公开(公告)号：US11168287B2

公开(公告)日：2021-11-09

申请号：US16301580

申请日：2016-05-26

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Kathleen C. Engelbrecht ,  Stacy A. Mundschau ,  David W. Koenig ,  Scott W. Wenzel

IPC: C11D3/48 ,  C11D17/04 ,  C11D3/37 ,  C11D3/20 ,  C11D3/26 ,  A61K8/02 ,  A61K8/88 ,  A61K8/81 ,  A61K8/85 ,  A61K8/86 ,  A61K8/90 ,  A61K8/37 ,  A61K8/40 ,  A61Q17/00 ,  A01N25/08 ,  A01N43/50 ,  A01N37/02 ,  A01N37/06 ,  A01N37/34 ,  A01N37/42 ,  A01N31/02 ,  A01N25/00 ,  C08L71/02 ,  A61K47/34 ,  A61K9/00 ,  A61K47/32 ,  A61K9/06 ,  A61Q19/10

Abstract: Methods of inhibiting microbes from attaching to a surface and anti-adherent compositions are disclosed. One method can include providing an anti-adherent composition that includes an anti-adherent agent configured to inhibit microbes from attaching to the surface. The anti-adherent agent can be: Acrylates Copolymer, Trimethylpentanediol/Adipic Acid/Glycerin crosspolymer, Trimethylpentanediol/Adipic Acid Copolymer, Ethylhexyl Stearate, Ethylhexyl Salicylate, Acrylates/C12-22 Alkylmethacrylate Copolymer, Octocrylene, Ethylene Oxide/Propylene Oxide Block Copolymer, Polyquaternium-101, or any combinations thereof. The method can include applying the composition to the surface and allowing at least some of the composition to remain on the surface such that the anti-adherent agent inhibits microbes from attaching to the surface. The anti-adherent composition can include a humectant and can be non-antimicrobial.

公开(公告)号：US20210092949A1

公开(公告)日：2021-04-01

申请号：US17111597

申请日：2020-12-04

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Amy L. Vanden Heuvel ,  Douglas R. Hoffman ,  Jeremy D. Paulsen ,  Rebecca Vongsa ,  Paige N. Anunson ,  Lisa M. Kroll ,  Corey T. Cunningham ,  David W. Koenig

IPC: A01N25/10 ,  A01N25/34 ,  A61L2/18 ,  C09D7/61 ,  C09D7/63 ,  A01N25/04 ,  A01N33/12 ,  A01N37/36 ,  A01N59/26 ,  C09D5/14 ,  C09D139/06

Abstract: A disinfectant composition that is capable of inactivating non-enveloped viruses as well as other microorganisms, such as gram negative and gram positive bacteria, fungi, parasites, enveloped viruses, etc., is provided. Through selective control over the nature of the acid(s) employed and the overall pH level, the present inventors have discovered that the composition can achieve rapid antiviral efficacy, particularly against non-enveloped viruses. Once applied to a surface (e.g., hard surface), the disinfectant composition forms a film that remains capable of providing residual antiviral activity. Notably, the present inventors have discovered that the use of a vinylpyrrolidone copolymer in combination with a polyquaternary ammonium polymer and cationic surfactant can have a synergistic effect on the stability of the film such that it can also achieve long-term, residual antiviral activity.

公开(公告)号：US10292916B2

公开(公告)日：2019-05-21

申请号：US16011248

申请日：2018-06-18

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Vinod Chaudhary ,  Scott W. Wenzel ,  Kathleen C. Engelbrecht ,  David W. Koenig ,  Amy L. Vanden Heuvel ,  Divesh Bhatt ,  Paige N. Hollmaier (Anunson) ,  Stacy A. Mundschau

IPC: A61K8/34 ,  C09D5/14 ,  C09D101/28 ,  A61K8/73 ,  A61Q17/00 ,  A61K8/81 ,  A61K8/02

Abstract: The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract Gram-negative and Gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include Hydroxypropyl methylcellulose, Cellulose gum, Acacia Senegal Gum; Polyacrylate Crosspolymer-11, VP/Dimethylaminoethylmethacrylate/Polycarbamyl Polyglycol Ester; Acrylates/Vinyl Neodecanoate Crosspolymer, hydroxypropyl methylcellulose, Hydroxypropylcellulose, Methylcellulose, Propylene Glycol Alginate, Polyacrylate Crosspolymer-6, VP/Polycarbamyl Polyglycol Ester, Acrylates/Steareth-20 Methacrylate Copolymer; Acrylates Copolymer, and any combination thereof. The anti-adherent may be applied to surfaces using a vehicle such as a wipe.

公开(公告)号：US20180098536A1

公开(公告)日：2018-04-12

申请号：US15561311

申请日：2015-04-01

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： David W. Koenig ,  Amy L. Vanden Heuvel ,  Vinod Chaudhary ,  Scott W. Wenzel ,  Divesh Bhatt ,  Kathleen Engelbrecht

IPC: A01N25/34

CPC classification number: A01N25/34 ,  A61K31/717 ,  A61K31/74 ,  D21J1/16 ,  Y02A50/473 ,  Y02A50/481 ,  A01N25/10 ,  A01N25/30

Abstract: A fibrous substrate for the removal of Gram negative bacteria (Escherichia coli) from a surface is provided. The fibrous substrate includes a capturing agent, and the affinity of capturing for the Gram negative bacteria allows the fibrous substrate to capture the Gram negative bacteria, thereby removing the Gram negative bacteria from the surface and also inhibiting the spread of the Gram negative bacteria to other surfaces that may contact the fibrous substrate. Of particular advantage, the presence of the capturing agent on the fibrous substrate may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics.

公开(公告)号：US20170303535A1

公开(公告)日：2017-10-26

申请号：US15329799

申请日：2015-04-01

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Kathleen C. Engelbrecht ,  Vinod Chaudhary ,  David W. Koenig ,  Divesh Bhatt ,  Amy L. Vanden Heuvel ,  Scott W. Wenzel ,  Paige N. Anunson ,  Stacy A. Mundschau

IPC: A01N25/34 ,  A01N25/02 ,  C09D183/08 ,  C09D183/06 ,  C09D183/04 ,  C09D179/08 ,  C09D177/00 ,  C09D175/08 ,  C09D171/02 ,  C09D167/00 ,  C09D139/06 ,  C09D133/26 ,  C09D133/14 ,  C09D133/02 ,  C09D129/04 ,  C09D105/04 ,  C09D105/00 ,  C09D101/28 ,  C09D101/02 ,  C09D7/12 ,  C09D189/00 ,  A61L2/18 ,  A01N65/40 ,  A01N65/20 ,  A01N65/08 ,  A01N57/12 ,  A01N55/00 ,  A01N47/18 ,  A01N43/36 ,  A01N43/16 ,  A01N37/20 ,  A01N37/18 ,  A01N37/16 ,  A01N37/04 ,  A01N31/02 ,  C09D201/02 ,  C08K5/053

CPC classification number: A01N25/34 ,  A01N25/02 ,  A01N31/02 ,  A01N37/04 ,  A01N37/16 ,  A01N37/18 ,  A01N37/20 ,  A01N43/16 ,  A01N43/36 ,  A01N47/18 ,  A01N55/00 ,  A01N57/12 ,  A01N65/08 ,  A01N65/20 ,  A01N65/40 ,  A61L2/18 ,  C08K5/053 ,  C08L1/28 ,  C08L1/284 ,  C08L71/02 ,  C08L2203/02 ,  C09D7/63 ,  C09D101/02 ,  C09D101/284 ,  C09D105/00 ,  C09D105/04 ,  C09D129/04 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D139/06 ,  C09D167/00 ,  C09D171/02 ,  C09D175/08 ,  C09D177/00 ,  C09D179/08 ,  C09D183/04 ,  C09D183/06 ,  C09D183/08 ,  C09D189/00 ,  C09D201/025

Abstract: Compositions for inhibiting the attachment of microbes to surfaces are disclosed. The compositions include a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include Hydroxypropyl methylcellulose; Methylcellulose, Hydroxypropylcellulose, Hydroxyethylcellulose, Dimethicone PEG-7 Phosphate, Propylene Glycol Alginate, Bis-PEG-15 Dimethicone/IPDI Copolymer, Polyimide-1, Polyquaternium-101, Polyester-5, Hydrolyzed Wheat Protein/PVP Crosspolymer, Polymethacrylamidopropyl Trimonium Chloride, Ethylene Oxide/Propylene Oxide Block Copolymer, Trideceth-9 PG-Amodimethicone (and) Trideceth-12, PEG-12 Dimethicone, Cyclopentasiloxane (and) Caprylyl Dimethicone Ethoxy Glucoside, Dimethicone PEG-8 succinate, Linoleamidopropyl PG-Dimonium Chloride Phosphate Dimethicone, Polyvinyl Pyrrolidone; Gum; Polyacrylate Crosspolymer-11; PEG-8 SMDI Copolymer; Polyvinyl Alcohol; VP/Dimethylaminoethylmethacrylate/Polycarbamyl Polyglycol Ester; VP/Polycarbamyl Polyglycol Ester; VP/Dimethiconylacrylate/polycarbamyl Polyglycol Ester; Acrylates/Steareth-20 Methacrylate Copolymer; a mixture of Acrylates Copolymer and VP/Polycarbamyl Polyglycol Ester; and any combination thereof. Various delivery vehicles, such as wipes, may be used to deliver the composition to surfaces.

公开(公告)号：US20170210900A1

公开(公告)日：2017-07-27

申请号：US15329611

申请日：2015-04-01

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Kathleen C. Engelbrecht ,  Amy L. Vanden Heuvel ,  David W. Koenig ,  Divesh Bhatt ,  Vinod Chaudhary ,  Scott W. Wenzel ,  Stacy A. Mundschau

IPC: C08L101/00 ,  A61K8/02 ,  C08L83/04 ,  C08J3/02

CPC classification number: C08L101/00 ,  A61K8/0208 ,  A61K8/731 ,  A61K8/8117 ,  A61K8/8152 ,  A61K8/817 ,  A61K8/8182 ,  A61K8/84 ,  A61K8/891 ,  A61Q17/005 ,  C08G77/045 ,  C08G77/16 ,  C08G77/46 ,  C08J3/02 ,  C08L83/04 ,  C09D183/04

Abstract: Compositions for inhibiting the attachment of microbes to a biotic or abiotic surface are disclosed. The compositions include a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include Cyclopentasiloxane (and) Dimethiconol, sodium polystyrene sulfonate, Acrylates/Vinyl Neodecanoate Crosspolymer, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polyquaternium-22, Hydroxypropyl methylcellulose, Polyquaternium-7, Acrylates/Aminoacrylates/C10-30 Alkyl PEG-20 Itaconate Copolymer and combinations thereof. Various delivery vehicles, such as wipes, may be used to deliver the composition to surfaces.

公开(公告)号：US20170208798A1

公开(公告)日：2017-07-27

申请号：US15329653

申请日：2015-04-01

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Vinod Chaudhary ,  Kathleen C. Engelbrecht ,  David W. Koenig ,  Divesh Bhatt ,  Amy L. Vanden Heuvel ,  Scott W. Wenzel ,  Stacy A. Mundschau

IPC: A01N31/02 ,  A01N25/02 ,  A01N47/20 ,  A01N55/00 ,  A01N43/36 ,  A01N45/00 ,  A01N63/02 ,  A01N37/44 ,  A01N65/00 ,  A01N25/08 ,  A01N41/08

CPC classification number: A01N31/02 ,  A01N25/02 ,  A01N25/08 ,  A01N37/44 ,  A01N41/08 ,  A01N43/36 ,  A01N45/00 ,  A01N47/20 ,  A01N55/00 ,  A01N63/02 ,  A01N65/00 ,  A01N65/12 ,  A01N65/18 ,  A61K8/0208 ,  A61K8/8152 ,  A61K8/8158 ,  A61K8/86 ,  A61K8/891 ,  A61K8/893 ,  A61K8/895 ,  A61K8/898 ,  A61K8/90 ,  A61K8/922 ,  A61K8/925 ,  A61K8/97 ,  A61Q17/005 ,  C08G2650/58 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/02

Abstract: Compositions for inhibiting the attachment of microbes to a biotic or abiotic surface are disclosed. The compositions include a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include Dimethicone Propyl PG-Betaine, PEG-150/Decyl Alcohol/SMDI Copolymer, Ammonium Acryloyl Dimethyltaurate/Carboxyethyl, Acrylate Crosspolymer, PEG-20 Soy Sterol, PEG/PPG-25/25 Dimethicone, PEG-12 Dimethicone, Dimethicone, Cyclopentasiloxane (and) PEG-12 Dimethicone Crosspolymer, PPG-12-PEG-50 Lanolin, Glycerin (and) Glycine Max (Soybean) Seed Extract, VP/Dimethiconylacrylate/Polycarbamyl/Polyglycol Ester, PEG-10 Sunflower Glycerides, PEG-8 Amodimethicone, PEG/PPG 20/23 Dimethicone Isobutylene/Ethylmaleimide/Hydroxyethylmaleimide Copolymer, Methacryloyl Ethyl Betaine/Acrylates Copolymer, Poloxamer 407, Ethylene Oxide/Propylene Oxide Block Copolymer, PEG-200 Hydrogenated Castor Oil/IPDI Copolymer, PEG-15 Soyamine/IPDI Copolymer Dimer Dilinoleate, Dimethicone PEG-7 Isostearate, PEG-12 Dimethicone, PEG-17 Dimethicone, Polyoxyethylene Polyoxypropylene block copolymer, Polyalkyleneoxide modified silicone copolymer, Disteareth-75 IPDI, and combinations thereof. Various delivery vehicles, including wipes, may be used to deliver the composition to surfaces.

公开(公告)号：US20240307428A1

公开(公告)日：2024-09-19

申请号：US18673865

申请日：2024-05-24

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay A. Peed ,  Paige N. Hollmaier ,  Rebecca A. Vongsa ,  David W. Koenig ,  Cheryce F. Joyner

IPC: A61K31/7068 ,  A61K31/198 ,  A61K45/06

CPC classification number: A61K31/7068 ,  A61K31/198 ,  A61K45/06

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally include a first therapeutic agent including α methyl-D glucoside and a second therapeutic agent including a nitrogen containing compound at a therapeutic amount. In some embodiments, the nitrogen containing compound can be, for example, L-Cysteine, Cytidine, D-Asparagine, Pyrimidine, D-Alanine, D-Glucosamine HCL, and N-Acetyl-D-Glucosamine.

公开(公告)号：US20240057591A1

公开(公告)日：2024-02-22

申请号：US18547596

申请日：2022-03-30

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： David W. Koenig ,  Salvador E. Escobar ,  Andrew R. Kischnick ,  Brian T. Roessler ,  Jane Ballesteros

IPC: A01N25/34 ,  A01P1/00 ,  A01N59/04

CPC classification number: A01N25/34 ,  A01P1/00 ,  A01N59/04

Abstract: Described herein is an antimicrobial wet wipe including a wet wipe formulation. Also described herein is a method of preserving the wet wipe formulation. Also described herein is a method of manufacturing the wet wipe formulation.

公开(公告)号：US20230400438A1

公开(公告)日：2023-12-14

申请号：US18034776

申请日：2020-12-07

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Elizabeth M. Doney ,  Kathleen C. Engelbrecht ,  David W. Koenig ,  Stephen Quirk ,  Kassi Kosnicki

IPC: G01N30/72 ,  G01N33/68

CPC classification number: G01N30/72 ,  G01N33/6848 ,  G01N2800/341 ,  G01N2030/027

Abstract: Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, allo-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.