公开(公告)号：US20180200356A1

公开(公告)日：2018-07-19

申请号：US15743869

申请日：2016-08-05

申请人： TORAY INDUSTRIES, INC.

发明人： Akira KURIHARA ,  Fumiyoshi OKANO

IPC分类号： A61K39/00 ,  C07K14/47 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K35/15 ,  A61K35/17 ,  A61K35/76 ,  A61K39/00 ,  A61K39/39 ,  A61K45/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/572 ,  A61P35/00 ,  C07K14/47 ,  C07K14/4702 ,  C12N5/10 ,  C12N15/09

摘要： An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 35 to 67; or (b) a polypeptide comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

公开(公告)号：US20180185469A1

公开(公告)日：2018-07-05

申请号：US15841928

申请日：2017-12-14

申请人： OHIO STATE INNOVATION FOUNDATION

发明人： Renukaradhya J. Gourapura ,  Varun Dwivedi ,  Basavaraj S. Binjawadagi ,  Jordi Torrelles

IPC分类号： A61K39/12 ,  C07K16/10 ,  A61K35/74 ,  A61K35/76 ,  A61K39/385 ,  A61K39/39 ,  C12N7/00 ,  A61K9/14 ,  A61K39/00 ,  A61K9/51 ,  B82Y5/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/5153 ,  A61K35/74 ,  A61K35/76 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/5258 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55594 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/58 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/6093 ,  B82Y5/00 ,  C07K14/005 ,  C07K16/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/10021 ,  C12N2770/10023 ,  C12N2770/10034 ,  C12N2770/10061 ,  C12N2770/10063 ,  C12N2770/10071

摘要： Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.

公开(公告)号：US09943580B2

公开(公告)日：2018-04-17

申请号：US15023653

申请日：2014-09-11

申请人： STC.UNM ,  LEIDOS, INC

发明人： David S. Peabody ,  Bryce Chackerian ,  James Pannucci ,  Gabriel M. Gutierrez ,  Amy Rene Noe ,  Scott Budd Winram ,  Steve Chienwen Huang

IPC分类号： A61K39/39 ,  A61K39/015 ,  C12N7/00 ,  C12N15/10 ,  A61K39/00 ,  A61K35/76

CPC分类号： A61K39/015 ,  A61K35/76 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  C07K2319/40 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18134 ,  Y02A50/412

摘要： Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.

公开(公告)号：US20180092386A1

公开(公告)日：2018-04-05

申请号：US15566267

申请日：2016-04-15

申请人： Kennesaw State University Research and Service Foundation, Inc.

发明人： Zhongjing LU

IPC分类号： A23L3/3463 ,  C12Q1/04 ,  C12N7/04 ,  C12Q1/70 ,  G01N33/569

CPC分类号： A23L3/3463 ,  A61K35/76 ,  C12N7/00 ,  C12N7/045 ,  C12N2795/10021 ,  C12N2795/10032 ,  C12Q1/04 ,  C12Q1/70 ,  G01N33/56916 ,  Y02A50/473

摘要： Phage φ241 specific for Escherichia coli O157:H7 was isolated from an industrial cucumber fermentation where both acidity (pH≦3.7) and salinity (≧5% NaCI) were high. A method for preparing a food item at least substantially free of Escherichia coli O157:H7 contamination contacted the food item with a bacteriophage φ241 under conditions for the bacteriophage φ241 to lyse all or substantially all the Escherichia coli O157:H7 present in the food item, while Escherichia coli strains other than O157:H7 were not affected. A method for detecting the presence of Escherichia coli O157:H7 by contacting a bacteriophage φ241 with a food item is also disclosed.

公开(公告)号：US09919042B2

公开(公告)日：2018-03-20

申请号：US15040277

申请日：2016-02-10

申请人： FluGen, Inc.

发明人： Pamuk Bilsel ,  Yasuko Hatta

IPC分类号： A61K45/06 ,  A61K39/145 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K35/76 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16162 ,  C12N2760/16171 ,  C12N2760/16234 ,  C12N2760/16262

摘要： Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.

公开(公告)号：US20180055997A1

公开(公告)日：2018-03-01

申请号：US15804960

申请日：2017-11-06

申请人： GLOBAL BIO THERAPEUTICS, INC.

发明人： Jose Gustavo Cabrera Aquino ,  Blanca Angelica Segura Pacheco

IPC分类号： A61M5/178 ,  A61K35/76 ,  A61K48/00 ,  A61M39/00 ,  A61M5/00 ,  A61M5/30

CPC分类号： A61M5/178 ,  A61K35/76 ,  A61K48/005 ,  A61K48/0075 ,  A61M5/00 ,  A61M5/30 ,  A61M39/00 ,  A61M2210/1071 ,  A61P1/16 ,  A61P7/00 ,  C12N2799/022

摘要： Provided herein is a method of delivering nucleic acid molecules to a compartmentalized tissue or organ of a subject. Also provided herein are uses and processes for delivering a nucleic acid molecule to the parenchyma of a compartmentalized tissue or organ. The methods and uses can be used in the treatment of diseases and conditions and in industrial, agricultural and veterinary applications. Also provided herein are compositions containing an adenovirus or adeno-associated virus or other recombinant virus formulated for administration to the parenchyma of a tissue or organ.

公开(公告)号：US20180050098A1

公开(公告)日：2018-02-22

申请号：US15799793

申请日：2017-10-31

申请人： PrimeVax Immuno-Oncology, Inc.

发明人： Bruce W. LYDAY

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K35/76 ,  C12N5/0784

CPC分类号： A61K39/0011 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5154 ,  A61K2039/572 ,  A61K2039/585 ,  C12N5/0639 ,  C12N2501/998 ,  C12N2770/24132 ,  C12N2770/24171 ,  Y02A50/386

摘要： Described herein are compositions and methods for treating cancer through the combination of tumor antigen-pulsed dendritic cells and Dengue Virus. The combination of the two forms of therapeutic intervention provides enhanced tumor cell reduction compared to either alone. The cancer targeted by compositions and methods described herein may be a solid cancer or blood cancer.

公开(公告)号：US09850467B2

公开(公告)日：2017-12-26

申请号：US14895541

申请日：2014-06-03

申请人： Warszawski Uniwersytet Medyczny ,  Instytut Immunologii I Terapii Doswiadczalnej im. Ludwika Hirszfelda PAN we Wroclawiu

发明人： Renata Jakubowska-Zahorska ,  Maciej Przybylski ,  Jan Borysowski ,  Andrzej Gorski ,  Beata Weber-Dabrowska

IPC分类号： C12N7/00 ,  A61K35/76

CPC分类号： C12N7/00 ,  A61K35/76 ,  C12N2795/10132

摘要： We disclose the use of a strain of bacteriophages in the manufacturing of a preparation for improving the state of health of patients infected with adenoviruses, wherein preferably the preparation produced is used for the treatment or prevention of adenoviral infections, particularly those caused by HAdV, preferably HAdV-5.

公开(公告)号：US20170326239A1

公开(公告)日：2017-11-16

申请号：US15517568

申请日：2015-02-17

申请人： UNIVERSIDAD DEL VALLE

发明人： Jaime VELASCO MEDINA ,  John Michael ESPINOSA DURÁN ,  Julio César ARCE CLAVIJO

IPC分类号： A61K47/06 ,  A61K35/76 ,  A61K9/51 ,  B82Y5/00 ,  C01B32/159

CPC分类号： A61K47/06 ,  A61K9/0019 ,  A61K9/51 ,  A61K9/5115 ,  A61K35/76 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C01B32/159

摘要： The invention relates to an artificial bacteriophage for supplying medicaments, nutrients, proteins, DNA/RNA or other type of molecules to bacteria and/or diseased cells, directly to the cytoplasm, passing through the cell membrane thereof, through a pore of said membrane. The artificial bacteriophage is based on carbon nanostructures and comprises a nanocontainer for medicaments, a channel for transporting medicaments and a tip together with an array of linker proteins and protein receptors.

公开(公告)号：US20170319715A1

公开(公告)日：2017-11-09

申请号：US15428097

申请日：2017-02-08

申请人： Circuit Therapeutics, Inc.

发明人： Christopher L. Towne ,  Dan Andersen

IPC分类号： A61K48/00 ,  A61K38/16 ,  A61K41/00 ,  A61N5/06 ,  C12N15/113 ,  A61K9/00 ,  A61K35/76 ,  C12N7/00 ,  A61N5/067

CPC分类号： A61K48/0066 ,  A61K9/0019 ,  A61K35/76 ,  A61K38/16 ,  A61K41/00 ,  A61K48/0075 ,  A61N5/06 ,  A61N5/0616 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0635 ,  A61N2005/0651 ,  A61N2005/0653 ,  A61N2005/0656 ,  A61N2005/0664 ,  A61N2005/067 ,  C12N7/00 ,  C12N15/1138 ,  C12N15/87 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2750/14143

摘要： One embodiment is directed to a method for altering the function of the sensory unit that innervates a targeted tissue region in a mammal comprising the steps of identifying the targeted tissue region; cutaneously administering into the targeted tissue region an adeno-associated virus wherein the viral genome encodes at least one exogenous protein; expressing the exogenous protein in the targeted sensory unit; and altering the function of the targeted sensory unit to treat or restore the sensory response because of the exogenous protein expression while not impacting the function of nearby sensory units.