摘要:
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(RW1)RW2, or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.
摘要:
An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor, and an elongate shaft having one or more lumens located therein. An articulation joint at the distal end of the endoscope allows the distal end to be oriented by the actuators in the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.
摘要:
The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
摘要:
Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.
摘要:
A laminate wrap constructed in accordance with the invention is provided which is formed and shipped in a flat shape, and which may be converted into a rigid L, U or square/rectangular shipping or storage container for the protection of long articles during shipping and storage. The laminate wrap is constructed to allow for ease in formation and handling, but after formation into an L, U or other shaped shipping or storage container, to produce a rigid storage structure or tube.
摘要:
The novel graphics system (10) includes multiple displays (20 and 22) supported by a single frame buffer (18) thereby reducing hardware requirements and costs. The system (10) further includes an operating system driver interface (12), a software driver interface (14) and graphics circuitry (16). In one embodiment, the graphics circuitry (16) includes a graphics chip (34) for providing an analog output (36) and a digital output (38). The digital output (38) is processed by a data reformatter (40) and a digital-to-analog converter (42) to provide an analog signal (44). The invention thus takes advantage of existing mixed output chips to implement a multiple analog CRT monitor system in a cost effective manner.
摘要:
A cartridge case trimming device having mounted on a base a horizontally movable case carriage and case cutting device; the carriage includes cradle, trough, carriage groove, case retainer and toggle clamp; the cutting device includes an arbor head whose height is finely adjustable and an arbor shaft carrying at one end a combination chuck and cutter and on the other end a flexible coupling attached to a motor shaft.
摘要:
A phone and system is disclosed which includes a programmed button(s) that initiates a telephone call from the phone to a second phone. In some embodiments, the phone may be a toy or instructional equipment configured to provide for example, children a device to learn how to converse over a telephone call with trusted parties. The phone may initiate a phone call request when a programmed button is pressed by connecting with a computing device that has a wireless local area network (LAN) transceiver and a connection to the telephone network (for example, a smartphone, a tablet, or a wearable device). The phone call request may then be re-routed through the telephone network to the second phone being called and communication may occur between the two phones through the intermediary device. Trusted and restricted communication may thus occur between parents/grandparents and children.
摘要:
An apparatus and method for minimally invasive suturing is disclosed. A suturing device for minimally invasive suturing includes proximal section having a proximal end, a distal end, and a longitudinal axis therebetween; a suture head assembly extending from the distal end of the proximal section; a suturing needle having a pointed end and a blunt end, the suturing needle capable of rotating about an axis approximately perpendicular to a longitudinal axis of the proximal section, wherein the pointed end of the suturing needle is positioned within the suture head assembly prior to and after rotation of the suturing needle; and an actuator extending from the proximal end of the proximal section to actuate a drive mechanism having a needle driver for engaging and rotating the suturing needle.