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45 条记录 (耗时 0.048 秒)

    Fast-dispersing dosage forms containing fish gelatin
    34.
    发明授权
    Fast-dispersing dosage forms containing fish gelatin 有权

    公开(公告)号：US06709669B1

    公开(公告)日：2004-03-23

    申请号：US09959018

    申请日：2001-10-16

    申请人： Owen Murray ,  Michael Hall ,  Patrick Kearney ,  Richard Green

    发明人： Owen Murray ,  Michael Hall ,  Patrick Kearney ,  Richard Green

    IPC分类号： A61K964

    CPC分类号： A61K9/2063 ,  A61K9/0056 ,  A61K47/42

    摘要： The invention disclosed herein relates to a pharmaceutical composition comprising a carrier and an active ingredient, wherein the carrier is fish gelatin and the composition is a fast-dispersing dosage form designed to release the active ingredient rapidly on contact with a fluid. In one embodiment, the composition is designed for oral administration and releases the active ingredient rapidly in the oral cavity on contact with saliva. The fish gelatin can be obtained from cold water fish sources and is preferably the non-gelling, non-hydrolyzed form. A process for preparing such a composition and a method of using fish gelatin in a fast dispersing dosage form are also provided.

    Process for preparing fast dispersing solid oral dosage form
    35.
    发明授权
    Process for preparing fast dispersing solid oral dosage form 失效
    快速分散固体口服剂型的制备方法

    公开(公告)号：US5976577A

    公开(公告)日：1999-11-02

    申请号：US891205

    申请日：1997-07-11

    申请人： Richard Green ,  Patrick Kearney

    发明人： Richard Green ,  Patrick Kearney

    IPC分类号： A61K9/19 ,  A61K9/00 ,  A61K9/20 ,  A61K31/167 ,  A61K31/192 ,  A61K47/10 ,  A61K47/42 ,  A61K9/14

    CPC分类号： A61K9/2095 ,  A61K9/0056 ,  B29K2627/08

    摘要： Process is provided for preparing an oral solid rapidly disintegrating freeze-dried dosage form of a pharmaceutically active substance having an unacceptable taste, wherein prior to freeze drying, a suspension of uncoated or coated coarse particles of a pharmaceutically active substance in a carrier material is cooled to reduce the viscosity and minimize release of the active substance during processing, as well as beyond the point of disintegration of the form in the mouth, to minimize bad taste from the drug.

    摘要翻译： 提供了制备具有不可接受味道的药物活性物质的口服固体快速崩解冷冻干燥剂型的方法，其中在冷冻干燥之前，将药物活性物质的未包衣或包被的粗颗粒悬浮液在载体材料中冷却 以减少加工过程中活性物质的粘度和最小化活性物质的释放，以及超过口腔中形式分解的程度，以最大限度地减少药物的不良味道。

    Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
    36.
    发明授权
    Process for preparing solid pharmaceutical dosage forms of hydrophobic substances 失效
    制备疏水物质固体药物剂型的方法

    公开(公告)号：US5827541A

    公开(公告)日：1998-10-27

    申请号：US663103

    申请日：1996-07-18

    申请人： Richard John Yarwood ,  Patrick Kearney ,  Andrew Roy Thompson

    发明人： Richard John Yarwood ,  Patrick Kearney ,  Andrew Roy Thompson

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/14

    CPC分类号： A61K9/2095 ,  A61K9/0056

    摘要： Process for preparing an oral rapidly disintegrating dosage form of a hydrophobic pharmaceutically active substance comprising forming a suspension of the hydrophobic pharmaceutically active substance in a solvent containing a pharmaceutically acceptable surfactant together with a water-soluble or water-dispersible carrier material, forming discrete units of the suspension and removing solvent from the discrete units under conditions whereby a network of the carrier material carrying a dosage of the hydrophobic pharmaceutically active substance is formed.

    摘要翻译： PCT No.PCT / GB95 / 02485第 371日期：1996年7月18日 102（e）1996年7月18日PCT PCT 1995年10月20日PCT公布。 公开号WO96 / 13251 日期1996年5月9日制备疏水性药物活性物质的口服快速崩解剂型的方法，包括将疏水性药物活性物质的悬浮液与含有药学上可接受的表面活性剂的溶剂与水溶性或水分散性载体材料一起形成， 形成悬浮液的离散单元并在离散单元中除去溶剂，在此条件下形成载有剂量的疏水性药物活性物质的载体材料的网络。

    Method for making freeze dried drug dosage forms
    37.
    发明授权
    Method for making freeze dried drug dosage forms 失效
    冷冻干燥药物剂型的制备方法

    公开(公告)号：US5631023A

    公开(公告)日：1997-05-20

    申请号：US481287

    申请日：1995-06-07

    申请人： Patrick Kearney ,  Sang K. Wong

    发明人： Patrick Kearney ,  Sang K. Wong

    IPC分类号： A61J3/06 ,  A61K9/20 ,  A61K31/425 ,  A61K47/42 ,  A61P1/04

    CPC分类号： A61K9/2095

    摘要： The present invention discloses an improved technique for preparing a rapidly dispersing pharmaceutic tablet of a granular therapeutic agent which has both relatively low solubility and relatively large particle size. Xanthan gum is added to a liquid admixture of solvent, carrier components, and the granular therapeutic agent. The xanthan gum not only facilitates suspension of the granular therapeutic agent in the liquid admixture, but, more surprisingly, does so without adversely effecting the dispersion qualities and texture of the tablet in the patient's mouth upon administration.

    摘要翻译： PCT No.PCT / US94 / 07618 Sec。 371日期：1995年6月7日 102（e）日期1995年6月7日PCT 1994年7月8日PCT公布。 第WO95 / 01782号公报 日期1995年1月19日本发明公开了一种制备粒度治疗剂快速分散药物片剂的改进技术，其具有较低的溶解度和较大的粒径。 将黄原胶加入到溶剂，载体组分和颗粒状治疗剂的液体混合物中。 黄原胶不仅有助于粒状治疗剂在液体混合物中的悬浮，而且更令人惊奇的是，在施用时不会不利地影响患者口腔中片剂的分散质量和质地。

    Fast-Dispersing solid oral dosage form containing coarse particles
    38.
    发明授权
    Fast-Dispersing solid oral dosage form containing coarse particles 有权
    快速分散固体口服剂型，含有粗颗粒

    公开(公告)号：US06413549B2

    公开(公告)日：2002-07-02

    申请号：US09335177

    申请日：1999-06-17

    申请人： Richard Green ,  Patrick Kearney

    发明人： Richard Green ,  Patrick Kearney

    IPC分类号： A61K916

    CPC分类号： A61K9/2095 ,  A61K9/0056 ,  B29K2627/08

    摘要： This invention is directed to an oral solid, rapidly disintegrating, freeze-dried dosage form containing coarse particles of a pharmaceutically active material which are uncoated or coated with a polymer or lipid material. Preferably, the oral dosage form comprises coarse particles having a size in the range of 50 micron to 400 micron. The oral solid rapidly disintegrating dosage form according to the present invention preferably disintegrates in the oral cavity in less than 10 seconds.

    摘要翻译： 本发明涉及含有未涂覆或用聚合物或脂质材料涂覆的药物活性物质粗颗粒的口服固体，快速崩解的冷冻干燥剂型。 优选地，口服剂型包含尺寸在50微米至400微米范围内的粗颗粒。 根据本发明的口服固体快速崩解剂型优选在少于10秒内在口腔中崩解。

    Floatable fishing device
    39.
    发明授权
    Floatable fishing device 失效
    浮动钓鱼装置

    公开(公告)号：US3973347A

    公开(公告)日：1976-08-10

    申请号：US403636

    申请日：1973-10-04

    申请人： Patrick Kearney

    发明人： Patrick Kearney

    IPC分类号： A01K93/02 ,  A01K97/12

    CPC分类号： A01K93/02

    摘要： A floatable fishing device comprising a float and fishing lamps to indicate catches of fish on hooks associated with the device. A pair of pendulum operated switches actuate two lamps, of different colors, depending on the direction of the swinging of the pendulum when the float is inclined by the pull of caught fish. The float is provided with a guide rod. A ring secured to the free end of a fishing line is slidable on the guide rod. A plurality of hooks are attached to the fishing line in spaced relationship. The device permits the fisherman to fish at a remote distance.

    摘要翻译： 一种可漂浮的钓鱼装置，其包括浮子和钓鱼灯，以指示与该装置相关联的钩上的钓鱼钩。 一对摆锤操作的开关驱动两个不同颜色的灯，这取决于当浮子被捕获的鱼倾斜时摆锤摆动的方向。 浮子设有导杆。 固定在钓线自由端的环可以在导杆上滑动。 多个钩以相互间隔的关系连接在钓鱼线上。 该设备允许渔民在远距离钓鱼。