公开(公告)号：US20100311787A1

公开(公告)日：2010-12-09

申请号：US12718366

申请日：2010-03-05

申请人： Shoujun Chen ,  Jun Jiang ,  Hao Li ,  David James ,  Dinesh Chimmanamada ,  Christopher Borella ,  Lijun Sun ,  Yu Xie ,  Mats Holmqvist ,  Jerome Mahiou ,  Zhi Qiang Xia

发明人： Shoujun Chen ,  Jun Jiang ,  Hao Li ,  David James ,  Dinesh Chimmanamada ,  Christopher Borella ,  Lijun Sun ,  Yu Xie ,  Mats Holmqvist ,  Jerome Mahiou ,  Zhi Qiang Xia

IPC分类号： A61K31/437 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/433 ,  A61P37/00 ,  A61P35/00 ,  A61P17/06 ,  A61P1/04 ,  A61P3/10 ,  A61P19/02 ,  A61P11/00 ,  A61P25/28 ,  C12N5/0783

CPC分类号： A61K31/437 ,  A61K31/403 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/537 ,  C07D235/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/24 ,  C07D235/28 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  Y02A50/422

摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

公开(公告)号：US20100273129A1

公开(公告)日：2010-10-28

申请号：US12766602

申请日：2010-04-23

申请人： Qingsong Yu ,  Hao Li ,  Meng Chen

发明人： Qingsong Yu ,  Hao Li ,  Meng Chen

IPC分类号： A61C5/00

CPC分类号： A61C5/30 ,  A61C5/00 ,  A61C13/0001

摘要： The provision of dental restorations can be improved by generating a cold atmospheric plasma inside the mouth of the patient and then applying that cold atmospheric plasma onto a dental restoration site. The dental restoration site can be composed of either or both of dentin and enamel. Further, the provision of dental restorations can also be improved by introducing a dental adhesive onto a dental restoration site and treating it with a cold atmospheric plasma.

摘要翻译： 可以通过在患者口内产生冷的大气血浆，然后将该冷的大气血浆施加到牙齿修复部位来改善牙科修复体的提供。 牙齿修复部位可以由牙质和牙釉质中的一种或两者组成。 此外，还可以通过将牙科粘合剂引入牙齿修复部位并用冷的大气等离子体进行处理来提高牙科修复体的提供。

公开(公告)号：US20100207705A1

公开(公告)日：2010-08-19

申请号：US12704716

申请日：2010-02-12

申请人： Haizhao Wang ,  Guangfu Si ,  Naier Meng ,  Bo Yang ,  Puke Zhou ,  Shengxiang Gao ,  Yi Zhang ,  Weihua Sun ,  Jianjun Zhou ,  Ke Zhang ,  Hao Li ,  Zhiwei Shang ,  Runxiao Zhang

发明人： Haizhao Wang ,  Guangfu Si ,  Naier Meng ,  Bo Yang ,  Puke Zhou ,  Shengxiang Gao ,  Yi Zhang ,  Weihua Sun ,  Jianjun Zhou ,  Ke Zhang ,  Hao Li ,  Zhiwei Shang ,  Runxiao Zhang

IPC分类号： H01P5/12

CPC分类号： H03H7/463 ,  H01P1/213 ,  H01P1/2136 ,  H01P1/2138 ,  H01P11/007 ,  H05K7/20409

摘要： The present disclosure relates to telecommunication, and in particular, to a base station Radio Frequency (RF) duplexer, an RF module, and an RF system. A base station RF apparatus provided herein includes: an enclosure, an intermediate RF processing unit, and a duplexer. The enclosure is located on the duplexer; the intermediate RF processing unit is located inside a cavity enclosed by the enclosure and the duplexer, or on the duplexer; a duplexer cavity and a heat dissipation part exist on the surface of the duplexer; the opening of the duplexer cavity is opposite to or against the enclosure; the heat dissipation part is designed to dissipate heat of the intermediate RF processing unit; and the duplexer is integrally molded. The foregoing technical solution requires no external fasteners, reduces the time of production and assembly. In addition, waterproof design and shielding design are not required, and thus improves the reliability.

摘要翻译： 本公开涉及电信，特别是涉及基站射频（RF）双工器，RF模块和RF系统。 本文提供的基站RF装置包括：外壳，中间RF处理单元和双工器。 外壳位于双工器上; 中间RF处理单元位于由外壳和双工器包围的腔内，或位于双工器上; 在双工器的表面上存在双工器腔和散热部分; 双工器腔的开口与外壳相对或相对; 散热部分设计用于散发中间RF处理单元的热量; 双工器整体模制。 上述技术方案不需要外部紧固件，减少生产和组装的时间。 另外，不需要防水设计和屏蔽设计，从而提高了可靠性。

公开(公告)号：US07654688B2

公开(公告)日：2010-02-02

申请号：US12024966

申请日：2008-02-01

申请人： Hao Li ,  Yong-Dong Chen ,  Shih-Hsun Wung

发明人： Hao Li ,  Yong-Dong Chen ,  Shih-Hsun Wung

IPC分类号： F21V21/00 ,  F21V29/00

CPC分类号： F21V29/74 ,  F21S8/026 ,  F21V21/046 ,  F21V29/004 ,  F21V29/763 ,  F21Y2115/10

摘要： A recessed LED lamp for being mounted in a wall or a ceiling, includes a housing (10), a printed circuit board (20) received in the housing, a plurality of LEDs (22) mounted on the printed circuit board, a casing (40) surrounding the housing, a pair of arms (50) resiliently and pivotably attached on the casing, and a heat sink (30) secured below the housing. The heat sink includes a base (32) contacting the printed circuit board and thermally connecting therewith, a plate (34) extending outwardly from the base and a plurality of fins (36) extending downwardly from the plate (34).

摘要翻译： 一种用于安装在墙壁或天花板中的嵌入式LED灯，包括壳体（10），容纳在壳体中的印刷电路板（20），安装在印刷电路板上的多个LED（22），壳体（ 40）围绕所述壳体，弹性地且可枢转地附接在所述壳体上的一对臂（50）以及固定在所述壳体下方的散热器（30）。 散热器包括接触印刷电路板并与其热连接的基座（32），从基座向外延伸的板（34）和从板（34）向下延伸的多个翅片（36）。

公开(公告)号：US20090283424A1

公开(公告)日：2009-11-19

申请号：US12400425

申请日：2009-03-09

申请人： Charles A. Carson ,  Hao Li ,  Qingsong Yu

发明人： Charles A. Carson ,  Hao Li ,  Qingsong Yu

IPC分类号： G01N27/26

CPC分类号： G01N27/3278 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/6825 ,  Y10S977/924

摘要： A sensor electrode for the detection of nucleotides in a biological sample is described. The sensitivity of the electrode is enhanced by the nanostructured sensor architecture that increases the available surface area of the electrode. The electrode detects nucleotides using standard electrochemical methods.

摘要翻译： 描述了用于检测生物样品中核苷酸的传感器电极。 通过增加电极的可用表面积的纳米结构传感器架构来增强电极的灵敏度。 电极使用标准电化学方法检测核苷酸。

公开(公告)号：US07615552B2

公开(公告)日：2009-11-10

申请号：US10985627

申请日：2004-11-10

申请人： Mitsunori Ono ,  Lijun Sun ,  Yumiko Wada ,  Teresa Przewloka ,  Hao Li ,  Zachary Demko ,  Dinesh Chimmanamada

发明人： Mitsunori Ono ,  Lijun Sun ,  Yumiko Wada ,  Teresa Przewloka ,  Hao Li ,  Zachary Demko ,  Dinesh Chimmanamada

IPC分类号： A61K31/517 ,  A61K31/5377 ,  C07D265/30 ,  C07D413/04

CPC分类号： C07D239/95 ,  C04B35/632 ,  C07D215/40 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D471/04 ,  C07D475/06 ,  C07D491/04

摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.

摘要翻译： 本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

公开(公告)号：US20070244328A1

公开(公告)日：2007-10-18

申请号：US11628818

申请日：2005-06-30

申请人： Wie Wang ,  Jian Wang ,  Hao Li

发明人： Wie Wang ,  Jian Wang ,  Hao Li

IPC分类号： C07D207/10 ,  C07C205/04 ,  C07C381/00 ,  C07D315/00 ,  C07F11/00 ,  C07D333/22 ,  C07D211/00 ,  C07C45/00

CPC分类号： C07D207/09 ,  C07B2200/07 ,  C07C45/511 ,  C07C45/54 ,  C07C45/72 ,  C07C45/74 ,  C07C47/56 ,  C07C49/203 ,  C07C49/21 ,  C07C49/235 ,  C07C49/647 ,  C07C49/653 ,  C07C49/683 ,  C07C49/697 ,  C07C49/753 ,  C07C49/86 ,  C07C67/343 ,  C07C201/12 ,  C07C205/44 ,  C07C205/45 ,  C07C213/02 ,  C07C215/42 ,  C07C227/32 ,  C07C239/20 ,  C07C253/30 ,  C07C319/14 ,  C07C391/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07D309/30 ,  C07D317/72 ,  C07D333/22 ,  C07C49/258 ,  C07C49/245 ,  C07C69/76 ,  C07C323/22 ,  C07C255/56 ,  C07C229/22 ,  C07C229/28 ,  C07C229/30 ,  C07C229/36

摘要： The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH2, N—Ra, O, S or C═O; Y is CH2, N—Ra, O, S or C═O, with the proviso that at least one of X or Y is CH2, and preferably both of X and Y are CH2; Ra is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6alkyl including a C3-C6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; Rb is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 acyclic or a a C3-C6 cyclic alkyl group, CIIO, N(Me)O, CO(S)Ra or the group of Formula (III). Where Rc and Rd are each independently H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C12 alkyl, more preferably a C1-C6 alkyl, and an optionally substituted aryl group, or together Rc and Rd form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R1 is OH, OR, NR′R″, NHC(═O)R, NHSO2R; R2 is H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1C6 alkyl, an optionally substituted aryl group or a ═O group (which establishes a carbonyl group with the carbon to which ═O is attached; R3 is H, OH, F, Cl, Br, I, Cl, an optionally substituted C1-C20 alkyl, alkenyl or alkynyl (“hydrocarbyl”) group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl, such that the carbon to which R3 is attached has an R or S configuration; R is II, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group, R′ and R″ are each independently H, an optionally substituted C1-C20 alkyl group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group; or together R′ and R″ form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R′ and R″ are attached; and wherein said compound is free from a metal catalyst.

公开(公告)号：US20060122156A1

公开(公告)日：2006-06-08

申请号：US11271704

申请日：2005-11-10

申请人： Lijun Sun ,  Shijie Zhang ,  Keizo Koya ,  Dinesh Chimmanamada ,  Hao Li ,  David James ,  Elena Kostik

发明人： Lijun Sun ,  Shijie Zhang ,  Keizo Koya ,  Dinesh Chimmanamada ,  Hao Li ,  David James ,  Elena Kostik

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/655

CPC分类号： C07D213/75 ,  C07D213/77 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/56 ,  C07D251/42 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D491/10

摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.

摘要翻译： 本发明涉及式（I）化合物：它们的组成及其使用方法。 化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

公开(公告)号：US20050250774A1

公开(公告)日：2005-11-10

申请号：US10985696

申请日：2004-11-10

申请人： Mitsunori Ono ,  Lijun Sun ,  Yumiko Wada ,  Teresa Przewloka ,  Hao Li ,  Howard Ng ,  Zachary Demko

发明人： Mitsunori Ono ,  Lijun Sun ,  Yumiko Wada ,  Teresa Przewloka ,  Hao Li ,  Howard Ng ,  Zachary Demko

IPC分类号： A61K20060101 ,  A61K31/5375 ,  A61K31/5377 ,  C07D213/77 ,  C07D401/12 ,  C07D405/12 ,  C07D413/02 ,  C07D413/04 ,  C07D413/12

CPC分类号： C07D413/12 ,  C04B35/632 ,  C07D213/77 ,  C07D401/12 ,  C07D405/12

摘要： This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.

摘要翻译： 本发明的特征在于式（I）化合物：化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

公开(公告)号：US06958348B2

公开(公告)日：2005-10-25

申请号：US10232394

申请日：2002-08-29

申请人： Keizo Koya ,  Lijun Sun ,  Mitsunori Ono ,  Guiqing Liang ,  David James ,  Hao Li ,  Zhi-Qiang Xia

发明人： Keizo Koya ,  Lijun Sun ,  Mitsunori Ono ,  Guiqing Liang ,  David James ,  Hao Li ,  Zhi-Qiang Xia

IPC分类号： A61K31/405 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  A61K31/435 ,  C07D453/02

CPC分类号： C07D249/08 ,  C07D209/12 ,  C07D209/18 ,  C07D231/12 ,  C07D233/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

摘要： Disclosed is an anti-cancer compound represented by Structural Formula (I): The variables in Structural Formula (I) are described hereinbelow. Also disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by Structural Formula (I) (preferably an effective amount). Also disclosed is a method of treating a subject with cancer by administering to the subject an effective amount of a compound represented by Structural Formula (I).

摘要翻译： 公开了由结构式（I）表示的抗癌化合物：结构式（I）中的变量如下所述。 还公开了包含药学上可接受的载体或稀释剂和由结构式（I）表示的化合物（优选有效量））的药物组合物。 还公开了通过向受试者施用有效量的由结构式（I）表示的化合物来治疗患有癌症的受试者的方法。