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    Polynucleotide encoding macrophage inflammatory protein .gamma.
    51.
    发明授权
    Polynucleotide encoding macrophage inflammatory protein .gamma. 失效
    多核苷酸编码巨噬细胞炎症蛋白γ

    公开(公告)号：US5556767A

    公开(公告)日：1996-09-17

    申请号：US173209

    申请日：1993-12-22

    Applicant: Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    Inventor： Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    IPC: A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N15/12

    CPC classification number: C07K14/523 ,  C07K16/24 ,  A61K38/00

    Abstract: There is disclosed a human macrophage inflammatory protein-1 .gamma. (MIP-1 .gamma.) polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases.

    Abstract translation: 公开了人巨噬细胞炎症蛋白-1（MIP-1γ）多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。 本发明的另一方面提供本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

    LUNG CANCER MARKERS, AND USES THEREOF
    52.
    发明申请
    LUNG CANCER MARKERS, AND USES THEREOF 有权
    肺癌标志物及其用途

    公开(公告)号：US20090176228A1

    公开(公告)日：2009-07-09

    申请号：US12273994

    申请日：2008-11-19

    Applicant: Charles BIRSE ,  Marcia LEWIS ,  Steven Ruben ,  Mehdi Meari

    Inventor： Charles BIRSE ,  Marcia LEWIS ,  Steven Ruben ,  Mehdi Meari

    IPC: C12Q1/68 ,  G01N33/574

    CPC classification number: G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

    Abstract: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    Abstract translation: 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂），以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

    HEMCM42 antibodies
    54.
    发明申请
    HEMCM42 antibodies 有权
    HEMCM42抗体

    公开(公告)号：US20080004432A1

    公开(公告)日：2008-01-03

    申请号：US11801040

    申请日：2007-05-07

    Applicant: Steven Ruben ,  Craig Rosen ,  Gregory Endress

    Inventor： Steven Ruben ,  Craig Rosen ,  Gregory Endress

    IPC: C07K16/00 ,  C07K16/18

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K16/00

    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    T1 Receptor-Like Ligand II and Uses Thereof
    55.
    发明申请
    T1 Receptor-Like Ligand II and Uses Thereof 审中-公开
    T1受体样配体II及其用途

    公开(公告)号：US20070280903A1

    公开(公告)日：2007-12-06

    申请号：US11554432

    申请日：2006-10-30

    Applicant: Jian Ni ,  Reiner Gentz ,  Steven Ruben

    Inventor： Jian Ni ,  Reiner Gentz ,  Steven Ruben

    IPC: A61K38/19 ,  A61K38/17 ,  C12Q1/68 ,  A61K38/18

    CPC classification number: G01N33/564 ,  A61K38/1709 ,  A61K38/20 ,  A61K45/06 ,  A61K48/00 ,  C07K14/54 ,  C12N2799/026 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2800/24 ,  G01N2800/2821 ,  G01N2800/368

    Abstract: The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.

    Abstract translation: 本发明涉及一种新颖的T1受体（T1R）样配体II蛋白。 特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。 还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。 本发明还涉及包含T1R样配体II的药物组合物和制剂。 还提供了用于治疗和诊断目的的T1R样配体II多核苷酸，多肽，抗体或激动剂/拮抗剂的方法。 还提供诊断试剂盒。

    Novel Metalloproteinases
    57.
    发明申请
    Novel Metalloproteinases 审中-公开
    新型金属蛋白酶

    公开(公告)号：US20070238130A1

    公开(公告)日：2007-10-11

    申请号：US11627246

    申请日：2007-01-25

    Applicant: Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    Inventor： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC: C12P1/04 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06

    CPC classification number: C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    Abstract: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    Abstract translation: 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Human G-protein chemokine receptor (CCR5) HDGNR10
    58.
    发明申请
    Human G-protein chemokine receptor (CCR5) HDGNR10 有权
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20070122405A1

    公开(公告)日：2007-05-31

    申请号：US11518949

    申请日：2006-09-12

    Applicant: Viktor Roschke ,  Craig Rosen ,  Steven Ruben

    Inventor： Viktor Roschke ,  Craig Rosen ,  Steven Ruben

    IPC: G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28

    CPC classification number: C07K16/2866 ,  C07K14/7158 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/715

    Abstract: The present invention relates to a human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this human protein and these human antibodies.

    Abstract translation: 本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该人类蛋白质和这些人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

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