公开(公告)号：US20190000990A1

公开(公告)日：2019-01-03

申请号：US16124954

申请日：2018-09-07

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K47/69 ,  C08G69/48 ,  C08G59/40 ,  A61K47/54 ,  C12N15/113 ,  C08G69/40 ,  C08G65/337 ,  A61K31/704 ,  A61K31/337 ,  A61K9/14 ,  A61K31/4745 ,  A61K9/51 ,  A61K47/59 ,  A61K31/713 ,  A61K47/64

CPC classification number: A61K47/6935 ,  A61K9/14 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/713 ,  A61K47/545 ,  A61K47/549 ,  A61K47/595 ,  A61K47/644 ,  C08G59/4078 ,  C08G65/337 ,  C08G69/40 ,  C08G69/48 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

公开(公告)号：US10155051B2

公开(公告)日：2018-12-18

申请号：US15885944

申请日：2018-02-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K9/00 ,  A61K47/69 ,  C08G59/40 ,  C08G69/48 ,  A61K9/51 ,  A61K31/4745 ,  A61K9/14 ,  A61K31/337 ,  A61K31/704 ,  A61K31/713 ,  C08G65/337 ,  C08G69/40 ,  C12N15/113 ,  A61K47/54 ,  A61K47/64 ,  A61K47/59

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

公开(公告)号：US09913911B2

公开(公告)日：2018-03-13

申请号：US15371640

申请日：2016-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K9/00 ,  A61K47/48 ,  C08G59/40 ,  C08G69/48 ,  A61K9/51 ,  A61K31/4745 ,  A61K9/14 ,  A61K31/337 ,  A61K31/704 ,  A61K31/713 ,  C08G65/337 ,  C08G69/40 ,  C12N15/113 ,  A61K47/54 ,  A61K47/64 ,  A61K47/69

CPC classification number: A61K47/6935 ,  A61K9/14 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/713 ,  A61K47/545 ,  A61K47/549 ,  A61K47/595 ,  A61K47/644 ,  C08G59/4078 ,  C08G65/337 ,  C08G69/40 ,  C08G69/48 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

公开(公告)号：US09908783B2

公开(公告)日：2018-03-06

申请号：US14602415

申请日：2015-01-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Joel E. Schmidt ,  Mark E. Davis

IPC: B01J29/70 ,  C01B39/48 ,  C01B39/08 ,  C01B39/06 ,  B01J29/068 ,  C01B39/12 ,  B01J29/064 ,  B01J29/06 ,  B01J29/86 ,  B01J29/89 ,  B01J29/072 ,  B01J29/87 ,  B01J29/88 ,  B01J29/04 ,  B01J37/08 ,  C01B39/00 ,  C07C1/20 ,  B01D53/02 ,  C07C2/00 ,  C07C2/12 ,  C07C5/25 ,  C07C5/27 ,  C07C6/06 ,  C07C7/13 ,  C07C209/14 ,  C10G11/05 ,  C10G35/00 ,  C10G47/04 ,  C07C209/16 ,  C10G29/20 ,  C10G35/06 ,  C10G47/16 ,  C10G49/08 ,  C10G50/00 ,  B01J29/035 ,  C07C67/37 ,  B01J29/85

CPC classification number: C01B39/48 ,  B01D53/02 ,  B01D2253/106 ,  B01D2253/108 ,  B01D2253/1085 ,  B01D2253/1124 ,  B01D2253/20 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2257/404 ,  B01J29/035 ,  B01J29/041 ,  B01J29/061 ,  B01J29/064 ,  B01J29/068 ,  B01J29/072 ,  B01J29/70 ,  B01J29/7015 ,  B01J29/85 ,  B01J29/86 ,  B01J29/87 ,  B01J29/88 ,  B01J29/89 ,  B01J37/08 ,  B01J37/082 ,  C01B39/00 ,  C01B39/06 ,  C01B39/065 ,  C01B39/08 ,  C01B39/082 ,  C01B39/085 ,  C01B39/087 ,  C01B39/12 ,  C07C1/20 ,  C07C2/00 ,  C07C2/12 ,  C07C5/2518 ,  C07C5/2737 ,  C07C5/2775 ,  C07C6/06 ,  C07C7/13 ,  C07C67/37 ,  C07C209/14 ,  C07C209/16 ,  C07C2529/70 ,  C10G11/05 ,  C10G29/205 ,  C10G35/00 ,  C10G35/065 ,  C10G47/04 ,  C10G47/16 ,  C10G49/08 ,  C10G50/00 ,  Y02P30/42 ,  C07C211/04 ,  C07C69/14 ,  C07C11/02

Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having RTH topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.

公开(公告)号：US20180030207A1

公开(公告)日：2018-02-01

申请号：US15482483

申请日：2017-04-07

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Hector Gonzalez ,  Suzie Hwang Pun

IPC: C08G75/06 ,  B82Y5/00 ,  C08G69/40 ,  C08B37/16 ,  C08G73/02 ,  C08G73/06 ,  A61K47/69 ,  C08G69/48

CPC classification number: C08G75/06 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0012 ,  C08G69/40 ,  C08G69/48 ,  C08G73/02 ,  C08G73/06

Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

公开(公告)号：US09861968B2

公开(公告)日：2018-01-09

申请号：US14602449

申请日：2015-01-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Joel E. Schmidt ,  Mark E. Davis

IPC: C01B39/46 ,  B01J29/70 ,  C01B39/48 ,  C01B39/08 ,  C01B39/06 ,  B01J29/068 ,  C01B39/12 ,  B01J29/064 ,  B01J29/06 ,  B01J29/86 ,  B01J29/89 ,  B01J29/072 ,  B01J29/87 ,  B01J29/88 ,  B01J29/04 ,  B01J37/08 ,  C01B39/00 ,  C07C1/20 ,  B01D53/02 ,  C07C2/00 ,  C07C2/12 ,  C07C5/25 ,  C07C5/27 ,  C07C6/06 ,  C07C7/13 ,  C07C209/14 ,  C10G11/05 ,  C10G35/00 ,  C10G47/04 ,  C07C209/16 ,  C10G29/20 ,  C10G35/06 ,  C10G47/16 ,  C10G49/08 ,  C10G50/00 ,  B01J29/035 ,  C07C67/37 ,  B01J29/85

CPC classification number: C01B39/48 ,  B01D53/02 ,  B01D2253/106 ,  B01D2253/108 ,  B01D2253/1085 ,  B01D2253/1124 ,  B01D2253/20 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2257/404 ,  B01J29/035 ,  B01J29/041 ,  B01J29/061 ,  B01J29/064 ,  B01J29/068 ,  B01J29/072 ,  B01J29/70 ,  B01J29/7015 ,  B01J29/85 ,  B01J29/86 ,  B01J29/87 ,  B01J29/88 ,  B01J29/89 ,  B01J37/08 ,  B01J37/082 ,  C01B39/00 ,  C01B39/06 ,  C01B39/065 ,  C01B39/08 ,  C01B39/082 ,  C01B39/085 ,  C01B39/087 ,  C01B39/12 ,  C07C1/20 ,  C07C2/00 ,  C07C2/12 ,  C07C5/2518 ,  C07C5/2737 ,  C07C5/2775 ,  C07C6/06 ,  C07C7/13 ,  C07C67/37 ,  C07C209/14 ,  C07C209/16 ,  C07C2529/70 ,  C10G11/05 ,  C10G29/205 ,  C10G35/00 ,  C10G35/065 ,  C10G47/04 ,  C10G47/16 ,  C10G49/08 ,  C10G50/00 ,  Y02P30/42 ,  C07C211/04 ,  C07C69/14 ,  C07C11/02

Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having HEU topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.

公开(公告)号：US09334367B2

公开(公告)日：2016-05-10

申请号：US14805831

申请日：2015-07-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K31/765 ,  C08G69/48 ,  C08G59/40 ,  A61K47/48 ,  A61K9/51 ,  A61K31/4745 ,  A61K9/14 ,  A61K31/337 ,  A61K31/704

CPC classification number: A61K47/6935 ,  A61K9/14 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/713 ,  A61K47/545 ,  A61K47/549 ,  A61K47/595 ,  A61K47/644 ,  C08G59/4078 ,  C08G65/337 ,  C08G69/40 ,  C08G69/48 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

公开(公告)号：US09108979B2

公开(公告)日：2015-08-18

申请号：US14282099

申请日：2014-05-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Joshua Pacheco

IPC: C07C51/353 ,  C07D493/08 ,  C07C2/86 ,  C07C29/32 ,  C07C67/343 ,  C07C45/70

CPC classification number: C07D493/08 ,  B01J29/0341 ,  B01J29/035 ,  B01J29/047 ,  B01J29/405 ,  B01J29/7057 ,  B01J29/89 ,  B01J2229/183 ,  C07C2/862 ,  C07C2/865 ,  C07C29/32 ,  C07C45/70 ,  C07C51/353 ,  C07C67/343 ,  C07C67/347 ,  C07C2529/00 ,  C07C2529/70 ,  C07C2529/89 ,  Y02P20/52 ,  C07C69/76 ,  C07C65/01 ,  C07C65/21 ,  C07C63/04 ,  C07C63/26 ,  C07C47/542 ,  C07C33/26 ,  C07C47/56 ,  C07C69/82 ,  C07C63/06 ,  C07C15/08

Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.

Abstract translation: 本公开涉及基本上没有强布朗斯台德酸性质的二氧化硅基路易斯酸催化剂，以及它们对含有氧化取代基的二烯和亲烯体的[4 + 2]环加成和脱水芳构化的能力，以形成取代的苯产物。 在一些实施方案中，该方法包括使生物质衍生的底物与乙烯接触以形成对苯二甲酸及其衍生物。

公开(公告)号：US08968714B2

公开(公告)日：2015-03-03

申请号：US13852303

申请日：2013-03-28

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K31/74 ,  A61K9/14 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/48

CPC classification number: A61K47/6935 ,  A61K9/14 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/713 ,  A61K47/545 ,  A61K47/549 ,  A61K47/595 ,  A61K47/644 ,  C08G59/4078 ,  C08G65/337 ,  C08G69/40 ,  C08G69/48 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

公开(公告)号：US08940269B2

公开(公告)日：2015-01-27

申请号：US13855180

申请日：2013-04-02

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Bingjun Xu ,  Yashodhan Bhawe

IPC: C01B3/06 ,  C01B3/04 ,  C01B13/02

CPC classification number: C01B3/063 ,  C01B3/042 ,  C01B13/0207 ,  Y02E60/364

Abstract: The present invention is directed to a method of thermochemical forming H2, O2, or a combination thereof from water, said method comprising the steps of contacting a composition comprising a spinel-type transition metal oxide of formula M3O4 with an alkali metal carbonate bicarbonate, or mixture thereof in the presence of H2O to form H2, CO2, and an alkali metal ion-transition metal oxide; hydrolytically extracting at least a portion of alkali metal ions from the alkali metal ion-transition metal oxide by the reaction with CO2 and liquid H2O; and thermochemically reducing the resulting oxidized-transition metal oxide. The thermochemical reduction of CO2 based on analogous methods is also disclosed.

Abstract translation: 本发明涉及一种从水中热化学形成H 2，O 2或其组合的方法，所述方法包括以下步骤：将包含式M3O4的尖晶石型过渡金属氧化物的组合物与碱金属碳酸氢盐碳酸氢盐接触，或 其混合物在H 2 O的存在下形成H 2，CO 2和碱金属离子过渡金属氧化物; 通过与CO 2和液体H 2 O的反应从碱金属离子过渡金属氧化物中水解提取至少一部分碱金属离子; 并热氧化还原所得氧化过渡金属氧化物。 还公开了基于类似方法的CO 2的热化学还原。