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公开(公告)号：US10005677B2
公开(公告)日：2018-06-26
申请号：US14404575
申请日：2013-05-31
发明人： Gil Lee , Mark Platt , James O'Mahony
IPC分类号： A61K9/51 , C01G49/02 , A61K9/50 , B01J13/04 , B01J13/12 , H01F1/00 , B01F3/08 , B01F3/22 , B01F7/00 , B01F15/02 , A61B5/055 , B01F15/06
CPC分类号： C01G49/02 , A61B5/055 , A61K9/5094 , B01F3/0811 , B01F3/0853 , B01F3/223 , B01F7/00 , B01F15/0203 , B01F2015/062 , B01J13/043 , B01J13/125 , C01P2004/61 , C01P2006/42 , H01F1/0054
摘要： There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.
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公开(公告)号：US09771449B2
公开(公告)日：2017-09-26
申请号：US14791255
申请日：2015-07-03
CPC分类号： C08G59/188 , B01J13/04 , B01J13/125 , C08G59/182
摘要： A method for nanoencapsulation of an amine adduct in a polymeric shell includes steps of emulsifying a first aqueous solution including the amine adduct into an organic solution including an organic solvent and a polymer to obtain a primary emulsion; emulsifying the primary emulsion into a second aqueous phase including a stabilizer to obtain a secondary emulsion; removing the organic solvent by evaporation to form solid nanocapsules; and separating the formed solid nanocapsules by centrifugation. The nanocapsules have an average size of between about 30 nm and about 597 nm.
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公开(公告)号：US09730892B2
公开(公告)日：2017-08-15
申请号：US15249195
申请日：2016-08-26
IPC分类号： B01D11/04 , B01D11/02 , A61K9/127 , B01D1/16 , A61K31/4458 , B01F3/08 , B01F5/10 , B01F7/00 , A61K9/48 , A61M11/00 , B01J13/04 , B01J13/12 , A61K31/445 , B01F3/04 , B01F15/06
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K9/4833 , A61K31/445 , A61K31/4458 , A61M11/00 , B01D1/16 , B01F3/04049 , B01F3/0807 , B01F3/088 , B01F5/104 , B01F7/0075 , B01F15/065 , B01F2015/061 , B01F2215/0032 , B01J13/043 , B01J13/125
摘要： The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
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公开(公告)号：US09724302B2
公开(公告)日：2017-08-08
申请号：US13786378
申请日：2013-03-05
IPC分类号： B01D11/04 , B01D15/00 , B01D24/00 , A61K9/127 , B01D1/16 , A61K31/4458 , B01F3/08 , B01F5/10 , B01F7/00 , A61K9/48 , A61M11/00 , B01J13/04 , B01J13/12 , A61K31/445 , B01F3/04 , B01F15/06
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K9/4833 , A61K31/445 , A61K31/4458 , A61M11/00 , B01D1/16 , B01F3/04049 , B01F3/0807 , B01F3/088 , B01F5/104 , B01F7/0075 , B01F15/065 , B01F2015/061 , B01F2215/0032 , B01J13/043 , B01J13/125
摘要： The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
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公开(公告)号：US09687450B2
公开(公告)日：2017-06-27
申请号：US15054479
申请日：2016-02-26
申请人： Covidien LP
IPC分类号： A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
CPC分类号： A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
摘要： A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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公开(公告)号：US20170042812A1
公开(公告)日：2017-02-16
申请号：US15336131
申请日：2016-10-27
申请人： FUJIFILM Corporation
发明人： Makoto ONO , Kohei ONO , Yuuko IGARASI
IPC分类号： A61K9/127 , A61K31/7068
CPC分类号： A61K9/127 , A61K8/14 , A61K9/1271 , A61K9/1277 , A61K31/7068 , A61K47/10 , A61K47/14 , A61K2800/10 , A61Q19/00 , B01J13/125 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： Provided is a method for producing a liposome having safety and stability. According to the present invention, it is possible to provide a method for producing a liposome, including a step of mixing an oil phase with at least one lipid dissolved in an organic solvent and a water phase and stirring an aqueous solution containing the lipids, and a step of evaporating the organic solvent from the aqueous solution containing the liposomes obtained in the stirring step, in which the organic solvent is a mixed solvent of a water-soluble organic solvent and an ester-based organic solvent.
摘要翻译： 提供一种具有安全性和稳定性的脂质体的制造方法。 根据本发明，可以提供一种生产脂质体的方法，包括将油相与溶于有机溶剂中的至少一种脂质和水相混合并搅拌含有脂质的水溶液的步骤，以及 从在搅拌步骤中得到的含有脂质体的水溶液中蒸发有机溶剂的步骤，其中有机溶剂是水溶性有机溶剂和酯类有机溶剂的混合溶剂。
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37.发明授权公开(公告)号：US09550161B2
公开(公告)日：2017-01-24
申请号：US14402950
申请日：2013-05-17
申请人： DSM IP ASSETS B.V.
发明人： Nanning Joerg Arfsten , Roberto Arnoldus Dominicus Maria Habets , Michael Alphonsus Cornelis Johannes Van Dijck
IPC分类号： C09D5/00 , B05D5/06 , B05D3/02 , B01J13/12 , B01J13/18 , C03C17/00 , G02B1/11 , H01L31/0216 , H01L31/0232 , H01L31/0236 , C01G23/047 , C01G25/02 , C08J3/12 , C09D7/12 , C01B33/143 , C01B33/145 , C01B33/149 , G02B1/111
CPC分类号： B01J13/125 , B01J13/18 , B05D3/0254 , B05D5/061 , C01B33/143 , C01B33/145 , C01B33/149 , C01G23/047 , C01G25/02 , C01P2004/34 , C01P2004/64 , C03C17/007 , C03C2217/425 , C03C2217/732 , C08J3/128 , C09D5/006 , C09D7/67 , C09D7/70 , G02B1/11 , G02B1/111 , H01L31/02168 , H01L31/02325 , H01L31/02366 , Y02E10/50 , Y10T428/24997
摘要： The invention relates to a coating composition for making a porous inorganic oxide coating layer on a substrate, the composition comprising an inorganic oxide precursor as binder, a solvent, and a synthetic polyampholyte as pore forming agent. The size of the pores in the coating can be advantageously controlled by the comonomer composition of the polyampholyte, and/or by selecting conditions like temperature, pH, salt concentration, and solvent composition when making the composition. The invention also relates to a method of making such coating composition, to a process of applying a coating on a substrate using such composition, and to such coated substrate showing a specific combination of optical and mechanical properties.
摘要翻译： 本发明涉及一种用于在基材上制备多孔无机氧化物涂层的涂料组合物，该组合物包含作为粘合剂的无机氧化物前体，溶剂和作为成孔剂的合成聚阴离子。 涂层中的孔的大小可以有利地通过聚阴离子的共聚单体组成控制，和/或通过在制备组合物时选择诸如温度，pH，盐浓度和溶剂组成的条件。 本发明还涉及制备这种涂料组合物的方法，使用这种组合物在基材上涂布涂料的方法，以及显示光学和机械性能的特定组合的涂布基材。
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公开(公告)号：US20140134256A1
公开(公告)日：2014-05-15
申请号：US14156714
申请日：2014-01-16
IPC分类号： A61K9/16
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
摘要翻译： 提供了活性药物成分的微粒，包含其的药物递送载体及其制备方法。
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公开(公告)号：US20130306759A1
公开(公告)日：2013-11-21
申请号：US13786364
申请日：2013-03-05
IPC分类号： A61M11/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K9/4833 , A61K31/445 , A61K31/4458 , A61M11/00 , B01D1/16 , B01F3/04049 , B01F3/0807 , B01F3/088 , B01F5/104 , B01F7/0075 , B01F15/065 , B01F2015/061 , B01F2215/0032 , B01J13/043 , B01J13/125
摘要： The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
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40.发明授权Method for producing vesicle, vesicle obtained by the production method, and W/O/W emulsion for producing vesicle 有权生产泡囊的方法，通过生产方法获得的囊泡和用于制备囊泡的W / O / W乳液公开(公告)号：US08501204B2
公开(公告)日：2013-08-06
申请号：US12993954
申请日：2009-05-21
申请人： Sosaku Ichikawa , Takashi Kuroiwa
发明人： Sosaku Ichikawa , Takashi Kuroiwa
IPC分类号： A61K8/02
CPC分类号： B01J13/125 , A23L27/80 , A23P10/35 , A61K8/14 , A61K9/127 , A61K2800/412 , A61Q19/00
摘要： A vesicle is produced by: a step of producing a W/O emulsion from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an organic solvent phase containing a lipid having emulsification capacity, which can constitute the vesicle; a step of producing a W/O/W emulsion from the W/O emulsion and an external water phase solution of a water-soluble emulsifier, which does not destroy a vesicle lipid membrane; and a step of removing the organic solvent phase from the W/O/W emulsion, so as to form a vesicle. This method simultaneously achieves a high entrapment yield of an active ingredient and the control of a particle diameter.
摘要翻译： 囊泡是通过以下步骤生产的：从含有待溶解或悬浮状态的囊泡中的物质的水溶液和含有具有乳化能力的脂质的有机溶剂相制备W / O乳液的步骤，其可以构成 囊泡 从W / O乳液和不破坏小泡脂质膜的水溶性乳化剂的外部水相溶液制备W / O / W乳液的步骤; 以及从W / O / W乳液除去有机溶剂相以形成囊泡的步骤。 该方法同时实现了活性成分的高捕获收率和粒径的控制。
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