公开(公告)号：US07943902B2

公开(公告)日：2011-05-17

申请号：US11916355

申请日：2006-05-26

Applicant: Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

Inventor： Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/4295 ,  H01J49/0072 ,  H01J49/0095 ,  H01J49/062

Abstract: A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.

Abstract translation: 描述了将离子引入离子阱和离子存储装置的方法。 引入装置用于通过离子阱的入口将第一离子引入离子阱。 引入装置的操作条件被调整以使得与第一离子不同的第二离子通过相同的入口孔引入离子阱。

公开(公告)号：US20090055797A1

公开(公告)日：2009-02-26

申请号：US11844121

申请日：2007-08-23

Applicant: Li Ding ,  Donald J. Yantzi

Inventor： Li Ding ,  Donald J. Yantzi

IPC: G06F9/44

CPC classification number: G06F8/00

Abstract: A method and computer program product of incrementally visualizing graphical extensible models for legacy software applications via a user interface are provided. A graph of nodes and connections showing only the highest level of details are presented. Each node that contains additional, lower level, details is shown with an expansion icon that may be selected to see additional levels of detail for the node. When selected, the user interface drills down to show the next lowest level of details for that artifact within a visual boundary of the original artifact that was expanded. Because of the nested, hierarchical nature of the model, relationships between higher level artifacts can be inferred from explicit relationships between lower level artifacts. When the node is expanded, any connections that previously connected to the higher level artifact are updated to connect to the appropriate artifact in the lower level details.

Abstract translation: 提供了一种通过用户界面逐步可视化传统软件应用程序的图形可扩展模型的方法和计算机程序产品。 提出了仅显示最高级别细节的节点和连接图。 包含附加，较低级别的详细信息的每个节点都会显示一个扩展图标，该图标可能被选择以查看该节点的附加级别的详细信息。 当选择时，用户界面向下钻取，以便在扩展的原始工件的视觉边界内显示该工件的下一个最低级别的细节。 由于模型的嵌套层次性，可以从较低级别的工件之间的显式关系推断出较高级的工件之间的关系。 当节点扩展时，先前连接到较高级别工件的任何连接都将被更新，以连接到较低级别详细信息中的相应工件。

公开(公告)号：US20080300147A1

公开(公告)日：2008-12-04

申请号：US10590675

申请日：2005-03-28

Applicant: Nasser Chegini ,  Xiaoping Luo ,  Li Ding ,  R. Stan Williams

Inventor： Nasser Chegini ,  Xiaoping Luo ,  Li Ding ,  R. Stan Williams

IPC: C40B40/06 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/364

Abstract: The present invention provides a method for detecting a fibrotic disorder in a subject by: (a) providing a biological sample obtained from the subject (such as endometrium, peritoneal fluid, and/or smooth muscle cells); (b) analyzing the expression of at least one gene that is differentially expressed in the fibrotic disorder of interest; and (c) correlating the expression of the gene(s) with the presence or absence of the fibrotic disorder in the subject. The present invention also provides a method and compositions for modulating the expression of genes that are differentially expressed in fibrotic tissues, compared to normal tissues. Restoration of gene expression to levels associated with normal tissue is expected to ameliorate at least some of the symptoms of the fibrotic disorder. This method includes the step of contacting the tissue with an agent that modulates expression of one or more differentially expressed genes in the tissue. The present invention also includes arrays, such as microfluidic cards, for detecting differential gene expression in samples of fibrotic tissue.

Abstract translation: 本发明提供一种通过以下方法检测受试者中的纤维化病症的方法：（a）提供从受试者获得的生物样品（例如子宫内膜，腹膜液和/或平滑肌细胞）; （b）分析在感兴趣的纤维化疾病中差异表达的至少一种基因的表达; 和（c）将基因的表达与受试者中是否存在纤维化病症相关联。 本发明还提供了与正常组织相比调节在纤维组织中差异表达的基因表达的方法和组合物。 将基因表达恢复到与正常组织相关的水平，预期可以改善纤维化病症的至少一些症状。 该方法包括使组织与调节组织中一种或多种差异表达基因的表达的试剂接触的步骤。 本发明还包括用于检测纤维组织样品中差异基因表达的阵列，例如微流控卡。

公开(公告)号：US07326924B2

公开(公告)日：2008-02-05

申请号：US10558474

申请日：2004-06-02

Applicant: Li Ding ,  Francesco Lorenzo Brancia

Inventor： Li Ding ,  Francesco Lorenzo Brancia

IPC: H01J49/42 ,  H01J49/00 ,  B01D59/44

CPC classification number: H01J49/424 ,  H01J49/429

Abstract: A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.

Abstract translation: 使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比 其具有接近感兴趣的离子的质荷比的下限。 确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。

公开(公告)号：US07272807B2

公开(公告)日：2007-09-18

申请号：US11071121

申请日：2005-03-02

Applicant: Li Ding ,  Peivand Fallah Tehrani ,  Alireza Kasnavi

Inventor： Li Ding ,  Peivand Fallah Tehrani ,  Alireza Kasnavi

IPC: G06F17/50

CPC classification number: G06F17/5036 ,  G06F17/5031

Abstract: An equivalent waveform for a distorted waveform used in timing and signal integrity analysis in the design of an integrated circuit is automatically generated. The equivalent waveform is produced by calculating the transition quantity of a first non-distorted waveform. The transition quantity is the amount of transition of the first non-distorted waveform that is required for the cell to produce an output waveform with a predetermined end voltage. The end point of the transition period for the distorted waveform is then determined based on when the distorted waveform has accumulated the same transition quantity. The equivalent waveform can then be formed by computing a second non-distorted waveform such that the end point of the transition period for the second non-distorted waveform coincides with the end point of the transition period for the distorted waveform.

Abstract translation: 自动生成在集成电路设计中用于定时和信号完整性分析的失真波形的等效波形。 通过计算第一非失真波形的转移量来产生等效波形。 转换量是单元格产生具有预定端电压的输出波形所需的第一非失真波形的转变量。 然后，基于失真波形累积相同过渡量的时间来确定失真波形的转换周期的终点。 然后可以通过计算第二非失真波形来形成等效波形，使得第二非失真波形的转换周期的终点与失真波形的过渡周期的终点重合。

公开(公告)号：US20070092885A1

公开(公告)日：2007-04-26

申请号：US11378616

申请日：2006-03-20

Applicant: Henry Yue ,  Monique Yao ,  Ameena Gandhi ,  Mariah Baughn ,  Anita Swarnakar ,  Narinder Chawla ,  Madhusudan Sanjanwala ,  Michael Thornton ,  Vicki Elliott ,  Yan Lu ,  Kimberly Gietzen ,  Neil Burford ,  Li Ding ,  April Hafalia ,  Y. Tang ,  Olga Bandman ,  Bridget Warren ,  Cynthia Honchell ,  Dyung Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti Lal ,  Bao Tran ,  Craig Ison ,  Brendan Duggan ,  Stephanie Sapperstein

Inventor： Henry Yue ,  Monique Yao ,  Ameena Gandhi ,  Mariah Baughn ,  Anita Swarnakar ,  Narinder Chawla ,  Madhusudan Sanjanwala ,  Michael Thornton ,  Vicki Elliott ,  Yan Lu ,  Kimberly Gietzen ,  Neil Burford ,  Li Ding ,  April Hafalia ,  Y. Tang ,  Olga Bandman ,  Bridget Warren ,  Cynthia Honchell ,  Dyung Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti Lal ,  Bao Tran ,  Craig Ison ,  Brendan Duggan ,  Stephanie Sapperstein

IPC: C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C07K14/705

CPC classification number: C12N15/1055 ,  A61K39/3955 ,  A61K47/64 ,  A61K47/643 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/4711 ,  C07K14/4713 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/5023

Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

公开(公告)号：US20070075239A1

公开(公告)日：2007-04-05

申请号：US10558474

申请日：2004-06-02

Applicant: Li Ding ,  Francesco Brancia

Inventor： Li Ding ,  Francesco Brancia

IPC: H01J49/42

CPC classification number: H01J49/424 ,  H01J49/429

Abstract: A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.

Abstract translation: 使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比 其具有接近感兴趣的离子的质荷比的下限。 确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。

公开(公告)号：US07088143B2

公开(公告)日：2006-08-08

申请号：US10847018

申请日：2004-05-17

Applicant: Li Ding ,  Pinaki Mazumder

Inventor： Li Ding ,  Pinaki Mazumder

IPC: H03K19/096 ,  H03K19/00 ,  H03K19/20 ,  H03K19/094

CPC classification number: H03K19/0963

Abstract: A number of different dynamic circuits having improved noise tolerance and a method for designing same are provided. The circuits include a power supply node and a precharge node. Keeper circuitry is connected to the nodes and has a current-voltage characteristic that exhibits a negative differential resistance property to improve noise tolerance of the circuits.

Abstract translation: 提供了许多具有改进的噪声容限的不同动态电路及其设计方法。 电路包括电源节点和预充电节点。 Keeper电路连接到节点，并具有呈现负差分电阻特性的电流 - 电压特性，以改善电路的噪声容限。

公开(公告)号：US06927056B2

公开(公告)日：2005-08-09

申请号：US10363937

申请日：2001-09-06

Applicant: Stephen Todd ,  Angelo M. Delegeane ,  Ameena R. Gandhi ,  Danniel B. Nguyen ,  April J. A. Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine A. Lee ,  Narinder K. Chawla ,  Debopriya Das ,  Chandra S. Arvizu ,  Monique G. Yao ,  Deborah A. Kallick ,  Vicki S. Elliott ,  Li Ding ,  Henry Yue ,  Roopa M. Reddy ,  Dyung Aina M. Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine M. Tribouley ,  Neil Burford ,  Mariah R. Baughn ,  Preeti G. Lal ,  Mark L. Borowsky ,  Farrah A. Khan ,  Rajagopal Gururajan ,  Y. Tom Tang ,  Janice K. Au-Young ,  Bridget A. Warren ,  Roberto Hernandez ,  Brendan M. Duggan

Inventor： Stephen Todd ,  Angelo M. Delegeane ,  Ameena R. Gandhi ,  Danniel B. Nguyen ,  April J. A. Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine A. Lee ,  Narinder K. Chawla ,  Debopriya Das ,  Chandra S. Arvizu ,  Monique G. Yao ,  Deborah A. Kallick ,  Vicki S. Elliott ,  Li Ding ,  Henry Yue ,  Roopa M. Reddy ,  Dyung Aina M. Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine M. Tribouley ,  Neil Burford ,  Mariah R. Baughn ,  Preeti G. Lal ,  Mark L. Borowsky ,  Farrah A. Khan ,  Rajagopal Gururajan ,  Y. Tom Tang ,  Janice K. Au-Young ,  Bridget A. Warren ,  Roberto Hernandez ,  Brendan M. Duggan

IPC: A01K67/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12P21/06 ,  C12Q1/68 ,  C12N1/20 ,  C12N15/00 ,  C12N15/63

CPC classification number: C12N9/6421 ,  A01K2217/05 ,  A01K2217/075 ,  C07H21/04 ,  C12N9/6472 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  Y02A50/52

Abstract: The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.

Abstract translation: 本发明提供编码这些蛋白酶的人半胱氨酸蛋白酶和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂，以及用于诊断，治疗或预防与半胱氨酸蛋白酶异常表达相关的紊乱的方法。

公开(公告)号：US20050135974A1

公开(公告)日：2005-06-23

申请号：US10739784

申请日：2003-12-18

Applicant: Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

Inventor： Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

IPC: B01L3/00 ,  B01L9/00 ,  G01N1/31 ,  G01N31/22

CPC classification number: B01L3/50855 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/0822 ,  B01L2300/0829 ,  G01N1/312

Abstract: The present invention relates to a device for preparing assay samples using a number of microscope slides. Each slide has a number of assay reaction surface locations spaced on the planar surface of the slide. In preferred embodiments, the device comprises, in part, a microscope slide holder that has the exterior dimensions of a SBS standard microplate, such as a 96 well plate. The device accepts conventional microscope slides equipped with sixteen microarray surfaces spaced nine millimeters apart on center, or four for a 96 well plate. Individual chamber plates are placed on top of the slides, creating an individual well above each assay reaction surface location. In preferred embodiments, each assay reaction surface location can comprise a microarray of multiple reactive sites. Thus, parallel processing can be done of samples for genomic or proteomic profiling. An advantage of the present invention is that one can use the conventional high throughput assaying equipment for SBS standard microplates while using conventional microscope slides, thereby allowing the use of robotic assay reading equipment designed for slides.

Abstract translation: 本发明涉及使用多个显微镜幻灯片制备测定样品的装置。 每个载片具有在载玻片平面上间隔开的多个测定反应表面位置。 在优选实施例中，该装置部分地包括具有诸如96孔板的SBS标准微板的外部尺寸的显微镜载玻片保持器。 该装置接受传统的显微镜载玻片，其中装有十六个微阵列表面，中心隔开9毫米，或四个96孔板。 单独的室板放置在载玻片的顶部，在每个测定反应表面位置之上产生单个孔。 在优选实施方案中，每个测定反应表面位置可以包含多个反应性位点的微阵列。 因此，可以对基因组或蛋白质组图谱的样品进行并行处理。 本发明的一个优点是可以使用传统的高通量测定设备用于SBS标准微孔板，同时使用传统的显微镜载玻片，从而允许使用为幻灯片设计的机器人测定读数设备。