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    General method for designing self-assembling protein nanomaterials
    52.
    发明授权
    General method for designing self-assembling protein nanomaterials 有权
    自组装蛋白纳米材料的一般方法

    公开(公告)号：US08969521B2

    公开(公告)日：2015-03-03

    申请号：US13802464

    申请日：2013-03-13

    Applicant: University of Washington through its Center for Commercialization ,  The Regents of the University of California

    Inventor： David Baker ,  Neil King ,  William Sheffler ,  Todd Yeates

    IPC: C07K1/00 ,  C07H21/02 ,  C12N1/20 ,  C12N15/00 ,  G06F19/12 ,  G06F19/16

    CPC classification number: G06F19/12 ,  G06F19/16

    Abstract: Methods and systems for computationally designing self-assembling polypeptides are disclosed. A representation of a docked configuration of a symmetric protein architecture can be determined by a computing device configured to computationally symmetrically dock representations of protein building blocks within a representation of a symmetric protein architecture, where symmetrically docking a representation of a particular protein building block can include determining a configuration of the protein building blocks in three-dimensional space within the symmetric protein architecture configured to generate interfaces between building blocks suitable for computational protein interface design. The amino acid sequence of the docked protein building blocks can be computationally modified to specify protein-protein interfaces between the plurality of protein building blocks that are energetically favorable to drive self-assembly of a protein that includes the modified amino acid sequence.

    Abstract translation: 公开了用于计算设计自组装多肽的方法和系统。 对称蛋白质结构的对接配置的表示可以由计算设备确定，该计算设备被配置为计算对称地对接蛋白质构建块在对称蛋白质结构的表示内的表示，其中对称性地对接特定蛋白质构建块的表示可以包括 确定所述对称蛋白质结构内的三维空间中的蛋白质构建块的配置，其被配置为在适于计算蛋白质界面设计的构建块之间产生界面。 对接的蛋白质结构单元的氨基酸序列可以进行计算上的修改，以指定能够有利于驱动包含修饰的氨基酸序列的蛋白质的自组装的多个蛋白质结构单元之间的蛋白质 - 蛋白质界面。

    SELF-ASSSEMBLING NANOSTRUCTURE VACCINES
    55.
    发明公开
    SELF-ASSSEMBLING NANOSTRUCTURE VACCINES 审中-公开

    公开(公告)号：US20240165218A1

    公开(公告)日：2024-05-23

    申请号：US18359154

    申请日：2023-07-26

    Applicant: University of Washington

    Inventor： Neil King ,  David Baker ,  Lance Stewart ,  Brooke Fiala ,  Daniel Ellis ,  Lauren Carter ,  Rashmi Ravichandran ,  George Ueda ,  Jorge Fallas ,  Una Natterman

    IPC: A61K39/12 ,  C12N15/86

    CPC classification number: A61K39/12 ,  C12N15/86 ,  B82Y5/00

    Abstract: The present disclosure provides nanostructures and nanostructure-based vaccines. Some nanostructures of the present disclosure display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens. Some vaccines of the present disclosure are useful for preventing or decreasing the severity of infection with an infectious agent, including. for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus. flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means disclosed herein. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins. vaccine compositions, and methods of administration.

    High throughput protein-protein interaction screening in yeast liquid culture
    59.
    发明授权
    High throughput protein-protein interaction screening in yeast liquid culture 有权

    公开(公告)号：US11820970B2

    公开(公告)日：2023-11-21

    申请号：US17480078

    申请日：2021-09-20

    Applicant: University of Washington

    Inventor： David Baker ,  David Younger ,  Eric Klavins

    IPC: C12N15/81 ,  C12N15/10

    CPC classification number: C12N15/1055

    Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.

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