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    Ionizable lipidoids and their uses
    54.
    发明授权
    Ionizable lipidoids and their uses 有权

    公开(公告)号：US11459304B2

    公开(公告)日：2022-10-04

    申请号：US16556470

    申请日：2019-08-30

    Applicant: Massachusetts Institute of Technology

    Inventor： Lei Miao ,  Linxian Li ,  Daniel Griffith Anderson ,  Yuxuan Huang

    IPC: C07D233/40 ,  C07C251/08 ,  A61K39/39 ,  C07D403/06 ,  C07C237/06 ,  A61K39/00

    Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.

    SUPRAMOLECULAR MODIFICATION OF PROTEINS
    57.
    发明申请
    SUPRAMOLECULAR MODIFICATION OF PROTEINS 审中-公开

    公开(公告)号：US20180296680A1

    公开(公告)日：2018-10-18

    申请号：US15765585

    申请日：2016-10-06

    Applicant: Massachusetts Institute of Technology

    Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

    IPC: A61K47/54 ,  A61K38/28 ,  A61K47/68 ,  A61K38/26 ,  A61K47/60 ,  C07K16/28

    Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

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