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公开(公告)号：USD811519S1
公开(公告)日：2018-02-27
申请号：US29569589
申请日：2016-06-29
Applicant: EMD Millipore Corporation
Designer： Matthew Natale , Brian Hillier
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公开(公告)号：US09889214B2
公开(公告)日：2018-02-13
申请号：US15691290
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US20180024026A1
公开(公告)日：2018-01-25
申请号：US15548019
申请日：2016-01-12
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , Jeffrey Pearsons
IPC: G01M3/32
CPC classification number: G01M3/3218 , G01M3/3254 , G01M3/34
Abstract: A system and method for measuring integrity of flexible containers is disclosed. The system uses a low mass flow transducer to monitor the flow of fluid into the flexible container. Based on this flow rate, the existence of an orifice in the flexible container may be detected. The system also includes a second flow path to the flexible container to allow for faster fill times. Greater flow rates are achieve through the use of a second high mass flow transducer or a calibrated bypass path. These alternate paths allow greater flow rates until the flexible container is determined to be nearly full, at which point all flow passes with the low mass flow transducer.
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公开(公告)号：US20170360970A1
公开(公告)日：2017-12-21
申请号：US15691290
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US20170360969A1
公开(公告)日：2017-12-21
申请号：US15691286
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tracik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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Patent Agency Ranking
公开(公告)号：USD804653S1
公开(公告)日：2017-12-05
申请号：US29530023
申请日：2015-06-12
Applicant: EMD Millipore Corporation
Designer： Phillip Clark , Kurt Greenizen , Paul Sydlowski , Christopher A. Scott
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公开(公告)号：US09816901B2
公开(公告)日：2017-11-14
申请号：US14438961
申请日：2013-12-13
Applicant: EMD Millipore Corporation
Inventor： Benjamin Cacace
IPC: G01N30/00 , B01L3/00 , G01N1/34 , G01N1/40 , C07K1/14 , C07K1/36 , B01J39/26 , B01J41/20 , B01J47/022 , B01J47/014 , B01J47/127
CPC classification number: G01N1/34 , B01J39/26 , B01J41/20 , B01J47/014 , B01J47/022 , B01J47/127 , B01L3/505 , B01L2200/12 , B01L2300/0681 , B01L2300/123 , C07K1/14 , C07K1/36 , G01N1/405
Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.
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公开(公告)号：US09815050B2
公开(公告)日：2017-11-14
申请号：US14682456
申请日：2015-04-09
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01D15/36 , B01J20/28 , B01J47/12 , B01J39/26 , C12N7/02 , B01D15/32 , B01D15/38 , B01J20/285 , B01J20/287 , B01J20/32 , C07K1/18 , B01J41/20 , C07K16/00 , C12N7/00 , B01J47/014 , B01J47/127
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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公开(公告)号：US20170320027A1
公开(公告)日：2017-11-09
申请号：US15658503
申请日：2017-07-25
Applicant: EMD Millipore Corporation
Inventor： Martin Morrissey , Brian Pereira
CPC classification number: B01F15/0085 , B01F7/00241 , B01F13/0827 , B01F15/00487 , B01F2215/0034 , B01F2215/0073 , C12M23/14 , C12M27/02
Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.
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公开(公告)号：US09782704B2
公开(公告)日：2017-10-10
申请号：US14080971
申请日：2013-11-15
Applicant: EMD Millipore Corporation
Inventor： Felipe Merino , Luis Penacho , Miquel Iribarren , Antonio Vicente , Angel Cabria , Juan Carlos Pineiro
CPC classification number: B01D29/668 , B01D29/0077 , B01D29/6438 , B01D29/66 , B01D29/908 , B01D61/18 , B01D65/02 , B01D2201/086 , B01D2321/02 , B01D2321/04 , C02F1/444 , C02F2209/03 , C02F2209/40 , C02F2209/44 , C02F2301/024 , C02F2301/026
Abstract: A normal flow filtration system having a housing with one or more filters contained within a bowl and attached to the outlet of the system. Liquid enters the bowl, contacts the surfaces of the one or more filters. Impurities are trapped in the filter and the filtered liquid flows through to the outlet. Parameter(s) such as flow rate, transmembrane pressure drop and/or time are measured and when met, filtration ceases. A backflushing occurs through the filter(s) so as to remove the impurities from the filter. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the filter(s) can be used to provide a lateral washing of the filter(s). The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is then restarted.
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