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51.发明公开公开(公告)号：US20240102113A1
公开(公告)日：2024-03-28
申请号：US18255731
申请日：2021-12-02
Inventor： Karen ANDERSON , Mark KNAPPENBERGER , Siril AROCKIAM
IPC: C12Q1/70 , C12N9/22 , C12N15/11 , C12Q1/6818
CPC classification number: C12Q1/70 , C12N9/22 , C12N15/11 , C12Q1/6818 , C12Q1/6806
Abstract: The disclosure relates to methods of detecting a target nucleic acid in a sample using a deactivated RNA-guided nuclease and guide RNA complex. Some methods relate to isolating protein-nucleic acid complexes using silica-based chromatography with certain buffered solutions to better prevent complex dissociation. Some methods relate to isolating protein-nucleic acid complexes using a tagged ribonucleoprotein which binds to a target nucleic acid to form a detectable interconnected network comprising the target nucleic acid. Also provided herein are primer nucleic acids, buffer solutions, and kits for performing the methods of this disclosure for detecting a target nucleic acid in a sample.
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52.发明公开公开(公告)号：US20240099779A1
公开(公告)日：2024-03-28
申请号：US18525693
申请日：2023-11-30
Inventor： Lena Mary Houlihan , David Naughton , Mark C. Preul
CPC classification number: A61B34/10 , A61B34/25 , A61B2034/107 , A61B2034/256
Abstract: Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
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公开(公告)号：US20240078434A1
公开(公告)日：2024-03-07
申请号：US18241811
申请日：2023-09-01
Inventor： Zuwei Guo , Nahid Ul Islam , Jianming Liang
IPC: G06N3/0895 , G06N3/0455 , G06T7/00 , G06V10/774 , G06V10/82 , G06V20/50 , G06V20/70
CPC classification number: G06N3/0895 , G06N3/0455 , G06T7/0012 , G06V10/774 , G06V10/82 , G06V20/50 , G06V20/70 , G06T2207/20081 , G06T2207/20084 , G06T2207/30004 , G06V2201/03
Abstract: The system receives a plurality of medical images and integrates Self-Supervised machine Learning (SSL) instructions for performing a discriminative learning operation, a restorative learning operation, and an adversarial learning operation into a model for processing the received plurality of medical images. The model is configured with each of a discriminative encoder, a restorative decoder, and an adversarial encoder. Each of the discriminative encoder and the restorative decoder are configured to be skip connected, forming an encoder-decoder. Step-wise incremental training to incrementally train each of the discriminative encoder, the restorative decoder, and the adversarial encoder is performed, in particular: pre-training the discriminative encoder via discriminative learning; attaching the pre-trained discriminative encoder to the restorative decoder to configure the encoder-decoder as a pre-trained encoder-decoder; and training the pre-trained encoder-decoder of the model using joint discriminative and restorative learning. The pre-trained encoder-decoder is associated with the adversarial encoder. The pre-trained encoder-decoder associated with the adversarial encoder is trained through discriminative, restorative, and adversarial learning to render a trained model for the processing of the received plurality of medical images. The plurality of medical images are processed through the model using the trained model.
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公开(公告)号：US11915837B2
公开(公告)日：2024-02-27
申请号：US17378094
申请日：2021-07-16
Inventor： William Graves , Lucas Malin
IPC: G21K1/06 , H01S4/00 , H05G2/00 , G01N23/20008
CPC classification number: G21K1/062 , G01N23/20008 , H01S4/00 , H05G2/008 , G01N2223/0565 , G01N2223/102 , G21K2201/061 , G21K2201/067
Abstract: A method includes simulating diffraction in a transmission geometry of relativistic electron bunches from a crystallographic structure of a crystal thereby simulating diffraction of the relativistic electron bunches into a plurality of Bragg peaks. The method includes selecting a range of angles between a direction of propagation of the relativistic electron bunches and a normal direction of crystal including an angle at which a diffraction portion is maximized. The method includes sequentially accelerating a plurality of physical electron bunches to relativistic energies toward a physical crystal having the crystallographic structure and diffracting the plurality of physical electron bunches off the physical crystal at different angles and measuring the diffraction portion into the respective Bragg peak at the different angles. The method includes selecting a final angle based on the measured diffraction portion into the respective Bragg peak at the different angles and generating a pulse of light.
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公开(公告)号：US11913070B2
公开(公告)日：2024-02-27
申请号：US17184201
申请日：2021-02-24
Inventor： Stuart Lindsay
IPC: C12Q1/6869 , C12Q1/00 , G16B30/20 , G16B40/10 , G01N33/487 , G01N27/12
CPC classification number: C12Q1/6869 , C12Q1/005 , G01N33/48721 , G16B30/20 , G16B40/10 , G01N27/125
Abstract: The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer.
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Patent Agency Ranking
公开(公告)号：US20240052400A1
公开(公告)日：2024-02-15
申请号：US18453129
申请日：2023-08-21
Inventor： Alexander Green , Duo Ma , Anli Tang
IPC: C12Q1/6825 , C12Q1/6816
CPC classification number: C12Q1/6825 , C12Q1/6816 , Y02A50/30
Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.
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公开(公告)号：US20240049981A1
公开(公告)日：2024-02-15
申请号：US18266563
申请日：2021-12-09
Inventor： Visar Berisha , Julie Liss , Shira Hahn , Gabriela Stegmann , Jeremy Shefner
CPC classification number: A61B5/08 , G10L25/66 , G10L15/22 , G10L15/02 , A61B5/4803 , A61B5/7267 , A61B5/6898 , G16H10/20 , G16H10/60 , G16H20/30 , A61B2562/0204
Abstract: Described are platforms, systems, media, and methods for maintaining a database of items associated with one or more skill requirements and a visit duration; maintaining a database of experts associated with one or more skill proficiencies, a location, and a schedule; receiving a request from a consumer for delivery by an expert of one or more items in the database to a consumer address; identifying experts in the database having skill proficiencies matching the skill requirements of the one or more items and available in a timeslot for the visit duration of the one or more items; presenting timeslots for which one or more experts are identified to the consumer and allowing the consumer to select a timeslot; and selecting an expert from among the identified experts in the selected timeslot based on shortest travel time; provided that utilization of the selected expert exceeds a predetermined utilization threshold.
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58.发明公开公开(公告)号：US20240043853A1
公开(公告)日：2024-02-08
申请号：US18311587
申请日：2023-05-03
Inventor： Alexander Green , Fan Hong
IPC: C12N15/67 , C12Q1/6825 , C12Q1/6897
CPC classification number: C12N15/67 , C12Q1/6825 , C12Q1/6897
Abstract: Provided herein are highly sensitive compositions and methods for detection of at least one specific nucleic acid molecule in a sample. The presence of a specific nucleic acid provides a positive indicator of a pathogenic agent, contaminant, non-canonical bases, and/or wild-type or mutated genes in a sample or a cell. Applications for which the compositions and methods are particularly well suited include point-of-care disease diagnosis or cellular RNA imaging.
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公开(公告)号：US11875910B2
公开(公告)日：2024-01-16
申请号：US17350464
申请日：2021-06-17
Inventor： William Graves
IPC: G21K1/06
CPC classification number: G21K1/06 , G21K2201/064 , G21K2201/067
Abstract: An optical apparatus is provided for manipulating light from x-ray sources (e.g., free electron lasers). In some embodiments, the optical apparatus includes a first capillary optic having a first longitudinal axis and a second capillary optic having a second longitudinal axis that is angled with respect to the first longitudinal axis. The second capillary optic is positioned to receive light directly from the first capillary optic.
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公开(公告)号：US20240011065A1
公开(公告)日：2024-01-11
申请号：US18327434
申请日：2023-06-01
Inventor： Nicholas Stephanopoulos , Minghui Liu
CPC classification number: C12P19/34 , C12N15/111 , C12N2310/122 , B82Y40/00
Abstract: A photocaged DNA nano-tweezer and methods of using said photocaged DNA nano-tweezer are described. In particular, provided herein is a DNA nano-tweezer comprising a hairpin with a single-stranded loop that comprises a first arm and a second arm; and a trigger strand complementary to the single-stranded loop and comprising at least one photocaged residue with a protecting group.
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