公开(公告)号：US20170302291A1

公开(公告)日：2017-10-19

申请号：US15298373

申请日：2016-10-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yossef EHRLICHMAN ,  Ofer AMRANI ,  Shlomo RUSCHIN

IPC: H03M1/70 ,  G02F1/225 ,  G02F7/00 ,  H04B10/556 ,  G02F1/01 ,  H04B10/54 ,  H04B10/516 ,  H04B10/2575 ,  H04B10/50 ,  G02F1/015 ,  G02F1/21

CPC classification number: H04B10/516 ,  G02F1/0121 ,  G02F1/015 ,  G02F1/225 ,  G02F7/00 ,  G02F2001/212 ,  G02F2203/19 ,  H03M1/002 ,  H03M1/70 ,  H04B10/2504 ,  H04B10/2575 ,  H04B10/505 ,  H04B10/5055 ,  H04B10/541 ,  H04B10/556

Abstract: A system for converting digital data into a modulated optical signal, comprises an electrically controllable device having M actuating electrodes. The device provides an optical signal that is modulated in response to binary voltages applied to the actuating electrodes. The system also comprises a digital-to-digital converter that provides a mapping of input data words to binary actuation vectors of M bits and supplies the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes, where M is larger than the number of bits in each input data word. The digital-to-digital converter is enabled to map each digital input data word to a binary actuation vector by selecting a binary actuation vector from a subset of binary actuation vectors available to represent each of the input data words.

公开(公告)号：US09784731B2

公开(公告)日：2017-10-10

申请号：US14280612

申请日：2014-05-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Reuven Tirosh ,  Fernando Patolsky ,  Hagit Peretz-Soroka

IPC: G01N33/50 ,  G01N33/84 ,  G06F19/12

CPC classification number: G01N33/5091 ,  G01N33/5005 ,  G01N33/5023 ,  G01N33/5038 ,  G01N33/5094 ,  G01N33/84 ,  G06F19/12

Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.

公开(公告)号：US20170272639A1

公开(公告)日：2017-09-21

申请号：US15459020

申请日：2017-03-15

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Alex Bronstein ,  Or Litany ,  Tal Remez ,  Yoseff Shachar

IPC: H04N5/235 ,  G06K9/20

CPC classification number: G06K9/209 ,  G06K9/6277 ,  G06T5/001 ,  G06T2207/20021 ,  G06T2207/20076 ,  G06T2207/20081 ,  G06T2207/20084 ,  H04N5/335

Abstract: A method for image reconstruction includes defining a dictionary including a set of atoms selected such that patches of natural images can be represented as linear combinations of the atoms. A binary input image, including a single bit of input image data per input pixel, is captured using an image sensor. A maximum-likelihood (ML) estimator is applied, subject to a sparse synthesis prior derived from the dictionary, to the input image data so as to reconstruct an output image comprising multiple bits per output pixel of output image data.

公开(公告)号：US09750817B2

公开(公告)日：2017-09-05

申请号：US15236875

申请日：2016-08-15

Applicant: Ramot at Tel-Aviv University Ltd. ,  Technion Research & Development Foundation Ltd.

Inventor： Itai Benhar ,  Nir Osherov ,  Vladimir Dergachev ,  Alex Martin Szpilman

IPC: C07H17/08 ,  A61K47/48 ,  C08G65/08 ,  C08G65/329 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333

CPC classification number: A61K47/60 ,  A61K31/7048 ,  C07H17/08 ,  C08G65/08 ,  C08G65/329 ,  C08G65/3312 ,  C08G65/3314 ,  C08G65/3322 ,  C08G65/333

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

公开(公告)号：US09734638B2

公开(公告)日：2017-08-15

申请号：US14177359

申请日：2014-02-11

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel Cohen-Or ,  Ariel Shamir ,  Tao Chen

IPC: G06F17/50 ,  G06T19/20 ,  G06T17/10

CPC classification number: G06T19/20 ,  G06T17/10 ,  G06T2200/08 ,  G06T2219/2021

Abstract: A method of obtaining a three-dimensional digital model of an artificial object, made up of a plurality of geometric primitives, the artificial object being in a single two-dimensional photograph, the method comprising: using edge detection to define a two-dimensional outline of the artificial object within the photograph; interactively allowing a user to define two-dimensional profiles of successive ones of the geometric primitives; interactively allowing a user to sweep respective profiles over an extent of a corresponding one of the geometric primitives within the image; generating successive three-dimensional model parts from existing detected edges of the corresponding geometric primitives and the sweeping of the respective profile; and aligning the plurality of three-dimensional model parts to form the three-dimensional model.

公开(公告)号：US20170209845A1

公开(公告)日：2017-07-27

申请号：US15482867

申请日：2017-04-10

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud GAZIT ,  Meital RECHES

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  B01J2219/00709 ,  B01J2219/00725 ,  B81B2203/0361 ,  B81C1/00031 ,  B81C2201/0149 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07K5/06078 ,  C07K17/14 ,  Y10S977/793 ,  Y10S977/896

Abstract: A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.

公开(公告)号：US20170202916A1

公开(公告)日：2017-07-20

申请号：US15129007

申请日：2015-03-30

Applicant: Ramot at Tel-Aviv University Ltd. ,  Mor Research Applications Ltd.

Inventor： Ruth SHALGI ,  Dana CHUDERLAND ,  Hadas BAR-JOSEPH ,  Keren GOLDBERG ,  Irit BEN-AHARON ,  Salomon M. STEMMER

IPC: A61K38/18 ,  C12N5/075 ,  G01N33/74 ,  A61K31/704 ,  A61K31/138

CPC classification number: A61K38/18 ,  A61K31/138 ,  A61K31/704 ,  C12N5/0609 ,  C12N2501/10 ,  G01N33/74 ,  G01N2333/475 ,  G01N2800/34 ,  G01N2800/36 ,  G01N2800/52 ,  G01N2800/709 ,  A61K2300/00

Abstract: A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.

公开(公告)号：US20170174791A1

公开(公告)日：2017-06-22

申请号：US15447244

申请日：2017-03-02

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Itai BENHAR ,  Lilach VAKS

IPC: C07K16/46

Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain. Methods of generating same and uses thereof are also provided.

公开(公告)号：US09675567B2

公开(公告)日：2017-06-13

申请号：US15259064

申请日：2016-09-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Simon Edwards ,  Ruth Meriel Kimberley ,  Richard Edward Armer ,  Mohammed Nawaz Khan

IPC: C07C237/20 ,  A61K31/165 ,  A61K31/198 ,  A61K45/06 ,  C07D213/40 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/5375

CPC classification number: A61K31/165 ,  A61K31/198 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/5375 ,  A61K45/06 ,  C07C237/20 ,  C07D213/40

Abstract: Compounds of formula (I): and pharmacologically acceptable salts and pro-drugs thereof, wherein the variables are as defined in the specification, are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.

公开(公告)号：US20170143641A1

公开(公告)日：2017-05-25

申请号：US15402444

申请日：2017-01-10

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER

IPC: A61K9/51 ,  C12N15/113

CPC classification number: A61K9/5161 ,  A61K9/1272 ,  A61K9/5123 ,  A61K47/6849 ,  A61K47/6935 ,  A61K47/6939 ,  B82Y5/00 ,  C12N15/113 ,  C12N15/87 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/141 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: A method of generating a particle is disclosed, the particle being for delivery of a polynucleotide to a target cell. The method comprises (a) contacting the polynucleotide with a composition comprising cationic molecules, wherein the cationic molecules condense the polynucleotide by electrostatic interactions to generate a complex, wherein the cationic molecules are not comprised in a liposome; and (b) covalently binding the complex to a targeting moiety at a pH equal to or below about 4.5, thereby generating the particle for delivery of the polynucleotide agent to the target cell. Use of the particles and compositions comprising same are also disclosed.