公开(公告)号：US20100204213A1

公开(公告)日：2010-08-12

申请号：US12763072

申请日：2010-04-19

申请人： Yingfu LI ,  Akihiko Watanabe ,  Timothy B. Lowinger ,  Kevin Bacon ,  Norihiro Kawamura ,  Takuya Shintani ,  Tetsuo Kikuchi ,  Toshiya Moriwaki ,  Klaus Urbahns ,  Keiko Eukushima ,  Noriko Nunami ,  Takashi Yoshino ,  Toshiki Murata ,  Megumi Yamauchi ,  Hiroko Yoshino

发明人： Yingfu LI ,  Akihiko Watanabe ,  Timothy B. Lowinger ,  Kevin Bacon ,  Norihiro Kawamura ,  Takuya Shintani ,  Tetsuo Kikuchi ,  Toshiya Moriwaki ,  Klaus Urbahns ,  Keiko Eukushima ,  Noriko Nunami ,  Takashi Yoshino ,  Toshiki Murata ,  Megumi Yamauchi ,  Hiroko Yoshino

IPC分类号： A61K31/551 ,  C07D241/04 ,  A61K31/495 ,  C07D403/12 ,  A61K31/496 ,  C07D243/08 ,  A61P25/28 ,  A61P19/02 ,  A61P11/06 ,  A61P9/10 ,  A61P31/18 ,  A61P11/00

CPC分类号： C07D213/70 ,  C07C311/29 ,  C07C323/67 ,  C07D207/14 ,  C07D207/48 ,  C07D209/08 ,  C07D211/28 ,  C07D211/58 ,  C07D211/96 ,  C07D213/65 ,  C07D213/71 ,  C07D213/75 ,  C07D213/76 ,  C07D213/80 ,  C07D241/04 ,  C07D241/06 ,  C07D243/08 ,  C07D257/04 ,  C07D295/088 ,  C07D295/13 ,  C07D295/194 ,  C07D295/26 ,  C07D307/14 ,  C07D333/38 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。

公开(公告)号：US07750014B2

公开(公告)日：2010-07-06

申请号：US10585429

申请日：2005-01-19

申请人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

发明人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC分类号： C07D487/04

摘要： The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US07643205B2

公开(公告)日：2010-01-05

申请号：US12396759

申请日：2009-03-03

申请人： Takashi Yoshino

发明人： Takashi Yoshino

IPC分类号： G02F1/35

CPC分类号： G02F1/3775 ,  G02F2201/066 ,  G02F2202/20

摘要： A harmonics generating device including a supporting substrate; a wavelength conversion layer having a three-dimensional optical waveguide provided with a periodic domain inversion structure therein, a base adhesive layer for adhering a lower face of the wavelength conversion layer to the supporting substrate; an upper-side substrate provided on an upper face side of the wavelength conversion layer; an upper-side adhesive layer for adhering the wavelength conversion layer to the upper-side substrate; an incident face of a fundamental wave, a projection face of higher harmonics, a first side face between the incident face and the projection face; and a second side face opposing the first side face. A first conductive material contacts the first side face, a second conductive material contacts the second side face, and the first and second conductive materials are electrically connected.

摘要翻译： 一种谐波发生装置，包括支撑基板; 具有在其中设置有周期性畴反转结构的三维光波导的波长转换层，用于将波长转换层的下表面粘附到支撑基板的基底粘合剂层; 设置在所述波长转换层的上表面侧的上侧基板; 用于将波长转换层粘合到上侧基板的上侧粘合剂层; 基波的入射面，高次谐波的投影面，入射面与投影面之间的第一侧面; 以及与第一侧面相对的第二侧面。 第一导电材料接触第一侧面，第二导电材料接触第二侧面，并且第一和第二导电材料电连接。

公开(公告)号：US20090256444A1

公开(公告)日：2009-10-15

申请号：US12393437

申请日：2009-02-26

申请人： Kenji Suzuki ,  Takashi Yoshino

发明人： Kenji Suzuki ,  Takashi Yoshino

IPC分类号： H01L41/107

CPC分类号： H03H9/02834 ,  H03H3/10 ,  H03H9/02574

摘要： A surface acoustic wave device has a supporting substrates, a propagation substrate 3A made of a piezoelectric single crystal, an organic adhesive layer 2 having a thickness of 0.1 to 1.0 μm and bonding the supporting substrate 1 and the propagation substrate 3A, and a surface acoustic wave filter or resonator provided on the propagation substrate. The temperature coefficient of frequency of the surface acoustic wave device can be thereby reduced.

摘要翻译： 表面声波装置具有支撑基板，由压电单晶构成的传播基板3A，厚度为0.1〜1.0μm的有机粘合层2，并且将支撑基板1和传播基板3A接合，以及表面声学 设置在传播基板上的滤波器或谐振器。 能够降低声表面波装置的频率的温度系数。

公开(公告)号：US20090231679A1

公开(公告)日：2009-09-17

申请号：US12395926

申请日：2009-03-02

申请人： Takashi Yoshino

发明人： Takashi Yoshino

IPC分类号： G02F1/355 ,  G02F1/35 ,  G02F1/365

CPC分类号： G02F1/3558 ,  G02F1/3775 ,  G02F2001/3548

摘要： A harmonics generating device has a periodic domain inversion structure 18 for converting a wavelength of laser beam to generate higher harmonics. An angle θ formed by a domain inversion plane P of the periodic domain inversion structure 8 and a propagation direction L of the laser beam is from 80 degrees to 89 degrees.

摘要翻译： 谐波产生装置具有用于转换激光束的波长以产生高次谐波的周期性域反转结构18。 由周期性畴反转结构8的域反转面P和激光束的传播方向L形成的角度θ为80度至89度。

公开(公告)号：US20070166053A1

公开(公告)日：2007-07-19

申请号：US11619743

申请日：2007-01-04

申请人： Jungo Kondo ,  Osamu Mitomi ,  Kenji Aoki ,  Takashi Yoshino ,  Keiji Matsuhiro

发明人： Jungo Kondo ,  Osamu Mitomi ,  Kenji Aoki ,  Takashi Yoshino ,  Keiji Matsuhiro

IPC分类号： H04B10/04

CPC分类号： H04B1/408 ,  G01S7/35 ,  G01S13/345 ,  G01S13/931 ,  G01S2013/9321 ,  G01S2013/9325 ,  H04B1/04 ,  H04B2001/0491 ,  H04B2210/006

摘要： It is provided a practical radio oscillating system for a radar system to alleviate the necessity of a reception filter of severe specification of pass band and an oscillating system and an amplifier of high performance and high reliability. The radio oscillating system has an optical modulator 2 for oscillation; a modulating means 6 for modulating a carrier wave “P” passing through the optical modulator 2 so as to superimpose sideband waves “Q” and “R” onto the carrier wave; an optical receiver 7 for oscillation to receive outgoing light “B” from the optical modulator 2 and to convert the outgoing light into an electrical signal; and a radiating means 8 for radiating radio signal “C” based on the electrical signal.

摘要翻译： 提供了一种用于雷达系统的实用的无线电振荡系统，以减轻严格规范的通带的接收滤波器以及具有高性能和高可靠性的振荡系统和放大器的必要性。 无线电振荡系统具有用于振荡的光调制器2。 调制装置6，用于调制通过光调制器2的载波“P”，以将边带波“Q”和“R”叠加到载波上; 用于振荡以从光调制器2接收出射光“B”并将出射光转换成电信号的光接收器7; 以及用于基于电信号辐射无线电信号“C”的辐射装置8。

公开(公告)号：US07164525B2

公开(公告)日：2007-01-16

申请号：US11223227

申请日：2005-09-09

申请人： Ken-ichi Noda ,  Makoto Iwai ,  Takashi Yoshino

发明人： Ken-ichi Noda ,  Makoto Iwai ,  Takashi Yoshino

IPC分类号： G02F1/355

CPC分类号： G02F1/3551 ,  G02F1/377 ,  G02F2001/3505 ,  G02F2203/60

摘要： Wavelength conversion devices for converting fundamental waves to light of a different wavelength are provided. The devices have a wavelength converting layer comprising a plate-shaped body of a non-linear optical crystal having a first main face and a second main face. A supporting body is joined with the first main face of the wavelength converting layer. An additional supporting body may also be joined with the second main face of the wavelength converting layer.

摘要翻译： 提供了用于将基波转换成不同波长的光的波长转换装置。 这些器件具有包括具有第一主面和第二主面的非线性光学晶体的板状体的波长转换层。 支撑体与波长转换层的第一主面接合。 附加的支撑体也可以与波长转换层的第二主面接合。

公开(公告)号：US5924290A

公开(公告)日：1999-07-20

申请号：US019736

申请日：1998-02-06

申请人： Takashi Yoshino

发明人： Takashi Yoshino

IPC分类号： G02B6/42 ,  H01L23/38 ,  H01S5/00 ,  H01S5/022 ,  H01S5/024 ,  F25B21/02 ,  F28F7/00 ,  H01L23/34

CPC分类号： H01L33/645 ,  G02B6/4208 ,  G02B6/4271 ,  G02B6/4272 ,  H01L23/38 ,  H01S5/02415 ,  G02B6/4269 ,  G02B6/4285 ,  G02B6/4286 ,  H01L2924/0002 ,  H01S5/02284 ,  H01S5/02438

摘要： An optoelectronic element module is provided, which has improved reliability in cooling performance. This module is comprised of an optoelectronic element, a Peltier unit for cooling the optoelectronic element, and a package encapsulating the optoelectronic element and the Peltier unit. The optoelectronic element is mounted directly on or indirectly through a supporting member on a first surface of the Peltier unit. A second surface of the Peltier unit is engaged with a mounting surface of the package by an engaging structure while allowing the Peltier unit to shift along the mounting surface of the package. A thermal stress caused by a difference between thermal expansion coefficients of the second surface of the Peltier unit and the mounting surface of the package is relaxed by a positional shift of the Peltier unit along the mounting surface of the package with respect to the package. Preferably, the engaging structure produces a magnetic-field force or elastic force for engagement.

摘要翻译： 提供了一种光电元件模块，提高了冷却性能的可靠性。 该模块由光电子元件，用于冷却光电子元件的珀尔帖单元和封装光电元件和珀耳帖单元的封装构成。 光电子元件直接安装在珀尔帖单元的第一表面上或间接通过支撑构件。 珀尔帖单元的第二表面通过接合结构与包装的安装表面接合，同时允许珀尔帖单元沿着包装的安装表面移动。 珀尔帖单元沿着封装的安装表面相对于封装件的位置偏移，使珀尔帖单元的第二表面的热膨胀系数与封装的安装表面之间的差异引起的热应力被松弛。 优选地，接合结构产生用于接合的磁场力或弹性力。

公开(公告)号：US5416869A

公开(公告)日：1995-05-16

申请号：US34467

申请日：1993-03-19

申请人： Takashi Yoshino

发明人： Takashi Yoshino

IPC分类号： H01S5/00 ,  G02B6/42

CPC分类号： G02B6/4207

摘要： In a semiconductor laser device used as an optical time domain reflectometer, a polarizer is inserted in the path of the laser light. The plane of polarization of the polarizer is aligned to the plane of polarization of the emitted laser light, and the polarizer transmits the emitted laser light without attenuation. A reflected laser light from an optical fiber under test is a non-polarized light and receives a substantial attenuation by the polarizer. Thus, problems associated with reradiation echoes are prevented.

摘要翻译： 在用作光时域反射计的半导体激光器件中，在激光的路径中插入偏振器。 偏振器的偏振平面与所发射的激光的偏振平面对准，并且偏振器透射发射的激光而没有衰减。 来自被测光纤的反射激光是非偏振光，并且通过偏振器接收实质上的衰减。 因此，防止与再辐射回波有关的问题。

公开(公告)号：US09486745B2

公开(公告)日：2016-11-08

申请号：US13508693

申请日：2010-12-20

申请人： Kentaro Takagi ,  Tomoko Mitsuhata ,  Takao Sasaki ,  Takeharu Inoue ,  Takashi Yoshino ,  Kiyohiko Takaya ,  Yutaro Suzuki

发明人： Kentaro Takagi ,  Tomoko Mitsuhata ,  Takao Sasaki ,  Takeharu Inoue ,  Takashi Yoshino ,  Kiyohiko Takaya ,  Yutaro Suzuki

IPC分类号： B01D39/00 ,  B01D39/14 ,  B05D5/00 ,  B01D67/00 ,  B01D71/56 ,  C02F1/44 ,  B01D61/02 ,  C08K5/23

CPC分类号： B01D67/0093 ,  B01D61/025 ,  B01D71/56 ,  B01D2323/12 ,  B01D2323/30 ,  C02F1/441 ,  C08K5/23

摘要： Provided is a semipermeable membrane having at least a separating functional layer, wherein azo compounds are retained in the separating functional layer, and the separating functional layer has a yellow index of 10 to 40. Also provided is a method of producing the semipermeable membrane. The present invention provides a semipermeable membrane having not only high water permeability but also high rejection performance even for substances that are nondissociative in the neutral range, such as boric acid, and showing high durability and a manufacturing method therefor.

摘要翻译： 提供了至少具有分离功能层的半透膜，其中偶氮化合物保留在分离功能层中，分离功能层具有10至40的黄色指数。还提供了制备半透膜的方法。 本发明提供了一种半透膜，即使对于在中性范围内的非离解性物质如硼酸，并且具有高耐久性的物质及其制造方法，其透水性也具有高的排斥性能。