公开(公告)号：US09603561B2

公开(公告)日：2017-03-28

申请号：US14260755

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US09575030B2

公开(公告)日：2017-02-21

申请号：US14028331

申请日：2013-09-16

Applicant: Michael Adams

Inventor： Michael Adams

IPC: G01N27/41 ,  G01N27/416

CPC classification number: G01N27/4163 ,  G01N27/41

Abstract: An apparatus and method are provided for digitally controlling an oxygen sensor. The apparatus comprises a computer and digital circuitry coupled to the oxygen sensor to convey information between the oxygen sensor and the computer. The oxygen sensor includes a pump cell and at least one Nernst cell configured to indicate the difference in oxygen content in a test medium relative to a reference medium. A pump control circuit operates the pump cell according to signals received from the computer based on output signals from the Nernst cell. A reference voltage circuit enables the computer to determine impedances of the oxygen sensor as a function of sensor temperature and pressure. A Nernst read circuit transmits output signals from the oxygen sensor digitally to the computer. Digital signals received by the computer are compared with stored reference information so as to determine the oxygen content of the test medium.

Abstract translation: 提供了一种用于数字控制氧传感器的装置和方法。 该装置包括耦合到氧传感器以在氧传感器和计算机之间传送信息的计算机和数字电路。 氧传感器包括泵电池和至少一个能斯特电池，其配置为指示测试介质中的氧含量相对于参考介质的差异。 泵控制电路根据来自能斯特电池的输出信号根据从计算机接收的信号来操作泵浦单元。 参考电压电路使计算机能够根据传感器的温度和压力来确定氧传感器的阻抗。 能斯读取电路将氧传感器的输出信号数字地传输到计算机。 由计算机接收的数字信号与存储的参考信息进行比较，以确定测试介质的氧含量。

公开(公告)号：US20170023511A1

公开(公告)日：2017-01-26

申请号：US14660870

申请日：2015-03-17

Applicant: MATRIX SENSORS, INC.

Inventor： Paul R. Wilkinson ,  Steven Yamamoto

IPC: G01N27/22 ,  G01L1/10

CPC classification number: G01L1/10 ,  G01N27/221 ,  G01N27/4163 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2406 ,  G01N29/4427 ,  G01N33/0006 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: An array of resonant sensors self-corrects measured values for the effects of environmental conditions, such as operating temperature, pressure or humidity. The resonant sensors have varied frequency responses to N environmental parameters and M chemical parameters. Each of the sensors has a different, non-zero frequency response to at least two of the parameters. The device also comprises at least one detector for detecting frequency responses of the resonant sensors. Individual parameter values are determined for each of the N environmental parameters and M chemical parameters according to the detected frequency responses and a system of equations using calibration terms that relate the frequency responses to the individual parameter values.

Abstract translation: 谐振传感器阵列可自动校正环境条件（如工作温度，压力或湿度）影响的测量值。 谐振传感器对N个环境参数和M个化学参数具有不同的频率响应。 每个传感器对至少两个参数具有不同的非零频率响应。 该装置还包括用于检测谐振传感器的频率响应的至少一个检测器。 根据检测到的频率响应，确定N个环境参数和M个化学参数中的每一个的各个参数值​​，以及使用将频率响应与各个参数值​​相关联的校准项的方程组。

公开(公告)号：US20170014592A1

公开(公告)日：2017-01-19

申请号：US15281176

申请日：2016-09-30

Applicant: Mallinckrodt Hospital Products IP Limited

Inventor： Craig R. Tolmie ,  Jeff Milsap ,  Jaron M. Acker

IPC: A61M16/10 ,  G01N27/416 ,  G01N33/00 ,  A61M16/00 ,  A61M16/20

CPC classification number: A61M16/0051 ,  A61M16/0003 ,  A61M16/024 ,  A61M16/085 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/16 ,  A61M16/201 ,  A61M2016/102 ,  A61M2016/1035 ,  A61M2202/0275 ,  A61M2205/18 ,  A61M2205/27 ,  A61M2205/33 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/70 ,  A61M2205/702 ,  G01N27/4163 ,  G01N33/0006 ,  G01N33/0008 ,  G01N33/0037 ,  Y02A50/245 ,  A61M2202/0007

Abstract: Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used reduce the amount of times the sensor goes offline. Systems and methods described may factor in in actions occurring at the delivery system and/or aspects of the surrounding environment, prior to performing a baseline calibration, and may postpone the calibration and/or rejected using the sensor's output for the calibration.

Abstract translation: 描述了用于补偿用于将治疗性一氧化氮（NO）气体输送给患者的系统中的催化型电化学气体传感器的长期灵敏度漂移的系统和方法，其通过补偿在传递治疗剂的系统中非典型使用的传感器特异性的漂移 一氧化氮气体给患者。 在至少一些情况下，催化型电化学气体传感器的长期灵敏度漂移可以使用校准计划进行解决，这可以考虑可以驱动一个或多个基线校准的NO递送给患者的设定剂量的绝对变化。 可以使用校准计划来减少传感器脱机的次数。 所描述的系统和方法可以在执行基线校准之前考虑在递送系统和/或周围环境的方面发生的动作，并且可以使用传感器的输出推迟校准和​​/或拒绝校准。

公开(公告)号：US09470653B2

公开(公告)日：2016-10-18

申请号：US14806636

申请日：2015-07-22

Applicant: Hyundai Autron Co., Ltd.

Inventor： Young Ho Jun

IPC: G01N27/409 ,  G01N27/416 ,  G01N27/406

CPC classification number: G01N27/4163 ,  F01N2560/025 ,  G01N27/4065 ,  G01N27/409 ,  G01N27/4175 ,  G01N27/419

Abstract: A method for diagnosing disconnection of an oxygen sensor includes measuring, by a controller, a voltage supplied to an oxygen sensor through a voltage divider; measuring a voltage of a reference cell of the oxygen sensor; determining whether the voltage supplied to the oxygen sensor and the voltage of the reference cell fall within a reference range from preset reference values, respectively; and determining that a ground wire of the oxygen sensor is disconnected, when the voltage of the oxygen sensor or the voltage of the reference cell deviates from the reference range.

Abstract translation: 用于诊断氧传感器断开的方法包括通过控制器测量通过分压器提供给氧传感器的电压; 测量氧传感器的参考单元的电压; 确定提供给氧传感器的电压和参考单元的电压是否分别落在参考范围内的参考范围内; 并且当氧传感器的电压或参考单元的电压偏离参考范围时，确定氧传感器的接地线断开。

公开(公告)号：US09410915B2

公开(公告)日：2016-08-09

申请号：US14330610

申请日：2014-07-14

Applicant: Roche Operations Ltd. ,  Roche Diabetes Care, Inc.

Inventor： Michael J. Celentano ,  Henning Groll ,  James L. Pauley ,  Steven K. Moore

IPC: G01N27/327 ,  G01N27/416

CPC classification number: G01N27/327 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/4163

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

公开(公告)号：US09408567B2

公开(公告)日：2016-08-09

申请号：US13778391

申请日：2013-02-27

Applicant: MEDTRONIC MINIMIED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/053 ,  A61B5/1495 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  G01N27/416 ,  A61B5/00 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09360449B2

公开(公告)日：2016-06-07

申请号：US14310107

申请日：2014-06-20

Applicant: SIEMENS AKTIENGESELLSCHAFT

Inventor： Aleksandar Duric

IPC: G08B21/00 ,  G01N27/416 ,  G08B21/14

CPC classification number: G01N27/4163 ,  G08B21/14

Abstract: An electrolytic gas sensor which is sensitive to a specific gas and has a working, reference and counter electrode is functionally monitored. A differential voltage between the reference and working electrodes is amplified and the potential of the counter electrode is regulated to minimize the differential voltage. Then a measured current flowing into the counter electrode approximately proportionally to the gas concentration of the gas to be detected arises. Independently of the determination of the gas concentration, a working, counter and reference voltage which is present at the three electrodes in each case is captured and monitored for an impermissible deviation. In an impermissible case an assigned error message is then output. Online monitoring of the gas sensor is thus possible and no interruption of the measurement operation for test purposes and additional components are required.

Abstract translation: 对特定气体敏感并具有工作参考电极和对电极的电解气体传感器进行功能监控。 放大参考电极和工作电极之间的差分电压，并调节对电极的电位以最小化差分电压。 然后产生大致与待检测气体的气体浓度成比例地流入对电极的测量电流。 独立于气体浓度的确定，捕获并监视在每种情况下存在于三个电极处的工作，对抗和参考电压以获得不允许的偏差。 在不允许的情况下，输出分配的错误消息。 因此，气体传感器的在线监测是可能的，并且不需要中断试验目的的测量操作和附加部件。

公开(公告)号：US09357958B2

公开(公告)日：2016-06-07

申请号：US13778416

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  G01N27/416 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20160123922A1

公开(公告)日：2016-05-05

申请号：US14896100

申请日：2014-06-04

Applicant: DENSO CORPORATION

Inventor： Katsuhide AKIMOTO ,  Shuuichi NAKANO ,  Yushi FUKUDA ,  Tomofumi FUJII ,  Takahito MASUKO ,  Toshihide KUMAZAKI

IPC: G01N27/416 ,  G01N27/406 ,  G01N27/41

CPC classification number: G01N27/4163 ,  F02D41/1454 ,  F02D41/222 ,  G01N27/4065 ,  G01N27/41 ,  G01N27/4175 ,  Y02T10/40

Abstract: A sensor element of an A/F sensor AS has a solid electrolyte layer, a first electrode arranged on one side of the solid electrolyte layer so as to be exposed to the exhaust gas of an internal combustion engine, and a second electrode arranged on the other side of the solid electrolyte layer so as to face an atmospheric air chamber. The sensor element generates a sensor output according to the oxygen concentration in the exhaust gas. A microcomputer supplies oxygen to the first electrode side from the second electrode side via the solid electrolyte layer by applying a predetermined voltage between the pair of electrodes and of the sensor element. Moreover, the microcomputer determines a crack abnormality of the solid electrolyte layer based on electric current between the pair of electrodes which is generated with start of the oxygen supply.

Abstract translation: A / F传感器AS的传感器元件具有固体电解质层，布置在固体电解质层的一侧以暴露于内燃机的废气的第一电极和布置在该固体电解质层上的第二电极 固体电解质层的另一侧面向大气空气室。 传感器元件根据废气中的氧气浓度产生传感器输出。 微型计算机通过在一对电极和传感器元件之间施加预定电压，经由固体电解质层从第二电极侧向第一电极侧提供氧。 此外，微计算机基于在氧供应开始时产生的一对电极之间的电流来确定固体电解质层的裂纹异常。