公开(公告)号：US11733216B2

公开(公告)日：2023-08-22

申请号：US16917178

申请日：2020-06-30

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Geoff Gerhardt ,  James P. Murphy

IPC: B01D15/08 ,  B01D15/16 ,  B01D15/40 ,  G01N30/32 ,  G01N30/86 ,  G01N30/02

CPC classification number: G01N30/32 ,  B01D15/08 ,  B01D15/161 ,  B01D15/163 ,  B01D15/40 ,  G01N30/8658 ,  G01N2030/025 ,  G01N2030/324

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

公开(公告)号：US10830742B2

公开(公告)日：2020-11-10

申请号：US16197601

申请日：2018-11-21

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/84 ,  G01N30/68 ,  G01N27/62

Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

公开(公告)号：US20190170710A1

公开(公告)日：2019-06-06

申请号：US16242754

申请日：2019-01-08

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/68 ,  F23D14/00

Abstract: The present disclosure relates to burner assemblies of flame-based detectors. These burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.

公开(公告)号：US10071374B2

公开(公告)日：2018-09-11

申请号：US14904135

申请日：2014-08-04

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  James P. Murphy ,  Michael O. Fogwill ,  Keith Fadgen ,  Geoff Gerhardt ,  Gary W. Bertone

IPC: B01D1/02 ,  B01L3/00 ,  B01L7/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894

Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.

公开(公告)号：US20180246087A1

公开(公告)日：2018-08-30

申请号：US15905935

申请日：2018-02-27

Applicant: Waters Technologies Corporation

Inventor： Gregory T. Roman ,  James P. Murphy

IPC: G01N33/543 ,  G01N21/33

CPC classification number: G01N33/54346 ,  G01N21/33 ,  G01N33/6848 ,  G01N33/6851

Abstract: The present disclosure relates devices and methods for analyzing intact antibodies, antibody subunits, antibody drug conjugate subunits, antibody drug conjugates, and intact proteins in a biological mixture.

公开(公告)号：US10006890B2

公开(公告)日：2018-06-26

申请号：US14782476

申请日：2014-05-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/30 ,  G01N30/72 ,  G01N30/16 ,  G01N30/84 ,  B01D15/40 ,  G01N30/34 ,  B01D15/16 ,  G01N30/32

CPC classification number: G01N30/30 ,  B01D15/161 ,  B01D15/40 ,  G01N30/16 ,  G01N30/32 ,  G01N30/34 ,  G01N30/7213 ,  G01N30/84 ,  G01N2030/3038

Abstract: A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.

公开(公告)号：US09804135B2

公开(公告)日：2017-10-31

申请号：US14594644

申请日：2015-01-12

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  James P. Murphy ,  Dennis DellaRovere

IPC: G01L1/04 ,  G01N30/60 ,  B01L3/00 ,  G01N30/46 ,  B01D15/22 ,  B01D15/42 ,  G01N30/72 ,  G01N30/88 ,  G01N30/08 ,  G01N30/02

CPC classification number: G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

Abstract: An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

公开(公告)号：US09768004B2

公开(公告)日：2017-09-19

申请号：US14552872

申请日：2014-11-25

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff C. Gerhardt

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/04

CPC classification number: H01J49/10 ,  H01J49/0431 ,  Y10T29/5313

Abstract: The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume.

公开(公告)号：US09719971B2

公开(公告)日：2017-08-01

申请号：US14483389

申请日：2014-09-11

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff Gerhardt

IPC: G01N30/68 ,  G01N30/60

CPC classification number: G01N30/68 ,  G01N30/6095

Abstract: The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.

公开(公告)号：US20160018367A1

公开(公告)日：2016-01-21

申请号：US14773786

申请日：2014-01-31

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Geoff Gerhardt ,  James P. Murphy

IPC: G01N30/32 ,  B01D15/16 ,  B01D15/40 ,  B01D15/08

CPC classification number: G01N30/32 ,  B01D15/08 ,  B01D15/161 ,  B01D15/163 ,  B01D15/40 ,  G01N30/8658 ,  G01N2030/025 ,  G01N2030/324

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

Abstract translation: 色谱系统中使用的热调节变量限制器可以独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 用于配置独立控制可压缩流动相的系统压力和质量流量的色谱系统的方法包括确定用于色谱系统的色谱分离柱的类型，将热调节的可变限制器与色谱分离的类型相匹配 色谱柱在色谱系统运行期间一起使用，并将色谱柱与其匹配的热调节变量限制器捆绑在一起，作为单个包装进行分配。