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41.发明申请公开(公告)号：US20180364205A1
公开(公告)日：2018-12-20
申请号：US16011761
申请日：2018-06-19
摘要： A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.
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公开(公告)号：US10088459B2
公开(公告)日：2018-10-02
申请号：US15028492
申请日：2014-12-19
发明人： Yugo Onoda , Shoji Tomida , Kouichi Sugimoto , Takashi Yagi , Tetsuya Watanabe
摘要： A liquid-mixing device that minimizes solvent leakage and reduces creep of or damage to the component parts of said liquid-mixing device even at ultrahigh pressures of 100 MPa and up. Also, a liquid chromatography device using said liquid-mixing device. Said liquid chromatography device is provided with a supply pump that supplies a plurality of different solutions, a liquid-mixing device that mixes the supplied solutions, a sample injection device that injects a sample into the mixture of solutions, a column that separates the components of the injected sample, and a detector that detects the separated components. The liquid-mixing device has an inlet-side connector through which the plurality of different solutions flow in, a liquid-mixing section in which said solutions are mixed, and an outflow-side connector through which the mixed solutions flow out. The inlet-side connector and the liquid-mixing section are directly bonded to each other via diffusion bonding, as are the liquid-mixing section and the exit-side connector.
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公开(公告)号：US10060886B2
公开(公告)日：2018-08-28
申请号：US14612532
申请日：2015-02-03
CPC分类号： G01N30/34 , F04B23/04 , F04B49/065
摘要： Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time. Initiations of the pump strokes of the second pump are offset in time relative to initiations of the pump strokes of the first pump such that variations in the flow rates of the first and second pumps due to initiation do not overlap in time. The volume of liquid contributed by a pump stroke is controlled according to the relative contribution of the respective pump to the composition gradient.
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公开(公告)号：US10005006B2
公开(公告)日：2018-06-26
申请号：US14661793
申请日：2015-03-18
申请人： DIONEX SOFTRON GMBH
CPC分类号： B01D15/166 , G01N30/34
摘要： The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≤ΔGDV=GDVtarget−GDVactual≤Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.
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公开(公告)号：US09945762B2
公开(公告)日：2018-04-17
申请号：US14586882
申请日：2014-12-30
CPC分类号： G01N1/28 , G01N30/20 , G01N30/36 , G01N2030/202 , G01N2030/207 , G01N2030/342
摘要： A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.
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46.发明申请公开(公告)号：US20180052141A1
公开(公告)日：2018-02-22
申请号：US15558117
申请日：2016-03-10
摘要： A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.
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公开(公告)号：US20180008907A1
公开(公告)日：2018-01-11
申请号：US15533551
申请日：2015-12-17
摘要： A system for blending solutions and a buffer solution is disclosed. In this system a switch valve is present capable of flowing one or more solutions, a low pressure pump for pumping the one or more solutions through the switch valve and a T-joint capable of receiving the one or more solutions through the low pressure pump and blending the one or more solutions with a buffer solution. A high pressure pump is present for collecting a blended solution.
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公开(公告)号：US20170269041A1
公开(公告)日：2017-09-21
申请号：US15309725
申请日：2015-05-08
摘要： A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more solvents and water, and the method comprises the steps of: calculating pH and/or solvent concentration at a particular time t from a user-determined gradient function; and, based on the values obtained, calculating percent acid, percent base, percent solvent and percent water in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided.
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公开(公告)号：US09766216B2
公开(公告)日：2017-09-19
申请号：US10821657
申请日：2004-04-08
IPC分类号： C12Q1/68 , G01N30/86 , G01N33/53 , G01N33/538 , G01N33/561 , B01L3/00 , G01N30/02 , G01N30/34
CPC分类号： G01N30/8644 , B01L3/5027 , B01L3/502753 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/34 , G01N33/5306 , G01N33/538 , G01N33/561 , B01D15/34
摘要： This invention provides methods and compositions, e.g., to reduce interference from non-specific binding sample constituents in a migration shift assay. Interference due to non-specific binding of sample constituents to an affinity substance (e.g., an affinity molecule or a conjugate of an affinity molecule and a charged carrier molecule) is prevented by, e.g., binding the constituents to charged polymers such as heparin sulfate.The present invention also provides methods to concentrate an analyte of interest with high concentration and to detect the analyte with high sensitivity, and further to optimize the reaction conditions for easily concentrating the analyte. Such objects of the present invention are attained, for example, by concentrating a complex of the analyte and a conjugate which is formed by contacting the analyte in a sample with an affinity molecule bound to a charged carrier molecule such as DNA.
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公开(公告)号：US09527010B2
公开(公告)日：2016-12-27
申请号：US12566701
申请日：2009-09-25
申请人： Alan M. Williams , Adam Kaletski , Lisa Stack , Daniel Go , John Krasnansky , David A. Wareheim , Bin Lin
发明人： Alan M. Williams , Adam Kaletski , Lisa Stack , Daniel Go , John Krasnansky , David A. Wareheim , Bin Lin
IPC分类号： B01D35/14 , C02F1/00 , C12M1/00 , B01D15/18 , G01N30/28 , G01N30/46 , G01N30/24 , G01N30/34 , B01D15/36
CPC分类号： B01D15/1871 , B01D15/1864 , B01D15/362 , G01N30/24 , G01N30/28 , G01N30/34 , G01N30/465 , B01D15/363
摘要： A separation system comprises (i) at least two separation units, each separation unit comprising a fluid inlet and a fluid outlet, wherein the separation units are connected in series outlet to inlet to form a line of separation units, and (ii) sensing and adjustment means, provided in-line between each separation unit, for continuously monitoring and adjusting at least one environmental property parameter of fluid flowing from one separation unit to a subsequent separation unit in the line of separation units. Uses of the separation system and a method for purification of a liquid containing a desired species, using separation units and in-line adjustment of a fluid flow or flows, are also disclosed.
摘要翻译： 分离系统包括（i）至少两个分离单元，每个分离单元包括流体入口和流体出口，其中分离单元以串联出口连接到入口以形成一行分离单元，以及（ii）感测和 在每个分离单元之间在线设置的调节装置，用于连续地监测和调节从一个分离单元流向分离单元的后续分离单元的流体的至少一个环境属性参数。 还公开了分离系统的使用以及使用分离单元和流体流或流的在线调节来纯化含有所需物质的液体的方法。
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