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    Miniaturized Ion Mobility Spectrometer
    23.
    发明申请
    Miniaturized Ion Mobility Spectrometer 有权

    公开(公告)号：US20150303044A1

    公开(公告)日：2015-10-22

    申请号：US14597132

    申请日：2015-01-14

    Applicant: Rapiscan Systems, Inc.

    Inventor： William J Kaye ,  Robert M. Stimac

    IPC: H01J49/00 ,  H01J49/02

    CPC classification number: H01J49/0013 ,  G01N27/622 ,  H01J49/00 ,  H01J49/022

    Abstract: By utilizing the combination of a unique electronic ion injection control circuit in conjunction with a particularly designed drift cell construction, the instantly disclosed ion mobility spectrometer achieves increased levels of sensitivity, while achieving significant reductions in size and weight. The instant IMS is of a much simpler and easy to manufacture design, rugged and hermetically sealed, capable of operation at high temperatures to at least 250° C., and is uniquely sensitive, particularly to explosive chemicals.

    MASS SPECTROMETER
    24.
    发明申请
    MASS SPECTROMETER 审中-公开
    质谱仪

    公开(公告)号：US20150187554A1

    公开(公告)日：2015-07-02

    申请号：US14643899

    申请日：2015-03-10

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Hidetoshi MOROKUMA ,  Koji ISHIGURO ,  Shun KUMANO

    IPC: H01J49/04 ,  H01J49/10 ,  H01J49/24 ,  H01J49/00

    CPC classification number: H01J49/0404 ,  H01J49/00 ,  H01J49/005 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0431 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/24

    Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.

    Abstract translation: 提供能够容易地进行交换测定样品并抑制残留物的质谱仪。 质谱仪包括质谱分析部分，离子源的内部压力通过来自质谱分析部分的差分泵浦而被离子源离子化，离子源使样品气体离子化，其中样本气体通过汽化 测量样品，将样品容器中产生的样品气体引入离子源的细管，连接样品容器和细管的可打开和关闭的弹性管，一对关闭或打开弹性管的堰 夹着弹性管，以及将样品容器，细管和弹性管整合在一起的药筒，并且能够与质谱仪的主体一体地分离。

    Miniaturized ion mobility spectrometer
    26.
    发明授权
    Miniaturized ion mobility spectrometer 有权
    小型离子迁移谱仪

    公开(公告)号：US08963082B2

    公开(公告)日：2015-02-24

    申请号：US11760388

    申请日：2007-06-08

    Applicant: William J. Kaye ,  Robert M. Stimac

    Inventor： William J. Kaye ,  Robert M. Stimac

    IPC: H01J49/00 ,  G01N27/62

    CPC classification number: H01J49/0013 ,  G01N27/622 ,  H01J49/00 ,  H01J49/022

    Abstract: By utilizing the combination of a unique electronic ion injection control circuit in conjunction with a particularly designed drift cell construction, the instantly disclosed ion mobility spectrometer achieves increased levels of sensitivity, while achieving significant reductions in size and weight. The instant IMS is of a much simpler and easy to manufacture design, rugged and hermetically sealed, capable of operation at high temperatures to at least 250° C., and is uniquely sensitive, particularly to explosive chemicals.

    Abstract translation: 通过利用独特的电子离子注入控制电路与特别设计的漂移电池结构的组合，立即公开的离子迁移谱仪实现了增加的灵敏度水平，同时实现了尺寸和重量的显着减小。 即时IMS简单易用，易于制造设计，坚固耐用且密封，能够在高温至少250°C的条件下运行，特别适用于爆炸性化学品。

    SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS
    27.
    发明申请
    SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS 审中-公开
    用于发现和分析标记的系统和方法

    公开(公告)号：US20140374584A1

    公开(公告)日：2014-12-25

    申请号：US14166626

    申请日：2014-01-28

    Applicant: John T. Stults ,  Alfred Greenquist ,  Alexander Sassi

    Inventor： John T. Stults ,  Alfred Greenquist ,  Alexander Sassi

    IPC: G01N33/50 ,  G01N27/26 ,  A61B5/15 ,  H01J49/00

    CPC classification number: G01N33/50 ,  A61B5/150755 ,  G01N27/26 ,  G16B20/00 ,  G16B40/00 ,  H01J49/00 ,  H01J49/0027 ,  H01J49/165 ,  Y02A90/22 ,  Y02A90/26 ,  Y10T436/117497

    Abstract: A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.

    Abstract translation: 用于分类患者样本的商业方法。 该方法包括收集代表临床表型状态的病例样本和对照样品的步骤，所述样品代表没有所述临床表型状态的患者。 优选地，系统使用质谱平台系统来鉴定所述病例样品和对照样品中多肽的模式，而不考虑至少一些所述多肽的特异性同一性。 基于确定的状态的代表性模式，业务方法使用代表性模式提供诊断产品的营销。 本发明涉及用于鉴定新标记，诊断具有生物学感兴趣的患者的系统和方法，以及销售/商业化这种诊断。 本发明涉及具有更大灵敏度，特异性和/或成本效益的系统和方法。

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