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公开(公告)号：US09783488B2
公开(公告)日：2017-10-10
申请号：US14776280
申请日：2014-03-10
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Gilles Raphy , Alan F. Haughan , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Perla Breccia , Grant Wishart , Samantha J. Hughes , Daniel R. Allen , Stephen D. Penrose
IPC分类号： A61K31/133 , C07C233/60 , C07D263/56 , C07D215/14 , C07D231/12 , C07D231/56 , C07D333/54 , C07D235/08 , C07D239/26 , C07D471/04 , C07D265/36 , C07D277/64 , C07D295/073 , C07D213/54 , C07D213/56 , C07D307/79 , C07C259/08 , C07D209/46 , C07D213/58 , C07D215/06 , C07D235/06 , C07D263/57 , C07D265/30 , C07D277/66 , C07D307/81 , C07D311/96 , C07D401/12 , C07D413/06
CPC分类号： C07C233/60 , C07C259/08 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/46 , C07D213/54 , C07D213/56 , C07D213/58 , C07D215/06 , C07D215/14 , C07D231/12 , C07D231/56 , C07D235/06 , C07D235/08 , C07D239/26 , C07D263/56 , C07D263/57 , C07D265/30 , C07D265/36 , C07D277/64 , C07D277/66 , C07D295/073 , C07D307/79 , C07D307/81 , C07D311/96 , C07D333/54 , C07D401/12 , C07D413/06 , C07D471/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20170283439A1
公开(公告)日：2017-10-05
申请号：US15507203
申请日：2015-08-28
发明人： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel CLark-Frew
IPC分类号： C07D519/00 , A61K51/04 , C07D471/04
CPC分类号： C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20160333001A1
公开(公告)日：2016-11-17
申请号：US15148884
申请日：2016-05-06
发明人： Celia Dominguez , Michel C. Maillard , Perla Breccia , Alan F. Haughan , Rebecca E. Jarvis , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Andrew J. Stott , Amanda Van de Poël , Michael Wall , Grant Wishart
IPC分类号： C07D413/12 , C07D491/107
CPC分类号： C07D413/12 , C07D491/107
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US12036291B2
公开(公告)日：2024-07-16
申请号：US17353611
申请日：2021-06-21
发明人： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Thomas Martin Krülle , Daniel Clark-Frew , Sarah Hayes
IPC分类号： A61K51/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14
CPC分类号： A61K51/0455 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14 , C07B2200/05
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US11992535B2
公开(公告)日：2024-05-28
申请号：US17125905
申请日：2020-12-17
发明人： Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Christopher John Brown , Sarah Hayes , Adrian Kotey , Matthew Robert Mills , Michael Edward Prime
IPC分类号： A61K51/04 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107
CPC分类号： A61K51/0455 , A61K51/0459 , A61K51/0468 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07B2200/05
摘要： Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11851446B2
公开(公告)日：2023-12-26
申请号：US17353627
申请日：2021-06-21
发明人： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC分类号： C07D519/00 , C07D471/04 , A61K51/04
CPC分类号： C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20220409615A1
公开(公告)日：2022-12-29
申请号：US17318693
申请日：2021-05-12
发明人： Celia Dominguez , Elizabeth M. Doherty , Longbin Liu , Matthew Lee , Mark Stuart Chambers , Karine Fabienne Malagu , Perla Breccia , Alan F. Haughan , Huw D. Vater , Andrew J. Stott , William R. K. Esmieu , Stephen John Webster , Amanda J. Van De Poël
IPC分类号： A61K31/497 , C07D471/04 , C07D519/00 , A61K31/4985 , C07D487/04 , C07D403/14 , A61K31/506 , A61K31/501 , C07D413/14 , A61P25/28
摘要： Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US20220372045A1
公开(公告)日：2022-11-24
申请号：US17729881
申请日：2022-04-26
发明人： Longbin Liu , Celia Dominguez , Jonathan Bard , Vinod Khetarpal , Ashley Jarvis , Sarah Hayes , John E. Mangette
IPC分类号： C07D498/04 , A61K51/04
摘要： Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11421007B2
公开(公告)日：2022-08-23
申请号：US16386885
申请日：2019-04-17
摘要： The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
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公开(公告)号：US20210380608A1
公开(公告)日：2021-12-09
申请号：US17353627
申请日：2021-06-21
发明人： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC分类号： C07D519/00 , C07D471/04 , A61K51/04
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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