公开(公告)号：US09905005B2

公开(公告)日：2018-02-27

申请号：US15409355

申请日：2017-01-18

Applicant: Cellular Research, Inc.

Inventor： Glenn Fu ,  Roger Rudoff ,  David Stern ,  George T. Wu ,  Stephen P. A. Fodor ,  Geoffrey Facer

IPC: G06K9/00 ,  G06T7/00 ,  G01N21/64 ,  G06K9/62

CPC classification number: G06T7/0012 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6439 ,  G01N2201/129 ,  G06K9/6267 ,  G06T7/277 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30072 ,  G06T2207/30242

Abstract: Methods, systems and platforms for digital imaging of multiple regions of an array, and detection and counting of the labeled features thereon, are described.

公开(公告)号：US20180031478A1

公开(公告)日：2018-02-01

申请号：US15222000

申请日：2016-07-28

Applicant: Allan Wexler ,  Steven C. Switalski ,  Grace Ann Bennett ,  Kimberly S. Lindner

Inventor： Allan Wexler ,  Steven C. Switalski ,  Grace Ann Bennett ,  Kimberly S. Lindner

IPC: G01N21/64 ,  G01N27/02

CPC classification number: G01N21/6428 ,  G01N21/6456 ,  G01N21/8851 ,  G01N2021/6421 ,  G01N2201/129

Abstract: A surface evaluation system is described for evaluating a surface. A chromophore application system is used for applying a monolayer of a voltage sensitive chromophore to the surface, wherein the applied voltage sensitive chromophore is covalently bound to the surface and has a fluorescence emission spectrum which varies in accordance with a characteristic of the surface. An irradiation source irradiates the monolayer of the covalently bound voltage sensitive chromophore with actinic radiation. A fluorescence sensing system measures a fluorescence emission spectrum from the irradiated monolayer of the covalently bound voltage sensitive chromophore, and an analysis system analyzes the measured fluorescence emission spectrum to evaluate the characteristic of the surface.

公开(公告)号：US09877655B2

公开(公告)日：2018-01-30

申请号：US14768521

申请日：2014-02-19

Applicant: National University of Singapore

Inventor： Zhiwei Huang ,  Mads Sylvest Bergholt ,  Wei Zheng ,  Khek Yu Ho

IPC: A61B5/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  G02B23/24 ,  G02B23/26 ,  G01J3/02 ,  A61B1/00 ,  G01J3/18

CPC classification number: A61B5/0075 ,  A61B1/00165 ,  A61B5/0084 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/18 ,  G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/129 ,  G02B23/2469 ,  G02B23/26

Abstract: A diagnostic instrument comprises a monochromatic light source, transmission means to transmit light from the light source to a test site, collection means to transmit scattered light from the test site, and spectral analysis apparatus to receive light from the collection means, the spectral analysis apparatus comprising a diffraction grating having a first grating element and a second grating element, wherein the first grating element diffracts light within a first wavelength range and the second grating element diffracts light within a second wavelength range, the spectral analysis apparatus further comprising a light-sensing apparatus, the first grating element arranged to diffract light onto a first area of the light-sensing apparatus and the second grating element arranged to diffract light onto a second area of the light-sensing apparatus.

公开(公告)号：US09861286B1

公开(公告)日：2018-01-09

申请号：US15686198

申请日：2017-08-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01N21/3563 ,  G01N21/359 ,  G01J3/453 ,  A61B5/145 ,  A61B5/1455 ,  H01S3/30 ,  G01N21/39 ,  G01M3/38 ,  G01J3/28 ,  G01J3/10 ,  G01J3/18 ,  G01J3/14

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.

公开(公告)号：US09797874B2

公开(公告)日：2017-10-24

申请号：US14830365

申请日：2015-08-19

Applicant: China Agricultural University

Inventor： Yankun Peng ,  Juan Zhao

IPC: G01N21/25 ,  G01N33/12 ,  G01N21/31 ,  G01N21/47 ,  G01J3/10 ,  G01J3/12

CPC classification number: G01N33/12 ,  G01J3/10 ,  G01J2003/1282 ,  G01N21/255 ,  G01N21/31 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2201/0627 ,  G01N2201/129

Abstract: An optical testing system includes: a testing probe, a collecting unit, and a processing unit, wherein the testing probe includes a plurality of spectrum photodiodes used for emitting and casting monochromatic light to a sample, wherein the wavelength of the light emitted by at least one spectrum photodiode is different from that of any other. The collecting unit collects multi-way signal light obtained after the emitted monochromatic light is reflected by the sample surface. The processing unit includes a photoelectric conversion module, an adding module and a testing module. The photoelectric conversion module converts the collected multi-way signal light respectively to multi-way electrical signals. The adding module performs an adding operation for the multi-way electrical signal to obtain an operation result. The testing module tests a quality parameter of the sample according to the operation result, and outputs a testing result.

公开(公告)号：US09733183B2

公开(公告)日：2017-08-15

申请号：US14413376

申请日：2014-02-20

Applicant: Halliburton Energy Services, Inc.

Inventor： David L. Perkins ,  Robert Paul Freese ,  Christopher Michael Jones ,  Richard Neal Gardner

IPC: G01N21/45 ,  G02B5/28 ,  G01N21/85

CPC classification number: G01N21/45 ,  G01N21/85 ,  G01N2201/061 ,  G01N2201/068 ,  G01N2201/12 ,  G01N2201/129 ,  G02B5/28 ,  G02B5/285

Abstract: Disclosed are improved integrated computational elements for use in optical computing devices. One integrated computational element includes an optical substrate, first and second pluralities of optical thin film layers alternatingly deposited on the optical substrate to form a thin film stack, wherein each optical thin film layer of the first plurality exhibits a first refractive index and each optical thin film layer of the second plurality exhibits a second refractive index different than the first refractive index, and at least one additional optical thin film layer arranged in or on the thin film stack and in optical communication with at least one of the optical thin film layers of the first and second pluralities, the at least one additional optical thin film layer exhibiting a third refractive index that is different than the first and second refractive indices.

公开(公告)号：US20170177835A1

公开(公告)日：2017-06-22

申请号：US15192708

申请日：2016-06-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Jose Cardoso-Menezes ,  Stefan Buziol ,  Pedro Felizardo

IPC: G06F19/00 ,  G01N35/00 ,  G01N21/27 ,  G01N21/359 ,  G01N21/65

CPC classification number: G16C20/70 ,  G01N21/278 ,  G01N21/359 ,  G01N21/65 ,  G01N35/00693 ,  G01N2035/0097 ,  G01N2201/129 ,  G16C20/20

Abstract: The present invention describes a method that is comprised of creating a set of synthetic samples that mimic a dynamic process or a specific process step or a variation thereof, to be used to develop multivariate monitoring calibrations and process supervisory control systems.

公开(公告)号：US09664680B2

公开(公告)日：2017-05-30

申请号：US15059797

申请日：2016-03-03

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/49 ,  G01N33/574 ,  G01N21/552 ,  G01N33/00 ,  G01N33/566 ,  C40B30/04 ,  G01N21/35 ,  G01J3/433 ,  G01N21/63 ,  G01N30/74 ,  G01N21/31

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

公开(公告)号：US09662047B2

公开(公告)日：2017-05-30

申请号：US13167445

申请日：2011-06-23

Applicant: Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Jonathan Feld ,  David Feld ,  Alison Hearn ,  Chae-Ryon Kong ,  Jeon Woong Kang

Inventor： Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Chae-Ryon Kong ,  Jeon Woong Kang

IPC: A61B5/1455 ,  A61B5/145 ,  G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/4312 ,  A61B5/444 ,  A61B2560/0223 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/129

Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.

公开(公告)号：US09651533B2

公开(公告)日：2017-05-16

申请号：US14875709

申请日：2015-10-06

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J5/20 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.