公开(公告)号：US20200368962A1

公开(公告)日：2020-11-26

申请号：US16761643

申请日：2018-12-03

Applicant: Massachusetts Institute of Technology

Inventor： Hyunwoo Yuk ,  Xuanhe Zhao

IPC: B29C64/118 ,  B29C64/393 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y30/00 ,  B29C64/209

Abstract: Systems and methods for three-dimensionally printing different configurations of a printed fiber using a single nozzle are provided. The provided systems and methods harness deformation, instability, and fracture of viscoelastic materials to adjust dimensionless parameters related to a speed of extrusion and a height of a nozzle to create the different configurations. A controller of the system can operate to create these different configurations using the single nozzle without having to change out hardware during the process. Instead, the dimensionless parameters can be adjusted while the printing is occurring to achieve the different configurations. The disclosure provides various systems for carrying out the printing, and methods of using the same.

公开(公告)号：US20190125934A1

公开(公告)日：2019-05-02

申请号：US15794432

申请日：2017-10-26

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  German Alberto Parada Hernandez ,  Hyunwoo Yuk

IPC: A61L29/14 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L29/16 ,  G01N21/80

Abstract: Hydrogel-substrate laminate structures and tough biocompatible hydrogel coatings for various equipment such as medical devices and underwater equipment, in which robust interfaces are formed between the hydrogel coatings and the substrate/equipment surface(s). The hydrogel coatings provide a highly-hydrated, ultra-low friction structure that does not rupture or delaminate under stress. The hydrogel coatings may further incorporate a variety of therapeutic agents and/or sensing mechanisms to provide for environmental sensing and therapeutic agent release.

公开(公告)号：US09878506B2

公开(公告)日：2018-01-30

申请号：US14970704

申请日：2015-12-16

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk

IPC: A61K9/00 ,  B29C71/00 ,  A61K49/22 ,  A61B8/00 ,  C08J3/075 ,  C08J3/24 ,  B29K105/00 ,  A61B17/225

CPC classification number: B29C71/0009 ,  A61B8/4281 ,  A61B2017/2253 ,  A61K49/226 ,  B29K2105/0061 ,  B29K2995/0078 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/14 ,  C08J2300/208 ,  C08J2333/26

Abstract: Method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy. The precursor hydrogel is stretched to a multiple of its original length to form a pre-stretched hydrogel. The pre-stretched hydrogel is allowed to relax and is soaked in a biocompatible solvent to reach equilibrium swelling of the pre-stretched hydrogel whereby shear modulus of the hydrogel is reduced.

公开(公告)号：US20170226339A1

公开(公告)日：2017-08-10

申请号：US15172131

申请日：2016-06-02

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk ,  Teng Zhang ,  German Alberto Parada

IPC: C08L33/26 ,  C09D133/26 ,  C08L35/00 ,  B05D3/04 ,  C09D135/00 ,  H01B1/12 ,  B05D3/10 ,  C09J133/26 ,  C09J135/00

CPC classification number: C08L33/26 ,  B05D3/044 ,  B05D3/10 ,  B32B27/04 ,  B32B27/308 ,  C08L35/00 ,  C08L2205/04 ,  C09D133/26 ,  C09D135/00 ,  C09D201/02 ,  C09J133/26 ,  C09J135/00 ,  H01B1/122

Abstract: Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm−2.

公开(公告)号：US20170136180A1

公开(公告)日：2017-05-18

申请号：US15274218

申请日：2016-09-23

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk ,  Teng Zhang

IPC: A61M5/172 ,  A61K9/70 ,  A61K9/06 ,  A61M35/00 ,  A61K9/00

CPC classification number: A61M5/1723 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0053 ,  A61K9/0097 ,  A61K9/06 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/34 ,  A61M5/14 ,  A61M35/00 ,  A61M2230/005 ,  A61M2230/50

Abstract: A tough biocompatible hydrogel having one or more drug delivery components, deformable conductors, and/or rigid electronic components incorporated therein in such a way that robust interfaces are formed between the hydrogel and the various components. The resulting hydrogel device provides a highly deformable hydrogel composite in which the reliability and functionality of the incorporated components are maintained even under states of large deformation, and from which one or more drugs can be delivered in a controlled and sustained manner regardless of the state of deformation.

公开(公告)号：US20250084284A1

公开(公告)日：2025-03-13

申请号：US18792950

申请日：2024-08-02

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Hyunwoo Yuk ,  Xiaoyu Chen

IPC: C09J7/32 ,  A61L24/00 ,  C08K5/00 ,  C09J7/20 ,  C09J105/00 ,  C09J109/04 ,  C09J125/08 ,  C09J129/04 ,  C09J133/06 ,  C09J133/10 ,  C09J133/26 ,  C09J151/00 ,  C09J175/00 ,  C09J181/08

Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

公开(公告)号：US12054653B2

公开(公告)日：2024-08-06

申请号：US17327944

申请日：2021-05-24

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Hyunwoo Yuk ,  Xiaoyu Chen

IPC: C09J7/32 ,  A61L24/00 ,  C08K5/00 ,  C09J7/20 ,  C09J105/00 ,  C09J109/04 ,  C09J125/08 ,  C09J129/04 ,  C09J133/06 ,  C09J133/10 ,  C09J133/26 ,  C09J151/00 ,  C09J175/00 ,  C09J181/08

CPC classification number: C09J7/32 ,  A61L24/0031 ,  C08K5/0025 ,  C09J7/20 ,  C09J105/00 ,  C09J109/04 ,  C09J125/08 ,  C09J129/04 ,  C09J133/064 ,  C09J133/066 ,  C09J133/10 ,  C09J133/26 ,  C09J151/003 ,  C09J175/00 ,  C09J181/08 ,  C09J2301/10 ,  C09J2301/306 ,  C09J2301/502 ,  C09J2405/00 ,  C09J2429/00 ,  C09J2433/00 ,  C09J2451/00 ,  C09J2475/00

Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

公开(公告)号：US11904067B2

公开(公告)日：2024-02-20

申请号：US16846293

申请日：2020-04-11

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Hyunwoo Yuk

IPC: A61L24/00 ,  A61B5/00 ,  A61B5/11 ,  A61K9/70 ,  A61L24/04 ,  B32B9/02 ,  B32B29/00 ,  A61F13/00

CPC classification number: A61L24/0031 ,  A61B5/1102 ,  A61B5/68335 ,  A61K9/7084 ,  A61L24/043 ,  B32B9/02 ,  B32B29/002 ,  A61B2562/0261 ,  A61F2013/00676 ,  B32B2307/7163 ,  B32B2307/748 ,  B32B2405/00 ,  B32B2535/00 ,  A61L24/043 ,  C08L33/08 ,  A61L24/043 ,  C08L33/10 ,  A61L24/043 ,  C08L5/08

Abstract: Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

公开(公告)号：US11850290B2

公开(公告)日：2023-12-26

申请号：US16318958

申请日：2017-07-20

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Xinyue Liu ,  Tzu-Chieh Tang ,  Eléonore Claire Tham ,  Xuanhe Zhao

IPC: A61K49/00 ,  A61B5/00 ,  C12N11/04 ,  C12N11/10 ,  C12N15/63 ,  C12N15/70 ,  C12Q1/6897

CPC classification number: A61K49/0097 ,  A61B5/6806 ,  A61B5/6833 ,  A61K49/0073 ,  C12N11/04 ,  C12N11/10 ,  C12N15/63 ,  C12N15/70 ,  C12Q1/6897

Abstract: Provided herein, in some embodiments, are hydrogel-elastomer and hydrogel-alginate devices, compositions and associated methods to encapsulate living cells.

公开(公告)号：US20220403220A1

公开(公告)日：2022-12-22

申请号：US17833101

申请日：2022-06-06

Applicant: Massachusetts Institute of Technology

Inventor： Gang Chen ,  Xuanhe Zhao ,  Shaoting Lin ,  Yoichiro Tsurimaki

IPC: C09J183/06 ,  C09J7/30 ,  C09J7/24

Abstract: The present disclosure generally relates to a stretchable anti-fogging tape (SAT) that can be applied to diverse transparent materials with varied curvatures for persistent fogging prevention. The SAT comprises three synergistically-combined transparent layers: i) a stretchable middle layer with high elastic recovery to keep transparent materials tightly bound; ii) an anti-fogging top layer to impart hydrophilicity to transparent materials; and iii) an adhesive bottom layer to form robust yet reversible adhesion between transparent materials and SATs. The SAT can be configured to have water condensate form a predominantly continuous film thereon in response to a high humidity environment At least two applications are demonstrated, including the SAT-adhered eyeglasses and goggles for clear fog-free vision, and the SAT-adhered condensation cover for efficient solar-powered freshwater production.