公开(公告)号：US09855267B2

公开(公告)日：2018-01-02

申请号：US15335279

申请日：2016-10-26

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Perla Breccia ,  Christopher A. Luckhurst ,  Roland W. Bürli ,  Andrew J. Stott

IPC: A61K31/505 ,  A61K31/165 ,  A61K31/357 ,  A61K31/4418 ,  A61K31/421 ,  A61K31/426 ,  C07D213/74 ,  C07D311/58 ,  C07D319/18 ,  C07D401/04 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D417/04 ,  C07D263/32 ,  C07D277/30 ,  C07D213/56 ,  C07D213/61 ,  C07D263/56 ,  C07D215/18 ,  C07D277/64 ,  C07D295/155 ,  C07C259/08

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/357 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4418 ,  C07B2200/07 ,  C07C259/08 ,  C07C2601/02 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D215/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D263/32 ,  C07D263/56 ,  C07D277/30 ,  C07D277/64 ,  C07D295/155 ,  C07D311/58 ,  C07D319/18 ,  C07D401/04 ,  C07D417/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US09783488B2

公开(公告)日：2017-10-10

申请号：US14776280

申请日：2014-03-10

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Michel Maillard ,  Gilles Raphy ,  Alan F. Haughan ,  Christopher A. Luckhurst ,  Rebecca E. Jarvis ,  Roland W. Bürli ,  Perla Breccia ,  Grant Wishart ,  Samantha J. Hughes ,  Daniel R. Allen ,  Stephen D. Penrose

IPC: A61K31/133 ,  C07C233/60 ,  C07D263/56 ,  C07D215/14 ,  C07D231/12 ,  C07D231/56 ,  C07D333/54 ,  C07D235/08 ,  C07D239/26 ,  C07D471/04 ,  C07D265/36 ,  C07D277/64 ,  C07D295/073 ,  C07D213/54 ,  C07D213/56 ,  C07D307/79 ,  C07C259/08 ,  C07D209/46 ,  C07D213/58 ,  C07D215/06 ,  C07D235/06 ,  C07D263/57 ,  C07D265/30 ,  C07D277/66 ,  C07D307/81 ,  C07D311/96 ,  C07D401/12 ,  C07D413/06

CPC classification number: C07C233/60 ,  C07C259/08 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/46 ,  C07D213/54 ,  C07D213/56 ,  C07D213/58 ,  C07D215/06 ,  C07D215/14 ,  C07D231/12 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D239/26 ,  C07D263/56 ,  C07D263/57 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D277/66 ,  C07D295/073 ,  C07D307/79 ,  C07D307/81 ,  C07D311/96 ,  C07D333/54 ,  C07D401/12 ,  C07D413/06 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20170283439A1

公开(公告)日：2017-10-05

申请号：US15507203

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel CLark-Frew

IPC: C07D519/00 ,  A61K51/04 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K51/0455 ,  A61K51/0459 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20160333001A1

公开(公告)日：2016-11-17

申请号：US15148884

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Michel C. Maillard ,  Perla Breccia ,  Alan F. Haughan ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Andrew J. Stott ,  Amanda Van de Poël ,  Michael Wall ,  Grant Wishart

IPC: C07D413/12 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D491/107

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US12083108B2

公开(公告)日：2024-09-10

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/54

CPC classification number: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/555

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US12036292B2

公开(公告)日：2024-07-16

申请号：US17395055

申请日：2021-08-05

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Xuemei Chen ,  John E. Mangette

IPC: A61K51/04 ,  C07D239/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D471/04

CPC classification number: A61K51/0459 ,  C07D239/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D471/04 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20240199624A1

公开(公告)日：2024-06-20

申请号：US18521696

申请日：2023-11-28

Applicant: CHDI Foundation, Inc.

Inventor： Tasir Haque ,  Michel Maillard ,  Gareth Brace ,  George Ballantyne ,  Elizabeth Frush ,  Kim Hirst ,  Katherine Jones ,  Emanuela Gancia ,  Chris Lock ,  Cole Clissold

IPC: C07D487/04 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

CPC classification number: C07D487/04 ,  A61K9/02 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

Abstract: The present disclosure relates generally to small molecule inhibitors of MutSβ protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US11806346B2

公开(公告)日：2023-11-07

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  A61P25/28 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20230212190A1

公开(公告)日：2023-07-06

申请号：US17881895

申请日：2022-08-05

Applicant: CHDI Foundation, Inc.

Inventor： Celia DOMINGUEZ ,  Samuel COE ,  Peter David JOHNSON ,  Michael Edward PRIME ,  Christopher John BROWN ,  Sébastien René Gabriel GALAN ,  Paul Richard GILES ,  Jonathan BARD ,  Elise Lucienne Paulette GADOULEAU ,  Thomas Martin KRÜLLE ,  Daniel CLARK-FREW ,  John WITYAK ,  Alex KISELYOV ,  Sarah HAYES

IPC: A61K51/04 ,  A61B6/03 ,  A61B5/00

CPC classification number: A61K51/0459 ,  A61B6/037 ,  A61B5/0035 ,  A61B6/032

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20230159531A1

公开(公告)日：2023-05-25

申请号：US17988340

申请日：2022-11-16

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Nikolay V. Plotnikov ,  Alan Haughan ,  Andrew Stott ,  Brett Cosgrove ,  Cole Clissold ,  Huw Vater ,  Jonathan Spencer ,  William Esmieu ,  Karine Malagu ,  Mark Chambers

IPC: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.