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    System and method for forming microwells
    381.
    发明授权
    System and method for forming microwells 有权
    用于形成微孔的系统和方法

    公开(公告)号：US09476853B2

    公开(公告)日：2016-10-25

    申请号：US14566098

    申请日：2014-12-10

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Shifeng Li ,  Jordan Owens

    IPC: G01N27/414 ,  B01L3/00 ,  H01L21/302

    CPC classification number: G01N27/4145 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/12 ,  H01L21/302

    Abstract: A method of forming a sensor component includes forming a first layer over a sensor pad of a sensor of a sensor array. The first layer includes a first inorganic material. The method further includes forming a second layer over the first layer. The second layer includes a polymeric material. The method also includes forming a third layer over the second layer, the third layer comprising a second inorganic material; patterning the third layer; and etching the second layer to define a well over the sensor pad of the sensor array.

    Abstract translation: 形成传感器部件的方法包括在传感器阵列的传感器的传感器焊盘上形成第一层。 第一层包括第一无机材料。 该方法还包括在第一层上形成第二层。 第二层包括聚合材料。 该方法还包括在第二层上形成第三层，第三层包括第二无机材料; 图案化第三层; 并蚀刻第二层以在传感器阵列的传感器焊盘上限定一个孔。

    Methods and systems for in silico experimental designing and performing a biological workflow
    384.
    发明授权
    Methods and systems for in silico experimental designing and performing a biological workflow 有权
    计算机实验设计和执行生物工作流程的方法和系统

    公开(公告)号：US09465519B2

    公开(公告)日：2016-10-11

    申请号：US13724765

    申请日：2012-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Maurice Ling ,  Kok Hien Gan ,  Kevin Clancy ,  Raymond Tecotzky ,  Kin Chong Sam

    IPC: G06F3/0481 ,  G06F3/0484 ,  G06F19/28 ,  G06F19/26

    CPC classification number: G06F3/04847 ,  G06F3/0482 ,  G06F3/0484 ,  G06F19/26 ,  G06F19/28

    Abstract: Embodiments describe a non-transitory computer-readable storage medium encoded with instructions, executable by a processor, comprising instructions for a method for performing a biological workflow in silico comprising: presenting to a user a plurality of subroutines listed in a sequential order of the workflow, wherein at least two subroutines comprise two steps; providing the user ability to navigate to any subroutine and/or step, to select a subroutine, to view, set, or change one or more parameters associated with step/subroutine; providing option to display biomolecule(s) resulting from execution of the subroutines/steps; and providing an option to navigate to a prior subroutine and change a parameter of a step of the prior subroutine and execute the step of the prior subroutine, if the user is not satisfied with the displayed biomolecule(s). Computer systems and methods for performing a biological workflow in silico are also described.

    Abstract translation: 实施例描述了编码有可由处理器执行的指令的非瞬时计算机可读存储介质，包括用于执行计算机生物工作流的方法的指令，包括：向用户呈现以工作流的顺序列出的多个子例程 其中至少两个子程序包括两个步骤; 提供用户导航到任何子程序和/或步骤的能力，以选择子程序来查看，设置或更改与步骤/子程序相关联的一个或多个参数; 提供显示由执行子程序/步骤产生的生物分子的选项; 并且如果用户对所显示的生物分子不满意，则提供导航到先前子例程并改变先前子程序的步骤的参数并执行先前子程序的步骤的选项。 还描述了用于在计算机中执行生物工作流程的计算机系统和方法。

    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL REACTION SYSTEMS
    385.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL REACTION SYSTEMS 有权
    分析生物反应系统的方法和系统

    公开(公告)号：US20160275687A1

    公开(公告)日：2016-09-22

    申请号：US14778415

    申请日：2014-03-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Yong CHU ,  Jeffrey MARKS

    IPC: G06T7/00 ,  C12Q1/68 ,  G06T5/00

    CPC classification number: G06T7/74 ,  C12Q1/686 ,  G06K9/00 ,  G06K2209/07 ,  G06T5/002 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/136 ,  G06T7/194 ,  G06T2207/10064 ,  G06T2207/20024 ,  G06T2207/20208 ,  G06T2207/30072

    Abstract: A method for analyzing biological reaction systems is provided. The method includes receiving an image of a substrate including a plurality of reaction sites after a biological reaction has taken place. Next, the method includes removing a noise background from the first image. The method includes determining an initial position of each reaction site based on an intensity threshold to generate a initial position set, then refining the initial position set of each reaction site based on an expected pattern of locations of the plurality of reaction sites to generate a first refined position set. The method further includes determining a presence or absence of a fluorescent emission from each reaction site based on the first refined position set and the first image.

    Abstract translation: 提供了分析生物反应体系的方法。 该方法包括在发生生物反应之后接收包括多个反应位点的底物的图像。 接下来，该方法包括从第一图像中去除噪声背景。 该方法包括基于强度阈值确定每个反应位点的初始位置以产生初始位置集合，然后基于多个反应位点的预期位置模式来精化每个反应位点的初始位置集合，以产生第一 精致的位置集。 该方法还包括基于第一精制位置集和第一图像来确定来自每个反应位点的荧光发射的存在或不存在。

    Classification and Actionability Indices for Lung Cancer
    386.
    发明申请
    Classification and Actionability Indices for Lung Cancer 审中-公开
    肺癌分类及可行性指标

    公开(公告)号：US20160265065A1

    公开(公告)日：2016-09-15

    申请号：US15068011

    申请日：2016-03-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Santhoshi BANDLA ,  Douglas ROSS ,  Seth SADIS ,  Peter WYNGAARD

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

    Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.

    Abstract translation: 本公开提供了用于检测来自患有肺癌的受试者的样品中的多种基因和相关变体的组合物，试剂盒和方法。 组合物，试剂盒和方法包括一组寡核苷酸，通常可以杂交以鉴定基因变体的引物和/或探针。 本文公开的方法提供待确定的肿瘤的突变状态，并随后与可行动治疗推荐相关联。

    DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS
    388.
    发明申请
    DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS 有权
    DDAO化合物作为荧光参考标准

    公开(公告)号：US20160258004A1

    公开(公告)日：2016-09-08

    申请号：US15066248

    申请日：2016-03-10

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

    IPC: C12Q1/68 ,  C09B15/00

    CPC classification number: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

    Abstract translation: 根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物：在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号， 。 在一些实施方案中，组合物包含式（1）的参考染料，缓冲液，核苷酸和蛋白质的选择。

    System and Methods for Calibrating Binding Dyes
    389.
    发明申请
    System and Methods for Calibrating Binding Dyes 审中-公开
    校准结合染料的系统和方法

    公开(公告)号：US20160230209A1

    公开(公告)日：2016-08-11

    申请号：US15017034

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Yong Chu ,  Jacob Freudenthal ,  Jeffrey Marks

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/127

    Abstract: Some embodiments describe a computer-implemented method for calibrating a fluorescent dye. The method can comprise imaging a sample holder, loaded into an instrument, at more than one channel. The sample holder can comprise a plurality of reaction sites and more than one dye type, with each dye occupying more than one reaction site. The method can further comprise identifying a peak channel for each dye on the sample holder, normalizing each channel to the peak channel for each dye, and producing a dye matrix that can comprise a set of dye reference values.

    Abstract translation: 一些实施例描述了用于校准荧光染料的计算机实现的方法。 该方法可以包括在多个通道上成像加载到仪器中的样品架。 样品架可以包括多个反应位点和多于一种染料类型，每种染料占据多于一个反应位点。 该方法还可以包括鉴定样品架上每种染料的峰通道，将每个通道标准化为每种染料的峰通道，以及产生可包含一组染料参考值的染料基质。

    Thermal Cycler Cover
    390.
    发明申请
    Thermal Cycler Cover 审中-公开
    热循环器盖

    公开(公告)号：US20160228875A1

    公开(公告)日：2016-08-11

    申请号：US14778106

    申请日：2014-02-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Tiong Han Toh ,  Wuh Ken LOH ,  Kuan Moon BOO ,  Sandro David KLEIN ,  Daniel WELSH

    IPC: B01L7/00

    CPC classification number: B01L7/52 ,  B01L2300/043 ,  B01L2300/1822

    Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen and a link bar. The device lid portion is attached to the proximal side of the handle portion with a pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is operably connected to the device housing and the pin such that a distal side of the handle portion is elevated away from the device lid portion when the cover is moved to an open position.

    Abstract translation: 一方面，公开了一种热循环仪系统。 热循环仪可以由装置壳体和可操作地连接到装置壳体的盖组成。 盖可以包括手柄部分，装置盖部分，样品块压板和连杆。 装置盖部分用销钉安装在把手部分的近侧。 样品块压板可操作地连接到手柄部分，使得当手柄部分与装置盖部分齐平并且盖处于关闭位置时，样品块压板位于样品块上。 连杆可操作地连接到装置壳体和销上，使得当盖移动到打开位置时把手部分的远端从装置盖部分升高。

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