专利检索 ipc:C12P21/08 第 4 页

31.

发明授权
Anti-FcRn antibodies 有权

公开(公告)号：US10233243B2

公开(公告)日：2019-03-19

申请号：US14400812

申请日：2013-05-13

申请人： UCB Biopharma SPRL

发明人： Helene Margaret Finney , Alastair David Griffiths Lawson , Stevan Graham Shaw , Bryan John Smith , Kerry Louise Tyson , Lara Kevorkian , Christoph Meier , Kaushik Sarkar , Paul Alan Atherfold

IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C07K16/28 , G01N33/50 , G01N33/564 , G01N33/68 , A61K47/60 , A61K47/64 , C07K1/00 , A61K39/00

摘要： The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

32.

发明授权
Engineered monomeric antibody fragments 有权

公开(公告)号：US10233229B2

公开(公告)日：2019-03-19

申请号：US14650188

申请日：2013-11-25

申请人： Pfizer Inc.

发明人： Tetsuya Ishino , Weili Duan , Ronald William Kriz

IPC分类号： C07K1/00 , C07K16/00 , C12P21/08 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/00

摘要： The present invention relates to monomeric polypeptides comprising an engineered monomeric antibody fragment (e.g., monomeric Fc-containing polypeptides) wherein the monomeric Fc comprises one or more engineered N-linked glycosylation sites in the CH3-CH3 dimerization interface. Methods for producing such engineered monomeric antibody fragments and their use in diagnostics and therapeutics are also provided.

33.

发明授权
Anti-PACAP antibodies and uses thereof 有权

公开(公告)号：US10202435B2

公开(公告)日：2019-02-12

申请号：US15487607

申请日：2017-04-14

申请人： ALDER BIOPHARMACEUTICALS, INC.

发明人： Maria-Cristina Loomis , Leon Garcia-Martinez , Benjamin H. Dutzar , Daniel S. Allison , Katherine Lee Hendrix , Ethan W. Ojala , Pei Fan , Jeffrey T. L. Smith , John A. Latham , Charlie Karasek , Jenny Mulligan , Michelle Scalley-Kim , Erica Stewart , Vanessa Lisbeth Rubin , Jens J. Billgren

IPC分类号： A61K49/00 , A61K39/395 , A61K39/00 , A61K49/16 , C07K16/00 , G01N33/53 , C12P21/08 , C07K14/705 , A61K38/17 , A61K38/22 , C07K14/47 , C07K14/72 , C07K16/18 , C07K16/28 , C12N5/07 , C07K16/26 , C07K16/42 , G01N33/68 , A61K38/00 , A61K48/00

摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.

34.

发明授权
MGMT-based method for obtaining high yeilds of recombinant protein expression 有权

公开(公告)号：US10017769B2

公开(公告)日：2018-07-10

申请号：US15377554

申请日：2016-12-13

申请人： INSTITUT PASTEUR

发明人： Philippe Despres , Sylvie Paulous , Elodie Crublet

IPC分类号： C12N9/10 , C12N9/96 , C12P19/34 , C12N15/00 , C12N5/10 , C12N5/07 , G01N33/53 , C12Q1/70 , A61K39/385 , A61K39/12 , C07K1/00 , C12P21/08 , C07K16/00 , C12N15/62 , C12N15/85 , C12N5/09 , C12P21/02

CPC分类号： C12N15/625 , C07K2319/00 , C07K2319/055 , C07K2319/20 , C07K2319/21 , C07K2319/50 , C12N5/0601 , C12N5/0693 , C12N9/1007 , C12N9/96 , C12N15/85 , C12N2015/8518 , C12N2510/02 , C12P21/02 , C12Y201/01063 , Y02A50/51 , Y02A50/53 , Y02A50/60

摘要： The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.

35.

发明授权
Polynucleotides encoding anti-Notch1 NRR antibody polypeptides 有权

公开(公告)号：US10005844B2

公开(公告)日：2018-06-26

申请号：US15722635

申请日：2017-10-02

申请人： Genentech, Inc.

发明人： Christian W. Siebel , Yan Wu

IPC分类号： C07K16/28 , C12N5/00 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12P21/08 , C07K16/30 , C07K14/705 , C07K14/71 , C07K14/715 , A61K39/00

CPC分类号： C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50

摘要： The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.

36.

发明授权
DC-STAMP antibodies 有权

公开(公告)号：US09988448B2

公开(公告)日：2018-06-05

申请号：US14678343

申请日：2015-04-03

申请人： UNIVERSITY OF ROCHESTER

发明人： Edward M. Schwarz , Kofi A. Mensah , Yahui Grace Chiu , Christopher T. Ritchlin

IPC分类号： C07K16/00 , C12P21/08 , C07K16/28 , C07K14/705

CPC分类号： C07K16/28 , C07K14/705 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2317/94

摘要： Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope comprises the amino acid sequence Glu-Val-His-Leu-Lys-Leu-His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:1). Optionally, the epitope comprises the amino acid sequence His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:2). Optionally, the epitope comprises the amino acid sequence Lys-Gln-Gly-Thr-Gln (SEQ ID NO:3).

37.

发明授权
Detection of antibodies using an improved immune complex (IC) ELISA 有权

公开(公告)号：US09945846B2

公开(公告)日：2018-04-17

申请号：US14000562

申请日：2012-02-21

申请人： Herbert Schmitz , Petra Emmerich-Paloh

发明人： Herbert Schmitz , Petra Emmerich-Paloh

IPC分类号： C07K16/00 , C07K16/28 , C12N15/00 , C12P21/08 , A61K38/00 , G01N33/543 , G01N33/68

CPC分类号： G01N33/54306 , G01N33/6854 , G01N2333/70535

摘要： The present invention relates to the field of diagnostic or analytic methods. In particular, the inventors teach that FcγR such as CD16, CD32 or CD64 may be used for in vitro quantification of antibodies in the form of immune complexes, i.e., complexes formed by antigen and specific antibody. A method for detection and quantification of antibodies in the form of immune complexes is also provided.

38.

发明授权
Antibody producing non-human mammals 有权

公开(公告)号：US09944695B2

公开(公告)日：2018-04-17

申请号：US14266540

申请日：2014-04-30

申请人： Merus B.V.

发明人： Ton Logtenberg , Mark Throsby , Robert A. Kramer , Rui Daniel Pinto , Cornelis A. De Kruif , Erwin Houtzager

IPC分类号： A01K67/027 , C12P21/08 , C07K16/12 , C07K14/47 , C07K16/24 , C12N15/85 , C12P21/00

CPC分类号： C07K16/1282 , A01K67/027 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K16/248 , C07K2317/24 , C12N15/8509 , C12P21/00

摘要： Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.