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155 条记录 (耗时 0.016 秒)

    Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
    21.
    发明申请
    Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation 审中-公开
    完全集成的蛋白质实验室芯片与智能微流体阵列生成

    公开(公告)号：US20050130226A1

    公开(公告)日：2005-06-16

    申请号：US10947576

    申请日：2004-09-22

    申请人： Chong Ahn ,  Junhai Kai ,  Young-Soo Sohn

    发明人： Chong Ahn ,  Junhai Kai ,  Young-Soo Sohn

    IPC分类号： C12M1/34 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  H01L21/00

    CPC分类号： B81C1/00206 ,  B81B2201/051 ,  G01N33/54353 ,  G01N33/54393

    摘要： Techniques for the fabrication of fully-integrated lab-on-a-chips (or biochips) specifically oriented towards point-of-care detection of biomolecules using immunoassay based detection techniques are disclosed. A primary task for the development of such biochips is the development of techniques to precisely deposit and localize the capture antibody on pre-determined locations over the biochip. The use of selective surface modification, specifically control over the surface energy, to achieve localized adsorption of the capture antibody is disclosed. Another approach, also disclosed, describes the use of smart passive microfluidics to confine the flow of the capture antibody along certain paths of the biochip and thereby control the locations over which the capture antibody is adsorbed. Furthermore, the use of an integrated microlens array as means of enhancing the detection sensitivity of the biochip is also disclosed.

    摘要翻译： 公开了使用基于免疫测定的检测技术来制造专门针对生物分子的护理点检测的完全整合的芯片上实验室（或生物芯片）的技术。 开发这样的生物芯片的主要任务是开发在生物芯片上的预定位置上精确沉积和定位捕获抗体的技术。 公开了使用选择性表面改性，特别是控制表面能来实现捕获抗体的局部吸附。 还公开了另一种方法，描述了使用智能被动微流体将捕获抗体的流动限制在生物芯片的某些路径上，从而控制捕获抗体吸附的位置。 此外，还公开了使用集成微透镜阵列作为增强生物芯片的检测灵敏度的手段。

    Suspended moving channels and channel actuators for microfluidic applications and method for making
    25.
    发明授权
    Suspended moving channels and channel actuators for microfluidic applications and method for making 失效
    用于微流控应用的悬挂移动通道和通道执行器和制造方法

    公开(公告)号：US06462391B1

    公开(公告)日：2002-10-08

    申请号：US09686885

    申请日：2000-10-12

    申请人： John M. Chong ,  Noel C. MacDonald

    发明人： John M. Chong ,  Noel C. MacDonald

    IPC分类号： H01L2982

    CPC分类号： B81C1/00587 ,  B81B2201/051 ,  Y10S366/03

    摘要： A microfabrication process for making enclosed, subsurface microfluidic tunnels, cavities, channels, and the like within suspended beams includes etching a single crystal silicon wafer to produce trenches defining a beam. The trench walls are oxidized, and the interior of the beam is etched through a channel via on the top of the beam to form a hollow beam with oxide sidewalls. The beam is released, and the via is then sealed to form an enclosed released channel beam.

    摘要翻译： 用于在悬挂梁内制造封闭的，地下微流体通道，空腔，通道等的微加工方法包括蚀刻单晶硅晶片以产生限定光束的沟槽。 沟槽壁被氧化，并且光束的内部通过在光束顶部上的通道蚀刻而形成具有氧化物侧壁的中空光束。 梁被释放，然后将通孔密封以形成封闭释放的通道梁。