公开(公告)号：US20160062098A1

公开(公告)日：2016-03-03

申请号：US14888257

申请日：2014-05-15

Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Inventor： Jonathon Quincy Brown

IPC: G02B21/16 ,  H04N5/225 ,  A61B10/02 ,  G06K9/52 ,  G01N1/30 ,  A61B5/00 ,  G02B21/36 ,  G06K9/62

CPC classification number: G02B21/16 ,  A61B5/0071 ,  A61B10/02 ,  A61B2090/366 ,  A61B2090/3941 ,  G01N1/30 ,  G01N21/6458 ,  G01N2001/302 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/129 ,  G02B21/0076 ,  G02B21/365 ,  G02B21/367 ,  G06K9/52 ,  G06K9/6267 ,  H04N5/2256

Abstract: Systems and methods are provided for evaluating a fresh tissue sample, prepared as to fluoresce under illumination, during a medical procedure. A structured light source is configured to project a spatially patterned light beam onto the fresh tissue sample. An imaging system is configured to produce an image from fluorescence emitted from the illuminated fresh tissue sample. A system control is configured to provide a human-comprehensible clinically useful output associated with the medical procedure.

Abstract translation: 提供了系统和方法，用于评估在医疗过程中制备为在照明下发荧光的新鲜组织样品。 结构化光源被配置为将空间图案化的光束投影到新鲜组织样本上。 成像系统被配置为从照亮的新鲜组织样品发射的荧光产生图像。 系统控制被配置为提供与医疗过程相关联的人类可理解的临床有用的输出。

公开(公告)号：US20160048739A1

公开(公告)日：2016-02-18

申请号：US14827312

申请日：2015-08-15

Applicant: SCANADU INCORPORATED

Inventor： Bernard Burg

IPC: G06K9/46 ,  G01J3/52 ,  G01N33/487 ,  G01J1/42 ,  G06T7/00 ,  G06T7/40

CPC classification number: G01J3/52 ,  G01J1/08 ,  G01J1/42 ,  G01J1/4204 ,  G01J3/0272 ,  G01J3/50 ,  G01J3/505 ,  G01J3/524 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/129 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/30004 ,  H04N9/735

Abstract: In one embodiment, a diagnostic system for biological samples is disclosed. The diagnostic system includes a diagnostic instrument, and a portable electronic device. The diagnostic instrument has a reference color bar and a plurality of chemical test pads to receive a biological sample. The portable electronic device includes a digital camera to capture a digital image of the diagnostic instrument in uncontrolled lightning environments, a sensor to capture illuminance of a surface of the diagnostic instrument, a processor coupled to the digital camera and sensor to receive the digital image and the illuminance, and a storage device coupled to the processor. The storage device stores instructions for execution by the processor to process the digital image and the illuminance, to normalize colors of the plurality of chemical test pads and determine diagnostic test results in response to quantification of color changes in the chemical test pads.

Abstract translation: 在一个实施方案中，公开了用于生物样品的诊断系统。 诊断系统包括诊断仪器和便携式电子设备。 诊断仪器具有参考色条和用于接收生物样品的多个化学测试垫。 便携式电子设备包括数字照相机，用于在不受控制的雷电环境中捕获诊断仪器的数字图像，用于捕获诊断仪器表面的照度的传感器，耦合到数字照相机的处理器和用于接收数字图像的传感器， 照度，以及耦合到处理器的存储装置。 存储装置存储由处理器执行以处理数字图像和照度的指令，使多个化学测试垫的颜色标准化并响应于化学测试垫中的颜色变化的量化来确定诊断测试结果。

公开(公告)号：US20160011103A1

公开(公告)日：2016-01-14

申请号：US14793539

申请日：2015-07-07

Applicant: Sumitomo Electric Industries, Ltd. ,  National University Corporation Kobe University

Inventor： Tetsu MORISHIMA ,  Akihiko KONDO ,  Tomohisa HASUNUMA ,  Akihito NAKANISHI

IPC: G01N21/3577 ,  G01N21/359 ,  G01N21/47

CPC classification number: G01N21/3577 ,  G01N21/359 ,  G01N21/4738 ,  G01N2021/4769 ,  G01N2201/129 ,  Y02E50/17

Abstract: An optical measuring method for measuring a concentration of a fermentation inhibitor included in a biomass-derived fermentation raw material includes acquiring a diffuse reflection spectrum or a transmission spectrum relating to a measurement target 40 which includes the biomass-derived fermentation raw material by radiating near-infrared light to the measurement target 40, and computing the concentration of the fermentation inhibitor based on the diffuse reflection spectrum or the transmission spectrum.

Abstract translation: 用于测定生物质衍生发酵原料中所含的发酵抑制剂的浓度的光学测定方法包括：通过辐射近红外光照射来获取与含有生物质的发酵原料相关的测定对象40的漫反射光谱或透射光谱， 红外光到测量对象40，以及基于漫反射光谱或透射光谱计算发酵抑制剂的浓度。

公开(公告)号：US09228892B2

公开(公告)日：2016-01-05

申请号：US14737622

申请日：2015-06-12

Applicant: PD-LD, Inc.

Inventor： Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

IPC: G01J3/00 ,  G01J3/10 ,  H01S5/40 ,  H01S5/00 ,  H01S5/32 ,  G01J3/44 ,  G01J3/18

CPC classification number: G01J3/0256 ,  G01J3/00 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/104 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/1793 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1296 ,  G02B6/29319 ,  H01S5/005 ,  H01S5/32 ,  H01S5/4012 ,  H01S5/4087

Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.

Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。

公开(公告)号：US20150305658A1

公开(公告)日：2015-10-29

申请号：US14650897

申请日：2013-12-17

Applicant: OMNI MEDSCI. INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: Non-invasive monitoring of blood constituents such as glucose, ketones, or hemoglobin A1c may be accomplished using near-infrared or short-wave infrared (SWIR) light sources through absorbance, diffuse reflection, or transmission spectroscopy. As an example, hydro-carbon related substances such as glucose or ketones have distinct spectral features in the SWIR between approximately 1500 and 2500 nm. An SWIR super-continuum laser based on laser diodes and fiber optics may be used as the light source for the non-invasive monitoring. Light may be transmitted or reflected through a tooth, since an intact tooth and its enamel and dentine may be nearly transparent in the SWIR. Blood constituents or analytes within the capillaries in the dental pulp may be detected. The non-invasive monitoring device may communicate with a device such as a smart phone or tablet, which may transmit a signal related to the measurement to the cloud with cloud-based value-added services.

Abstract translation: 通过吸收，漫反射或透射光谱可以使用近红外或短波红外（SWIR）光源实现对血液成分如葡萄糖，酮或血红蛋白A1c的非侵入性监测。 作为示例，水 - 碳相关物质如葡萄糖或酮在SWIR中在约1500和2500nm之间具有不同的光谱特征。 可以使用基于激光二极管和光纤的SWIR超连续激光器作为非侵入性监测的光源。 光可以通过牙齿传播或反射，因为完整的牙齿及其牙釉质和牙质在SWIR中可能几乎是透明的。 可以检测牙髓中毛细血管内的血液成分或分析物。 非侵入式监测设备可以与诸如智能电话或平板电脑的设备进行通信，智能电话或平板电脑可以使用基于云的增值业务将与测量相关的信号传输到云。

公开(公告)号：US09164032B2

公开(公告)日：2015-10-20

申请号：US14108986

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01N21/35 ,  G01N21/359 ,  A61B5/1455 ,  G01J3/453 ,  A61B5/00 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A system and method for using near-infrared or short-wave infrared (SWIR) light sources for identification of counterfeit drugs may perform spectroscopy using a super-continuum laser to provide detection in a non-contact and non-destructive manner at stand-off or remote distances with minimal sample preparation. Also, near-infrared or SWIR light may penetrate through plastic containers and packaging, permitting on-line inspection and rapid scanning. The near-infrared or SWIR spectroscopy may also be used to detect illicit drugs and their chemical composition. Moreover, the spectroscopic techniques may also be applied to quality assessment and control in pharmaceutical manufacturing, thus permitting the implementation of smart manufacturing with feedback control. Fiber super-continuum lasers may emit light in the near-infrared or SWIR between approximately 1.4-1.8 microns, 2-2.5 microns, 1.4-2.4 microns, 1-1.8 microns. In particular embodiments, the detection system may be a dispersive spectrometer, a Fourier transform infrared spectrometer, or a hyper-spectral imaging detector or camera.

Abstract translation: 使用近红外或短波红外（SWIR）光源识别假冒药物的系统和方法可以使用超连续激光器进行光谱，以在非接触和非破坏性方式提供检测 或距离最小的样品制备。 此外，近红外或SWIR光可以穿透塑料容器和包装，允许在线检查和快速扫描。 近红外或SWIR光谱也可用于检测非法药物及其化学成分。 此外，光谱技术还可以应用于药物制造中的质量评估和控制，从而允许通过反馈控制实现智能制造。 光纤超连续激光器可以在大约1.4-1.8微米，2-2.5微米，1.4-2.4微米，1-1.8微米之间的近红外或者SWIR发光。 在具体实施例中，检测系统可以是色散光谱仪，傅里叶变换红外光谱仪或超光谱成像检测器或照相机。

公开(公告)号：US20150208983A9

公开(公告)日：2015-07-30

申请号：US13145927

申请日：2010-01-23

Applicant: Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal- to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination/modulation subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Abstract translation: 一种用于通过定量红外光谱法非侵入性地确定人体组织属性的装置和方法，其临床相关的精度和准确性水平。 该系统包括针对组织谱的复杂性，高信噪比和光度精度要求进行优化的子系统，组织抽样误差，校准维护问题和校准传递问题。 子系统包括照明/调制子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。

公开(公告)号：US09063085B2

公开(公告)日：2015-06-23

申请号：US14184781

申请日：2014-02-20

Applicant: Materialytics, LLC

Inventor： Catherine E. McManus ,  James W. Dowe, III ,  Tristan M. Likes ,  James W. Dowe, IV

IPC: G01J3/30 ,  G01J3/36 ,  G01N21/62 ,  G01N21/63 ,  G06F17/00 ,  G01N21/71

CPC classification number: G01N21/62 ,  G01N21/63 ,  G01N21/718 ,  G01N21/87 ,  G01N2201/129 ,  G06F17/00 ,  G06F19/703

Abstract: This disclosure relates to a method for analyzing a sample of material. The method includes (a) converting a portion of the sample into a plasma multiple times; (b) recording a spectrum of electromagnetic radiation emitted in response to each of the sample conversions to define a sequence of spectra for the sample, in which each member of the sequence corresponds to the spectrum recorded in response to a different one of the sample conversions; (c) using an electronic processor to compare the sequence of spectra for the sample to a sequence of spectra for each of at least one reference sample in a reference library; and (d) using the electronic processor to determine information about the sample based on the comparison to the reference samples in the library.

Abstract translation: 本公开涉及一种用于分析材料样品的方法。 该方法包括（a）将样品的一部分转换成等离子体多次; （b）响应于每个样品转换记录发射的电磁辐射谱，以定义样品的光谱序列，其中序列的每个成员对应于响应不同的样品转化而记录的光谱 ; （c）使用电子处理器将样品的光谱序列与参考文库中的至少一个参考样品中的每一个的光谱序列进行比较; 以及（d）使用电子处理器基于与图书馆中的参考样本的比较来确定关于样本的信息。

公开(公告)号：US20150169847A1

公开(公告)日：2015-06-18

申请号：US14109926

申请日：2013-12-17

Applicant: ALLTECH, INC.

Inventor： Kyle McKinney ,  Allyson Lovell ,  Benjamin Henry ,  Patrick Becker ,  Rebecca A. Timmons

IPC: G06F19/00

CPC classification number: G06F19/704 ,  A23K10/14 ,  A23K50/30 ,  A23K50/75 ,  G01N21/359 ,  G01N21/68 ,  G01N2201/129 ,  G06F19/00 ,  G06F19/703 ,  G06F19/707 ,  G16H50/50

Abstract: The present application provides systems and methods for analyzing animal feeds and for adjusting animal feeds to improve the digestibility of animal feed components. Digestibility of animal feed can be determined by performing in vitro digestion of the feed and analyzing concentrations of residual components in the digested feed by NIR spectroscopy. Animal feed compositions can be adjusted to improve digestibility of components in the feed. The systems and methods of the present application can be used to determine the effect of an additive on the digestibility of feed.

Abstract translation: 本申请提供了用于分析动物饲料和调整动物饲料以提高动物饲料组分的消化率的系统和方法。 动物饲料的消化率可以通过进行饲料的体外消化和通过NIR光谱分析消化的饲料中残留组分的浓度来测定。 可以调节动物饲料组合物以改善饲料中组分的消化率。 本申请的系统和方法可用于确定添加剂对饲料消化率的影响。

公开(公告)号：US20150168292A1

公开(公告)日：2015-06-18

申请号：US14568038

申请日：2014-12-11

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka

IPC: G01N21/25

CPC classification number: G06K9/6242 ,  G01N21/65 ,  G01N2201/129 ,  G06K9/00127 ,  G06K2009/4657

Abstract: A data processing apparatus that processes data including a plurality of spectra includes a group setting unit, an extracted data generation unit, and a base vector obtaining unit. The group setting unit classifies the plurality of spectra into a plurality of groups. The extracted data generation unit selects at least one spectrum from each of the groups set by the group setting unit and generates extracted data including the selected spectra. The base vector obtaining unit obtains, from the extracted data generated by the extracted data generation unit, base vectors for attributing the spectra to corresponding components.

Abstract translation: 处理包括多个频谱的数据的数据处理装置包括组设定单元，提取数据生成单元和基本矢量取得单元。 组设定单元将多个频谱分类为多个组。 所提取的数据生成单元从组设定单元设定的组中选择至少一个频谱，并生成包括所选频谱的提取数据。 基本向量获取单元从提取的数据生成单元生成的提取数据中获得用于将频谱归属于相应分量的基本向量。