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31.发明授权Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same 失效钝化和稳定的多孔矿物氧化物载体及其制备和使用方法
公开(公告)号：US5268097A
公开(公告)日：1993-12-07
申请号：US956404
申请日：1992-10-05
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/206 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide supports are disclosed that are stabilized against leaching under harsh environmental conditions by the application of a thin, protective polymeric coating atop their porous surfaces and that are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by the use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction between biomolecules and the protective polymeric coating on the surfaces of the mineral oxide matrix.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔无机氧化物载体，其在恶劣的环境条件下通过在其多孔表面顶上施加薄的保护性聚合物涂层而稳定化，并且其特征在于基本上不伴随非特异性吸附的可逆的高吸附能力 或与生物分子相互作用。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除生物分子与生物分子之间不合需要的非特异性相互作用 矿物氧化物基体表面上的保护性聚合物涂层。
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公开(公告)号：US09205053B2
公开(公告)日：2015-12-08
申请号：US12534070
申请日：2009-07-31
Applicant: Jean-Marie Vogel , Richard Thomas , Egisto Boschetti
Inventor： Jean-Marie Vogel , Richard Thomas , Egisto Boschetti
IPC: A61K9/14 , A61K9/00 , A61K47/48 , A61K49/04 , A61L27/38 , A61L27/50 , A61L31/00 , A61L31/14 , A61K31/78 , A61K31/785 , A61K9/16
CPC classification number: A61K9/14 , A61K9/0019 , A61K9/16 , A61K9/1635 , A61K9/1641 , A61K31/78 , A61K31/785 , A61K47/6925 , A61K47/6927 , A61K49/0442 , A61K49/048 , A61L27/38 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.
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33.发明授权公开(公告)号：US08673266B2
公开(公告)日：2014-03-18
申请号：US12686320
申请日：2010-01-12
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US20130344567A1
公开(公告)日：2013-12-26
申请号：US13976557
申请日：2011-12-30
Applicant: Egisto Boschetti , Gérald Perret
Inventor： Egisto Boschetti , Gérald Perret
CPC classification number: C12N9/6437 , B01J20/289 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3278 , C07H21/02 , C07H21/04 , C07K1/22
Abstract: The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.
Abstract translation: 本发明涉及通过接枝在活化的固体底物上固定含有至少一种反应性胺官能团的核酸配体的方法，包括将pH值小于6的所述活化的固体底物上的所述核酸偶联的步骤。
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公开(公告)号：US20110250167A1
公开(公告)日：2011-10-13
申请号：US12822800
申请日：2010-06-24
Applicant: Egisto Boschetti , Lee O. Lomas
Inventor： Egisto Boschetti , Lee O. Lomas
IPC: A61K38/20 , A61K38/22 , A61K38/18 , A61K39/00 , A61K39/395 , A61K38/28 , A61K38/49 , A61K38/21 , A61P37/02 , A61P35/00 , A61P19/00 , A61P31/12 , A61P17/06 , C40B40/04 , C40B60/12 , A61K38/43
Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.
Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，结合污染蛋白质和少数靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。
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Patent Agency Ranking
36.发明授权Chromatographic material for the absorption of proteins at physiological ionic strength 有权用于在生理离子强度下吸收蛋白质的色谱材料公开(公告)号：US08021889B2
公开(公告)日：2011-09-20
申请号：US10583509
申请日：2005-01-14
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。
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公开(公告)号：US20110033508A1
公开(公告)日：2011-02-10
申请号：US12534070
申请日：2009-07-31
Applicant: Jean-Marie VOGEL , Richard Thomas , Egisto Boschetti
Inventor： Jean-Marie VOGEL , Richard Thomas , Egisto Boschetti
IPC: A61K8/02 , A61K9/14 , A61K31/74 , A61K31/78 , A61K8/81 , A61K31/765 , A61K8/89 , A61K31/785 , A61P17/02 , A61P1/04 , A61P13/00 , A61Q19/00 , A61M5/178
CPC classification number: A61K9/14 , A61K9/0019 , A61K9/16 , A61K9/1635 , A61K9/1641 , A61K31/78 , A61K31/785 , A61K47/6925 , A61K47/6927 , A61K49/0442 , A61K49/048 , A61L27/38 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.
Abstract translation: 本发明涉及用于真皮增生和组织膨胀的弹性，亲水和基本上球形的微球。 本发明提供了包含微球和用于真皮增生的生物相容性载体的可注射组合物。 本发明还提供使用可注射组合物的皮肤增强和组织膨胀的方法，特别是用于治疗皮肤轮廓缺陷，胃食管反流病，尿失禁和尿反流疾病的方法。
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38.发明申请DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES 审中-公开分散化学图书馆附有具有参照性质的小颗粒公开(公告)号：US20090247421A1
公开(公告)日：2009-10-01
申请号：US12162125
申请日：2006-03-22
Applicant: Egisto Boschetti , Lee Lomas
Inventor： Egisto Boschetti , Lee Lomas
CPC classification number: C07K1/047 , G01N33/54326 , G01N33/6848
Abstract: The present invention provides diverse chemical libraries bound to small particle with paramagnetic properties. Typically, the chemical structures comprise a plurality of different chemical moieties, the particles are paramagnetic and have a diameter between about 100 nm and about 10 microns, the chemical structures bound to each particular particle have substantially the same structure and the combinatorial library comprises at least 100,000 different chemical structures.
Abstract translation: 本发明提供了与具有顺磁性质的小颗粒结合的不同化学文库。 通常，化学结构包括多个不同的化学部分，颗粒是顺磁性的并且具有约100nm至约10微米之间的直径，与每个特定颗粒结合的化学结构具有基本上相同的结构，组合文库至少包含 100,000种不同的化学结构。
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39.发明申请公开(公告)号：US20090117196A1
公开(公告)日：2009-05-07
申请号：US12348867
申请日：2009-01-05
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: A61K9/14
CPC classification number: A61K9/1635 , A61K47/6927
Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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40.发明申请Chromatographic material for the absorption of proteins at physiological ionic strength 有权用于在生理离子强度下吸收蛋白质的色谱材料公开(公告)号：US20070151910A1
公开(公告)日：2007-07-05
申请号：US10583509
申请日：2005-01-14
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01D15/08
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。
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