公开(公告)号：US20080197430A1

公开(公告)日：2008-08-21

申请号：US11791963

申请日：2005-11-29

申请人： Robert Aigner ,  Ralf Brederlow ,  Lude Elbrecht ,  Heinrich Heiss ,  Stephan Marksteiner ,  Werner Simburger ,  Roland Thewes ,  Hans-Jorg Timme

发明人： Robert Aigner ,  Ralf Brederlow ,  Lude Elbrecht ,  Heinrich Heiss ,  Stephan Marksteiner ,  Werner Simburger ,  Roland Thewes ,  Hans-Jorg Timme

IPC分类号： H01L27/00 ,  H01L21/00 ,  G01N29/00

CPC分类号： G01N29/036 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0819 ,  G01N33/02 ,  G01N33/15 ,  G01N33/48707 ,  G01N2291/0256 ,  H01L2224/81801 ,  H01L2924/01068 ,  H01L2924/13091 ,  H01L2924/00

摘要： A biochemical semiconductor chip laboratory is disclosed including a coupled address and control chip for biochemical analyses and a method for producing the same. In at least one embodiment the semiconductor chip laboratory has a semiconductor sensor chip, which provides numerous analytical positions for biochemical samples in a matrix. The sensor chip is located on the address and control chip and the analytical positions are in electric contact with a printed contact structure on the upper face of the address and control chip via low-resistance through-platings through the semiconductor substrate of the semiconductor chip.

摘要翻译： 公开了一种生物化学半导体芯片实验室，其包括用于生化分析的耦合地址和控制芯片及其制造方法。 在至少一个实施例中，半导体芯片实验室具有半导体传感器芯片，其为矩阵中的生物化学样品提供许多分析位置。 传感器芯片位于地址和控制芯片上，并且分析位置通过半导体芯片的半导体衬底的低电阻穿透与地址和控制芯片的上表面上的印刷接触结构电接触。

公开(公告)号：US07379766B2

公开(公告)日：2008-05-27

申请号：US10931482

申请日：2004-09-01

申请人： Reinhard Gabl ,  Tamara Birkenmaier ,  Bjorn-Oliver Eversmann ,  Peter Fromherz ,  Martin Jenkner ,  Matthias Schreiter ,  Roland Thewes ,  Wolfram Wersing

发明人： Reinhard Gabl ,  Tamara Birkenmaier ,  Bjorn-Oliver Eversmann ,  Peter Fromherz ,  Martin Jenkner ,  Matthias Schreiter ,  Roland Thewes ,  Wolfram Wersing

IPC分类号： A61B5/04 ,  H01L21/16

CPC分类号： C12N5/0619 ,  G01N33/4833

摘要： Biochip for capacitive stimulation and/or detection of biological tissues. The biochip has a carrier structure, at least one stimulation and/or sensor device, which is arranged in or at the carrier structure, and at least one dielectric layer, one layer area of which is arranged at the stimulation and/or sensor device and the opposite layer area of which forms a stimulation and/or sensor area for capacitive simulation and/or detection of biological tissues, wherein the dielectric layer comprises TiO2.

摘要翻译： 用于电容刺激和/或检测生物组织的生物芯片。 生物芯片具有载体结构，布置在载体结构中或载体结构中的至少一个刺激和/或传感器装置，以及至少一个电介质层，其一个区域布置在刺激和/或传感器装置处， 其相对层区域形成用于电容模拟和/或检测生物组织的刺激和/或传感器区域，其中该介电层包含TiO 2。

公开(公告)号：US20080036444A1

公开(公告)日：2008-02-14

申请号：US11663078

申请日：2005-09-01

申请人： Christian Paulus ,  Meinrad Schienle ,  Claudio Stagni Degli Esposti ,  Roland Thewes

发明人： Christian Paulus ,  Meinrad Schienle ,  Claudio Stagni Degli Esposti ,  Roland Thewes

IPC分类号： G01R27/26 ,  C12Q1/68

CPC分类号： G01N27/3276

摘要： A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridisation between trap molecules and the particles for recording, has occurred.

摘要翻译： 公开了一种包括控制电路的传感器装置。 在至少一个实施例中，可以对至少一个传感器电极进行充电和/或放电，以及用于将所述至少一个电极的提供的电压与参考电压进行比较的比较器单元。 确定至少一个传感器电极的充电/放电所需的持续时间，由此，从所确定的持续时间确定是否发生了陷阱分子和用于记录的颗粒之间的杂交形式的传感器事件 。

公开(公告)号：US20060289726A1

公开(公告)日：2006-12-28

申请号：US11450276

申请日：2006-06-12

申请人： Christian Paulus ,  Roland Thewes

发明人： Christian Paulus ,  Roland Thewes

IPC分类号： G06M7/00

CPC分类号： G01N27/3275 ,  H01L27/092

摘要： A circuit arrangement is disclosed. The circuit arrangement includes a substrate, at least one sensor array arranged on and/or in the substrate, and at least one operating circuit integrated on and/or in the substrate and serving for driving the at least one sensor array. The operating circuit and the sensor array are arranged in a manner spatially separate from one another.

摘要翻译： 公开了一种电路装置。 电路装置包括衬底，布置在衬底上和/或衬底中的至少一个传感器阵列，以及集成在衬底上和/或衬底中的至少一个操作电路，用于驱动至少一个传感器阵列。 操作电路和传感器阵列以空间上彼此分离的方式排列。

公开(公告)号：US20060226030A1

公开(公告)日：2006-10-12

申请号：US10562040

申请日：2004-05-11

申请人： Hans-Christian Hanke ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Hans-Christian Hanke ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01F1/64 ,  G01N33/487

CPC分类号： G01N33/54346 ,  B01L3/5027 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N27/3276 ,  G01N33/5438

摘要： A sensor element is for detecting DNA single strands which are possibly contained in an analyte. The sensor element includes a substrate and at least two electrodes in and/or on the substrate. In a surface area of the substrate, catcher molecules are immobilized and are adapted to hybridize to DNA single strands that are possibly contained in an analyte. The DNA single strands include a label that has dielectric properties that are different from those of the analyte. The electrodes are coupled to a detection device for detecting a change in the capacitative portion of the impedance between the electrodes due to a label that is present in an area surrounding the electrodes as a result of the hybridization event.

摘要翻译： 传感器元件用于检测可能包含在分析物中的DNA单链。 传感器元件包括衬底和衬底中和/或上的至少两个电极。 在底物的表面区域中，捕获剂分子被固定并适于与可能包含在分析物中的DNA单链杂交。 DNA单链包括具有不同于分析物的介电性质的标记。 电极耦合到检测装置，用于由于杂交事件的结果，由于存在于电极周围的区域中的标签，用于检测电极之间的阻抗的电容部分的变化。

公开(公告)号：US06922081B2

公开(公告)日：2005-07-26

申请号：US10399355

申请日：2001-10-16

申请人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

IPC分类号： G01N33/53 ,  G01D3/02 ,  G01N27/02 ,  G01N27/22 ,  G01N27/327 ,  G01N27/333 ,  G01N27/414 ,  G01N27/416 ,  G01N27/49 ,  G01N37/00 ,  H03K19/0175 ,  G01R27/26

CPC分类号： G01D3/02 ,  G01N27/3277

摘要： In a first phase a first sensor signal, essentially comprising the current offset signal of the sensor, is applied to the input of an electronic circuit. The first sensor signal is fed to a first signal path and stored therein. In a second phase a second sensor signal, comprising the current offset signal and a time-dependent measured signal, is applied to the input and the stored first sensor signal is fed to the input by means of the first signal path, such that essentially the time dependent measured signal is fed by means of a second signal path coupled to the input.

摘要翻译： 在第一阶段中，基本上包括传感器的当前偏移信号的第一传感器信号被施加到电子电路的输入。 第一传感器信号被馈送到第一信号路径并存储在其中。 在第二阶段，包括当前偏移信号和时间相关测量信号的第二传感器信号被施加到输入端，并且所存储的第一传感器信号通过第一信号路径馈送到输入端，使得基本上 时间相关测量信号通过耦合到输入的第二信号路径馈送。

公开(公告)号：US20050107893A1

公开(公告)日：2005-05-19

申请号：US10964560

申请日：2004-10-12

申请人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

发明人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

IPC分类号： A61B5/04 ,  G05B13/02 ,  G06N3/06

CPC分类号： A61B5/7264 ,  A61B5/04001 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7282 ,  A61B2562/0209 ,  A61B2562/046 ,  G06N3/061

摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.

摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。

公开(公告)号：US06856161B2

公开(公告)日：2005-02-15

申请号：US10239438

申请日：2001-03-29

申请人： Roland Thewes

发明人： Roland Thewes

IPC分类号： G01N27/414 ,  G01N27/416 ,  G01R29/12 ,  G01R31/27 ,  G01R31/28 ,  G01R31/317 ,  H01L29/78 ,  G01R31/26

CPC分类号： G01R31/31702 ,  G01N27/4145 ,  G01N27/4148 ,  G01R29/12 ,  G01R31/27 ,  G01R31/2829 ,  H03F3/505 ,  H03F2203/5031

摘要： A sensor array is provided including transistors that are coupled together. The transistors are designed as sensors and wherein the sensor array has switching devices for selecting a transistor and wherein the selected transistor's condition may be detected. The sensor array is set up so that the selected transistor is driven as a source follower and at least some of the transistors are MOS field effect transistors that are configured so that at least some of the transistors are capable of detecting biological material.

摘要翻译： 提供了传感器阵列，其包括耦合在一起的晶体管。 晶体管被设计为传感器，并且其中传感器阵列具有用于选择晶体管的开关装置，并且其中可以检测所选择的晶体管的状态。 设置传感器阵列使得所选择的晶体管被​​驱动为源极跟随器，并且至少一些晶体管是被配置为使得至少一些晶体管能够检测生物材料的MOS场效应晶体管。

公开(公告)号：US09135964B2

公开(公告)日：2015-09-15

申请号：US13456020

申请日：2012-04-25

申请人： Richard Ferrant ,  Roland Thewes

发明人： Richard Ferrant ,  Roland Thewes

IPC分类号： G11C7/12 ,  G11C7/02 ,  G11C7/06 ,  G11C11/4091 ,  G11C11/4094

CPC分类号： G11C7/065 ,  G11C7/12 ,  G11C11/4091 ,  G11C11/4094 ,  G11C2211/4016

摘要： A differential sense amplifier for sensing data stored in a plurality of memory cells of a memory cell array, including a first CMOS inverter having an output connected to a first bit line (BL) and an input connected to a second bit line complementary to the first bit line and a second CMOS inverter having an output connected to the second bit line (/BL) and an input connected to the first bit line. Each CMOS inverter includes pull-up and pull-down transistors, wherein the sources of either of the pull-up transistors or the pull-down transistors are electrically coupled and connected to a pull-up voltage source or a pull-down voltage source without an intermediate transistor between the sources of the transistors and the voltage source.

摘要翻译： 一种用于感测存储在存储单元阵列的多个存储单元中的数据的差分读出放大器，包括连接到第一位线（BL）的输出的第一CMOS反相器和连接到与第一位线互补的第二位线的输入端 位线和具有连接到第二位线（/ BL）的输出的第二CMOS反相器和连接到第一位线的输入。 每个CMOS反相器包括上拉和下拉晶体管，其中上拉晶体管或下拉晶体管中的任一个的源极电耦合并连接到上拉电压源或下拉电压源，而没有 在晶体管的源极和电压源之间的中间晶体管。

公开(公告)号：US08953399B2

公开(公告)日：2015-02-10

申请号：US13456047

申请日：2012-04-25

申请人： Richard Ferrant ,  Roland Thewes

发明人： Richard Ferrant ,  Roland Thewes

IPC分类号： G11C7/08 ,  G11C7/06 ,  G11C7/12 ,  G11C11/4091

CPC分类号： G11C7/065 ,  G11C11/4091 ,  G11C2207/002

摘要： A differential sense amplifier for sensing data stored in a plurality of memory cells of a memory cell array, including a first CMOS inverter having an output connected to a first bit line and an input connected to a second bit line complementary to the first bit line, and a second CMOS inverter having an output connected to the second bit line and an input connected to the first bit line. Each CMOS inverter includes a pull-up transistor and a pull-down transistor, and the sense amplifier has a pair of pass-gate transistors arranged to connect the first and second bit lines to a first and a second global bit lines. Advantageously, the pass-gate transistors are constituted by the pull-up transistors or the pull-down transistors.

摘要翻译： 一种用于感测存储在存储单元阵列的多个存储单元中的数据的差分读出放大器，包括连接到第一位线的输出的第一CMOS反相器和连接到与第一位线互补的第二位线的输入端， 以及具有连接到第二位线的输出和连接到第一位线的输入的第二CMOS反相器。 每个CMOS反相器包括上拉晶体管和下拉晶体管，并且读出放大器具有一对传输栅晶体管，被布置为将第一和第二位线连接到第一和第二全局位线。 有利的是，栅极晶体管由上拉晶体管或下拉晶体管构成。