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公开(公告)号：US5681987A
公开(公告)日：1997-10-28
申请号：US631555
申请日：1996-04-12
Applicant: Ronald C. Gamble
Inventor： Ronald C. Gamble
IPC: G01Q60/52 , G01B11/30 , G01B21/30 , G01R31/303
CPC classification number: G01Q60/34 , B82Y35/00 , G01Q20/02 , Y10S977/85 , Y10S977/873
Abstract: The resonance contact scanning force microscope includes a reflective cantilever arm which is oscillated at a high harmonic of the resonance frequency of the cantilever arm, while the probe tip is maintained in substantially constant contact with the surface of the specimen. The motion of the free end of the cantilever arm is measured, to generate a deflection signal indicative of the amount of actual deflection of the probe tip. The method and apparatus permit high speed scans and real time imaging of the surface of a specimen with a substantial reduction in noise normally arising due to tip-surface interaction and acoustic noise.
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公开(公告)号：US5481908A
公开(公告)日：1996-01-09
申请号：US55236
申请日：1993-04-28
Applicant: Ronald C. Gamble
Inventor： Ronald C. Gamble
CPC classification number: G01Q60/34 , B82Y35/00 , G01Q20/02 , Y10S977/851
Abstract: The resonance contact scanning force microscope includes a reflective cantilever arm which is oscillated at a high harmonic of the resonance frequency of the cantilever arm, while the probe tip is maintained in substantially constant contact with the surface of the specimen. The motion of the free end of the cantilever arm is measured, to generate a deflection signal indicative of the amount of actual deflection of the probe tip. The method and apparatus permit high speed scans and real time imaging of the surface of a specimen with a substantial reduction in noise normally arising due to tip-surface interaction and acoustic noise.
Abstract translation: 共振接触扫描力显微镜包括以悬臂的谐振频率的高谐波振荡的反射悬臂，同时探针头保持与试样的表面基本恒定接触。 测量悬臂的自由端的运动，以产生指示探针尖端的实际偏转量的偏转信号。 该方法和装置允许通过尖端表面相互作用和声学噪声通常产生的噪声的显着降低来高速扫描和样品表面的实时成像。
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公开(公告)号：US4783220A
公开(公告)日：1988-11-08
申请号：US944675
申请日：1986-12-18
Applicant: Ronald C. Gamble , Micheal C. Hair , Sava R. Lukac , Michael G. Taylor
Inventor： Ronald C. Gamble , Micheal C. Hair , Sava R. Lukac , Michael G. Taylor
CPC classification number: C09D11/30 , A61K9/127 , A61K9/1272 , C09D11/02
Abstract: Ink compositions consisting of small unilamellar or multilamellar vesicles formed from surfactants of anionic, cationic, zwitterionic and nonionic molecules having an oil soluble dye, inclusive of a lipid-soluble dye associated therewith are described. The dye to surfactant ratio is preferably from about 1:1 to about 1:10. The compositions are useful in traditional printing techniques such as flexography and rotogravure and in electronic printing systems such as with an ink-jet printer.
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公开(公告)号：US06987263B2
公开(公告)日：2006-01-17
申请号：US10736154
申请日：2003-12-13
Applicant: Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
Inventor： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
CPC classification number: G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
Abstract: Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.
Abstract translation: 提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。 多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。 模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。 模块优选地设置在空间紧凑的二维阵列中。 共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来保持光谱仪内的差分真空条件。 通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。 用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。
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25.发明授权
公开(公告)号：US6015880A
公开(公告)日：2000-01-18
申请号：US213857
申请日：1994-03-16
Applicant: John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
Inventor： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC: C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00 , A61K38/00
CPC classification number: B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
Abstract: A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
Abstract translation: 提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。 通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。
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Patent Agency Ranking
公开(公告)号：US5625142A
公开(公告)日：1997-04-29
申请号：US500544
申请日：1995-07-11
Applicant: Ronald C. Gamble
Inventor： Ronald C. Gamble
CPC classification number: G01Q60/34 , B82Y35/00 , G01Q20/02 , Y10S977/851
Abstract: The resonance contact scanning force microscope includes a reflective cantilever arm which is oscillated at a high harmonic of the resonance frequency of the cantilever arm, while the probe tip is maintained in substantially constant contact with the surface of the specimen. The motion of the free end of the cantilever arm is measured, to generate a deflection signal indicative of the amount of actual deflection of the probe tip. The method and apparatus permit high speed scans and real time imaging of the surface of a specimen with a substantial reduction in noise normally arising due to tip-surface interaction and acoustic noise.
Abstract translation: 共振接触扫描力显微镜包括以悬臂的谐振频率的高谐波振荡的反射悬臂，同时探针头保持与试样的表面基本恒定接触。 测量悬臂的自由端的运动，以产生指示探针尖端的实际偏转量的偏转信号。 该方法和装置允许通过尖端表面相互作用和声学噪声通常产生的噪声的显着降低来高速扫描和样品表面的实时成像。
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公开(公告)号：US5507179A
公开(公告)日：1996-04-16
申请号：US360588
申请日：1994-12-21
Applicant: Ronald C. Gamble , Paul E. West , Marc R. Schuman
Inventor： Ronald C. Gamble , Paul E. West , Marc R. Schuman
CPC classification number: G01Q10/06 , B82Y35/00 , Y10S977/85 , Y10S977/851
Abstract: The synchronous sampling scanning force microscope includes a reflective cantilever arm having a free end which is oscillated at a frequency different from the resonance frequency of the cantilever arm. The motion of the oscillating cantilever arm is measured, to generate a deflection signal indicative of the amplitude of deflection or phase shift of the cantilever arm. Selected portions of cycles of the output signal are sampled, for generating output signal data indicative of deflection of the near and far excursions of the probe. The method and apparatus permit monitoring of compliance of the surface of the specimen by multiple sampling at a rate greater than the period of oscillation of the cantilever probe of the microscope.
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28.发明授权Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy 失效用于中子捕获肿瘤治疗的脂质体包封的化合物的组合物和方法
公开(公告)号：US5328678A
公开(公告)日：1994-07-12
申请号：US998886
申请日：1992-12-28
Applicant: Gary Fujii , Paul G. Schmidt , Ronald C. Gamble
Inventor： Gary Fujii , Paul G. Schmidt , Ronald C. Gamble
CPC classification number: A61K51/1234 , A61K41/009 , A61K41/0095 , A61K9/127 , A61K2121/00
Abstract: Liposomes with hyperosmotic concentration of compounds encapsulated therein are targeted to tumors for neutron capture therapy. The compounds have an element with a large neutron capture cross section and an isotope that emits alpha particles when bombarded with neutrons. A method employing such liposomes for neutron capture therapy is also described.
Abstract translation: 其中封装有高渗透浓度的化合物的脂质体靶向肿瘤用于中子捕获治疗。 这些化合物具有大的中子捕获截面的元素和当用中子轰击时发射α粒子的同位素。 还描述了使用这种脂质体进行中子捕获治疗的方法。
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公开(公告)号：US5319960A
公开(公告)日：1994-06-14
申请号：US847160
申请日：1992-03-06
Applicant: Ronald C. Gamble , Paul E. West
Inventor： Ronald C. Gamble , Paul E. West
IPC: G01B21/30 , G01B7/34 , G01Q10/00 , G01Q20/02 , G01Q30/08 , G01Q30/14 , G01Q70/02 , H01J37/28 , G01B5/28
Abstract: The scanning force microscope is an improved free standing type scanning force microscope with integrated scanning drivers for examination of a wide range of sizes and weights of stationary specimens, with the capability of scanning a sample in contact with a fluid. The scanning force microscope also includes motorized driver legs for operating the approach of the optical lever arm and sensor head to the sample, to allow for automation of the approach of the sensor head to the specimen.
Abstract translation: 扫描力显微镜是具有集成扫描驱动器的改进的独立式扫描力显微镜，用于检查固定样品的宽范围尺寸和重量，具有扫描样品与流体接触的能力。 扫描力显微镜还包括用于操作光学杠杆臂和传感器头到样品的接近的电动驱动器腿，以允许传感器头对样本的接近的自动化。
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公开(公告)号：US4728575A
公开(公告)日：1988-03-01
申请号：US720954
申请日：1985-04-10
Applicant: Ronald C. Gamble , Paul G. Schmidt
Inventor： Ronald C. Gamble , Paul G. Schmidt
IPC: A61B10/00 , A61B5/05 , A61B5/055 , A61K20060101 , A61K39/395 , A61K49/00 , A61K49/18 , A61K51/00 , G01N24/08 , G01N33/483 , G01R33/28 , B32B5/16
CPC classification number: G01R33/5601 , A61K49/1812
Abstract: An agent for contrast enhancement in nuclear magnetic resonance imaging is disclosed. Micellular particles such as phospholipid vesicles are associated with or enclose a paramagnetic material. The particles may be formulated with an agent, such as cholestrol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.
Abstract translation: 公开了核磁共振成像中的对比度增强剂。 诸如磷脂囊泡的胶束颗粒与顺磁材料相关联或包围顺磁性材料。 可以用诸如胆甾醇之类的试剂配制颗粒，以促进囊泡稳定性和穿过囊泡双层的水交换。 囊泡可以具有或可以不具有连接到表面上的抗体或其它细胞识别靶向剂以提供特异性靶向。 囊泡提供增强的靶特异性，减少有毒对比材料的负担和放大的对比度增强。
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