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    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    32.
    发明申请
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 审中-公开
    多重探测目标相互作用模式的自动分析：模式匹配与识别

    公开(公告)号：US20110077167A1

    公开(公告)日：2011-03-31

    申请号：US12961086

    申请日：2010-12-06

    Applicant: Xiongwu Xia ,  Michael Seul

    Inventor： Xiongwu Xia ,  Michael Seul

    IPC: C40B30/04

    CPC classification number: C12Q1/6827 ,  G16B20/00 ,  G16B30/00

    Abstract: Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.

    Abstract translation: 公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。 优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入， 出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。 它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于 等位基因

    Directed assembly of functional heterostructures
    33.
    发明授权
    Directed assembly of functional heterostructures 失效
    定向组装功能异质结构

    公开(公告)号：US07625765B2

    公开(公告)日：2009-12-01

    申请号：US11253452

    申请日：2005-10-19

    Applicant: Sukanta Banerjee ,  Kairali Podual ,  Michael Seul

    Inventor： Sukanta Banerjee ,  Kairali Podual ,  Michael Seul

    IPC: G01N33/551

    CPC classification number: C08J3/075 ,  C08J3/28 ,  C08J2333/26 ,  C08J2425/06 ,  C12Q1/6837 ,  G01N33/5005 ,  G01N33/545 ,  G03F7/0047 ,  G03F7/164 ,  Y10T428/249952 ,  Y10T428/25

    Abstract: The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology.

    Abstract translation: 本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装 定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。 本发明还涉及这种功能组件在材料科学和生物学中的应用。 其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。 用于生成多功能薄膜的小型化格式。 提供简单的设置来合成定制组合和形态的薄膜。

    Pricing of the identification service by a registry which identifies prospective donors having particular bloodtypes to a requisitioner
    34.
    发明授权
    Pricing of the identification service by a registry which identifies prospective donors having particular bloodtypes to a requisitioner 有权
    通过注册机构对身份识别服务进行定价，该注册管理机构将具有特定血型的潜在捐赠者识别给申购者

    公开(公告)号：US07613573B2

    公开(公告)日：2009-11-03

    申请号：US11412667

    申请日：2006-04-27

    Applicant: Yi Zhang ,  Michael Seul

    Inventor： Yi Zhang ,  Michael Seul

    IPC: G01N33/48

    CPC classification number: G06F19/327 ,  G06F19/00 ,  G06Q30/02 ,  G06Q30/0202 ,  G06Q50/22 ,  G06Q50/24 ,  G16H40/20

    Abstract: Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.

    Abstract translation: 公布了候选人输血捐助者的登记册，该登记处援引了库存管理政策，以创建和主动管理候选人捐助者名单，以便最大限度地减少多个地区和多个捐助者和接受者之间的需求与供应之间的不平衡。 与基因分型实验室一起，注册管理机构确实针对招募潜在的捐赠者，这些捐赠者是针对一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变体和可能的其他抗原如HLA 和HPA。 注册管理机监测输血抗原基因型的输入需求，最好将需求分为一组代表稳定亚群体的类别，并将应用本文所披露的策略来调整候选捐献者名单的组成以匹配需求，从而避免过多和不必要的 ，候选人捐款人的打字。

    Optimization of Gene Expression Analysis using Immobilized Capture Probes
    35.
    发明申请
    Optimization of Gene Expression Analysis using Immobilized Capture Probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US20090263820A1

    公开(公告)日：2009-10-22

    申请号：US12480215

    申请日：2009-06-08

    Applicant: Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    Abstract translation: 公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括 目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译 位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

    Dynamically configurable electrode formed of pixels
    36.
    发明授权
    Dynamically configurable electrode formed of pixels 有权
    由像素组成的动态配置电极

    公开(公告)号：US07604718B2

    公开(公告)日：2009-10-20

    申请号：US10778520

    申请日：2004-02-14

    Applicant: Yi Zhang ,  Michael Seul

    Inventor： Yi Zhang ,  Michael Seul

    IPC: B03C5/00

    CPC classification number: B01L3/502715 ,  B01J2219/00653 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0415 ,  B03C5/005 ,  B03C5/026

    Abstract: A dynamically configurable electrode includes a first planar electrode and a planar array of pixels in a different plane, wherein a polarizable liquid medium (including electrolyte solutions) is to reside in the gap between electrodes. The pixels are individually addressable by a time-varying voltage, and adjacent pixels receive, at any instant in time, either the same voltage waveform or a different voltage waveform. Adjacent pixels receiving different voltage waveforms generate corresponding movement of dipolar entities, including dipolar particles, ions, or dipolar molecules in the polarizable liquid medium between the electrodes, which can in turn generate fluid flow and movement of particles suspended in the fluid along the planar array surface.

    Abstract translation: 动态配置的电极包括第一平面电极和不同平面中的平面像素阵列，其中可极化液体介质（包括电解质溶液）驻留在电极之间的间隙中。 这些像素可以通过时变电压单独寻址，并且相邻像素在任何时刻接收相同的电压波形或不同的电压波形。 接收不同电压波形的相邻像素产生偶极实体的相应运动，包括在电极之间的可极化液体介质中的偶极子，离子或偶极子分子，这反过来又会沿平面阵列产生悬浮在流体中的流体流动和运动 表面。

    Optimization of gene expression analysis using immobilized capture probes
    37.
    发明授权
    Optimization of gene expression analysis using immobilized capture probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US07563569B2

    公开(公告)日：2009-07-21

    申请号：US10974036

    申请日：2004-10-26

    Applicant: Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    Abstract translation: 公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括 目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译 位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

    Programmable Illumination Pattern for Transporting Microparticles
    39.
    发明申请
    Programmable Illumination Pattern for Transporting Microparticles 有权
    用于运输微粒的可编程照明模式

    公开(公告)号：US20080173544A1

    公开(公告)日：2008-07-24

    申请号：US12029189

    申请日：2008-02-11

    Applicant: Michael Seul ,  Chiu Wo Chau

    Inventor： Michael Seul ,  Chiu Wo Chau

    IPC: C25D13/00

    CPC classification number: B01L3/502792 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0454 ,  C12Q1/6837 ,  G01N15/0266 ,  G01N30/0005 ,  G01N33/54313 ,  G01N2015/0288 ,  G01N2015/149 ,  C12Q2565/607 ,  C12Q2563/155

    Abstract: An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles: the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects them onto planar surfaces. i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.

    Abstract translation: 公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。 该装置实现LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装：电解质/氧化硅/硅界面的图案化以对组装过程施加空间控制; 并通过外部照明实现对装配过程的实时控制。 该设备产生照明模式并将其投影到平面上。 即LEAPS电极。 这使得能够使用个人计算机上的图形设计或绘图软件来创建图案，并且使用液晶显示器（LCD）面板将所述图案或图案序列（“时变图案”）投影到界面上 将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

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