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公开(公告)号：US20070034579A1
公开(公告)日：2007-02-15
申请号：US11584414
申请日：2006-10-19
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
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42.发明授权RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR USE 失效具有尺寸的可回收生物植入物允许氧气的快速扩张和对生理变化的快速生物反应，其制造方法及其使用方法公开(公告)号：US06372244B1
公开(公告)日：2002-04-16
申请号：US09648050
申请日：2000-08-25
IPC分类号： A61F1300
摘要： Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
摘要翻译： 描述了生物人造植入物及其制造和使用的方法，特别是生物人造胰腺。 特别地，植入物可以是包围细胞的薄片，可以在延长的时间段内完全生物相容，并且可能不诱导纤维化。 含高密度细胞的薄片优选是完全可回收的，并且具有允许通过营养物和氧气的快速扩散维持最佳组织存活力的尺寸，并且还允许胰岛素和/或其它生物活性剂在分解速率方面的快速变化 改变生理学。 包含在生物人造植入物中的活细胞，组织，药物，药物和/或酶的植入物可以进行治疗和/或预防疾病。
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43.发明授权Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change, processes for their manufacture, and methods for their use 有权可回收的生物人造植入物具有允许氧的快速扩散和对生理变化的快速生物反应的尺寸，其制造方法及其使用方法
公开(公告)号：US6165225A
公开(公告)日：2000-12-26
申请号：US128188
申请日：1998-08-03
摘要： Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
摘要翻译： 描述了生物人造植入物及其制造和使用的方法，特别是生物人造胰腺。 特别地，植入物可以是包围细胞的薄片，可以在延长的时间段内完全生物相容，并且可能不诱导纤维化。 含高密度细胞的薄片优选是完全可回收的，并且具有允许通过营养物和氧气的快速扩散维持最佳组织存活力的尺寸，并且还允许胰岛素和/或其它生物活性剂在分解速率方面的快速变化 改变生理学。 包含在生物人造植入物中的活细胞，组织，药物，药物和/或酶的植入物可以进行治疗和/或预防疾病。
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公开(公告)号：US20160325039A1
公开(公告)日：2016-11-10
申请号：US15217635
申请日：2016-07-22
申请人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant Cunningham , Randel Dorian , Richard Wood Storrs , Scott R. King
发明人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant Cunningham , Randel Dorian , Richard Wood Storrs , Scott R. King
CPC分类号： A61M1/3692 , A61M1/0281 , A61M1/3678 , A61M2202/0429 , A61M2205/3375 , B01D21/283 , B01L3/502761 , B01L9/527 , B01L2200/025 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/089 , B01L2400/0436 , C12M47/02 , C12N5/0641 , C12N13/00
摘要： Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can include a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface, an opposing second surface, a first side, and an opposing second side. The channel can extend along a longitudinal axis from a first end to an opposing second end. The first acoustic wave generator can be coupled to the first surface. The second acoustic wave propagating component can be coupled to the second surface. The first acoustic wave generator and second acoustic wave propagating component can be configured to generate a bulk standing acoustic wave in the channel.
摘要翻译： 公开了一种用于从多组分流体分离细胞组分的装置。 该装置可以包括主体，第一声波发生器和第二声波传播部件。 主体可以限定具有第一表面，相对的第二表面，第一侧和相对的第二侧的通道。 通道可以沿着纵向轴线从第一端延伸到相对的第二端。 第一声波发生器可以耦合到第一表面。 第二声波传播部件可以耦合到第二表面。 第一声波发生器和第二声波传播部件可以被配置为在通道中产生体声驻波。
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公开(公告)号：US08337711B2
公开(公告)日：2012-12-25
申请号：US12395085
申请日：2009-02-27
CPC分类号： C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
摘要： Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
摘要翻译： 公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。 例如，可以获取并破坏脂肪组织样品。 然后可以分离和纯化破碎的组织样品。 分离的组分可以包括多能，多能或其他细胞群体。
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46.发明授权Method and apparatus for preparing platelet rich plasma and concentrates thereof 失效制备富血小板血浆及其浓缩物的方法和装置公开(公告)号：US08133389B2
公开(公告)日：2012-03-13
申请号：US13193849
申请日：2011-07-29
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。
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公开(公告)号：US20120027746A1
公开(公告)日：2012-02-02
申请号：US12846944
申请日：2010-07-30
CPC分类号： C12N9/6429 , A61K38/00 , A61K38/4833 , C12Y304/21005
摘要： Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen.
摘要翻译： 提供产生凝血酶的方法和将凝结组织密封剂施用于受试者的部位的方法。 可以从受试者获得包含血小板的血液成分。 低渗组合物与固体基质接触以形成含凝血酶的液体，其中低渗组合物包括水，钙，包含血小板的血液成分和任选的螯合剂。 钙在低渗组合物中的存在量大于可由螯合剂络合的钙的量。 然后将含凝血酶的液体与低渗组合物分离，并且可以应用于受试者的位点以形成凝块，例如通过与纤维蛋白原组合。
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公开(公告)号：US07992725B2
公开(公告)日：2011-08-09
申请号：US12101586
申请日：2008-04-11
CPC分类号： A61M1/029 , A61K35/00 , A61M1/3693 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。
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公开(公告)号：US20110065183A1
公开(公告)日：2011-03-17
申请号：US12951701
申请日：2010-11-22
IPC分类号： C12N5/078
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US20090236297A1
公开(公告)日：2009-09-24
申请号：US12476838
申请日：2009-06-02
IPC分类号： B01D33/27
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译： 具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。
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