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公开(公告)号：US11772104B2
公开(公告)日：2023-10-03
申请号：US16908341
申请日：2020-06-22
IPC分类号： B04B1/20
CPC分类号： B04B1/20 , B04B1/2008
摘要： A decanter centrifuge includes one or more nozzles through which a slurry may be discharged from a feed chamber into a separation zone within a centrifuge bowl. A scroll conveyor may be coaxially aligned in the separation zone within the centrifuge bowl around the circumference of the feed chamber. In the separation zone, the slurry can be separated into at least a light phase and a heavy phase by centrifugal acceleration generated by rotation of the centrifuge bowl, the feed chamber, and/or the scroll conveyor. Each separated phase can discharge from the centrifuge bowl via respective discharge ports. Each nozzle may include a rectangular aperture and differentiated profiles of its leading edge and trailing edge. In some embodiments, the leading edge of the aperture comprises a rounded profile, while the trailing edge comprises an abrupt edge or a less-rounded edge.
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公开(公告)号：US11766508B2
公开(公告)日：2023-09-26
申请号：US16767403
申请日：2018-12-06
申请人： Biosafe S.A.
发明人： Julien Camisani , Pau Mato Sabat
CPC分类号： A61M1/0209 , A61M1/025 , A61M1/0272 , B01D21/262 , B01D21/302 , B01D21/34 , B04B5/0442 , B04B13/00 , B04B15/02 , A61M2202/0413 , A61M2205/3372 , A61M2205/3673
摘要： Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12, 22, 32, 42) and via one or more valve arrangement.
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公开(公告)号：US20230294113A1
公开(公告)日：2023-09-21
申请号：US18022979
申请日：2021-06-29
发明人： Ryo Sato , Masayuki Shiina , Hidetaka Osawa , Ken Asakura , Hiroshi Hayasaka
CPC分类号： B04B15/06 , B04B5/0414 , B04B13/00
摘要： A washing liquid distribution element attached to an upper portion of a rotor body includes an upper distribution element and a lower distribution element. A washing liquid is supplied from a washing liquid introduction port during rotation of a rotor and enters a recessed inner portion of the lower distribution element. The washing liquid entered in the inner portion moves from the vicinity of rotation center toward a radially outer side to climb an inclined part by centrifugal force. Washing liquid passages are formed in a radial pattern at a lower annular part at a tip of the inclined part, and the washing liquid is discharged radially outward from discharge ports of the washing liquid passages. Formation of the inclined part makes it possible to evenly distribute the washing liquid into test tubes.
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公开(公告)号：US20230294111A1
公开(公告)日：2023-09-21
申请号：US18183662
申请日：2023-03-14
申请人： Fenwal, Inc.
发明人： Mark C. Weber , Mark Ern , Michael J. Kast , James C. Han
CPC分类号： B04B5/10 , B04B7/08 , A61M1/3693 , H02J50/005 , B04B2013/006
摘要： A centrifuge assembly including a rotating component and an active electronic device associated with the rotating component. The active electronic device being powered by a contactless power source.
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公开(公告)号：US20230271199A1
公开(公告)日：2023-08-31
申请号：US18313639
申请日：2023-05-08
CPC分类号： B04B13/00 , B01L3/502715 , B01L3/50273 , B04B5/02 , G01N21/07 , G01N35/00069 , G01N35/04 , B01L2200/0647 , B01L2200/143 , B01L2300/0803 , B01L2400/0409 , G01N2035/0491 , G01N2201/06113 , G01N2201/1087
摘要： Provided are methods and apparatuses for controlling a position of a target point on a processing result relative to a focus point of a focusing sensor system for determining properties of the processing result. The method includes the steps of determining an initial focus point of the focusing sensor system, controlling rotation of the cartridge and disc, checking whether the initial focus point of the focusing sensor system corresponds to the target point on the processing result, comparing (x, y) target positions in captured images with the initial focus point of the focusing sensor system, adjusting rotation of the cartridge and disc such that the focus point of the focusing sensor system corresponds to the target point on the processing result, and detecting and examining signals received from the focusing sensor system for determining properties of the processing result.
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公开(公告)号：US11717769B2
公开(公告)日：2023-08-08
申请号：US16985894
申请日：2020-08-05
CPC分类号： B01D11/048 , B01D11/0434 , B01D11/0461 , B01D11/0484 , B04B1/02 , G01H9/004
摘要： Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation.
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公开(公告)号：US11707749B2
公开(公告)日：2023-07-25
申请号：US16955688
申请日：2018-12-04
发明人： Kenji Morita
摘要： A disc-type centrifuge is configured to use clean water as sealing water to be supplied at high pressure to a sealing mechanism unit. A pump is disposed on a circulation pathway connecting a sealing water tank, in which the sealing water is stored, and the sealing mechanism unit. The sealing water (clean water) is circulated between the sealing water tank and the sealing mechanism unit by the pump. The pump is connected to the drive shaft of a motor that supplies a driving force to a rotating shaft and bowl and is configured so that the pump is operated by receiving the driving force of the motor.
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公开(公告)号：US11692170B2
公开(公告)日：2023-07-04
申请号：US16915818
申请日：2020-06-29
申请人： Terumo BCT, Inc.
CPC分类号： C12N5/0641 , A61M1/0209 , A61M1/26 , A61M1/262 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3616 , A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
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公开(公告)号：US11679193B2
公开(公告)日：2023-06-20
申请号：US16226452
申请日：2018-12-19
申请人： Fenwal, Inc.
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/3683 , A61M1/3693 , A61M1/38 , B01D17/0217 , B04B13/00 , A61M1/303 , A61M2202/0439 , A61M2205/053 , A61M2205/3368 , B01D2221/10
摘要： A method for prophylaxis or treatment of a graft's rejection of a recipient, driven and adjusted by a microprocessor-based controller. Provided is a fluid circuit comprising a first container configured to receive a transplant component and a second container configured to receive an apoptotic component. Provided is a separator configured to associate with the fluid circuit and separate whole blood into a red blood cell component, a plasma component, and a white blood cell component. Whole blood is directed into the fluid circuit and the separator. The whole blood is separated into the red blood cell component, the plasma component, and the white blood cell component. A first portion comprising the transplant component of the white blood cell component is directed to the first container. A second portion of the white blood cell component is directed to the second container and the second portion is rendered apoptotic.
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公开(公告)号：US20230176062A1
公开(公告)日：2023-06-08
申请号：US18083279
申请日：2022-12-16
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/034 , B03C1/288 , B03C1/0332 , B03C1/0335 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B5/0442 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , B01L3/5021 , B03C2201/18 , B03C2201/26
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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