公开(公告)号：US5984892A

公开(公告)日：1999-11-16

申请号：US714354

申请日：1996-09-16

Applicant: William Bedingham

Inventor： William Bedingham

IPC: A61M1/36 ,  A61M1/00

CPC classification number: A61M1/0031 ,  A61M1/3669 ,  Y10S128/13

Abstract: A blood aspirator is composed of a suction circuit adapted to receive a flow of blood, a sensor associated with the suction circuit for generating a signal relating to the presence of bubbles in aspirated blood in the suction circuit, a variable speed pump coupled to the suction circuit and adapted to pump blood through the suction circuit, and a controller for controlling the speed of the pump. The controller causes the pump to adjust the blood flow through the suction circuit so that a predetermined, nonzero concentration of bubbles flows through the suction circuit.

Abstract translation: 吸血器由适于接收血流的吸入回路组成，与抽吸回路相关联的传感器，用于产生与吸入回路中的吸入血液中存在气泡有关的信号;耦合到吸力的变速泵 并且适于通过吸入回路泵血，以及用于控制泵的速度的控制器。 控制器使泵调节通过抽吸回路的血流，使得预定的非零浓度的气泡流过吸入回路。

公开(公告)号：US5685989A

公开(公告)日：1997-11-11

申请号：US305953

申请日：1994-09-16

Applicant: Nikolai M. Krivitski ,  David R. MacGibbon

Inventor： Nikolai M. Krivitski ,  David R. MacGibbon

IPC: A61B5/026 ,  A61M1/14 ,  A61M1/36 ,  A61B5/0275 ,  A61B8/06

CPC classification number: A61M1/3653 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/367 ,  A61M1/3669 ,  Y10S210/929

Abstract: The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

Abstract translation: 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US5298171A

公开(公告)日：1994-03-29

申请号：US927101

申请日：1992-08-07

Applicant: Wolfgang Biesel

Inventor： Wolfgang Biesel

IPC: A61M1/02 ,  A61M1/36 ,  B01D21/30 ,  B01D21/26

CPC classification number: A61M1/3693 ,  A61M1/3696 ,  A61M1/3669 ,  A61M2202/0429

Abstract: In a separation device for separation of blood into its components, the hematocrit value of the blood to be separated plays a significant role relative to the sedimentation of cellular blood components. Since in blood processing, particularly in the intraoperative area, significant fluctuations of the incoming hematocrit value may occur, for example, due to infused volume expander, irrigation solutions, anticoagulant additives, etc., it is useful for maintenance of a blood separation working with constant values, particularly a constant hematocrit value of the erythrocyte fraction, to take the preset hematocrit value of the blood to be separated into account. According to the invention, the rate of blood flow through the separation device is automatically adjusted as a function of the hematocrit value of the incoming blood.

Abstract translation: 在用于将血液分离成其组分的分离装置中，待分离血液的血细胞比容值相对于细胞血液成分的沉降起着重要作用。 由于在血液处理方面，特别是在术中区域，例如由于输注体积扩张器，灌注溶液，抗凝血剂添加剂等引起的血细胞比容值的显着波动可能发生，因此维持血液分离工作是有用的 恒定值，特别是红细胞分数的恒定血细胞比容值，以考虑要分离的血液的预设血细胞比容值。 根据本发明，通过分离装置的血液流量的速率被自动调整为进入血液的血细胞比容值的函数。

公开(公告)号：US4835477A

公开(公告)日：1989-05-30

申请号：US86495

申请日：1987-08-14

Applicant: Hans-Dietrich Polaschegg ,  Detlef Westphal ,  Klaus Metzner

Inventor： Hans-Dietrich Polaschegg ,  Detlef Westphal ,  Klaus Metzner

IPC: G01N33/49 ,  A61M1/36 ,  G01N27/02 ,  G01N27/06 ,  G01N27/416 ,  G01N33/487

CPC classification number: A61M1/3669 ,  A61M1/3609 ,  G01N33/492

Abstract: There is described a method and apparatus for the determination of hematocrit levels in which both the conductivity of whole blood and the conductivity of blood plasma are determined together. While a conductivity cell (18) is being used for the determination of the conductivity of whole blood, the conductivity of plasma is calculated in a computer (30) with the aid of ion selective electrodes (14, 16) from the sodium or potassium concentrations.

Abstract translation: 描述了用于确定血细胞比容水平的方法和装置，其中全血的电导率和血浆的电导率都同时确定。 虽然电导率电池（18）被用于确定全血的电导率，但是在计算机（30）中借助离子选择电极（14,16）从钠或钾浓度计算出等离子体的电导率 。

公开(公告)号：US4529397A

公开(公告)日：1985-07-16

申请号：US460483

申请日：1983-07-24

Applicant: Kurt Hennemuth ,  Heinz G. Kohn ,  Erich Knothe ,  Gunter Pradel

Inventor： Kurt Hennemuth ,  Heinz G. Kohn ,  Erich Knothe ,  Gunter Pradel

IPC: A61B17/00 ,  A61M1/10 ,  A61M1/34 ,  A61M1/36 ,  A61M1/03

CPC classification number: A61M1/3621 ,  A61M1/3603 ,  A61M1/3646 ,  A61M1/34 ,  A61M1/3669 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393

Abstract: A cardioplegic controlling and regulating device for the dosed perfusion of cardioplegic perfusion solution in open-heart surgery has a storage container for receiving the cardioplegic solution, which container is part of a scale and can be connected to the heart over a tubular conduit. A pressure-controlled dosing pump which acts on the tubular conduit and cooperates with a second, reversible pump which is constructed as an exhaust pump and is selectively operable synchronously or asynchronously within controllable tolerance limits with the first dosing pump during the perfusion and sustaining of the perfusion. An ultrafilter for the mixture of blood and cardioplegic solution removed from the patient's heart is located in a removal line. An outlet for the blood separated form the ultrafilter is connected by a conduit to a blood storage container and the permeate or filtrate outlet of which ends in a filtrate line or in a filtrate collector vessel. The ultrafilter is located in a by-pass line to a blood storage container so that the patient's blood mixed with cardioplegic solution can be prepared to a hemoconcentrate after the perfusion has been completed. In the same manner, other blood removed by suction from the patient during the operation can be prepared by this by-pass line and the ultrafilter. Another pressure-controlled dosing pump sustains the first dosing pump and is connected to it in parallel.

Abstract translation: 用于心脏开放心脏手术的心脏停搏灌注溶液的计量灌注灌注的心脏停搏控制和调节装置具有用于接收心脏停搏液的储存容器，该容器是水垢的一部分，并且可以通过管状导管连接到心脏。 压力控制计量泵，其作用在管状管道上并与第二可逆泵配合，第二可逆泵构造为排气泵，并且在灌注和维持期间可选择地与第一计量泵同步或异步地在可控公差范围内操作 灌注。 用于从患者心脏去除的血液和心脏停搏液的混合物的超滤器位于去除线中。 用于从超滤器分离的血液出口通过导管连接到血液储存容器，并且其渗透物或滤液出口在滤液线或滤液收集器容器中终止。 超滤器位于血液存储容器的旁路线中，使得在灌注完成后可以将与心脏停搏液混合的患者血液制备成血液浓缩物。 以相同的方式，通过该旁路线路和超滤器可以制备在操作期间从患者抽吸而除去的其它血液。 另一个压力控制计量泵维持第一计量泵并且并联连接到它。

公开(公告)号：US4469593A

公开(公告)日：1984-09-04

申请号：US473574

申请日：1983-03-09

Applicant: Toshikazu Ishihara ,  Tomoyuki Kitano ,  Kenji Maeda ,  Toru Shinzato

Inventor： Toshikazu Ishihara ,  Tomoyuki Kitano ,  Kenji Maeda ,  Toru Shinzato

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  B01D13/00

CPC classification number: A61M1/16 ,  A61M1/34 ,  A61M1/3406 ,  A61M1/3427 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3669 ,  A61M1/342

Abstract: A blood purification apparatus includes an extracorporeal circulation system, a blood purifier provided in the system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulation blood volume measuring instrument for measuring changes in a circulating blood volume within a patient's body, a control section comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, the program being matched to the condition of a patient, and a regulator connected to the extracorporeal circulation system and the control section, for controlling the circulating blood volume, the regulator being controlled by the control section on the basis of the circulating blood volume measured during blood purification and the programmed amount. In this apparatus, optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.

Abstract translation: 一种血液净化装置，包括体外循环系统，通过半透膜进行透析或过滤而提供血液净化的血液净化装置，用于测定患者体内的循环血液量的变化的循环血液量测定装置， 该部分包括用于存储用于在血液净化期间循环血液量的变化模式的程序的存储器，该程序与患者的状况相匹配，以及连接到体外循环系统和控制部分的调节器，用于控制 循环血液量，调节器由控制部分根据血液净化期间测量的循环血液量和编程量控制。 在该装置中，在将循环血量保持在规定水平的同时进行最佳的血液净化。

公开(公告)号：US20240350040A1

公开(公告)日：2024-10-24

申请号：US18657286

申请日：2024-05-07

Applicant: GAMBRO LUNDIA AB

Inventor： Paolo ROVATTI ,  Enrico RAVAGLI ,  Stefano SEVERI

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/026 ,  A61B5/1455 ,  A61B8/00 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61B5/14535 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/6866 ,  A61B8/00 ,  A61M1/1603 ,  A61M1/1619 ,  A61M1/3601 ,  A61M1/3609 ,  A61M1/3612 ,  A61M1/3669 ,  A61B2562/00 ,  A61B2562/04 ,  A61B2562/146 ,  A61B2562/16 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/228 ,  A61M1/1605 ,  A61M1/1613 ,  A61M2205/3306 ,  A61M2205/3334

Abstract: An apparatus for extracorporeal treatment of blood comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line; a non-invasive blood volume sensor for determining an additional property of blood is active on a tube segment of the blood withdrawal line or of the blood return line; the sensor includes one source for directing a signal towards the blood, a plurality of detectors for receiving the signal, and a controller receiving the output signals from the detectors and determining a blood volume variation and a value of sodium concentration in the blood (NaPl) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.

公开(公告)号：US09823207B2

公开(公告)日：2017-11-21

申请号：US13697132

申请日：2011-05-11

Applicant: Sebastian Wieskotten ,  Tobias Groeber ,  Paul Chamney ,  Peter Wabel ,  Ulrich Moissl

Inventor： Sebastian Wieskotten ,  Tobias Groeber ,  Paul Chamney ,  Peter Wabel ,  Ulrich Moissl

IPC: B01D35/00 ,  G01N27/00 ,  A61M1/36 ,  G01N33/487

CPC classification number: G01N27/00 ,  A61M1/3626 ,  A61M1/3669 ,  A61M2205/3317 ,  G01N33/48735

Abstract: Method and device according to the method for determining intracellular and/or extracellular, in particular macromolecular fractions of fluids, preferably of body fluids of living organisms, with the steps: coupling-in a measurement signal through an electrically non-conductive wall into the fluid to be measured; coupling-out an electrical measurement value that is thereby generated in the fluid to be measured; detecting the coupled-out electrical measurement value at a plurality of different frequencies of the electrical measurement signal; determining the intracellular and/or extracellular, in particular macromolecular fractions of the fluid to be measured by means of evaluation of the detected electrical measurement value at a plurality of frequencies of the measurement signal.

公开(公告)号：US20140031736A1

公开(公告)日：2014-01-30

申请号：US13984087

申请日：2012-01-18

Applicant: Nigel Wright ,  Gregory Jubic

Inventor： Nigel Wright ,  Gregory Jubic

IPC: A61M1/14 ,  G01R33/02

CPC classification number: A61M1/14 ,  A61M1/342 ,  A61M1/3458 ,  A61M1/3462 ,  A61M1/3669 ,  A61M1/367 ,  A61M2205/3317 ,  A61M2205/502 ,  G01R33/02

Abstract: This invention relates generally to magnetic sensors and related systems and methods. In some aspects of the invention, a magnetic sensor assembly includes a housing configured to releasably hold a medical fluid tube and a sensor secured to the housing, the sensor configured to detect a change in a strength of a magnetic field when a medical fluid passes through the medical fluid tube.

Abstract translation: 本发明一般涉及磁传感器及相关的系统和方法。 在本发明的一些方面中，磁传感器组件包括构造成可释放地保持医疗流体管和固定到壳体的传感器的壳体，所述传感器构造成当医疗流体通过时检测磁场强度的变化 医用流体管。

公开(公告)号：US08506162B2

公开(公告)日：2013-08-13

申请号：US12407553

申请日：2009-03-19

Applicant: Karl G. Schick ,  David Uhen

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N25/00 ,  G01R27/00

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor on in a barcode printed on the sensor. The sensors are calibrated using 0.100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器被设计为将传感器特定信息（例如校准和生产信息）存储在印刷在传感器上的条形码上的传感器上的非易失性存储器芯片中。 传感器在25摄氏度下使用0.100摩尔氯化钾（KCl）溶液进行校准。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。