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    User interface for a fluidic system of a flow cytometer
    31.
    发明申请
    User interface for a fluidic system of a flow cytometer 有权
    用于流式细胞仪流体系统的用户界面

    公开(公告)号：US20090104075A1

    公开(公告)日：2009-04-23

    申请号：US11549560

    申请日：2006-10-13

    Applicant: Collin A. Rich

    Inventor： Collin A. Rich

    IPC: G01N35/08 ,  G05D7/06 ,  B01L3/00 ,  G05B13/02

    CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/115831 ,  Y10T436/117497

    Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

    Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

    SYSTEM AND METHOD OF CAPTURING MULTIPLE SOURCE EXCITATIONS FROM A SINGLE LOCATION ON A FLOW CHANNEL
    32.
    发明申请
    SYSTEM AND METHOD OF CAPTURING MULTIPLE SOURCE EXCITATIONS FROM A SINGLE LOCATION ON A FLOW CHANNEL 有权
    从流动通道上的单个位置捕获多个源的激活的系统和方法

    公开(公告)号：US20080055595A1

    公开(公告)日：2008-03-06

    申请号：US11848229

    申请日：2007-08-30

    Applicant: David C. Olson ,  Collin A. Rich

    Inventor： David C. Olson ,  Collin A. Rich

    IPC: G01J3/30 ,  G01J3/443

    CPC classification number: G01J3/4338 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

    Abstract: The invention includes a system and a method for capturing multi source excitations from a single location on a flow channel. The system preferably includes a light subsystem that emits light onto a single location on a flow channel, a detector subsystem to detect light emitted from the single location on the flow channel, and a processor to separate the detected light. The method preferably includes emitting light onto a single location on a flow channel, detecting light emitted from the single location on the flow channel, and separating the detected light.

    Abstract translation: 本发明包括一种用于从流通道上的单个位置捕获多源兴奋的系统和方法。 该系统优选地包括将光发射到流动通道上的单个位置的光子系统，用于检测从流动通道上的单个位置发射的光的检测器子系统以及用于分离检测到的光的处理器。 该方法优选地包括将光发射到流动通道上的单个位置，检测从流动通道上的单个位置发射的光并分离检测到的光。

    Systems and user interface for collecting a data set in a flow cytometer
    34.
    发明授权
    Systems and user interface for collecting a data set in a flow cytometer 有权
    用于在流式细胞仪中收集数据集的系统和用户界面

    公开(公告)号：US09280635B2

    公开(公告)日：2016-03-08

    申请号：US13820968

    申请日：2011-10-25

    Applicant: Collin A. Rich

    Inventor： Collin A. Rich

    IPC: G01N33/48 ,  G01N33/50 ,  G01N31/00 ,  G06F19/10 ,  G06F19/26 ,  G01N15/14 ,  G06F19/12 ,  G06M11/02

    CPC classification number: G01N15/1434 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/18 ,  G01J3/36 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1429 ,  G06F19/10 ,  G06F19/12 ,  G06F19/26 ,  G06M11/02

    Abstract: Systems in a flow cytometer having an interrogation zone and illumination impinging the interrogation zone include: a lens subsystem including a collimating element that collimates light from the interrogation zone, a light dispersion element that disperses collimated light into a light spectrum, and a focusing lens that focuses the light spectrum onto an array of adjacent detection points; a detector array, including semiconductor detector devices, that collectively detects a full spectral range of input light signals, in which each detector device detects a subset spectral range of the full spectral range of light signals; and a user interface that enables a user to create a set of virtual detector channels by grouping detectors in the detector array, such that each virtual detector channel corresponds to a detector group and has a virtual detector channel range including the sum of subset spectral ranges of the detectors in the corresponding detector group.

    Abstract translation: 具有询问区和照射询问区的照明的流式细胞仪中的系统包括：透镜子系统，包括准直来自询问区的光的准直元件，将准直光分散到光谱中的光分散元件和聚焦透镜， 将光谱聚焦到相邻检测点的阵列上; 检测器阵列，包括半导体检测器装置，其共同地检测输入光信号的全光谱范围，其中每个检测器装置检测光信号的全光谱范围的子集光谱范围; 以及用户界面，其使得用户能够通过对检测器阵列中的检测器进行分组来创建一组虚拟检测器通道，使得每个虚拟检测器通道对应于检测器组并且具有虚拟检测器通道范围，该虚拟检测器通道范围包括： 相应检测器组中的检测器。

    Flow cell for a flow cytometer system
    35.
    发明授权
    Flow cell for a flow cytometer system 有权
    流式细胞仪用于流式细胞仪系统

    公开(公告)号：US08445286B2

    公开(公告)日：2013-05-21

    申请号：US12514052

    申请日：2007-11-07

    Applicant: Nathaniel C. Bair ,  Collin A. Rich ,  Mark Robert Eadie ,  Rebecca Ann Lehrmann

    Inventor： Nathaniel C. Bair ,  Collin A. Rich ,  Mark Robert Eadie ,  Rebecca Ann Lehrmann

    IPC: G01N33/48 ,  G01N35/08 ,  G01N21/00 ,  G01N33/00 ,  G01N35/00

    CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  Y10T29/49826 ,  Y10T137/0352 ,  Y10T137/0379 ,  Y10T137/0419 ,  Y10T436/115831 ,  Y10T436/117497

    Abstract: The flow cytometer system of the preferred embodiment includes a flow cell body that functions to contain, protect, and align the components of the flow cytometer system; a flow channel, coupled to the flow cell body, that functions to conduct and focus sample fluid through an interrogation zone; and a sample injection probe, removably coupled to the flow cell body, that functions to provide a uniform flow of sample fluid to the flow channel. The flow cytometer system is preferably designed for the flow cytometer field. The flow cytometer system, however, may be alternatively used in any suitable environment and for any suitable reason.

    Abstract translation: 优选实施例的流式细胞仪系统包括流动池体，其用于容纳，保护和对准流式细胞仪系统的组件; 耦合到流动池主体的流动通道，其用于将样品流体引导和聚焦通过询问区; 以及可移除地耦合到流动池主体的样​​品注入探针，其用于提供样品流体到流动通道的均匀流动。 流式细胞仪系统优选设计用于流式细胞仪领域。 然而，流式细胞仪系统可以替代地在任何合适的环境中用于任何合适的原因。

    SYSTEM AND METHOD FOR CREATING A FLOW CYTOMETER NETWORK
    36.
    发明申请
    SYSTEM AND METHOD FOR CREATING A FLOW CYTOMETER NETWORK 有权
    用于创建流动计量网络的系统和方法

    公开(公告)号：US20130080082A1

    公开(公告)日：2013-03-28

    申请号：US13697739

    申请日：2011-06-14

    Applicant: Grant C. Howes ,  Collin A. Rich

    Inventor： Grant C. Howes ,  Collin A. Rich

    IPC: G01F1/00 ,  G06F17/00 ,  G01F25/00

    CPC classification number: G01F1/00 ,  G01F25/0007 ,  G01N15/14 ,  G01N35/00871 ,  G06F17/00 ,  G06F19/28

    Abstract: A system for creating a flow cytometer network includes: a flow cytometer with an interrogation zone and a fixed gain detection system that collects sample data from the interrogation zone; a flow cytometer data center that stores and manages sample- related data from the flow cytometer; and a network communication module that communicates sample-related data between the flow cytometer and the data center. The system may include a second flow cytometer and a second network communication module, where the first and second flow cytometers are calibrated to have substantially identical fixed gain settings. A method for creating a flow cytometer network includes: calibrating first and second flow cytometers with a calibration solution; collecting sample data with a fixed gain detection system; uploading data to a flow cytometer data center; retrieving data from the data center; and performing data analysis on the retrieved data.

    Abstract translation: 用于产生流式细胞仪网络的系统包括：具有询问区的流式细胞仪和从询问区收集样本数据的固定增益检测系统; 流式细胞仪数据中心，用于存储和管理来自流式细胞仪的样品相关数据; 以及在流式细胞仪和数据中心之间传送样本相关数据的网络通信模块。 该系统可以包括第二流式细胞仪和第二网络通信模块，其中第一和第二流式细胞仪被校准以具有基本相同的固定增益设置。 创建流式细胞仪网络的方法包括：用校准溶液校准第一和第二流式细胞仪; 用固定增益检测系统收集样本数据; 将数据上传到流式细胞仪数据中心; 从数据中心检索数据; 并对所检索的数据执行数据分析。

    Flow cytometer system with unclogging feature
    37.
    发明授权
    Flow cytometer system with unclogging feature 有权
    流式细胞仪系统具有不记录功能

    公开(公告)号：US08262990B2

    公开(公告)日：2012-09-11

    申请号：US12857405

    申请日：2010-08-16

    Applicant: Nathaniel C. Bair ,  Collin A. Rich

    Inventor： Nathaniel C. Bair ,  Collin A. Rich

    IPC: G01N21/00 ,  B08B7/00 ,  F17D1/00 ,  G01N35/08

    CPC classification number: F04B23/04 ,  F04B43/0081 ,  F04B43/12 ,  F04B2201/1201 ,  F04B2205/09 ,  G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T137/0352 ,  Y10T137/0379 ,  Y10T137/0402 ,  Y10T137/85986 ,  Y10T436/115831 ,  Y10T436/117497

    Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

    Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

    Flow cytometer system with sheath and waste fluid measurement
    38.
    发明授权
    Flow cytometer system with sheath and waste fluid measurement 有权
    流式细胞仪系统用护套和废液测量

    公开(公告)号：US07981661B2

    公开(公告)日：2011-07-19

    申请号：US11736412

    申请日：2007-04-17

    Applicant: Collin A. Rich

    Inventor： Collin A. Rich

    IPC: C12M1/36 ,  G01N33/48 ,  G01N27/22

    CPC classification number: G01N15/1404 ,  G01N2015/1409 ,  Y10T436/115831

    Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, a sheath volume measurement device to measure the fluid in the sheath container, a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone into a waste container, and a waste volume measurement device to measure the fluid in the waste container. The system also includes a controller connected to the sheath pump, the waste pump, and the volume measurement devices. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone, which functions to provide a location for the fluidic system and an optical system of the flow cytometer to cooperatively facilitate the analysis of the sample fluid.

    Abstract translation: 优选实施例的流体系统包括鞘套泵，以将护套流体从护套容器泵送到询问区域中;护套体积测量装置，用于测量护套容器中的流体;泵送护套流体的废泵和样品流体 作为从询问区到废物容器的废液，以及用于测量废物容器中的流体的废物体积测量装置。 该系统还包括连接到护套泵，废水泵和体积测量装置的控制器。 护套泵和/或废液泵将样品流体从样品容器抽入询问区，其功能是提供流体系统的位置和流式细胞计数器的光学系统，以便协调地促进样品流体的分析。

    Optical system for a flow cytometer with an interrogation zone
    39.
    发明申请
    Optical system for a flow cytometer with an interrogation zone 有权
    具有询问区的流式细胞仪的光学系统

    公开(公告)号：US20110058163A1

    公开(公告)日：2011-03-10

    申请号：US12939836

    申请日：2010-11-04

    Applicant: Collin A. Rich

    Inventor： Collin A. Rich

    IPC: G01N1/10

    CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G02B27/141 ,  G02B27/145

    Abstract: The optical system of the preferred embodiments includes a first light source that creates a first beam of a first wavelength, a first collimating element that collimates the first beam, a second light source 102 that creates a second beam of a second wavelength, a second collimating element that collimates the second beam, a beam combining element that combines the collimated beams, and a focusing element that focuses the combined collimated beam to a single point.

    Abstract translation: 优选实施例的光学系统包括产生第一波长的第一光束的第一光源，准直第一光束的第一准直元件，产生第二波长的第二光束的第二光源102，第二准直 对第二光束进行准直的元件，组合准直光束的光束组合元件以及将组合的准直光束聚焦到单个点的聚焦元件。

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