公开(公告)号：US20170043183A1

公开(公告)日：2017-02-16

申请号：US15212005

申请日：2016-07-15

申请人： Vladimir Balakin

发明人： Vladimir Balakin

IPC分类号： A61N5/10 ,  A61B6/00 ,  A61B6/02

CPC分类号： A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

摘要： The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

摘要翻译： 本发明涉及一种用于控制带电粒子癌症治疗系统的方法和装置。 治疗传递控制系统用于直接控制癌症治疗系统的多个子系统，而不选择子系统之间的直接通信，这增强了安全性，简化了质量保证和质量控制，并且有助于编程。 例如，处理递送控制系统直接控制成像系统，定位系统，注射系统，射频四极杆系统，环形加速器或同步加速器，提取系统，束线，照射中的一个或多个 喷嘴，龙门架，显示系统，瞄准系统和验证系统。 通常，控制系统集成子系统和/或将上述癌症治疗系统元件中的一个或多个的输出与上述癌症治疗系统元件中的一个或多个的输入集成。

公开(公告)号：US20170021194A1

公开(公告)日：2017-01-26

申请号：US15288998

申请日：2016-10-07

申请人： Sun Nuclear Corporation

发明人： BENJAMIN E. NELMS

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61B6/50 ,  A61B6/5294 ,  A61B6/58 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N2005/1041

摘要： A system for evaluating radiation treatment planning generates a fictitious treatment dose matrix with a quality of dose placement beyond that achievable with physically realizable radiation therapy machines. Such a fictitious treatment dose matrix provides an objective measure that is readily tailored to different clinical situations, and although unattainable, thereby provides a benchmark allowing evaluation of radiation plan goals and the radiation plans between different multiple clinical situations and individuals.

摘要翻译： 用于评估放射治疗计划的系统产生具有超过可利用物理可实现的放射治疗机实现的剂量放置质量的虚构治疗剂量矩阵。 这样一个虚构的治疗剂量矩阵提供了一个客观的测量方法，可以很容易地针对不同的临床情况进行定制，虽然不可实现，从而提供了一个基准测试，可以评估不同的多种临床情况和个体之间的辐射计划目标和辐射计划。

公开(公告)号：US09545527B2

公开(公告)日：2017-01-17

申请号：US14888363

申请日：2014-04-30

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  PURDUE RESEARCH FOUNDATION

发明人： Vadim Moskvin ,  Keith Michael Stantz

IPC分类号： A61N5/00 ,  A61N5/10 ,  A61B8/08 ,  A61B19/00

CPC分类号： A61N5/1071 ,  A61B8/08 ,  A61B8/0833 ,  A61B8/483 ,  A61B2019/524 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1075 ,  A61N2005/1034 ,  A61N2005/1076 ,  A61N2005/1087

摘要： A method of verifying therapeutic beam delivery accuracy by ultrasound tomographic imaging to map three dimensional (3D) dose through the detection of ionizing radiation induced thermo-acoustic signal from the proton beam.

摘要翻译： 一种通过超声断层成像来验证治疗束传递精度的方法，通过从质子束检测电离辐射引起的热声信号来映射三维（3D）剂量。

公开(公告)号：US20170013703A1

公开(公告)日：2017-01-12

申请号：US15115335

申请日：2014-04-04

申请人： Mitsubishi Electric Corporation

发明人： Kengo SUGAHARA ,  Shuhei ODAWARA ,  Kazuhiro NISHI

IPC分类号： H05H7/12 ,  H05H7/00 ,  A61N5/10

CPC分类号： H05H7/12 ,  A61N5/1043 ,  A61N5/1071 ,  A61N2005/1087 ,  H05H7/001 ,  H05H7/10 ,  H05H13/04 ,  H05H2007/004 ,  H05H2007/008 ,  H05H2277/11

摘要： A device controller controls an acceleration-related devices and an extraction-related devices of an accelerator for accelerating and extracting a particle beam, in such a way that the controller checks, at a time point when receiving a master clock pulse, that preparation for operating the acceleration-related devices is completed and then commands the acceleration-related devices to operate in accordance with an operation pattern corresponding to a prescribed energy of the particle beam, and commands the acceleration-related devices to operate in accordance with an extracting operation pattern when an extraction enable signal indicating that the particle beam reaches the prescribed energy is turned ON and an extraction-related device setting-status signal indicating that completion of setting the extraction-related devices for the prescribed energy is ON.

摘要翻译： 设备控制器控制用于加速和提取粒子束的加速器相关设备和加速器的提取相关设备，使得控制器在接收到主时钟脉冲的时间点检查该操作的准备 加速相关装置完成，然后根据与粒子束的规定能量相对应的操作模式命令加速相关装置，并且根据提取操作模式命令加速度相关装置进行操作，当 指示粒子束达到规定能量的提取使能信号被接通，并且指示指定能量的提取相关装置的设定完成为ON的提取相关装置设定状态信号。

公开(公告)号：US20160361194A1

公开(公告)日：2016-12-15

申请号：US15121392

申请日：2015-02-26

申请人： KONINKLIJKE PHILIPS N.V.

发明人： GUILLAUME LEOPOLD THEODORUS FREDERIK HAUTVAST ,  DIRK BINNEKAMP

IPC分类号： A61F7/00 ,  A61N5/02 ,  A61N1/40 ,  A61N5/10 ,  A61N7/02

CPC分类号： A61F7/00 ,  A61B18/14 ,  A61B18/1815 ,  A61B18/24 ,  A61B2017/3413 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2018/2294 ,  A61B2034/2061 ,  A61B2090/378 ,  A61F2007/0086 ,  A61F2007/0088 ,  A61F2007/0096 ,  A61N1/406 ,  A61N5/025 ,  A61N5/1001 ,  A61N5/1027 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1071 ,  A61N7/02 ,  A61N7/022 ,  A61N2005/067

摘要： The invention relates to a system for applying radiation to a target region within a subject. An introduction element (12) like a brachytherapy catheter is inserted into the subject and a radiation source (10) is moved within the introduction element such that it is located within or close to the target region. The target region is heated, wherein the movement of the radiation source within the introduction element is controlled depending on the temperature along the introduction element. The susceptibility of the subject for the radiation emitted by the radiation source at a respective location along the length of the introduction element can depend on the temperature at the respective location such that by controlling the movement of the radiation source depending on the temperature along the length of the introduction element the application of the radiation can be optimized.

摘要翻译： 本发明涉及一种向受试者内的目标区域施加辐射的系统。 诸如近距离放射治疗导管的引入元件（12）被插入到受试者中，并且辐射源（10）在引入元件内移动，使得其位于或接近目标区域。 目标区域被加热，其中辐射源在引入元件内的移动根据引入元件的温度来控制。 辐射源在沿着导入元件的长度的相应位置处发射的辐射的受试者的敏感性可以取决于相应位置处的温度，使得通过根据沿着长度的温度控制辐射源的移动 的引入元件可以优化辐射的应用。

公开(公告)号：US20160339270A1

公开(公告)日：2016-11-24

申请号：US15115153

申请日：2015-01-30

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Susannah ELLSWORTH ,  Eric FORD ,  Stuart A. GROSSMAN ,  Robert HOBBS ,  Lawrence KLEINBERG

IPC分类号： A61N5/10

CPC分类号： A61N5/1071

摘要： The present invention discloses systems and methods for calculating the radiation doses received by circulating blood cells. The present method may be applicable for calculating the radiation doses by circulating blood cells through any site in a patient. The present invention also discloses computer systems for calculating radiation doses received by circulating blood cells in a patient.

摘要翻译： 本发明公开了用于计算通过循环血细胞接收的辐射剂量的系统和方法。 本方法可以适用于通过使血细胞循环通过患者的任何部位来计算辐射剂量。 本发明还公开了用于计算通过在患者中循环血细胞而接收的辐射剂量的计算机系统。

公开(公告)号：US20160339266A1

公开(公告)日：2016-11-24

申请号：US15189396

申请日：2016-06-22

申请人： BEST MEDICAL INTERNATIONAL, INC.

发明人： Manny Subramanian

IPC分类号： A61N5/10 ,  A61M25/00 ,  A61M25/10

CPC分类号： A61N5/1002 ,  A61M25/0017 ,  A61M25/1011 ,  A61M25/10181 ,  A61M2210/1067 ,  A61M2210/1089 ,  A61N5/1071 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1018 ,  A61N2005/1021

摘要： According to one general aspect, there is a multi-balloon catheter for medical applications that includes a multi-balloon inflator that inflates multiple balloons on a single catheter, an extraction point used to remove human fluids from the human body, and a connecting point that allows a syringe or a machine to insert air or any other liquid, such as a liquid saline solution, for inflation of a corresponding balloon of the multiple balloons or insert radioactive isotopes into the multi-balloon inflator.

摘要翻译： 根据一个一般方面，存在用于医疗应用的多气囊导管，其包括在单个导管上使多个气囊膨胀的多气囊充气器，用于从人体去除人体流体的提取点，以及连接点 允许注射器或机器插入空气或任何其它液体，例如液体盐水溶液，用于充气多个气球的相应球囊或将放射性同位素插入到多气球充气机中。

公开(公告)号：US09480858B2

公开(公告)日：2016-11-01

申请号：US13035364

申请日：2011-02-25

申请人： John Allen ,  Kevin John Brown

发明人： John Allen ,  Kevin John Brown

IPC分类号： G21K1/02 ,  A61N5/10 ,  G01R33/48

CPC分类号： A61N5/1049 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1054 ,  A61N2005/1055 ,  G01R33/4808

摘要： A radiotherapy system comprises a patient support, moveable along a translation axis, an imaging apparatus, comprising a first magnetic coil and a second magnetic coil, the first and second magnetic coils having a common central axis parallel to the translation axis, and being displaced from one another along the central axis to form a gap therebetween, the imaging apparatus being configured to obtain an image of a patient on the patient support, a source of radiation mounted on a chassis, the chassis being rotatable about the central axis and the source being adapted to emit a beam of radiation through the gap along a beam axis that intersects with the central axis, a multi-leaf collimator comprising a plurality of elongate leaves movable between at least a withdrawn position in which the leaf lies outside the beam, and an extended position in which the leaf projects across the beam, and a radiation detector mounted to the chassis opposite the source, the radiation detector having a plurality of detector elements aligned with the elongate leaves when projected onto an isocentric plane.

摘要翻译： 放射治疗系统包括可沿着平移轴线移动的患者支架，包括第一电磁线圈和第二电磁线圈的成像装置，所述第一和第二磁线圈具有平行于所述平移轴的公共中心轴线， 另一个沿着中心轴线在其间形成间隙，成像装置被配置为获得病人支撑物上的患者的图像，安装在底盘上的辐射源，底盘可围绕中心轴线旋转， 适于沿着与所述中心轴相交的束轴发射通过所述间隙的辐射束;多叶准直器，包括多个细长叶片，所述多叶片准直器至少在所述叶片位于所述梁的外部的撤回位置之间移动， 延伸位置，其中叶片跨过梁进行突出，以及辐射检测器，安装到底盘与源相对，辐射探测器具有ap 当投影到等中心平面上时，检测器元件与细长叶片对准的灵敏度。

公开(公告)号：US20160296766A1

公开(公告)日：2016-10-13

申请号：US15095827

申请日：2016-04-11

申请人： The General Hospital Corporation

发明人： Georges El Fakhri ,  Nathaniel Alpert ,  Xuping Zhu ,  Kira Grogg

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N2005/1052 ,  A61N2005/1087

摘要： The present disclosure provides a system and method for method for quantifying radioactivity production during a proton treatment of a patient. In some aspects, a method includes administering, using a proton delivery system, a proton treatment using at least one therapeutic proton beam generating positron emitting radionuclides within a region of interest (ROI) of a patient, and acquiring, using an emission tomography system, emission tomography data indicative of an activity of the positron emitting radionuclides in the ROI. The method also includes quantifying, based on a kinetic model, a radioactivity production rate of at least one positron emitting radionuclide using the emission tomography data. The method further includes generating at least one map indicative of the radioactivity production rate of the at least one positron emitting radionuclide.

摘要翻译： 本公开提供了一种用于在患者的质子治疗期间量化放射性产生的方法的系统和方法。 在一些方面，一种方法包括使用至少一种治疗性质子束来施用质子处理，质子治疗产生在患者的感兴趣区域（ROI）内发射放射性核素的正电子，并且使用发射断层摄影系统， 发射层析成像数据表示ROI中正电子发射放射性核素的活性。 该方法还包括基于动力学模型，使用发射断层摄影数据量化至少一个正电子发射放射性核素的放射性产生速率。 所述方法还包括产生至少一个指示所述至少一个正电子发射放射性核素的放射活性产生速率的图。

公开(公告)号：US20160279445A1

公开(公告)日：2016-09-29

申请号：US14778515

申请日：2014-03-18

申请人： SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

发明人： Sang Gyu JU

IPC分类号： A61N5/10 ,  B29C67/00 ,  G06F19/00

CPC分类号： A61N5/1075 ,  A61B6/583 ,  A61N5/1039 ,  A61N5/1045 ,  A61N5/1071 ,  A61N2005/1074 ,  A61N2005/1076 ,  B29C64/386 ,  B29L2031/753 ,  G09B23/286 ,  G09B23/30 ,  G16H50/50

摘要： An apparatus and method for generating print data about a phantom customized to a patent, the apparatus receive medical images including anatomical information of a patient's body and treatment plan information about a dose distribution of a radiation to be irradiated to a treatment area, reconstructs a three-dimensional phantom image in which internal and external structures of the patient's body are modeled which are based on the anatomical information and in which a space for a dosimeter is modeled which is to be inserted into the internal and external structures so as to verify the dose distribution according to the treatment plan information, and generates print data for three-dimensional printing, which is used for manufacturing the phantom customized to the patient on the basis of the reconstructed three-dimensional phantom image.

摘要翻译： 用于产生关于专利定制的幻影的打印数据的装置和方法，该装置接收包括患者身体的解剖信息的医学图像和关于待照射到治疗区域的辐射的剂量分布的治疗计划信息，重建三个 其中建模患者身体的内部和外部结构是基于解剖学信息并且其中用于剂量计的空间被建模以插入到内部和外部结构中以便验证剂量的维度幻影图像 根据处理计划信息分配，并且基于重建的三维幻影图像生成用于制造针对患者定制的体模的三维打印用打印数据。