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    Antimycotic Polymerisable Bone Cement and a Method for the Production Thereof
    32.
    发明申请
    Antimycotic Polymerisable Bone Cement and a Method for the Production Thereof 有权
    抗真菌可聚合骨水泥及其生产方法

    公开(公告)号：US20160235883A1

    公开(公告)日：2016-08-18

    申请号：US15016534

    申请日：2016-02-05

    申请人： Heraeus Medical Gmbh

    发明人： Sebastian VOGT

    IPC分类号： A61L24/04 ,  A61K31/7048 ,  A61L24/00

    CPC分类号： A61L24/043 ,  A61K31/7048 ,  A61L24/0015 ,  A61L24/0073 ,  A61L24/06 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/802 ,  A61L2430/02 ,  A61L2430/38

    摘要： The invention describes a bone cement with antimycotic efficacy based on organic polymers, such as polymethylmethacrylate. The bone cement comprises an antimycotic agent, in particular amphotericin B, that is released from the polymerised bone cement in the presence of water or aqueous media, such as body fluids. According to one alternative, the antimycotic agent is present in particulate form and is encapsulated, at least in part, by a mixture of at least one 1-methylamino-1-deoxy sugar alcohol and at least one fatty acid. In addition, a method for the production of a mixture comprising an antimycotic agent, such as amphotericin B particles, and 1-methylamino-1-deoxy sugar alcohol and at least one fatty acid is proposed. Preferably, the antimycotic agent is encapsulated, at least partially, by 1-methylamino-1-deoxy sugar alcohol and at least one fatty acid.

    摘要翻译： 本发明描述了一种基于有机聚合物（如聚甲基丙烯酸甲酯）具有抗真菌功效的骨水泥。 骨水泥包含抗真菌剂，特别是两性霉素B，其在水或含水介质如体液的存在下从聚合骨水泥中释放出来。 根据一个替代方案，抗真菌剂以颗粒形式存在，并且至少部分地由至少一种1-甲基氨基-1-脱氧糖醇和至少一种脂肪酸的混合物包封。 此外，提出了制备包含抗霉菌剂如两性霉素B颗粒和1-甲基氨基-1-脱氧糖醇和至少一种脂肪酸的混合物的方法。 优选地，抗真菌剂至少部分地由1-甲基氨基-1-脱氧糖醇和至少一种脂肪酸包封。

    Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same
    36.
    发明授权
    Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same 有权
    用于递送治疗剂的纤维的气球导管及其制备方法

    公开(公告)号：US09227041B2

    公开(公告)日：2016-01-05

    申请号：US13082562

    申请日：2011-04-08

    申请人： Jan Weber ,  John T. Clarke ,  Aiden Flanagan

    发明人： Jan Weber ,  John T. Clarke ,  Aiden Flanagan

    IPC分类号： A61M25/10 ,  A61L29/16

    CPC分类号： A61M25/1002 ,  A61L29/16 ,  A61L2300/602 ,  A61L2300/802 ,  A61L2420/02 ,  A61M2025/1031 ,  A61M2025/105

    摘要： A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer.

    摘要翻译： 医疗装置包括具有可扩张构件的导管，从可扩张构件的外表面延伸的纤维，以及涂覆在纤维上或被携带在纤维之间的空间中的治疗剂。 在可膨胀构件膨胀时，治疗剂从医疗装置输送。 可以在纤维上涂布表面活性剂。 一种制造方法包括用金属层涂覆可膨胀构件的外表面，用至少一个聚合物层涂覆金属层，在至少一个聚合物层中形成多个孔，在孔中形成纤维，并在 至少一个聚合物层。

    PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS
    37.
    发明申请
    PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS 审中-公开
    制备干燥和稳定的HEMOSTATIC组合物的方法

    公开(公告)号：US20150367022A1

    公开(公告)日：2015-12-24

    申请号：US14804084

    申请日：2015-07-20

    申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

    发明人： Andreas Goessl ,  Atsushi Edward Osawa ,  Cary J. Reich

    IPC分类号： A61L24/04 ,  A61K38/39 ,  B65B55/02 ,  A61K9/19 ,  B65B3/00 ,  B65B5/12 ,  A61K38/48 ,  A61L24/00

    CPC分类号： A61L24/043 ,  A61K9/0014 ,  A61K9/1658 ,  A61K9/19 ,  A61K38/39 ,  A61K38/4833 ,  A61L24/0015 ,  A61L24/10 ,  A61L24/106 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2400/06 ,  B65B3/003 ,  B65B5/12 ,  B65B55/02 ,  C12Y304/21005 ,  Y10T428/13

    摘要： Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.

    摘要翻译： 描述了制备干燥和稳定的止血组合物的方法，所述方法包括a）提供包含凝结诱导剂的干制剂的第一组分，b）提供第二组分，其包含适于用于 止血，c）以最终容器中的组合形式提供所述第一组分和所述第二组分，c1）通过将所述第一组分和所述第二组分填充到所述最终容器中以在所述最终容器中获得干混合物，c2 ）或通过在所述最终容器中提供所述第一组分或所述第二组分并加入所述第二组分或所述第一组分以获得所述第一组分与所述最终容器中的所述第二组分的组合，d）将最终容器整理成 一种包含所述第一组分和所述第二组分的可储存药物装置，其为组合形式，为干和稳定的止血组合物 。

    Coating Formulations for Scoring or Cutting Balloon Catheters
    39.
    发明申请
    Coating Formulations for Scoring or Cutting Balloon Catheters 审中-公开
    用于评分或切割气球导管的涂料配方

    公开(公告)号：US20150297797A1

    公开(公告)日：2015-10-22

    申请号：US14731715

    申请日：2015-06-05

    申请人： AngioScore, Inc.

    发明人： Ulrich Speck ,  Madeleine Caroline Berg

    IPC分类号： A61L29/08 ,  A61L29/16 ,  A61M25/10

    CPC分类号： A61L29/08 ,  A61B17/320725 ,  A61B2017/320733 ,  A61L29/143 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/109

    摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

    摘要翻译： 本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种氧化不敏感药物或不含氧化物的无氧化物的药物制剂和至少一种亲脂性抗氧化剂，其比例为3-100％ 所述至少一种亲脂性抗氧化剂相对于所述药物的100重量％，其中所述至少一种氧化不敏感药物选自紫杉烷，沙利度胺，他汀类，皮质激素和皮质激素的亲脂性衍生物，并且所述至少一种 亲脂性抗氧化剂选自去甲二氢愈创木酸，白藜芦醇和没食子酸丙酯。

    Process for preparing bioabsorbable sheet preparation holding thrombin
    40.
    发明授权
    Process for preparing bioabsorbable sheet preparation holding thrombin 有权
    制备保持凝血酶的生物可吸收片剂的方法

    公开(公告)号：US09149557B2

    公开(公告)日：2015-10-06

    申请号：US12988241

    申请日：2009-04-15

    申请人： Ryoichi Kawamura ,  Takayuki Imamura ,  Hitomi Owaki

    发明人： Ryoichi Kawamura ,  Takayuki Imamura ,  Hitomi Owaki

    IPC分类号： A61K38/43 ,  A61L15/44 ,  A61L15/64 ,  A61L31/14 ,  A61L31/16 ,  A61K38/00

    CPC分类号： A61L15/44 ,  A61K38/00 ,  A61L15/64 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04

    摘要： A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.

    摘要翻译： 提供了一种制备保持凝血酶的生物可吸收性片剂的方法。 一种制备保持凝血酶的生物可吸收性片剂的方法，该方法包括将由聚乙醇酸组成的生物可吸收片材浸入含有凝血酶作为活性成分的凝血酶溶液，甘油作为软化剂，吐温80作为渗透剂，以及任选的组氨酸和海藻糖 稳定剂，然后干燥以在所述生物可吸收性片材上保持凝血酶，以及通过所述方法制备保持凝血酶的生物可吸收性片剂制剂。