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    PRODUCTION METHOD FOR 1,4-BUTANEDIOL
    54.
    发明申请
    PRODUCTION METHOD FOR 1,4-BUTANEDIOL 审中-公开
    1,4-丁二醇的生产方法

    公开(公告)号：US20150087038A1

    公开(公告)日：2015-03-26

    申请号：US14560714

    申请日：2014-12-04

    Applicant: MITSUBISHI CHEMICAL CORPORATION ,  GENOMATICA, INC.

    Inventor： Masaru UTSUNOMIYA ,  Yusuke IZAWA ,  Norikazu KONISHI ,  Kota TANAKA ,  Shinichiro MATSUZONO ,  Takayuki SUZUKI ,  Michael JAPS ,  Mark BURK ,  Warren CLARK

    IPC: C07C29/84 ,  C12P7/18

    CPC classification number: C07C29/84 ,  B01D3/002 ,  B01D3/143 ,  C07C29/80 ,  C12P7/18 ,  C07C31/207

    Abstract: An object of the present invention is to provide high-quality 1,4BG capable of working out to a raw material of PBT with good color tone, by efficiently removing and refining impurities mixed when producing a biomass-derived 1,4BG on an industrial scale and the present invention relates to a production method of refined 1,4BG, where a crude 1,4BG-containing solution is obtained from refined raw material 1,4BG obtained by removing bacterial cells, salt contents and water from the fermentation culture medium, through a step of removing high-boiling-point components and/or low-boiling-point components by distillation and/or a step of converting an unsaturated compound to a hydride and the target product is obtained as a side stream in a further distillation step.

    Abstract translation: 本发明的目的是提供一种能够通过在工业规模生产生物质衍生的1,4BG时有效地除去和精制混合的杂质来提供具有良好色调的PBT原料的高质量的1,4BG 本发明涉及精制的1,4BG的制造方法，其中，通过从发酵培养基中除去细菌细胞，盐含量和水，通过从精制原料1,4BG获得粗制的含1,4BG的溶液，通过 通过蒸馏除去高沸点组分和/或低沸点组分的步骤和/或将不饱和化合物转化为氢化物的步骤，并在另外的蒸馏步骤中作为副产物获得目标产物。

    MICROORGANISMS AND PROCESSES FOR PRODUCING TEREPHTHALIC ACID AND ITS SALTS
    55.
    发明申请
    MICROORGANISMS AND PROCESSES FOR PRODUCING TEREPHTHALIC ACID AND ITS SALTS 审中-公开
    生产正辛酸及其盐的微生物和方法

    公开(公告)号：US20150080547A1

    公开(公告)日：2015-03-19

    申请号：US14373160

    申请日：2013-01-18

    Applicant: Genomatica, Inc.

    Inventor： Robin E. Osterhout ,  Anthony P. Burgard ,  Mark J. Burk

    IPC: C12P7/44 ,  C12P7/62 ,  C08G63/183 ,  C12P7/40

    CPC classification number: C12P7/44 ,  C07C51/43 ,  C07F9/091 ,  C08G63/183 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1007 ,  C12N9/1022 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/88 ,  C12P7/24 ,  C12P7/40 ,  C12P7/62 ,  C12P9/00 ,  C07C63/26 ,  C07C63/04

    Abstract: The invention provides non-naturally occurring microbial organisms having a (2-hydroxy-3-methyl-4-oxobutoxy) phosphonate (2H3M40P) pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce 2H3M40P, p-toluate or terephthalate. Also provided herein are processes for isolating bio-based aromatic carboxylic acid, in particular, p-toluic acid or terephthalic acid, from a culture medium, wherein the processes involve contacting the culture medium with sufficient carbon dioxide (C02) to lower the pH of the culture medium to produce a precipitate comprised of the aromatic carboxylic acid.

    Abstract translation: 本发明提供具有（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯（2H3M40P）途径，对甲苯甲酸途径和/或对苯二酸酯途径的非天然存在的微生物。 本发明另外提供了使用这些生物体来生产2H3M40P，对甲苯甲酸酯或对苯二甲酸酯的方法。 本文还提供了从培养基中分离生物基芳族羧酸，特别是对甲苯甲酸或对苯二甲酸的方法，其中所述方法包括使培养基与足够的二氧化碳（CO 2）接触以降低 该培养基产生由芳族羧酸组成的沉淀物。

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE
    56.
    发明申请
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE 审中-公开
    芳香族化合物的2,4-二戊二酸和1,3-丁二烯的生物合成的微生物和方法

    公开(公告)号：US20150064750A1

    公开(公告)日：2015-03-05

    申请号：US14226631

    申请日：2014-03-26

    Applicant: Genomatica, Inc.

    Inventor： Robin E. OSTERHOUT ,  Anthony P. Burgard ,  Priti Pharkya ,  Mark J. Burk

    IPC: C12P7/62 ,  C12P5/02

    CPC classification number: C12P7/62 ,  C12N15/52 ,  C12P5/005 ,  C12P5/026 ,  C12P7/16 ,  C12P7/40 ,  C12P9/00 ,  Y02E50/10

    Abstract: The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.

    Abstract translation: 本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯 ，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。 本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯 ，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。

    Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
    57.
    发明授权
    Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors 有权
    1,4-丁二醇及其前体的生物合成的组合物和方法

    公开(公告)号：US08969054B2

    公开(公告)日：2015-03-03

    申请号：US13717350

    申请日：2012-12-17

    Applicant: Genomatica, Inc.

    Inventor： Mark J. Burk ,  Stephen J. Van Dien ,  Anthony P. Burgard ,  Wei Niu

    IPC: C12P7/18 ,  C12N1/21 ,  C12P7/42 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/00 ,  C12P7/52 ,  C12P17/04

    CPC classification number: C12N15/52 ,  B01D3/002 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/88 ,  C12N9/93 ,  C12N15/70 ,  C12N15/81 ,  C12P7/18 ,  C12P7/42 ,  C12P7/52 ,  C12P17/04 ,  C12Y101/01061 ,  C12Y102/01076 ,  C12Y401/01071 ,  C12Y602/01004 ,  Y02P20/52

    Abstract: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO.

    Abstract translation: 本发明提供了一种非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）生物合成途径的微生物生物，其具有至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛 脱氢酶或α-酮戊二酸脱羧酶，其中外源核酸以足够的量表达以产生单体4-羟基丁酸（4-HB）。 还提供了非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）和1,4-丁二醇（BDO）生物合成途径的微生物生物，该途径包括至少一种编码4-羟基丁酸脱氢酶的外源核酸 ，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶，4-羟基丁酸酯：CoA转移酶，4-丁酸酯激酶，磷酸转移酶，α-酮戊二酸脱羧酶，醛脱氢酶，醇脱氢酶或醛/醇脱氢酶，其中外源核酸为 以足够的量表示产生1,4-丁二醇（BDO）。 另外提供了用于生产4-HB和BDO的方法。

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