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公开(公告)号：US20180024117A1
公开(公告)日：2018-01-25
申请号：US15648293
申请日：2017-07-12
申请人： Emulate Inc.
发明人： Daniel Levner , Kyung Jin Jang , Jacob Frase , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC分类号： G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
摘要： Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20180016537A1
公开(公告)日：2018-01-18
申请号：US15647879
申请日：2017-07-12
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US20180015466A1
公开(公告)日：2018-01-18
申请号：US15647853
申请日：2017-07-12
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
IPC分类号： B01L3/00
摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US12019083B2
公开(公告)日：2024-06-25
申请号：US17834165
申请日：2022-06-07
申请人： EMULATE, Inc.
发明人： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
CPC分类号： G01N35/00584 , B01L3/502761 , C12Q3/00 , G01N15/06 , G01N33/5008 , B01L3/502707 , B01L2200/0647 , B01L2200/148 , B01L2300/0681 , B01L2300/069 , B01L2300/10 , B01L2400/0406 , G01N2035/00544 , G01N2035/0097
摘要： The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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公开(公告)号：US11519903B2
公开(公告)日：2022-12-06
申请号：US15648319
申请日：2017-07-12
申请人： Emulate Inc.
发明人： Daniel Levner , Kyung Jin Jang , Jacob Fraser , S. Jordan Kerns , Antonio Varone , Dongeun Huh
IPC分类号： C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/50 , C07K14/78 , C12N5/071 , C12M3/06 , C12M1/00 , C12M1/12 , C12N5/077
摘要： Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20220334139A1
公开(公告)日：2022-10-20
申请号：US17834165
申请日：2022-06-07
申请人： EMULATE, Inc.
发明人： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
摘要： The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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公开(公告)号：US20220282194A1
公开(公告)日：2022-09-08
申请号：US17725034
申请日：2022-04-20
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US11371000B2
公开(公告)日：2022-06-28
申请号：US15474214
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine A Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：US11141727B2
公开(公告)日：2021-10-12
申请号：US15647831
申请日：2017-07-12
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US11065620B2
公开(公告)日：2021-07-20
申请号：US15647762
申请日：2017-07-12
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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