04 ,  F02D41/2416 ,  F02D41/263

摘要： In a two stroke fuel injection type internal combustion engine provided with intake and exhaust valves, a basic amount of fuel to be injected is calculated in accordance with an engine load and engine speed. Values of a factor corresponding to a ratio of air captured by an engine cylinder for combustion to the total amount of air introduced into the engine are stored in a memory in accordance with combinations of an engine load and engine speed. A value of a captured air factor corresponding to a detected combination of an engine load and speed is calculated by a map interpolation. The basic amount is corrected by the captured air factor so that a desired air-fuel ratio is obtained. The captured air factor may be further corrected in accordance with a secondary engine condition, other than an engine load and speed, such as a cooling water temperature, intake air temperature, atmospheric air temperature, atmospheric air pressure, exhaust gas temperature, or intake pressure.

摘要翻译： 在具有进气门和排气门的二冲程燃料喷射式内燃机中，根据发动机负荷和发动机转速来计算要喷射的基本燃料量。 根据发动机负荷和发动机转速的组合，与燃烧用发动机气缸捕获的空气与引入发动机的总空气量的比例对应的值的值存储在存储器中。 通过映射内插计算与检测到的发动机负载和速度的组合相对应的捕获空气因子的值。 通过捕获的空气系数来校正基本量，从而获得所需的空燃比。 捕获的空气因子可以根据二次发动机状态进一步校正，除了发动机负载和速度，例如冷却水温度，进气温度，大气温度，大气压力，排气温度或进气压力 。

公开(公告)号：US4732118A

公开(公告)日：1988-03-22

申请号：US59603

申请日：1987-06-08

申请人： Toshio Tanahashi ,  Norihiko Nakamura ,  Michiaki Uzihashi ,  Hiroshi Noguchi ,  Toshio Ito ,  Toyokazu Baika ,  Katsuhiko Hirose ,  Kingo Horii

发明人： Toshio Tanahashi ,  Norihiko Nakamura ,  Michiaki Uzihashi ,  Hiroshi Noguchi ,  Toshio Ito ,  Toyokazu Baika ,  Katsuhiko Hirose ,  Kingo Horii

IPC分类号： F02B1/04 ,  F02B11/00 ,  F02B17/00 ,  F02B23/08 ,  F02B25/00 ,  F02B25/14 ,  F02B27/02 ,  F02B31/00 ,  F02B31/02 ,  F02B31/08 ,  F02B75/02 ,  F02B75/18 ,  F02F1/42 ,  F02M25/07

CPC分类号： F02D13/028 ,  F02B17/00 ,  F02B25/145 ,  F02B27/06 ,  F02B31/085 ,  F02B75/02 ,  F02F1/4214 ,  F02M26/01 ,  F02B1/04 ,  F02B2031/006 ,  F02B2075/025 ,  F02B2075/1824 ,  F02M2026/009 ,  F02M26/03 ,  Y02T10/146 ,  Y02T10/18

摘要： A two-cycle internal combustion engine comprises a cylinder head having an intake port and two exhaust ports opened to a combustion chamber, to which compressed fresh air is introduced via an intake valve. The intake valve and two exhaust valves are operated in response to a crank angle. One of the exhaust valves is opened earlier than the other exhaust valve and the intake valve when the speed of the downward movement of the piston is relatively high, such that a part of exhaust gas in the one exhaust port flows back to the combustion chamber in that condition. An exhaust gas swirl rotating around a cylinder axis is formed when the exhaust gas flows back and the fresh air is slowly introduced onto the exhaust gas swirl in that condition.

摘要翻译： 双循环内燃机包括具有进气口的气缸盖和通向燃烧室开口的两个排气口，压缩空气通过进气阀被引入。 进气门和两个排气门响应于曲轴角度而操作。 当活塞的向下运动的速度相对较高时，其中一个排气门比另一个排气阀和进气阀更早地打开，使得一个排气口中的排气的一部分回流到燃烧室 那个条件。 当废气流回时，形成围绕气缸轴线旋转的废气涡旋，并且在该状态下，新鲜空气缓慢地引入废气涡流。

公开(公告)号：US4685437A

公开(公告)日：1987-08-11

申请号：US772904

申请日：1985-09-05

申请人： Toshiaki Tanaka ,  Hitoshi Niwa ,  Hirokatsu Mukai ,  Naoto Miwa ,  Akio Nara ,  Etsuji Nomura ,  Makoto Hori ,  Koichi Hasegawa ,  Hiroshi Noguchi

发明人： Toshiaki Tanaka ,  Hitoshi Niwa ,  Hirokatsu Mukai ,  Naoto Miwa ,  Akio Nara ,  Etsuji Nomura ,  Makoto Hori ,  Koichi Hasegawa ,  Hiroshi Noguchi

IPC分类号： F02B3/06 ,  F02M29/04 ,  F02M31/13 ,  F02M31/12

CPC分类号： F02M31/13 ,  F02M29/04 ,  F02B3/06 ,  Y02T10/126

摘要： An air heater for heating intake air for an internal combustion engine only in cold start or further warming up operation, having a frame which defines an opening for passing air therethrough, and at least one heater element in the shape of a perforated plate such as a lattice or honeycomb plate supported by the frame so as to traverse only a part of the opening area of the air passage opening, while leaving a substantial part of the opening area free as untraversed by the heater element.

摘要翻译： 一种空气加热器，其仅在冷启动或进一步预热操作中为内燃机的进气供暖，其具有限定用于使空气通过的开口的框架，以及至少一个多孔板形状的加热元件，例如 格架或蜂窝板由框架支撑，以便只穿过空气通道开口的开口区域的一部分，同时使打开区域的大部分自由未被加热器元件拉开。

公开(公告)号：US4546839A

公开(公告)日：1985-10-15

申请号：US616802

申请日：1984-06-04

申请人： Hiroshi Noguchi

发明人： Hiroshi Noguchi

IPC分类号： B62D3/12 ,  B62D3/00 ,  B62D5/22 ,  B62D6/02 ,  F16F15/08 ,  B62D5/06

CPC分类号： B62D5/22 ,  B62D6/02

摘要： A gear housing is prevented from longitudinal movement by variable-resilience stopper means which are rotatable to have, with respect to a force of the same magnitude, a variable resilience or rigidity depending upon varying angular position of the stopper means. The angular position of the stopper means is controlled by driving means in such a manner that the stopper means have a minimum resilience or maximum rigidity upon vehicle low-speed running conditions and a maximum resilience or minimum rigidity upon vehicle high-speed running conditions.

摘要翻译： 通过可变回弹止动装置防止齿轮壳体的纵向移动，其可相对于相同大小的力具有根据阻挡装置的变化的角位置而具有可变回弹力或刚度的可变回弹力或刚度。 止动装置的角度位置由驱动装置控制，使得止动装置在车辆低速行驶条件下具有最小的弹性或最大刚度，并且在车辆高速行驶条件下具有最大的弹性或最小的刚性。

公开(公告)号：US4183990A

公开(公告)日：1980-01-15

申请号：US853794

申请日：1977-11-21

申请人： Toshio Uchida ,  Yorimiti Yabuta ,  Hiroshi Noguchi ,  Eiichi Hasegawa ,  Teppei Ikeda

发明人： Toshio Uchida ,  Yorimiti Yabuta ,  Hiroshi Noguchi ,  Eiichi Hasegawa ,  Teppei Ikeda

IPC分类号： G03B27/80 ,  G03C5/02 ,  G03C5/08 ,  G03F7/20 ,  B32B7/02 ,  G03C5/04

CPC分类号： G03C5/02 ,  Y10S428/913 ,  Y10T428/24942

摘要： A step tablet in which density steps of a definite shape, each density step having a specific optical density, form a series of decreasing or increasing densities, in which any two density steps contiguous to each other are disposed with a boundary space of a specific shape between the density steps.

摘要翻译： 一种步骤片，其中具有特定光密度的每个密度步长具有特定光密度的确定形状的密度阶梯形成一系列减小或增加的密度，其中彼此相邻的任何两个密度台阶均具有特定形状的边界空间 密度梯级之间。

公开(公告)号：US4160087A

公开(公告)日：1979-07-03

申请号：US795596

申请日：1977-05-10

申请人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： A61K31/545 ,  C07D501/34

CPC分类号： C07D501/34 ,  C07D501/24

摘要： A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.3 group or an --S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial and prepared by the reaction of a compound of the formula (II),ho--a--cooh (ii)wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III), ##STR2## wherein R and X are as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素衍生物，其中A是单环或多环杂芳环，其含有至少一个氮原子作为杂原子并且可以被一个或多个取代基取代; R是被至少一个选自氨基，羟基，脲基和羟甲基的取代基取代的苯基; 并且X是-OCOCH 3基团或-S-Het基团，其中Het是含有1至4个选自氮，氧和硫原子的杂原子的5或6元杂环，其可以被 一种或多种取代基及其无毒的药学上可接受的盐，其可用作抗微生物剂并通过式（II）化合物，其中A如上定义的HO-A-COOH（II） 或其活性衍生物与式（III）化合物，其中R和X如上所定义的其中，或其衍生物。

公开(公告)号：US4146717A

公开(公告)日：1979-03-27

申请号：US454284

申请日：1974-03-25

申请人： Michihiro Yamamoto ,  Shigeaki Morooka ,  Masao Koshiba ,  Toshiaki Komatsu ,  Hiroshi Noguchi ,  Shigeho Inaba ,  Hisao Yamamoto

发明人： Michihiro Yamamoto ,  Shigeaki Morooka ,  Masao Koshiba ,  Toshiaki Komatsu ,  Hiroshi Noguchi ,  Shigeho Inaba ,  Hisao Yamamoto

IPC分类号： C07D239/82

CPC分类号： C07D239/82

摘要： Viral infections caused by viruses which belong to, e.g. Pox, Herpes, Adeno, Myxo, Paramyxo groups are controlled by administering an effective amount of quinazoline derivatives of the formula ##STR1## wherein R.sub.1 is cyclo, C.sub.3 -C.sub.8 alkyl, cyclo C.sub.3 -C.sub.8 alkyl C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 -C.sub.4 alkyl, C.sub.2-C.sub.5 alkenyloxy C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkylthio C.sub.1 -C.sub.4 alkyl, polyhalo C.sub.1- C.sub.4 alkyl, a group of the formula ##STR2## (wherein m is an integer of 1 to 3; and R.sub.4 and R.sub.5 are individually C.sub.1 -C.sub.4 alkyl, and may form together with the adjacent nitrogen atom an unsubstituted or C.sub.1 -C.sub.4 alkyl substituted 3 to 6 membered saturated heterocyclic ring, which may contain another nitrogen or oxygen atom) or a group of the formula --C.sub.n H.sub.2n --R.sub.6 (wherein n is 0 or an integer of 1 to 3; and R.sub.6 is a phenyl group, a substituted phenyl group or an aromatic or non-aromatic 3 to 6 membered heterocyclic ring which contains one or two hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atom, and may be optionally substituted by one or two C.sub.1 -C.sub.4 alkyl, and further, those substituents on adjacent carbon atoms may be joined to form a benzene or cyclohexane ring); R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, trifluoromethyl or nitro; and R.sub.3 is phenyl, substituted phenyl, cyclo C.sub.3 -C.sub.6 alkyl, pyridyl, furyl, nitrofuryl, thienyl, nitrothienyl, methylthienyl or pyrimidinyl.

公开(公告)号：US4008220A

公开(公告)日：1977-02-15

申请号：US495914

申请日：1974-08-08

申请人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

发明人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

IPC分类号： C07D499/00 ,  C07D499/68 ,  C07D499/48

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： A penicillin of the formula: ##STR1## wherein ##STR2## is a six-membered heteroaromatic ring containing 1 or 2 nitrogen atoms as the hetero atom, Y is hydrogen, lower alkanoyl or lower alkoxycarbonyl, R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkanoyl, benzoyl, lower alkylmercapto, hydroxyl, mercapto, hydroxy(lower)alkyl, halogen or cyano or R.sub.1 and R.sub.2 may link together to form a lower alkylene chain which may be substituted with an oxo group, and Z is phenyl, hydroxyphenyl, lower alkyl, cyclohexadienyl, thienyl or isothiazolyl, which is prepared by reacting a compound of the formula: ##STR3## wherein Z is as defined above or its derivative with a carboxylic acid of the formula: ##STR4## wherein ##STR5## and R.sub.2 are each as defined above or its reactive derivative, if necessary, followed by hydrolysis or acylation of the resulting product and/or elimination of any protective group and which is useful as an antimicrobial agent against various gram-positive and gram-negative bacteria including Pseudomonas.

摘要翻译： 一种下式的青霉素：其中是含有1或2个氮原子作为杂原子的六元杂芳环，Y是氢，低级烷酰基或低级烷氧基羰基，R 1和R 2各自是氢，低级烷基 ，低级烷酰基，苯甲酰基，低级烷基巯基，羟基，巯基，羟基（低级）烷基，卤素或氰基，或者R 1和R 2可以连接在一起形成可被氧代基取代的低级亚烷基链，Z是苯基， 低级烷基，环己二烯基，噻吩基或异噻唑基，其通过使下式化合物：其中Z如上所定义或其衍生物与下式的羧酸反应制备：其中和R2 各自如上所定义，或其反应性衍生物，如果需要，随后水解或酰化所得产物和/或消除任何保护基团，并且其可用作针对各种革兰氏阳性和革兰氏阴性菌的抗微生物剂，包括 uding假单胞菌