公开(公告)号：US5705678A

公开(公告)日：1998-01-06

申请号：US775192

申请日：1996-12-30

申请人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

发明人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B61/00 ,  C07C45/51 ,  C07C45/54 ,  C07C45/72 ,  C07C49/17 ,  C07C67/31 ,  C07C67/343 ,  C07C67/347 ,  C07C69/732 ,  C07F7/00 ,  C07F7/28 ,  C07C69/73

CPC分类号： B01J31/223 ,  B01J31/2226 ,  C07C45/511 ,  C07C45/72 ,  C07C67/343 ,  C07C67/347 ,  C07F7/006 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2540/34

摘要： A novel oxotitanium complex represented by general formula (I) is disclosed: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a phenyl group, a substituted phenyl group, a trialkylsilyl group, a monoalkyldiphenylsilyl group, a dialkylmonophenylsilyl group, a triphenylsilyl group, a substituted triphenylsilyl group, or a lower alkoxycarbonyl group, provided that R.sup.1 and R.sup.2 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.1 and R.sup.2 are bonded; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a benzoyl group, a benzenesulfonyl group, or a halogen atom, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.3 and R.sup.4 are bonded; and n is 1 or 2. The novel oxotitanium complex is useful as an asymmetric reaction catalyst. A process for producing a .beta.-hydroxy ketone or an .alpha.-hydroxy carboxylic acid ester in the presence of the novel oxotitanium complex is also disclosed.

公开(公告)号：US5434289A

公开(公告)日：1995-07-18

申请号：US208379

申请日：1994-03-10

申请人： Koichi Mikami ,  Satoru Matsukawa ,  Masaki Shimizu ,  Masahiro Terada ,  Noboru Sayo

发明人： Koichi Mikami ,  Satoru Matsukawa ,  Masaki Shimizu ,  Masahiro Terada ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07C45/51 ,  C07C45/67 ,  C07C67/333 ,  C07C67/343 ,  C07C67/38 ,  C07C69/675 ,  C07C69/708 ,  C07C69/712 ,  C07C69/732 ,  C07C69/734 ,  C07C319/20 ,  C07C323/22 ,  C07C327/28 ,  C07C327/32 ,  C07C327/00 ,  C07C45/00 ,  C07C69/76

CPC分类号： C07C327/32 ,  C07C327/28 ,  C07C45/511 ,  C07C67/343

摘要： A process for producing an optically active .beta.-hydroxyketone represented by formula (I): ##STR1## by catalytic asymmetrical aldol reaction is disclosed, comprising reacting a silyl-enol ether represented by formula (II): ##STR2## with a substituted aldehyde represented by formula (III):R.sup.5 CHO (III)in the presence of a binaphthol-titanium complex represented by formula (IV): ##STR3## An optically active .beta.-hydroxyketone is efficiently produced with diastereo-specificity and enantio-specificity.

摘要翻译： 公开了由式（I）表示的光学活性β-羟基酮：通过催化不对称醛醇缩合反应制备的光学活性β-羟基酮的方法，包括使由式（II）表示的甲硅烷基烯醇醚： ）与由式（III）表示的取代的醛：R5CHO（III）在由式（IV）表示的联萘酚 - 钛络合物的存在下：以非对映特异性和对映体特异性有效地产生。

公开(公告)号：US20100249422A1

公开(公告)日：2010-09-30

申请号：US12682591

申请日：2008-10-10

申请人： Kazushi Mashima ,  Takashi Ohshima ,  Takanori Iwasaki ,  Noboru Sayo

发明人： Kazushi Mashima ,  Takashi Ohshima ,  Takanori Iwasaki ,  Noboru Sayo

IPC分类号： C07D211/34 ,  C07D207/08 ,  C07C69/78

CPC分类号： C07D213/55 ,  C07C67/03 ,  C07C67/08 ,  C07C213/06 ,  C07C231/02 ,  C07C253/30 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D211/34 ,  C07D295/195 ,  C07C69/618 ,  C07C69/24 ,  C07C69/612 ,  C07C69/76 ,  C07C69/78 ,  C07C219/14 ,  C07C219/18 ,  C07C219/22 ,  C07C233/69 ,  C07C233/73 ,  C07C255/57

摘要： Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically disclosed is a process for producing an ester compound, which is characterized in that an alcohol and a carboxylic acid ester compound are reacted in the presence of a compound containing zinc element, thereby selectively acylating a hydroxyl group of the alcohol.

摘要翻译： 公开了在化学温和条件下进行的醇羟基的选择性酯生产方法，同时具有足够的环境适应性，可操作性和经济效率。 具体公开了一种酯化合物的制造方法，其特征在于，在含有锌元素的化合物的存在下使醇和羧酸酯化合物反应，从而选择性地酰化醇的羟基。

公开(公告)号：US07754889B2

公开(公告)日：2010-07-13

申请号：US10594744

申请日：2005-03-28

申请人： Akira Amano ,  Daisuke Igarashi ,  Noboru Sayo

发明人： Akira Amano ,  Daisuke Igarashi ,  Noboru Sayo

IPC分类号： C07F15/00

CPC分类号： C07C211/49 ,  B01J31/0222 ,  B01J31/1805 ,  B01J31/4015 ,  B01J31/4038 ,  B01J2231/643 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/96 ,  C07B2200/07 ,  C07C29/143 ,  C07C211/27 ,  C07C311/18 ,  C07F15/0053 ,  C07F15/0073 ,  C07F15/008 ,  Y02P20/584 ,  C07C33/22

摘要： The present invention provides a water-soluble transition metal-diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting the ligand of the complex; and a catalyst for asymmetric synthesis which comprises these. The present invention relates to a water-soluble optically active transition metal-diamine complex represented by the formula (2): [wherein R1 and R2 each represents hydrogen, a hydrocarbon group, —SO2R13 (wherein R13 is a hydrocarbon group, substituted amino, etc.), etc.; R3 to R12 each represents hydrogen, a hydrocarbon group, alkoxy, substituted amino, etc.; M represents a transition metal; X represents halogen; L represents a ligand; and * indicates an asymmetric carbon atom; provided that at least one of R3 to R7 and R8 to R12 is substituted amino], a catalyst for asymmetric synthesis containing the complex, and a process for producing an optically active alcohol, which comprises using the catalyst to asymmetrically reduce a ketone.

摘要翻译： 本发明提供一种水溶性过渡金属 - 二胺络合物，其可以通过液体分离等容易地从反应产物中分离出来并且是可再循环的; 构成络合物配体的光学活性二胺化合物; 和包含这些的不对称合成催化剂。 本发明涉及由式（2）表示的水溶性光学活性过渡金属 - 二胺络合物：其中R1和R2各自表示氢，烃基，-SO2R13（其中R13为烃基，取代氨基， 等等） R3至R12各自表示氢，烃基，烷氧基，取代的氨基等; M表示过渡金属; X表示卤素; L表示配体; 和*表示不对称碳原子; 条件是R 3至R 7和R 8至R 12中的至少一个为取代的氨基]，含有络合物的不对称合成催化剂，以及制备光学活性醇的方法，其包括使用该催化剂不对称还原酮。

公开(公告)号：US20060142603A1

公开(公告)日：2006-06-29

申请号：US11353533

申请日：2006-02-13

申请人： Koichi Mikami ,  Noboru Sayo

发明人： Koichi Mikami ,  Noboru Sayo

IPC分类号： C07F15/00 ,  C07C29/14

CPC分类号： C07F9/65527 ,  B01J31/1805 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  C07B2200/07 ,  C07C29/145 ,  C07C211/65 ,  C07F9/5022 ,  C07F9/5027 ,  C07F9/65517 ,  C07F9/65522 ,  C07F15/0046 ,  C07F15/0053 ,  C07C33/22 ,  C07C33/18 ,  C07C33/46

摘要： A novel transition metal complex, preferably a ruthenium-phosphine complex or rhodium-phosphine complex, which is effectively usable in various asymmetric syntheses and, in particular, is more effectively usable in the asymmetric hydrogenation of various ketones; and a novel process for producing an optically active alcohol with the complex. The novel transition metal complex includes a ligand obtained by introducing a diarylphosphino group into each of the 2- and 2′-positions of diphenyl ether, benzophenone, benzhydrol, or the like. It preferably further includes an optically active 1,2-diphenylethylenediamine coordinated thereto. The complex preferably is a novel diphosphine-ruthenium-optically active diamine complex or diphosphine-rhodium-optically active diamine complex. The process comprises using the complex as an asymmetric hydrogenation catalyst to conduct the asymmetric hydrogenation of a ketone compound to thereby obtain an optically active alcohol in a high optical purity and a high yield.

摘要翻译： 一种新颖的过渡金属络合物，优选钌膦络合物或铑 - 膦配合物，其可有效地用于各种不对称合成，特别是更有效地用于各种酮的不对称氢化; 以及用该复合物生产光学活性醇的新方法。 新型过渡金属络合物包括通过将二芳基膦基引入二苯基醚，二苯甲酮，二苯甲醇等的2位和2位中的每一个得到的配位体。 其优选还包括与其配位的光学活性1,2-二苯基乙二胺。 络合物优选为新型二膦 - 钌 - 光学活性二胺络合物或二膦 - 铑光学活性二胺络合物。 该方法包括使用络合物作为不对称氢化催化剂进行酮化合物的不对称氢化，从而获得高光学纯度和高收率的光学活性醇。

公开(公告)号：US06596887B2

公开(公告)日：2003-07-22

申请号：US09805364

申请日：2001-03-14

申请人： Koichi Mikami ,  Toshinobu Korenaga ,  Noboru Sayo

发明人： Koichi Mikami ,  Toshinobu Korenaga ,  Noboru Sayo

IPC分类号： C07F1500

CPC分类号： C07F15/0053 ,  B01J31/1805 ,  B01J31/2409 ,  B01J31/2452 ,  B01J31/28 ,  B01J2231/643 ,  B01J2531/0266 ,  B01J2531/821 ,  C07C29/145 ,  C07C211/58 ,  C07C33/22 ,  C07C33/18

摘要： Provided is a process for preparing an optically active ruthenium-phosphine complex represented by the following formula (1): wherein L represents a bidentate ligand compound of a tertiary phosphine; X represents a halogen atom; and * means chiral center (L* is an optically active substance), which comprises reacting a ruthenium-phosphine complex represented by: RumXnLpAq or [RuX(D)(L)]X wherein, X and L have the same meanings as described above (L is a racemic modification); A represents triethylamine (Et3N), etc.; and m, n, p and q each stands for an integer and D represents benzene, etc. with ½ equivalent of a specific optically active chiral diamine, thereby inactivating one of the enantiomers; and then with a specific optically active diamine derivative, thereby activating the other enantiomer.

摘要翻译： 本发明提供一种由下式（1）表示的光学活性钌膦络合物的制备方法：其中L表示叔膦的二齿配体化合物; X表示卤原子; 和*表示手性中心（L *是光学活性物质），其包括使由下式表示的钌 - 膦配合物反应：其中X和L具有与上述相同的含义（L为外消旋修饰）。 A表示三乙胺（Et 3 N）等。 m，n，p和q各自表示整数，D表示苯等，与1/2当量的特定光学活性手性二胺，从而使一种对映体失活; 然后用特定的光学活性二胺衍生物，从而活化另一种对映异构体。

公开(公告)号：US5693868A

公开(公告)日：1997-12-02

申请号：US740506

申请日：1996-10-30

申请人： Noboru Sayo ,  Xiaoyong Zhang ,  Tatsuya Ohmoto ,  Akifumi Yoshida ,  Tohru Yokozawa

发明人： Noboru Sayo ,  Xiaoyong Zhang ,  Tatsuya Ohmoto ,  Akifumi Yoshida ,  Tohru Yokozawa

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F9/655 ,  C07F15/00 ,  C07F15/04 ,  C07F9/02

CPC分类号： C07F15/045 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/0066 ,  C07F15/008 ,  C07F9/46 ,  C07F9/5027 ,  C07F9/505 ,  C07F9/509 ,  C07F9/5325 ,  C07F9/65517

摘要： The present invention provides a method for producing novel optically active diphosphine compounds �2,2'-bis(di-substituted phosphino)-1,1'-binaphthyl compounds! having a selectivity (chemoselectivity or enantioselectivity) and catalytic activity different from those of conventional BINAP compounds. In a method of the present invention for producing an optically active diphosphine compound (i.e., 2,2-bis(di-substituted phosphino)-1,1'-binaphthyl), 2,2'-bis(trifluoromethanesulfonyloxy)-1,1'-binaphthyl is reacted, in the presence of a transition metal-phosphine complex, with a phosphineoxide compound represented by the following general formula: A.sub.2 P(O)H wherein A represents a phenyl group; a mono- to tri-substituted phenyl group, wherein each substituent in the substituted phenyl group is individually selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group or a lower halogenated-alkoxy group such that one or more of the substituents may be the same or different; a naphthyl group; a lower-alkyl naphthyl group; or a lower-alkoxy naphthyl group.

摘要翻译： 本发明提供了具有选择性（化学选择性或对映体选择性）和催化活性不同的新的光学活性二膦化合物[2,2'-双（二取代膦基）-1,1'-联萘化合物] 常规BINAP化合物。 在本发明的制备光学活性二膦化合物（即2,2-双（二取代膦基）-1,1'-联萘）的方法中，2,2'-双（三氟甲磺酰氧基）-1,1 在过渡金属 - 膦配合物的存在下，与通式为：A2P（O）H表示的膦氧化物化合物反应，其中A表示苯基; 取代苯基中的每个取代基分别选自卤素原子，低级烷基，低级烷氧基或低级卤代 - 烷氧基，使得一个或多个取代的苯基 更多的取代基可以相同或不同; 萘基; 低级烷基萘基; 或低级烷氧基萘基。