Fuel oil composition
    31.
    发明授权
    Fuel oil composition 有权
    燃油组成

    公开(公告)号:US07497880B2

    公开(公告)日:2009-03-03

    申请号:US10856724

    申请日:2004-05-28

    申请人: Graham Jackson

    发明人: Graham Jackson

    IPC分类号: C10L1/18

    摘要: A fuel oil composition comprising a fuel oil and 0.1 to 10,000 ppm of a polymeric condensation product which is formed by the reaction of an aliphatic aldehyde or ketone, or a reactive equivalent, with either (i) a straight or branched chain C1-C7 alkyl ester of p-hydroxybenzoic acid, or with (ii) a branched chain C8-C16 alkyl ester of p-hydroxybenzoic acid, or with (iii) a mixture of long chain C8-C18 alkyl esters of p-hydroxybenzoic acid, at least one of said alkyls being branched. The polymeric condensation product improves the cold flow characteristics of the fuel oil.

    摘要翻译: 一种燃料油组合物,其包含燃料油和0.1至10,000ppm的聚合缩合产物,其通过脂族醛或酮或反应性当量与(i)直链或支链C 1 -C 7烷基 对 - 羟基苯甲酸的酯或与(ii)对羟基苯甲酸的支链C 8 -C 16烷基酯或(iii)对羟基苯甲酸的长链C8-C18烷基酯的混合物,至少一种 的所述烷基是支链的。 聚合物缩合产物改善了燃油的冷流特性。

    Prion decontamination
    32.
    发明申请
    Prion decontamination 审中-公开
    朊病毒去污

    公开(公告)号:US20060217282A1

    公开(公告)日:2006-09-28

    申请号:US10532265

    申请日:2003-10-29

    IPC分类号: C11D3/386

    摘要: The present invention relates to methods for prion decontamination comprising (i) contacting an entity to be decontaminated with a detergent, (ii) contacting said entity with one or more protease(s), and optionally (iii) autoclaving said entity. The invention further relates to kits comprising detergents and proteases for prion decontamination, and compositions comprising detergents and proteases for prion decontamination.

    摘要翻译: 本发明涉及用于朊病毒去污的方法,其包括(i)使待去污染的实体与洗涤剂接触,(ii)使所述实体与一种或多种蛋白酶接触,和任选地(iii)高压灭菌所述实体。 本发明还涉及包含用于朊病毒去污的洗涤剂和蛋白酶的试剂盒,以及包含洗涤剂和蛋白酶用于朊病毒去污的组合物。

    Biological materials and methods useful in the diagnosis and treatment of diseases
    33.
    发明申请
    Biological materials and methods useful in the diagnosis and treatment of diseases 失效
    用于诊断和治疗疾病的生物材料和方法

    公开(公告)号:US20060029547A1

    公开(公告)日:2006-02-09

    申请号:US11140416

    申请日:2005-05-27

    IPC分类号: A61K49/00 C12P21/06 C07K14/47

    摘要: The present invention relates to a method of making a β-form of a prion protein which preferably has more β-sheet than α-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the β-form in medicine, especially for raising to antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native α-form of a prion protein to a β-form, and to uses of identified compounds in medicine.

    摘要翻译: 本发明涉及一种制备朊蛋白的β型的方法,其优选比α-螺旋结构具有更多的β-折叠,并且在不存在变性剂和/或非聚集的情况下是可溶的,并表现出对 用蛋白酶K消化。本发明还涉及β-形式在药物中的用途,特别是用于提供可用于治疗和/或诊断朊病毒疾病的抗体。 本发明还涉及筛选能够抑制和/或逆转天然α-形式的朊病毒蛋白转化为β型的化合物的方法,以及在药物中使用鉴定的化合物。

    Chemical compositions and their use as fuel additives
    39.
    发明授权
    Chemical compositions and their use as fuel additives 失效
    化学成分及其作为燃料添加剂的用途

    公开(公告)号:US5578091A

    公开(公告)日:1996-11-26

    申请号:US937906

    申请日:1992-10-13

    摘要: Compounds of general formula (I) wherein X and Y are the same or different and are selected from the group consisting of SO.sub.3 (--), --CO--, --C(O)O(--), --R.sup.4 --C(O)O--, --NR.sup.3 C(O)--, --R.sup.4 O--, --R.sup.4 --C(O)O--, --R.sup.4 -- and --NC(O)--, R.sup.4 being --(CH.sub.2).sub.m -- where m is from 0 to 5 and R.sup.3 is defined below; X.sup.1 and Y.sup.1 are the same or different and are selected from the group consisting of (a), R.sup.1 and R.sup.2 being independently selected from the group consisting of alkyl, alkoxy alkyl or polyalkoxyalkyl groups that contain at least 10 carbon atoms in their main chain, and R.sup.3 being a hydrocarbyl group, each R.sup.3 in a compound of formula (I) being the same of different; A is, together with the carbon atoms with which it constitutes the ring structure in formula (I), an aromatic, non-aromatic, or aliphatic group, where any of such groups can be mono- or polycyclic and/or can include one or more hetero atoms selected from nitrogen, sulphur and oxygen; and Z is selected from nitro, hydroxy, alkyl, alkoxy, carboxy acid and carboxy ester, and their use as low temperature flow improvers for distillate fuels.

    摘要翻译: PCT No.PCT / GB91 / 00623 Sec。 371日期:1992年10月13日 102(e)日期1992年10月13日PCT 1991年4月19日PCT PCT。 No.W091 / 16297 PCT出版物 (I)通式(I)的化合物,其中X和Y相同或不同,并且选自SO 3( - ), - CO - , - C(O) O( - ),-R4-C(O)O-,-NR3C(O) - ,-R4O-,-R4-C(O)O-,-R4-和-NC(O) (CH 2)m - ,其中m为0至5,并且R 3定义如下; X1和Y1相同或不同,并且选自(a),R 1和R 2独立地选自在其主链中含有至少10个碳原子的烷基,烷氧基烷基或聚烷氧基烷基, 并且R 3是烃基,式(I)化合物中的每个R 3是不同的; 与式(I)中其构成环结构的碳原子一起是芳族,非芳族或脂族基团,其中任何这些基团可以是单环或多环的,和/或可以包括一个或多个 更多的选自氮,硫和氧的杂原子; Z选自硝基,羟基,烷基,烷氧基,羧酸和羧基酯,它们用作馏出燃料的低温流动改进剂。