公开(公告)号：US06687010B1

公开(公告)日：2004-02-03

申请号：US09656799

申请日：2000-09-07

Applicant: Akihiro Horii ,  Mamoru Kaneko ,  Tadashi Hirata ,  Hitoshi Mizuno

Inventor： Akihiro Horii ,  Mamoru Kaneko ,  Tadashi Hirata ,  Hitoshi Mizuno

IPC: G01B902

CPC classification number: G01B9/02007 ,  G01B9/02003 ,  G01B9/0201 ,  G01B9/0205 ,  G01B9/02091 ,  G01B2290/20 ,  G01B2290/35 ,  G01B2290/40 ,  G01B2290/65 ,  G01B2290/70

Abstract: An optical imaging device includes a reference scanning unit offering a high signal-to-noise ratio and capable of scanning an object rapidly. An interference optical system can be realized inexpensively. In the optical imaging device, low coherent light passed through an optical coupler and another optical coupler, irradiated from an optical scanner probe, reflected from an observed point in a living tissue, returned to the optical coupler, propagated over a fourth SM optical fiber, and routed to another optical coupler shall be referred to as sample light. Light passed through an optical length variation optical system via the optical coupler and routed to the optical coupler shall be referred to as reference light. At this time, a difference between a delay time undergone by the sample light and a delay time undergone by the reference light is proportional to a difference between an optical length for the sample light and an optical length for the reference light. When the optical length difference falls within a coherence length, the sample light and reference light interfere with each other. An interfering signal is acquired into a computer through detectors, a differential amplifier, a demodulator, and an A/D converter.

公开(公告)号：US6157458A

公开(公告)日：2000-12-05

申请号：US70473

申请日：1998-04-30

Applicant: Paul Zorabedian

Inventor： Paul Zorabedian

IPC: G01B9/02

CPC classification number: G01B9/02007 ,  G01B2290/20 ,  G01B2290/70

Abstract: An improved interferometric system with reduced air turbulence error. The system includes an optical retarder that functions as a quarter wave plate for two harmonically related frequencies. The retarder may be formed by a pair of quartz disks cut so that the C axis lie in the plane of the disk and are oriented orthogonally relative to each other.

Abstract translation: 改进的干涉测量系统具有减少的空气湍流误差。 该系统包括用作两个谐波相关频率的四分之一波片的光学延迟器。 缓速器可以由一对切割的石英盘形成，使得C轴位于盘的平面中并相对于彼此正交定向。

公开(公告)号：US20180259316A1

公开(公告)日：2018-09-13

申请号：US15759486

申请日：2016-09-15

Applicant: Carl Zeiss Meditec, Inc. ,  Carl Zeiss Meditec AG

Inventor： Alexandre R. TUMLINSON ,  Nathan SHEMONSKI ,  Yuan LIU

IPC: G01B9/02 ,  H01S5/062 ,  H01S5/024

CPC classification number: G01B9/02004 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02047 ,  G01B9/02091 ,  G01B2290/20 ,  H01S5/02407 ,  H01S5/06216

Abstract: Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger the spectral output bandwidth under the equilibrium conditions.

公开(公告)号：US09097900B2

公开(公告)日：2015-08-04

申请号：US13523816

申请日：2012-06-14

Applicant: Evgenia Mikhailovna Kim ,  Robert John Filkins ,  Chulmin Joo

Inventor： Evgenia Mikhailovna Kim ,  Robert John Filkins ,  Chulmin Joo

IPC: G01B9/02 ,  G02B21/00 ,  G02B21/14 ,  G01B9/04 ,  G02B21/36

CPC classification number: G02B21/14 ,  G01B9/04 ,  G01B2290/20 ,  G02B21/0088 ,  G02B21/361

Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Abstract translation: 本文描述的一些系统包括频率相关相位板，用于产生每个来自不同频率范围的样品的多个相位对比图像，用于由被样品干涉的未衍射的光形成的光的频率范围的每个相位对比度图像 具有频率相关基准的相对于相位板相对相移的光。 在一些实施例中，多个相位对比图像可用于产生样本的定量相位图像。 相位对比图像或产生的定量相位图像可以具有足够的对比度，用于无标记的细胞体和核的自动分割。

公开(公告)号：US08804133B2

公开(公告)日：2014-08-12

申请号：US12816394

申请日：2010-06-16

Applicant: Dvir Yelin ,  Michal Merman

Inventor： Dvir Yelin ,  Michal Merman

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  G01B9/0201 ,  G01B9/02044 ,  G01B9/0209 ,  G01B2290/20

Abstract: A method of imaging at least a part of an object. The method comprises splitting electro-magnetic radiation to first and second portions, propagating the first and second portions, spectrally dispersing the first portion toward the part and the second portion toward a reference element, combining between reflections of the spectrally dispersed first and second portions to produce an interference signal, capturing an image of the part from the interference, and adjusting at least one of a tilt of said image plane and a curvature of the image by changing a deviation between the phase of at least one spectral component of the first portion and the phase of at least one spectral component of the second portion.

Abstract translation: 对物体的至少一部分进行成像的方法。 该方法包括将电磁辐射分成第一和第二部分，传播第一和第二部分，将第一部分朝向部分和第二部分光谱扩散到参考元件，将光谱分散的第一和第二部分的反射与 产生干扰信号，从干扰中捕获该部分的图像，并且通过改变第一部分的至少一个光谱分量的相位之间的偏差来调整所述图像平面的倾斜和图像的曲率中的至少一个 以及第二部分的至少一个光谱分量的相位。

公开(公告)号：US08570525B2

公开(公告)日：2013-10-29

申请号：US12441686

申请日：2007-06-22

Applicant: Pawel Wojdas ,  Grzegorz Slusarczyk ,  Tomasz Bajraszewski ,  Maciej Wojtkowski ,  Anna Szkulmowska ,  Piotr Targowski ,  Andrzej Kowalczyk

Inventor： Pawel Wojdas ,  Grzegorz Slusarczyk ,  Tomasz Bajraszewski ,  Maciej Wojtkowski ,  Anna Szkulmowska ,  Piotr Targowski ,  Andrzej Kowalczyk

IPC: G01B9/02

CPC classification number: G01B9/02044 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02008 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/20 ,  G01B2290/25 ,  G01N21/4795

Abstract: In an apparatus for imaging of objects by applying optical frequency domain tomography and provided with an adjusting system for setting a relative position of photosensitive elements (174) and a spectrum image (273), the adjusting system is an automatically controlled device causing a relative displacement of at least one photosensitive element (174) of the detection device (173) of the spectrum and the spectrum image (273) between each other. The adjusting system comprises at least one actuator (14, 16) acting on the dispersion device (171) and/or the set of optical elements (172) and/or the detection device (173) and movement of which causes the relative displacement between each other of at least one photosensitive element (174) of the detection device (173) of the spectrum and the spectrum image (273) of the resultant light beam (270).

Abstract translation: 在通过应用光学频域层析成像并设置有用于设置光敏元件（174）和光谱图像（273）的相对位置的调节系统的用于物体成像的装置中，调节系统是引起相对位移的自动控制装置 的光谱的检测装置（173）的至少一个感光元件（174）和彼此之间的光谱图像（273）。 调节系统包括作用在分散装置（171）和/或一组光学元件（172）和/或检测装置（173）上的至少一个致动器（14,16），并且其运动导致两者之间的相对位移 所述光谱的所述检测装置（173）的至少一个感光元件（174）和所得光束（270）的光谱图像（273）彼此相对。

公开(公告)号：US08077324B2

公开(公告)日：2011-12-13

申请号：US12304930

申请日：2007-06-14

Applicant: Jiang Xiangqian ,  Kaiwei Wang ,  Haydn Martin ,  Shuming Yang

Inventor： Jiang Xiangqian ,  Kaiwei Wang ,  Haydn Martin ,  Shuming Yang

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  G01B9/02004 ,  G01B9/02071 ,  G01B11/2441 ,  G01B2290/20 ,  G01B2290/70

Abstract: Light from the first and second different wavelength light sources is combined and supplied to a director that directs zeroth order light to a reference surface and other order, generally first order diffracted light to on a location of the sample surface which is dependent upon wavelength. Light reflected by the sample and reference surfaces interfere. A characteristic of a sample surface is determined from interference light of the first wavelength. Interference light of the second wavelength is used to enable phase-locking by adjusting the path length difference by moving the reference surface or changing the refractive index of a path portion to compensate for phase variation due to environmental effects. Non-mechanical scanning is used to scan the sample surface by using a variable wavelength source and a director providing different first order diffraction angles for different wavelengths or an acousto-optical device that provides a variable pitch acoustic diffraction grating.

Abstract translation: 来自第一和第二不同波长光源的光被组合并提供给导向器，导向器将零级光引导到参考表面和其它次序，通常将衍射光一阶地依赖于取决于波长的样品表面的位置。 由样品和参考表面反射的光线会干扰。 由第一波长的干涉光确定样品表面的特性。 使用第二波长的干涉光通过移动参考面或通过改变路径部分的折射率来调节路径长度差来补偿由于环境影响引起的相位变化来实现相位锁定。 使用非机械扫描通过使用可变波长源和为不同波长提供不同一级衍射角的导向器或提供可变间距声衍射光栅的声光装置来扫描样品表面。

公开(公告)号：US07929134B2

公开(公告)日：2011-04-19

申请号：US12154859

申请日：2008-05-27

Applicant: Zhilin Hu ,  Andrew M. Rollins

Inventor： Zhilin Hu ,  Andrew M. Rollins

IPC: G01J3/28

CPC classification number: G01J3/14 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/20 ,  G01J3/02 ,  G01J3/0208

Abstract: This application describes a spectrometer that includes a set of collimating optics to collimate received EMR to produce a collimated EMR. The spectrometer also includes a first dispersive optical element for dispersing the collimated EMR and a second dispersive optical element spaced apart from the first dispersive optical element to produce further dispersed EMR. The first dispersive optical element and the second dispersive optical element cooperate to disperse received EMR into a plurality of even frequency spaced EMR spectra. The spectrometer also includes a detector positioned to receive the EMR after passing though an optical path that includes the set of collimating optics, the first dispersive optical element, the second dispersive optical element, and a set of focusing optics.

Abstract translation: 该应用描述了一种光谱仪，其包括一组准直光学器件以准直所接收的EMR以产生准直的EMR。 光谱仪还包括用于分散准直EMR的第一色散光学元件和与第一色散光学元件间隔开的第二色散光学元件以产生进一步分散的EMR。 第一色散光学元件和第二色散光学元件协作以将接收到的EMR分散到多个均匀间隔的EMR光谱中。 光谱仪还包括一个检测器，定位成在通过包括准直光学器件组，第一分散光学元件，第二分散光学元件和一组聚焦光学器件的光路之后接收EMR。

公开(公告)号：US20100315652A1

公开(公告)日：2010-12-16

申请号：US12816394

申请日：2010-06-16

Applicant: Dvir YELIN ,  Michal Merman

Inventor： Dvir YELIN ,  Michal Merman

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  G01B9/0201 ,  G01B9/02044 ,  G01B9/0209 ,  G01B2290/20

Abstract: A method of imaging at least a part of an object. The method comprises splitting electro-magnetic radiation to first and second portions, propagating the first and second portions, spectrally dispersing the first portion toward the part and the second portion toward a reference element, combining between reflections of the spectrally dispersed first and second portions to produce an interference signal, capturing an image of the part from the interference, and adjusting at least one of a tilt of said image plane and a curvature of the image by changing a deviation between the phase of at least one spectral component of the first portion and the phase of at least one spectral component of the second portion.

Abstract translation: 对物体的至少一部分进行成像的方法。 该方法包括将电磁辐射分成第一和第二部分，传播第一和第二部分，将第一部分朝向部分和第二部分光谱扩散到参考元件，将光谱分散的第一和第二部分的反射与 产生干扰信号，从干扰中捕获该部分的图像，并且通过改变第一部分的至少一个光谱分量的相位之间的偏差来调整所述图像平面的倾斜和图像的曲率中的至少一个 以及第二部分的至少一个光谱分量的相位。

公开(公告)号：US07639368B2

公开(公告)日：2009-12-29

申请号：US11519037

申请日：2006-09-11

Applicant: David B. Needham

Inventor： David B. Needham

IPC: G01B11/02

CPC classification number: G01B9/0209 ,  G01B9/02083 ,  G01B11/14 ,  G01B2290/20 ,  G01B2290/25

Abstract: An algorithm and method for calculating an interferometric gap is disclosed that comprises providing an interferometric sensor having a first gap and an interferometric correlation element having a second gap placed in series with the first gap. A correlation burst waveform is generated having a plurality of features wherein the shape of the burst waveform evolves across the range of the second gap. Means are provided for tracking the features across the entire range of gaps and determining the dominant peak or dominant valley to determine the first gap.

Abstract translation: 公开了一种用于计算干涉间隙的算法和方法，其包括提供具有第一间隙的干涉测量传感器和具有与第一间隙串联放置的第二间隙的干涉相关元件。 产生具有多个特征的相关突发波形，其中突发波形的形状在第二间隙的范围内演变。 提供了用于跟踪整个间隙范围内的特征的装置，并且确定主峰或主谷以确定第一间隙。