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    Centrifuge and method for loading a device
    41.
    发明授权
    Centrifuge and method for loading a device 有权
    离心机和装载装置的方法

    公开(公告)号：US09346063B2

    公开(公告)日：2016-05-24

    申请号：US13828633

    申请日：2013-03-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kristopher Barbee ,  Ryan Jones ,  Sean McCusker ,  Maximilian Carpino ,  John Leamon ,  Jonathan Schultz

    IPC: B04B13/00 ,  B04B5/04 ,  G01N35/00 ,  G01N35/10

    CPC classification number: C12Q1/6806 ,  B04B5/0421 ,  B04B13/00 ,  C12Q1/6869 ,  G01N35/00693 ,  G01N35/1011 ,  G01N2035/00495 ,  G01N2035/1013 ,  G01N2035/103

    Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.

    Abstract translation: 一种装置包括机器人系统，该机器人系统在三个正交方向上提供可操作以接收移液管尖端的臂并促进流体进入和移出移液管尖端的运动。 此外，该装置可以包括用于接收移液管吸头的托盘，用于接收管的容器，用于形成乳液的装置，用于形成包括多核苷酸的拷贝的颗粒的装置，用于富集颗粒的装置和用于加载颗粒的装置 颗粒到传感器阵列上。 该装置还可以包括容纳试剂溶液容器的容器。 可选地，除了移液管接收臂之外，机器人还可以包括夹持臂。

    Methods and apparatus for measuring analytes using large scale FET arrays
    44.
    发明授权
    Methods and apparatus for measuring analytes using large scale FET arrays 有权

    公开(公告)号：US11530444B2

    公开(公告)日：2022-12-20

    申请号：US16882414

    申请日：2020-05-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  Kim L. Johnson ,  James Bustillo ,  John Leamon ,  Jonathan Schultz

    IPC: C12Q1/6874 ,  G01N27/414 ,  B01L3/00 ,  C12Q1/6869

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.

    Fluid interface to receive removable container
    46.
    发明授权
    Fluid interface to receive removable container 有权

    公开(公告)号：US11214478B2

    公开(公告)日：2022-01-04

    申请号：US17165196

    申请日：2021-02-02

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Roswech ,  Jonathan Schultz ,  Chun Ho

    IPC: B67D7/02 ,  B67D7/76 ,  B01L3/00 ,  G01N35/10

    Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.

    Fluid interface to receive removable container
    48.
    发明授权
    Fluid interface to receive removable container 有权

    公开(公告)号：US10427928B2

    公开(公告)日：2019-10-01

    申请号：US15259245

    申请日：2016-09-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Roswech ,  Jonathan Schultz ,  Chun Ho

    IPC: B67D7/76 ,  B01L3/00 ,  B67D7/02 ,  G01N35/10

    Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.

    Alternative nucleotide flows in sequencing-by-synthesis methods
    49.
    发明授权
    Alternative nucleotide flows in sequencing-by-synthesis methods 有权

    公开(公告)号：US10392660B2

    公开(公告)日：2019-08-27

    申请号：US15404735

    申请日：2017-01-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan Schultz ,  John Davidson

    IPC: B01L3/00 ,  C12Q1/6869 ,  C12Q1/6874

    Abstract: A method of sequencing a polynucleotide strand can include providing the polynucleotide strand with a primer annealed thereto and a polymerase operably bound to the polynucleotide strand; successively exposing the polynucleotide strand to the flow of four different dNTPs according to a first predetermined ordering; and successively exposing the polynucleotide strand to the flow of four different dNTPs according to a second predetermined ordering, wherein the second predetermined ordering is different from the first predetermined ordering.

    Phase-protecting reagent flow ordering for use in sequencing-by-synthesis
    50.
    发明授权
    Phase-protecting reagent flow ordering for use in sequencing-by-synthesis 有权

    公开(公告)号：US10370708B2

    公开(公告)日：2019-08-06

    申请号：US15236172

    申请日：2016-08-12

    Applicant: Life Technologies Corporation

    Inventor： Earl Hubbell ,  Jonathan Schultz

    IPC: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6874

    Abstract: A system and machine readable medium for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces disposed on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering.

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