公开(公告)号：US09381291B2

公开(公告)日：2016-07-05

申请号：US14003273

申请日：2012-03-09

Applicant: Daniel R. Boggs ,  Mark J. Brierton ,  Benjamin E. Kusters ,  Kyungyoon Min ,  Christopher J. Wegener

Inventor： Daniel R. Boggs ,  Mark J. Brierton ,  Benjamin E. Kusters ,  Kyungyoon Min ,  Christopher J. Wegener

IPC: A61M1/34 ,  A61M1/26 ,  B01D63/16 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  A61M1/38 ,  A61M1/36 ,  G06F19/00

CPC classification number: A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

Abstract: A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Abstract translation: 公开了一种用于血液处理程序的膜分离装置。 在一个实施方案中，提供了纺丝膜分离器，其中在纺丝膜和壳体之间的间隙中形成至少两个区域或区域，使得两个区域之间的流体的混合被相关联的径向肋或脊部抑制 通过纺丝膜减少纺丝膜和壳体之间的间隙以限定两个流体区域，脊部将两个区域中的流体隔离以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单位分离成选定的血液成分，例如浓缩红细胞和血浆，以单次从供体中直接收集红细胞和血浆，并进行细胞洗涤。 还公开了数据管理系统和方法以及启动方法。

公开(公告)号：US20160055303A1

公开(公告)日：2016-02-25

申请号：US14779461

申请日：2014-04-04

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Burkard KELLER

IPC: G06F19/00 ,  A61M1/34

CPC classification number: G16H40/63 ,  A61M1/14 ,  A61M1/3403 ,  A61M1/3496 ,  A61M2205/502 ,  A61M2205/505

Abstract: The present invention relates to the field of medical machines. The invention is based on the object of facilitating the operation of medical machines and making them safer. To do so, the invention proposes methods and devices with which a transparent display can be applied in front of at least parts of medical machines so that these parts of the medical machines are visible through the transparent display and information such as operating instructions or messages are displayed on the transparent display.

Abstract translation: 本发明涉及医疗机器领域。 本发明基于促进医疗机器的操作并使其更安全的目的。 为此，本发明提出了在医疗机器的至少一部分前面可以应用透明显示器的方法和装置，使得医疗机器的这些部分通过透明显示器可见，并且诸如操作说明或消息的信息是 显示在透明显示屏上。

公开(公告)号：US20150265756A1

公开(公告)日：2015-09-24

申请号：US14416458

申请日：2013-07-25

Applicant: ASAHI KASEI MEDICAL CO., LTD.

Inventor： Tomohisa Yokomizo

IPC: A61M1/02 ,  A61M1/34

CPC classification number: A61M1/0281 ,  A61M1/0218 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3635 ,  A61M1/3636 ,  A61M5/36 ,  A61M2202/0439 ,  B01D69/06

Abstract: A blood treatment filter including: a filter container that introduces blood from an inlet into an internal space, and discharges treated blood from an outlet; a filter material that is housed in the filter container to partition the internal space into an inlet side space and an outlet side space, and filters the passing blood to remove a specific component; an inlet port that forms an inlet channel through which the blood flowing from the inlet to the internal space passes; an outlet port that forms an outlet channel through which the blood flowing from the internal space to the outlet passes, wherein the outlet channel has a tapered outlet passage with an inner diameter increasing from the internal space side toward the outlet side.

Abstract translation: 一种血液处理过滤器，包括：将来自入口的血液引入内部空间并从出口排出经处理的血液的过滤容器; 过滤材料，其容纳在过滤容器中，以将内部空间分隔成入口侧空间和出口侧空间，并对通过的血液进行过滤以除去特定成分; 入口，其形成入口通道，血液从入口流经内部空间通过; 出口，其形成从内部空间流向出口的血液通过的出口通道，其中出口通道具有锥形出口通道，内径从内部空间侧向出口侧增加。

公开(公告)号：US09119914B2

公开(公告)日：2015-09-01

申请号：US13778474

申请日：2013-02-27

Applicant: Fenwal, Inc.

Inventor： Lan T. Nguyen ,  John T. Foley ,  Jonathan Prendergast ,  Matthew Schoonover

IPC: A61M1/16 ,  A61M1/36 ,  A61M1/34 ,  A61M1/30

CPC classification number: A61M1/16 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3609 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2202/0429 ,  A61M2205/12 ,  A61M2205/50 ,  A61M2240/00

Abstract: A method is disclosed for priming a kit for use in a therapeutic apheresis procedure with previously-collected blood prior to flowing the patient's whole blood into the inlet line of the kit, as part of a procedure in which a selected blood component is separated from a patient's whole blood, and replaced with a previously-collected blood component. The operator enters into the controller of the separation device the hematocrit value of the previously-collected blood. Then, in response to prompts by the controller, the operator enters a target hematocrit value for the previously-collected blood and an identification of the portion of the kit to be primed. The identified portion of the kit is automatically primed with the previously-collected blood. The patient is then connected to the inlet line of the kit in response to a prompt from the controller and the therapeutic procedure is commenced.

Abstract translation: 公开了一种用于在将患者的全血流入试剂盒的入口管线之前用先前收集的血液引发用于治疗性分离术的试剂盒的方法，作为将选择的血液成分与 患者的全血，并用以前收集的血液成分代替。 操作者将分离装置的控制器输入先前收集的血液的血细胞比容值。 然后，响应于控制器的提示，操作者输入先前收集的血液的目标血细胞比容值和待引发的试剂盒的部分的标识。 试剂盒的识别部分会自动使用以前收集的血液进行预处理。 然后响应于来自控制器的提示将患者连接到试剂盒的入口管线，并且治疗程序开始。

公开(公告)号：US09117012B2

公开(公告)日：2015-08-25

申请号：US12935868

申请日：2009-04-02

Applicant: Gianni Basaglia

Inventor： Gianni Basaglia

IPC: A61M37/00 ,  G06F19/00 ,  A61M1/16 ,  A61M1/34

CPC classification number: G06F19/3418 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/3496 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/505 ,  G06F19/00 ,  G16H40/63

Abstract: A medical apparatus comprises a machine (2) for treatment of fluids provided with means (3) for treating a patient's blood which exhibits a control unit (4) for sending command signals and receiving information relating to the treatment under way on the patient. The machine further comprises an internet web server (11) containing a predetermined number of web pages which are remotely accessible and consultable via a common web browser (18). At least a web page reproduces the graphic user interface on the display (6) of the medical machine (2) substantially in real-time. A plurality of further information and data relating to the medical machine is further published in the web pages.

Abstract translation: 一种医疗装置，包括：用于处理流体的机器（2），该流体具有用于治疗患者血液的装置（3），其具有用于发送指令信号的控制单元（4），并接收与患者正在进行的治疗有关的信息。 该机器还包括互联网网络服务器（11），其包含经由公共网络浏览器（18）可远程访问和可咨询的预定数量的网页。 至少网页基本上实时地再现医疗机器（2）的显示器（6）上的图形用户界面。 有关医疗机器的多个进一步的信息和数据进一步公布在网页中。

公开(公告)号：US20150218517A1

公开(公告)日：2015-08-06

申请号：US14422032

申请日：2013-03-11

Applicant: Fenwal, Inc.

Inventor： Benjamin Kusters ,  Kyungyoon Min ,  Christopher Wegener ,  William H. Cork

IPC: C12N5/078

CPC classification number: A61M1/3496 ,  A01N1/0242 ,  A61M1/0272 ,  A61M1/265 ,  A61M1/342 ,  A61M1/3635 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/3672 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/6072 ,  A61M2205/7554 ,  B01D61/18 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2313/243 ,  B01D2315/02 ,  C12N5/0641

Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

公开(公告)号：US20150209494A1

公开(公告)日：2015-07-30

申请号：US14417429

申请日：2013-07-18

Applicant: MEMBRANA GmbH

Inventor： Roland Müller ,  Bodo Von Harten

IPC: A61M1/02 ,  A61M1/34 ,  B01D63/02

CPC classification number: A61M1/0209 ,  A61M1/0218 ,  A61M1/0272 ,  A61M1/3496 ,  B01D63/02 ,  B01D2319/04

Abstract: A mobile system for separating donor blood by gravitational force into erythrocyte concentrate and plasma. The system includes a first bag serving as a reservoir for the blood to be separated and at least a second and third bag for respectively receiving the erythrocyte concentrate and plasma, and also multiple tubes for connecting the flexible bags to a separator module having a separating membrane in the form of a bundle of hollow fibers. This system is divided into at least one first and one second sterilely packaged, individual subsystem. The first subsystem includes the individual bags and associated connection tubes and the second subsystem includes the separator module, and male/female connectors.

Abstract translation: 用于通过重力将供体血液分离成红细胞浓缩物和血浆的移动系统。 该系统包括用作待分离血液的储存器的第一袋和用于分别接收红细胞浓缩物和等离子体的至少第二和第三袋，以及用于将柔性袋连接到具有分离膜的分离器模块的多个管 以一束中空纤维的形式。 该系统被分成至少一个第一和第二个无菌封装的单个子系统。 第一子系统包括单个袋和相关连接管，第二子系统包括分离器模块和公/母连接器。

公开(公告)号：US20150115180A1

公开(公告)日：2015-04-30

申请号：US14068241

申请日：2013-10-31

Applicant: FENWAL, INC.

Inventor： Matthew Schoonover ,  Lan T. Nguyen ,  David Stude ,  Elizabeth Nelson

IPC: G01N21/84 ,  G01N33/49 ,  G01N33/487

CPC classification number: G01N21/84 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3455 ,  A61M1/3496 ,  A61M2205/18 ,  A61M2205/27 ,  A61M2205/3306 ,  A61M2205/60 ,  A61M2205/6009 ,  G01N33/487 ,  G01N33/49

Abstract: A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

Abstract translation: 提供了一种方法和装置，用于在治疗交换过程期间自动检测由操作者加载的替换流体的类型，并且如果使用不正确的流体，则提供警告报警。 在操作人员将替换流体的容器连接到一次性使用试剂盒的更换流体管线之后，将要执行的交换程序的标识输入到控制器中，更换的流体通过套件的一部分流过 传感器与检测流过该段的流体类型的硬件组件相关联。 控制器验证在段中检测到的替换流体是否对应于所选择的交换过程的替换流体，并且在已经加载不正确的替换流体的情况下通知操作者。

公开(公告)号：US09011359B2

公开(公告)日：2015-04-21

申请号：US13912337

申请日：2013-06-07

Applicant: Fenwal, Inc.

Inventor： Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  Prakash Mathew ,  Marc N. Weasler ,  Benjamin E. Kusters

IPC: A61M37/00 ,  A61M1/34 ,  A61M1/38 ,  A61M1/26 ,  A61M1/36 ,  B01D35/00 ,  B01D35/14 ,  B01D33/00 ,  C02F3/30

CPC classification number: A61M1/3496 ,  A61M1/262 ,  A61M1/3603 ,  A61M1/38 ,  A61M2202/0415

Abstract: Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.

Abstract translation: 某些实例描述了用于增加从供体血液中提取的血浆的系统和方法。 示例性方法包括接收从连接到采血机的供体供体的血液。 该示例性方法包括使用过滤装置过滤血液以去除包含在血液中的血浆中的至少一部分血浆以分离从血液中除去的血浆。 示例性方法包括将已去除的等离子体进行路由以进行采集。 示例性方法包括使用或过滤装置对剩余血液进行再过滤以从剩余血液中除去附加血浆。 示例性方法包括路由附加的等离子体以进行收集。

公开(公告)号：US20150101994A1

公开(公告)日：2015-04-16

申请号：US14050948

申请日：2013-10-10

Applicant: FENWAL, INC.

Inventor： Gert Najdeni

IPC: B01D61/24

CPC classification number: A61M1/367 ,  A61M1/3496 ,  B01D61/243

Abstract: Systems and methods for processing a fluid including a suspension of biological cellular components are disclosed including a single-use kit comprising a container for the fluid; a separation device for retaining selected biological cellular components and allowing other biological cellular components of said fluid to pass therethrough; a flow path connecting the container to the separation device, the container being configured, when in use, to be positioned so that gravity tends to flow fluid through the flow path. The flow path has a segment in close proximity to the container with a configuration including a positive slope, so that biological cellular components moving through the segment are subjected to a gravitational force tending to impede movement through the flow path segment. The flow path segment preferably has a generally circular configuration, and a diameter of approximately 1.5 inches. Alternatively, the flow path segment may have a generally S-shaped configuration.

Abstract translation: 公开了用于处理包括生物细胞组分的悬浮液的流体的系统和方法，其包括一次性试剂盒，其包括用于流体的容器; 用于保持选定的生物细胞组分并允许所述流体的其它生物细胞组分通过的分离装置; 将容器连接到分离装置的流路，所述容器在使用时被配置为使得重力倾向于使流体流过流路。 流动路径具有紧邻容器的段，其具有包括正斜率的构造，使得移动通过段的生物细胞组分受到倾向于阻碍通过流动路段的移动的重力。 流路段优选地具有大致圆形的构造，并且直径约为1.5英寸。 或者，流路段可以具有大致S形的构造。