公开(公告)号：US08568974B2

公开(公告)日：2013-10-29

申请号：US12734542

申请日：2008-11-14

Applicant: Cheryl L. Willman ,  Richard Harvey ,  George S. Davidson ,  Xuefei Wang ,  Susan R Atlas ,  Edward J. Bedrick ,  Iming L. Chen

Inventor： Cheryl L. Willman ,  Richard Harvey ,  George S. Davidson ,  Xuefei Wang ,  Susan R Atlas ,  Edward J. Bedrick ,  Iming L. Chen

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention relates to the identification of genetic markers patients with high risk B-precursor acute lymphoblastic leukemia (B-ALL) and associated methods and their relationship to therapeutic outcome. The present invention also relates to diagnostic, prognostic and related methods using these genetic markers, as well as kits which provide microchips and/or immunoreagents for performing analysis on leukemia patients.

Abstract translation: 本发明涉及高风险B-前体急性淋巴细胞性白血病（B-ALL）遗传标志物鉴定及相关方法及其与治疗结果的关系。 本发明还涉及使用这些遗传标记的诊断，预后和相关方法，以及提供用于对白血病患者进行分析的微芯片和/或免疫反应物的试剂盒。

公开(公告)号：USRE44533E1

公开(公告)日：2013-10-08

申请号：US13467514

申请日：2012-05-09

Applicant: Graham Timmins ,  Vojo P. Deretic

Inventor： Graham Timmins ,  Vojo P. Deretic

IPC: A61B5/08

CPC classification number: C12Q1/04 ,  A61K51/04 ,  A61K51/0406 ,  A61K51/1206 ,  G01N33/497 ,  G01N2333/21

Abstract: The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.

Abstract translation: 本发明涉及用于检测铜绿假单胞菌感染风险的患者肺部铜绿假单胞菌感染和细菌负担的方法，特别是包括囊性纤维化（CF）患者。 本方法提供了许多试验（呼吸，血液，尿液），其易于对患者施用，其将敏感且特异性地检测肺部感染铜绿假单胞菌（粘液样和非粘液样）的存在和程度，并允许监测细菌 负载作为监测治疗的参数。

公开(公告)号：US20130240832A1

公开(公告)日：2013-09-19

申请号：US13875264

申请日：2013-05-01

Applicant: Stephen D. Hersee

Inventor： Stephen D. Hersee

IPC: H01L27/15 ,  H01L33/06

CPC classification number: H01L27/15 ,  H01L25/167 ,  H01L29/2003 ,  H01L29/7787 ,  H01L33/0041 ,  H01L33/06 ,  H01L2224/32225 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Various embodiments provide materials and methods for integrating exemplary heterostructure field-effect transistor (HFET) driver circuit or thyristor driver circuit with LED structures to reduce or eliminate resistance and/or inductance associated with their conventional connections.

Abstract translation: 各种实施例提供用于将示例性异质结构场效应晶体管（HFET）驱动器电路或晶闸管驱动器电路与LED结构集成以减少或消除与其常规连接相关联的电阻和/或电感的材料和方法。

公开(公告)号：US20130214176A1

公开(公告)日：2013-08-22

申请号：US13835108

申请日：2013-03-15

Applicant: Steven Wayde Graves ,  Pearlson Prashanth Austin Suthanthiraraj ,  Andrew P. Shreve ,  Gabriel P. Lopez

Inventor： Steven Wayde Graves ,  Pearlson Prashanth Austin Suthanthiraraj ,  Andrew P. Shreve ,  Gabriel P. Lopez

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/14 ,  G01N15/1404 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N2015/142

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

Abstract translation: 具有显着增加的分析速率，体积样品递送和可用粒度的可负担的流式细胞计量系统，其包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光 流并将光成像到阵列检测器上。

公开(公告)号：US08501057B1

公开(公告)日：2013-08-06

申请号：US13010121

申请日：2011-01-20

Applicant: Xingmao Jiang ,  C. Jeffrey Brinker

Inventor： Xingmao Jiang ,  C. Jeffrey Brinker

IPC: B29C35/02

CPC classification number: C01B33/163 ,  B82Y30/00 ,  C01B13/328 ,  C01P2004/38 ,  C01P2004/62 ,  C01P2004/64

Abstract: Various embodiments provide materials and methods of forming hollow cubes. The hollow cubes can be formed to include a metal oxide shell layer encasing a cubic hollow space. In one embodiment, the hollow cubes can be formed from an emulsion having aqueous droplets with an interfacial layer encasing an aqueous core. By an exemplary freezing treatment, the aqueous droplets having a spherical shape can be transformed into ice components having a cubic shape. Metal oxide precursors can then be added to react with the encased cube-shaped ice core at the interface with the interfacial layer to form a sol-gel metal oxide shell layer. Hollow cubes can be formed by removing the cube-shaped ice core from the sol-gel metal oxide shell layer.

Abstract translation: 各种实施例提供了形成中空立方体的材料和方法。 中空立方体可以形成为包括包围立方中空空间的金属氧化物壳层。 在一个实施例中，中空立方体可以由具有包含水性芯的界面层的水性液滴的乳液形成。 通过示例性的冷冻处理，具有球形形状的水滴可以转变成具有立方体形状的冰组分。 然后可以加入金属氧化物前体以与包封的立方体冰芯在与界面层的界面处反应以形成溶胶 - 凝胶金属氧化物壳层。 可以通过从溶胶 - 凝胶金属氧化物壳层去除立方体状的冰芯来形成空心立方体。

公开(公告)号：US08488639B1

公开(公告)日：2013-07-16

申请号：US12699566

申请日：2010-02-03

Applicant: Jean-Claude Diels ,  Ladan Arissian

Inventor： Jean-Claude Diels ,  Ladan Arissian

IPC: H01S3/10

CPC classification number: H01S3/1112 ,  H01S3/083 ,  H01S3/10092 ,  H01S3/1121 ,  H01S3/1392 ,  H01S3/1398 ,  H01S3/2383

Abstract: Apparatus, systems, and methods having a frequency comb of large spacing can be used in a variety of applications. In various embodiments, a frequency comb is generated from a slave laser by injecting an optical output from a drive laser into the slave laser. One or more parameters of the drive laser and/or the slave laser can be adjusted such that a frequency comb can be generated at a multiple of the repetition rate of the drive laser. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 具有大间距的频率梳的装置，系统和方法可用于各种应用中。 在各种实施例中，通过将来自驱动激光器的光输出注入到从激光器中，从从激光器产生频梳。 可以调节驱动激光器和/或从属激光器的一个或多个参数，使得可以以驱动激光器的重复频率的倍数产生频率梳。 公开了附加装置，系统和方法。

公开(公告)号：US20130150336A1

公开(公告)日：2013-06-13

申请号：US13636785

申请日：2011-03-24

Applicant: WIlliam C. Burhans ,  Catherine E. Prudom ,  Christopher P. Allen ,  Oleg Ursu ,  Anna Waller ,  Larry A. Sklar

Inventor： WIlliam C. Burhans ,  Catherine E. Prudom ,  Christopher P. Allen ,  Oleg Ursu ,  Anna Waller ,  Larry A. Sklar

IPC: A61K31/58 ,  C12Q1/02 ,  A61K31/56

CPC classification number: A61K31/58 ,  A61K31/498 ,  A61K31/56 ,  C12Q1/025 ,  G01N2500/10 ,  G01N2800/7009

Abstract: Provided are methods and compositions for reducing superoxide anions such that a prophylactic or therapeutic effect against conditions associated with excess oxidative stress achieved. The compositions and methods provide for reducing inflammation and for enhancing lifespan of eukaryotic organisms. A screen for identifying compounds that can be used in these methods is also provided.

Abstract translation: 提供了用于减少超氧化物阴离子的方法和组合物，使得针对与过量氧化应激相关的病症达到预防或治疗效果。 组合物和方法提供减少炎症并增加真核生物的寿命。 还提供了用于鉴定可用于这些方法中的化合物的筛选。

公开(公告)号：US08426121B2

公开(公告)日：2013-04-23

申请号：US13022740

申请日：2011-02-08

Applicant: Steven R. J. Brueck ,  Andrew Frauenglass ,  Alexander K. Raub ,  Dong Li

Inventor： Steven R. J. Brueck ,  Andrew Frauenglass ,  Alexander K. Raub ,  Dong Li

IPC: G03F7/26

CPC classification number: H01L21/3086 ,  H01L21/0337 ,  H01L21/0338 ,  H01L21/3088 ,  H01L21/31144

Abstract: In accordance with the invention, there are methods for self-aligned spatial frequency doubling in one dimension and also in two dimension. The method for self-aligned spatial frequency doubling in one dimension can include forming a film stack over a substrate, wherein the film stack comprises a photoresist layer and forming a one-dimensional periodic first pattern having a first pitch p on the photoresist layer using an optical exposure, wherein the first pitch p is at least smaller than twice the bandpass limit for optical exposures. The method can also include forming a second pattern using the first pattern by nonlinear processing steps, wherein the second pattern has a second pitch p2=p/2.

Abstract translation: 根据本发明，在一维和二维中存在自对准空间倍频的方法。 在一个维度中自对准空间倍频的方法可以包括在衬底上形成膜堆叠，其中膜堆叠包括光致抗蚀剂层并且在光刻胶层上形成具有第一间距p的一维周期性第一图案，使用 光学曝光，其中第一间距p至少小于光学曝光的带通极限的两倍。 该方法还可以包括通过非线性处理步骤使用第一图案形成第二图案，其中第二图案具有第二间距p2 = p / 2。

公开(公告)号：US08410496B2

公开(公告)日：2013-04-02

申请号：US13231559

申请日：2011-09-13

Applicant: Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

Inventor： Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

IPC: H01L29/205 ,  H01L33/00

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

公开(公告)号：US20130026030A1

公开(公告)日：2013-01-31

申请号：US13644764

申请日：2012-10-04

Applicant: Cornelius F. Ivory ,  Sang M. Han ,  Youn-Jin Oh

Inventor： Cornelius F. Ivory ,  Sang M. Han ,  Youn-Jin Oh

IPC: G01N27/453 ,  C07K1/26 ,  G01N27/414

CPC classification number: G01N33/6803 ,  G01N27/414 ,  G01N27/4473 ,  G01N27/44795

Abstract: Various embodiments provide an exemplary lab-on-a-chip (LOC) system that serves as an analytical tool and/or as a separation medium for an electrolyte solution including various charged molecular species. The LOC system can include an integrated nanofluidic FET device in combination with suitable analysis systems. By applying and controlling a longitudinal electric field and a transverse electric potential, the flow and the pH of the electrolyte solution in the nanofluidic channels can be controlled.

Abstract translation: 各种实施例提供了一种示例性的片上实验室（LOC）系统，其用作用于包括各种带电分子种类的电解质溶液的分析工具和/或作为分离介质。 LOC系统可以与合适的分析系统结合使用集成的纳米流体FET器件。 通过施加和控制纵向电场和横向电势，可以控制纳米流体通道中的电解质溶液的流动和pH。