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41.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08321012B2
公开(公告)日：2012-11-27
申请号：US12655195
申请日：2009-12-22
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/18
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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公开(公告)号：US09019149B2
公开(公告)日：2015-04-28
申请号：US12930043
申请日：2010-12-22
申请人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas A. Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas A. Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： G06Q30/02 , G06Q30/0269
摘要： One or more micro-impulse radars (MIRs) are configured to determine the movement of at least one person. Media can be output to the person responsive to the movement.
摘要翻译： 一个或多个微脉冲雷达（MIR）被配置为确定至少一个人的移动。 可以将响应于移动的媒体输出给人。
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公开(公告)号：US09617157B2
公开(公告)日：2017-04-11
申请号：US12322367
申请日：2009-01-30
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
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公开(公告)号：US09187330B2
公开(公告)日：2015-11-17
申请号：US12283908
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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45.发明申请Systems, devices, and methods including infection-Fighting and monitoring shunts 失效系统，设备和方法，包括感染 - 战斗和监视分流公开(公告)号：US20100249692A1
公开(公告)日：2010-09-30
申请号：US12800791
申请日：2010-05-21
申请人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M5/00
CPC分类号： A61N5/0601 , A61B5/0084 , A61B5/053 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B18/20 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/24 , A61M5/14276 , A61M27/006 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787 , A61N1/40 , A61N1/403 , A61N5/02 , A61N5/0624 , A61N5/10 , A61N7/00 , A61N2005/0651 , A61N2005/0652 , A61N2005/0661
摘要： Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.
摘要翻译： 描述了用于提供被配置为例如监视，治疗或预防感染的主动控制分路的系统，装置，方法和组合物。
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公开(公告)号：US20100241054A1
公开(公告)日：2010-09-23
申请号：US12800792
申请日：2010-05-21
申请人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M1/00
CPC分类号： A61N5/0601 , A61B5/0084 , A61B5/053 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B18/20 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/24 , A61M5/14276 , A61M27/006 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787 , A61N1/40 , A61N1/403 , A61N5/02 , A61N5/0624 , A61N5/10 , A61N7/00 , A61N2005/0651 , A61N2005/0652 , A61N2005/0661
摘要： Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.
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47.发明申请Systems, devices and methods including infection-fighting and monitoring shunts 审中-公开系统，设备和方法，包括感染和监测分流公开(公告)号：US20100234793A1
公开(公告)日：2010-09-16
申请号：US12800780
申请日：2010-05-21
申请人： Ralph Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood , Clarence T. Tegreene
发明人： Ralph Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood , Clarence T. Tegreene
IPC分类号： A61M27/00
CPC分类号： A61N5/0601 , A61B5/0084 , A61B5/053 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B18/20 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/24 , A61M5/14276 , A61M27/006 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787 , A61N1/40 , A61N1/403 , A61N5/02 , A61N5/0624 , A61N5/10 , A61N7/00 , A61N2005/0651 , A61N2005/0652 , A61N2005/0661
摘要： Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.
摘要翻译： 描述了用于提供被配置为例如监测，治疗或预防感染的主动控制分路的系统，装置，方法和组合物。
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48.发明申请System, devices, and methods including actively-controllable sterilizing excitation delivery implants 有权系统，装置和方法，包括主动控制的消毒激励输送植入物公开(公告)号：US20100174346A1
公开(公告)日：2010-07-08
申请号：US12592976
申请日：2009-12-03
申请人： Edward S. Boyden , Ralph G. Dacey, JR. , Gregory J. Della Rocca , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Paul Santiago , Michael A. Smith , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Edward S. Boyden , Ralph G. Dacey, JR. , Gregory J. Della Rocca , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Paul Santiago , Michael A. Smith , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61F7/00
CPC分类号： A61F2/02 , A61F2/30 , A61F2002/009 , A61F2002/30087 , A61F2002/3067 , A61F2002/30677 , A61F2002/3068 , A61F2002/3084 , A61F2002/30932 , A61F2002/481 , A61F2002/482 , A61F2250/0002 , A61F2250/0068 , A61F2310/00616 , A61L2/0011 , A61L2/0023 , A61L2/0029 , A61L2/0088 , A61L2/025 , A61L2/03 , A61N1/205 , A61N1/36 , A61N1/37252 , A61N1/3785 , A61N1/3787
摘要： Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.
摘要翻译： 描述了用于提供主动控制的消毒可植入装置的系统，装置，方法和组合物，其被配置为例如治疗或预防生物学对象中的感染。
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49.发明申请Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states 有权系统，装置和方法，包括具有可在两个或多个润湿性状态之间主动控制的组分的导管公开(公告)号：US20110152789A1
公开(公告)日：2011-06-23
申请号：US12927284
申请日：2010-11-10
申请人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61F2/30 , A61F2/32 , A61F2002/30031 , A61F2002/30087 , A61F2002/30668 , A61F2002/3067 , A61F2002/30677 , A61F2002/48 , A61F2002/481 , A61F2002/482 , A61F2250/0001 , A61F2250/0002 , A61F2250/0056 , A61F2310/0097 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/14 , A61L2202/24 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787
摘要： Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.
摘要翻译： 描述了用于提供主动控制的消毒可植入装置的系统，装置，方法和组合物，其被配置为例如治疗或预防生物学对象中的感染。
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公开(公告)号：US20100241052A1
公开(公告)日：2010-09-23
申请号：US12800786
申请日：2010-05-21
申请人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Ralph G. Dacey, JR. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M39/00
CPC分类号： A61N5/0601 , A61B5/0084 , A61B5/053 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/412 , A61B18/20 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/24 , A61M5/14276 , A61M27/006 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787 , A61N1/40 , A61N1/403 , A61N5/02 , A61N5/0624 , A61N5/10 , A61N7/00 , A61N2005/0651 , A61N2005/0652 , A61N2005/0661
摘要： Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.
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