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    METHODS, SYSTEMS, AND DEVICES FOR POSITIVE PRESSURE PHARMACEUTICAL VIALS
    51.
    发明申请
    METHODS, SYSTEMS, AND DEVICES FOR POSITIVE PRESSURE PHARMACEUTICAL VIALS 审中-公开
    方法，系统和用于积极压力药用植物的装置

    公开(公告)号：US20150211950A1

    公开(公告)日：2015-07-30

    申请号：US14167854

    申请日：2014-01-29

    Applicant: TOKITAE LLC

    Inventor： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Nels R. Peterson ,  Lowell L. Wood, JR. ,  Victoria Y. H. Wood

    IPC: G01L19/08 ,  B65B7/16 ,  B65C3/06 ,  B65D41/00 ,  A61J1/06 ,  A61J1/14 ,  A61J1/18 ,  B65D25/20 ,  B65B3/00 ,  B65B31/08

    CPC classification number: G01L19/08 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2096 ,  A61J2200/70 ,  B65B3/003 ,  B65B7/2821 ,  B65B31/042 ,  B65B31/08 ,  B65B51/10 ,  B65B57/00

    Abstract: Methods, systems, and devices are described for calculating a push pressure for a pharmaceutical vial with a syringe, the method including accepting data regarding at least one parameter of the pharmaceutical vial, at least one parameter of a vial cap with a seal, at least one parameter of the syringe, and a single dose volume of a liquid pharmaceutical; calculating a volume of headspace over the liquid pharmaceutical with a computing device; calculating an ejection pressure based on the single dose volume of the liquid pharmaceutical and the volume of headspace; calculating a motive pressure based on a static force and a cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user. The method further includes calculating a molar amount of inert gas needed in the pharmaceutical vial to generate the calculated push pressure.

    Abstract translation: 描述了用于计算具有注射器的药物瓶的推压的方法，系统和装置，所述方法包括至少接收关于药瓶的至少一个参数的数据，至少具有密封的小瓶盖的参数 注射器的一个参数和单剂量的液体药物; 用计算装置计算液体药物上的顶空体积; 基于液体药物的单剂量体积和顶部空间体积来计算喷射压力; 基于注射器的静力和横截面面积来计算运动压力; 将推压力定义为喷射压力或动力压力的较大值; 并向用户报告推压。 该方法还包括计算药物小瓶中所需的惰性气体的摩尔量以产生计算出的推压。

    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS
    52.
    发明申请
    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
    微型或三维印刷的流感疫苗制剂

    公开(公告)号：US20150165020A1

    公开(公告)日：2015-06-18

    申请号：US14572631

    申请日：2014-12-16

    Applicant: Massachussetts Institute of Technology ,  Tokitae LLC

    Inventor： Ana Jaklenec ,  William Gates ,  Philip A. Eckhoff ,  Boris Nikolic ,  Lowell L. Wood, JR. ,  Robert S. Langer

    IPC: A61K39/39

    CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6093 ,  C12N2770/32634 ,  Y02A50/466

    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

    Abstract translation: 已经开发了用于单次注射抗原的乳液基和微成型（“MM”）或三维印刷（“3DP”）聚合物制剂，优选在两个或更多个时间段内释放。 制剂优选由生物相容的可生物降解的聚合物形成。 单独或与其他抗原，佐剂，稳定剂和释放调节剂组合的包封抗原的离散区域存在于制剂中。 抗原优选在给药时或赋形剂的表面存在于赋形剂中，用于立即释放，并且在初始释放抗原后10至45天，任选地以10至90天的间隔，并入引发至制剂内以释放 在一个或多个额外的时间段内释放抗原。 抗原可以通过使用稳定剂例如海藻糖玻璃来稳定。 在针对小儿麻痹症免疫的优选实施方案中，抗原在给药时释放，其后两个，四个月和六个月。

    DEVICES AND METHODS FOR STAINING AND MICROSCOPY
    53.
    发明申请
    DEVICES AND METHODS FOR STAINING AND MICROSCOPY 有权
    用于染色和显微镜的装置和方法

    公开(公告)号：US20150111216A1

    公开(公告)日：2015-04-23

    申请号：US14061009

    申请日：2013-10-23

    Applicant: Tokitae LLC

    Inventor： Charles Delahunt ,  David Gasperino ,  Matthew P. Horning ,  Kevin P. F. Nichols ,  Benjamin K. Wilson

    IPC: C12Q1/68

    CPC classification number: G02B21/34 ,  B01L3/5023 ,  B01L3/50273 ,  B01L9/527 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2400/0406 ,  C12Q2563/107 ,  G01N1/312

    Abstract: Devices and methods for preparing and assessing a liquid sample are described which include: a microfluidic microscopy device including an absorbent structure including at least one dry dye for a liquid and configured to convey a polar liquid from a first end of the absorbent structure through the at least one dry dye for a liquid to a second end of the absorbent structure, a support structure positioned adjacent to a first surface of the absorbent structure, a lid structure positioned adjacent to a second surface of the absorbent structure, and a clamping structure positioned to maintain a relative position of the support structure and the lid structure to form a tapered internal chamber adjacent to the second end of the absorbent structure.

    Abstract translation: 描述了用于制备和评估液体样品的装置和方法，其包括：微流体显微镜装置，其包括吸收结构，所述吸收结构包括用于液体的至少一种干染料，并且被配置为通过所述吸收结构的吸收结构的第一端输送极性液体 至少一个用于液体的干染料到吸收结构的第二端，邻近吸收结构的第一表面定位的支撑结构，邻近吸收结构的第二表面定位的盖结构，以及夹持结构，其定位成 保持支撑结构和盖结构的相对位置，以形成与吸收结构的第二端相邻的锥形内腔。

    INTERPOLATING A PORTION OF A SIGNAL IN RESPONSE TO A COMPONENT OF ANOTHER SIGNAL
    54.
    发明申请
    INTERPOLATING A PORTION OF A SIGNAL IN RESPONSE TO A COMPONENT OF ANOTHER SIGNAL 审中-公开
    插入一个信号部分对另一个信号的组件的响应

    公开(公告)号：US20140019065A1

    公开(公告)日：2014-01-16

    申请号：US13665894

    申请日：2012-10-31

    Applicant: TOKITAE LLC

    Inventor： Guillaume CHABOT-COUTURE

    IPC: G01C15/00 ,  G01N33/00

    CPC classification number: G06F17/18 ,  G01C15/00 ,  G01K7/42 ,  G01N33/0004 ,  G01W1/00 ,  G01W1/02 ,  G06F15/00 ,  G06F17/17

    Abstract: An embodiment of an apparatus includes a first component determiner configured to determine a component of a first signal, and an interpolator configured to interpolate a portion of the second signal in response to the component of the first signal. For example, such an apparatus may include an altitude-component determiner and an interpolator. The altitude-component determiner is configured to determine an altitude component of a first signal, and the interpolator is configured to interpolate an altitude component of a second signal in response to the altitude component of the first and to interpolate an empty portion of the second signal in response to the interpolated altitude component of the second signal.

    Abstract translation: 装置的一个实施例包括配置成确定第一信号的分量的第一分量确定器和配置成响应于第一信号的分量内插第二信号的一部分的内插器。 例如，这样的装置可以包括高度分量确定器和内插器。 高度分量确定器被配置为确定第一信号的高度分量，并且内插器被配置为响应于第一信号的高度分量内插第二信号的高度分量并且内插第二信号的空白部分 响应于第二信号的内插高度分量。

    INTERPOLATING A PORTION OF A SIGNAL IN RESPONSE TO A COMPONENT OF THE SIGNAL AND A COMPONENT OF ANOTHER SIGNAL
    55.
    发明申请
    INTERPOLATING A PORTION OF A SIGNAL IN RESPONSE TO A COMPONENT OF THE SIGNAL AND A COMPONENT OF ANOTHER SIGNAL 审中-公开
    插入信号部分对信号的组成部分和其他信号的组成部分

    公开(公告)号：US20140019048A1

    公开(公告)日：2014-01-16

    申请号：US13665896

    申请日：2012-10-31

    Applicant: TOKITAE LLC

    Inventor： Guillaume CHABOT-COUTURE

    IPC: G06F17/18 ,  G01W1/02 ,  G01K7/42

    CPC classification number: G06F17/18 ,  G01C15/00 ,  G01K7/42 ,  G01N33/0004 ,  G01W1/00 ,  G01W1/02 ,  G06F15/00 ,  G06F17/17

    Abstract: An embodiment of an apparatus includes a first component determiner configured to determine a component of a first signal, a second component determiner configured to determine a component of a second signal, and an interpolator configured to interpolate a portion of the second signal in response to the components of the first and second signals. For example, such an apparatus may include an altitude-component determiner, a lapse-rate-component determiner, and an interpolator. The altitude-component determiner is configured to determine an altitude component of a first signal, and the lapse-rate-component determiner is configured to determine a lapse-rate component of a second signal having an empty portion. And the interpolator is configured to interpolate an altitude component of the second signal in response to the altitude component of the first signal, and to interpolate the empty portion of the second signal in response to the lapse-rate and altitude components of the second signal.

    Abstract translation: 装置的实施例包括被配置为确定第一信号的分量的第一分量确定器，被配置为确定第二信号的分量的第二分量确定器，以及被配置为响应于第二信号来内插第二信号的一部分的内插器 第一和第二信号的分量。 例如，这样的装置可以包括高度分量确定器，流逝分量确定器和内插器。 高度分量确定器被配置为确定第一信号的高度分量，并且流逝分量确定器被配置为确定具有空白部分的第二信号的经过率分量。 并且内插器被配置为响应于第一信号的高度分量内插第二信号的高度分量，并且响应于第二信号的流逝率和高度分量来内插第二信号的空白部分。

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